• Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (cusabio.com)
  • In humans, deglycosylation of Gc-globulin, involving stepwise removal of [beta]-galactose and sialic acid from the trisaccharide, leaving N-acetyl-galactosamine (GalNAc), produces a potent macrophage-activating factor (Gc-MAF) (3). (thefreedictionary.com)
  • The objective of the review is to assess the current approaches and techniques for studying the effects of environmental chemicals on alveolar macrophages by illustrating the effects and chemical compounds that have been studied and relating the observed changes to the potential health risk of the host. (epa.gov)
  • The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. (up.ac.za)
  • It has become increasingly clear that tumor cells cooperate with environmental factors, including other cell types in the tumor, such as fibroblasts, macrophages, platelets, and endothelial cells, as well as extracellular matrix, to metastasize ( 5 - 7 ). (pnas.org)
  • For example, a majority of prostanoids produced by macrophages are PGE2 and TXA2, while the major prostanoid produced by vascular endothelial cells is PGI2. (biomedcentral.com)
  • In one study, it was shown that the number of macrophages, a type of immune cells, in an area of injury was 50% lower if the individual had a SCI and another study found that the properties of the healed skin was inferior in terms of strength and function in individuals with SCI. (willingsford.com)
  • In conclusion, AM stromal matrix induces apoptosis of IFN-gamma activated, but not non-activated macrophages, not through the generation of NO, but instead by down-regulating anti-apoptotic NF-kappaB and Akt-FKHR signalling pathways. (saladgaffe.cf)
  • Kate Sedivy-Haley is a PhD candidate in Dr. Robert E Hancock and is working to develop a screening technique using ES-cell derived macrophages. (ubc.ca)
  • For example, with gram-positive bacteria, bacterial peptidoglycan (from cell walls) is digested by macrophages, releasing somnogenic muramyl peptides (these are the monomeric building blocks of bacterial cell walls). (wsu.edu)
  • The inhibitory effect depended on the ability of mast cell-derived histamine, released from the exocytosed granules into the medium, to bind the copper ions necessary for propagation of the macrophage-initiated oxidation of LDL. (courtfield.tk)
  • Two bone-marrow-derived macrophage cell lines, c2d and c2dt, were isolated from major histocompatibility class ii negative knock-out mice! (fjaconsulting.com.au)
  • BURLINGAME, Calif.--(BUSINESS WIRE)--Humanigen, Inc., (HGEN) (Humanigen), a clinical stage biopharmaceutical company focused on preventing and treating cytokine storm with lenzilumab, the companys proprietary Humaneered anti-human granulocyte macrophage-colony stimulating factor (GM-CSF) monoclonal antibody, announced data on the first clinical use of lenzilumab in 12 COVID-19 patients. (stemcelltherapy.tv)