The endothelial abnormalities observed in patients with diabetes mellitus are poorly understood, and evidence suggests that endothelial dysfunction could be involved in the pathogenesis of diabetic macroangiopathy and microangiopathy. (elsevierpure.com)
Nephropathy4
Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Pathogenesis2
This article reviews the process of microvascular dysfunction and how it may relate to the pathogenesis of diabetic foot problems. (elsevierpure.com)
Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
Microangiopathy1
When there are two types of diabetes vascular lesion: large - macroangiopathy and small - microangiopathy. (rv.ua)
Microvascular3
Microvascular dysfunction is an important component of the pathologic processes that occur in diabetic foot disease. (elsevierpure.com)
In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Glucose7
Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
Triglyceride-glucose (TyG) index as a reliable surrogate of insulin resistance (IR) has been shown to be related to adverse clinical outcomes in patients with acute coronary syndrome, heart failure, ischemic stroke and so on. (biomedcentral.com)
This was a retrospective observational study that included 3026 patients who had an initial triglyceride and glucose data on the first day of ICU admission, and all data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. (biomedcentral.com)
On the other hand, fasting blood glucose level of the non-diabetics correlated strongly with the severity of hemiparesis and predicted stroke outcome. (docksci.com)
A statistically significant correlation was observed between blood glucose values and the volumes of cortical infarcts in non-diabetics. (docksci.com)
In clinical strdies the emphasis has been on blood glucose values during the first few days after stroke The clinical relevance of the blood glucose level is difficult to assess as the level is modified by many factors such as diabetes, latent diabetic state, timing of blood sampling, intravenous infusions containing glucose, and stress. (docksci.com)
1988a) did not find a correlation between admission serum glucose concentration and neurologic outcome in patients with cerebral infarction. (docksci.com)
Diabetes11
Frequent and serious complication of diabetes are also oklyuzionnye vascular limbs, which usually leads to the development of gangrene and amputation, which in turn causes the growth of early disability of patients and deaths. (rv.ua)
With this in mind, there is no doubt that, to prevent severe complications of diabetes and stabilization of the disease, patients should receive adequate systemic therapy aimed at improving the microcirculation in the tissues and the stabilization of metabolic processes in them. (rv.ua)
Along with medication, phytotherapeutic means having a mild and versatile effect, can be successfully used in conjunction with diet as a base therapy in the treatment of patients with latent or mild form of diabetes. (rv.ua)
For the treatment of patients with diabetes secondary to severe disease herbs can be used as aids to the calculation of the possible lower dosages of medicines, providing a more long-term remission, prevention of complications. (rv.ua)
Number of observations was 23 patients of different age and sex with different forms and severity of diabetes. (rv.ua)
Products selected for testing in patients with diabetes due to the possibility of its positive effects on different types of metabolism of the body and improve the trophic tissue. (rv.ua)
Precisely what causes it is not fully known, but diabetics have increased risk of both heart attack and stroke, so some of the tissue damage diabetes produces may be involved. (wikipedia.org)
In this review we highlight areas in which these studies provided vital insights into the criteria used to diagnose type 2 diabetes, the pathophysiologic changes that accompany the development of type 2 diabetes, and the course and determinants of diabetes complications-focusing specifically on diabetic kidney disease. (bvsalud.org)
We include data from our longitudinal population-based study of diabetes and its complications, studies on the role of insulin resistance and insulin secretion in the pathophysiology of type 2 diabetes, and in-depth studies of diabetic kidney disease that include measures of glomerular function and research kidney biopsies. (bvsalud.org)
This clinical study enrolled 163 type 2 diabetes mellitus (T2DM) patients, who were divided into the diabetes with DF (84 cases) group, diabetes with no DF (79 cases) group. (biomedcentral.com)
In Lebanon, the preva- could be achieved in order to support main indication was recorded for each lence of type 2 diabetes was 13.1% for the development of programmes for patient from either trauma, diabetes, those aged 30+ years in 1994-95 [2] amputation prevention and care. (who.int)
Complications2
By FIR irradiation, we can prove the protective effect of PLZF on vascular endothelium in diabetic vascular complications, and identify the detailed mechanism in this project. (tmu.edu.tw)
The finding in this project will provide a potential non-invasion therapy for diabetic vascular complications. (tmu.edu.tw)
Neuropathy4
Amyotrophy A type of diabetic neuropathy that causes muscle weakness and wasting. (wikipedia.org)
In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
RESULTS: Patients with more severe neuropathy had less corneal endothelial cells (3105 +/- 218 vs. 2537 +/- 142 vs. 2350 +/- 73/mm3 vs. 1914 +/- 465/mm3, P = 0.02), higher serum NGF (36 +/- 15 vs. 60 +/- 57.66 vs. 80 +/- 57.63 vs. 109 +/- 60.81 pg/mL, P = 0.39) and tear NGF levels (135.00 +/- 11.94 vs. 304.29 +/- 242.44 vs. 538.50 +/- 251.92 vs. 719.50 +/- 92.63 pg/mL, P = 0.01). (e-dmj.org)
Prevention2
Prevention of vascular disorders in diabetic patients using dietary supplements ART LIFE. (rv.ua)
Tomsk and Voronezh have been studied biologically active food additives (BAA) MEMORY RISE (production company ARTLIFE ) for the prevention and treatment of diabetic angiopathies, including diabetic foot. (rv.ua)
Disorders1
Among the several possibilities, e.g. micro- and macroangiopathy, hyperlipidemia and blood clotting disorders, the adverse effect of hyperglycemia on cerebral metabolism during ischemia have in the last decade been the focus of intensive research, both experimental Correspondence to: Karl Murros MD, Department of Neurology, Central Hospital of Central Finland, SF-40620 Jyviis~l[i, Finland. (docksci.com)
Severity2
Research suggests that fibrinogen (Fib) concentrations are used to assess the occurrence and severity of diabetic foot (DF) and to monitor the progression of diabetic foot in patients. (biomedcentral.com)
12 ] demonstrated that the critically ill patients occurred severe IR on the first day after admission to ICU, and IR was related to the severity of their condition rather than the different admission diagnoses of ICU patients. (biomedcentral.com)
Progression3
Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
The accumulation of advanced glycation end products (AGE) in diabetic patients can trigger apoptotic changes of vascular endothelial cells and involves in the development and progression of micro- and macroangiopathy. (tmu.edu.tw)
Complication3
Diabetic foot (DF) is a serious diabetic complication that refers to the destruction of the skin and deep tissues (including muscle and bone) distal to the ankle joint, often combined with arterial occlusion and infection of the lower extremity [ 1 ]. (biomedcentral.com)
A large clinical study found that peripheral vascular disease (PAD) in patients with T2DM is a serious complication. (biomedcentral.com)
Diabetic vascular complication accounts for disabilities and high mortality rates in diabetic patients. (tmu.edu.tw)
Insulin1
Diabetic patients must monitor their levels as body's inability to properly utilize and / or produce insulin can pose a serious threat to their health. (healthiack.com)
Mortality4
However, the relationship between TyG index and all-cause mortality in intensive care unit (ICU) patients remains unknown. (biomedcentral.com)
Kaplan-Meier analysis showed that the risk of all-cause mortality was significantly higher in patients with higher TyG index (log-rank P = 0.021). (biomedcentral.com)
TyG index is strongly related to the all-cause mortality increasing in critically ill patients. (biomedcentral.com)
Patients in intensive care unit (ICU) usually have a longer duration of mean stay and extremely high mortality rates, placing a heavy burden to the family and society [ 1 ]. (biomedcentral.com)
Biomarkers1
Therefore, we urgently need to explore novel biomarkers, mechanisms, and targeted measures in ICU patients. (biomedcentral.com)
Early2
Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
Accordingly, it is critical to identify early IR in critically ill patients. (biomedcentral.com)
Micro1
The occurrence of diabetic foot is closely related to micro-angiopathy, micro-thrombosis in the lower limb, which may predate the presentation of diabetic foot. (biomedcentral.com)
Type1
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
Blood1
Angiopathy A process that damages the blood vessels. (wikipedia.org)
Studies2
However, most of the relevant studies have focused on the analysis of risk factors associated with the diabetic foot and comprehensive management. (biomedcentral.com)
Some studies have included glycosylated haemoglobin (HbAlc) measurements in order to diagnose those patients with prestroke hyperglycemia. (docksci.com)
Serum3
We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
From IVCCM, we measured corneal nerve density, branch, and tortuosity, total corneal/epithelial thickness, and the number of endothelial/keratocyte cells, and we checked patients' biochemical profiles and serum and tear NGF levels. (e-dmj.org)
Medical1
It can lead to diabetic ketoacidosis, a medical emergency. (wikipedia.org)
Large1
A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
Risk factors1
The Framingham study revealed that the risk of ischemic brain infarction in diabetics, after adjustment for several other risk factors, is twice that of non-diabetics (Kannel and McGee 1979). (docksci.com)
Levels1
Produced in high levels during periods of stress, infection, etc possibly leading to diabetic ketoacidosis, a very serious condition. (wikipedia.org)
Years2
During 10.46 years of follow-up, 1148 (37.9%) patients died, of which 350 (11.6%) occurred during the hospital stay and 258 (8.5%) occurred during the ICU stay. (biomedcentral.com)
Summary From August 1987 through December 1989 all consecutive conscious patients younger than 70 years with a recent ( (docksci.com)
Data2
The data of cellular experiments will be further proved in streptozotocin(STZ)-induced diabetic mice. (tmu.edu.tw)
However, current data about associations between TyG index and critically ill patients are limited, whether TyG index was an independent factor of prognosis in ICU patients has not been determined yet. (biomedcentral.com)