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  • acute
  • Macrolides target cells of both the innate and adaptive immune systems, as well as structural cells, and are beneficial in controlling harmful inflammatory responses during acute and chronic bacterial infection. (hindawi.com)
  • cardiac
  • It follows research first reported by Pulse in September last year finding macrolides were associated with an increased risk of cardiac death. (pulsetoday.co.uk)
  • inflammation
  • With macrolide therapy in DPB, great reduction in bronchiolar inflammation and damage is achieved through suppression of not only neutrophil granulocyte proliferation but also lymphocyte activity and obstructive secretions in airways. (wikipedia.org)
  • These secondary anti-inflammatory activities of macrolides appear to be particularly effective in attenuating neutrophil-mediated inflammation. (hindawi.com)
  • treatment
  • It can be used in horses less than one year old, but care must be taken that other horses (such as a foal's mother) do not come in contact with the macrolide treatment. (wikipedia.org)
  • This is evident, as the treatment dosage is much too low to fight infection, and in DPB cases with the occurrence of the macrolide-resistant bacterium Pseudomonas aeruginosa, macrolide therapy still produces substantial anti-inflammatory results. (wikipedia.org)
  • clinical
  • We searched clinical trial registries for current and completed trials (9 May 2018) and checked the reference lists of included studies and of previous Cochrane Reviews on macrolides. (cochrane.org)
  • activity
  • Finally, the researchers found that the use of macrolides was associated with a decreased level of bile salt hydrolase, en enzyme in the intestinal microbiome, indicative of signaling between the host produced bile via the enzymatic activity of the intestinal microbiota and important regulators. (wur.nl)
  • patients
  • Dr Brian Crichton, honorary lecturer in therapeutics and pharmacology at the University of Warwick, said: 'It does create a question-mark over our use of macrolides in patients with CVD. (pulsetoday.co.uk)
  • agents
  • The ketolide, telithromycin, also has excellent penetration into bronchopulmonary tissues and macrophages, while macrolides and macrolide-like agents are also accumulated by polymorphonuclear leukocytes (PMNL), which, in turn, effect the active delivery of these agents to sites of bacterial infection [ 3 , 6 ]. (hindawi.com)