• Previously considered a pioneer for using both biological and synthetic scaffolds seeded with patients' own stem cells as trachea transplants, Macchiarini was a visiting professor and director on a temporary contract at Sweden's Karolinska Institutet (KI) from 2010. (wikipedia.org)
  • Macchiarini has been accused of unethically performing experimental surgeries, even on relatively healthy patients, resulting in fatalities for seven of the eight patients who received one of his synthetic trachea transplants. (wikipedia.org)
  • Macchiarini performed two synthetic trachea transplants on Yesim Cetir, 26, in Stockholm in 2012 and 2013, but she suffered brutal complications until her death. (thelocal.se)
  • The completely artificial trachea doesn't simply symbolize a more streamlined future of transplants, it also celebrates a "beautiful international collaboration," says Macchiarini. (collegenews.com)
  • Professor Macchiarini has previously performed successful transplants of tissue-engineered tracheas, but on those occasions the tracheas used were taken from organ donors and then reseeded with the patient s own stem cells. (regenerativemedicine.net)
  • tissue-engineered synthetic trachea transplants would, not least, be of great value for children, since the availability of donor tracheas is much lower than for adult patients. (regenerativemedicine.net)
  • In fact, trachea transplants have been one of the last big challenges in this area of medicine. (ctpublic.org)
  • I researched trachea transplant because I figured they do transplants for everything else. (ctpublic.org)
  • In a notable advance in organ transplants, surgeons at UC Davis Medical Center have restored the voice of a woman who couldn't speak on her own through a transplant of the larynx, thyroid and trachea. (plasticsurgeryinflorida.com)
  • a few months later he did a trachea transplant there which was widely covered in Russian media. (wikipedia.org)
  • To his patients, the Italian surgeon embodied a second chance at life through a first-of-its-kind synthetic trachea transplant. (flipboard.com)
  • The reason for that optimism was because since 2008 they have already been able to grow and transplant relatively 'uniform-shaped' organs like a trachea . (science20.com)
  • This is one of the most difficult to transplant organs of the human body, firstly, because of the huge number of small blood vessels, without which the trachea is not viable, and secondly, because of its proximity to the aggressive environment of the outside world and the high risk of infection. (vechnayamolodost.ru)
  • Headlines around the world once hailed Paolo Macchiarini as a super-surgeon, a stem cell trailblazer who was responsible for the ground-breaking, first-ever stem cell-based trachea transplant. (blogspot.com)
  • Macchiarini served on Belafsky's international team in 2010 when the Belafsky group performed the second-ever larynx transplant . (blogspot.com)
  • The statement also said that Martin Birchall of the United Kingdom, a co-leader with Macchiarini on his ground-breaking 2008 transplant surgery, served as a scientific advisor and assisted with the California larynx surgery. (blogspot.com)
  • Because the cells used to regenerate the trachea were the patient's own, there has been no rejection of the transplant, and the patient is not taking immunosuppressive drugs. (globenewswire.com)
  • The trachea is basically a tube that transports air to and from the lungs, so you might think it would be easy to transplant. (ctpublic.org)
  • But the biggest challenge in a transplant is getting blood to the trachea. (ctpublic.org)
  • This dogma kind of stuck, and so if you look at the literature, you'll see hundreds and hundreds of articles that start out 'here's how we are going to reconstruct the trachea because we can't transplant it,'" Genden says. (ctpublic.org)
  • Here is the amazing story of how a man with cancer of the trachea (and no other remaining treatment options) was treated with a tracheal transplant created from "scratch" in the tissue engineering lab, using the patient's own stem cells. (plasticsurgeryinflorida.com)
  • Only one of the patients survived after having a synthetic trachea, designed and implanted by Macchiarini, removed during a surgery in Russia in 2014. (thelocal.se)
  • For instance, an analysis of the rat trachea implantations carried out late in 2012 and early 2013, after the patients had been transplanted, will reveal that synthetic trachea implantation is a failure with the development of chronic inflammation and infection and finally graft occlusion. (sjukhuslakaren.se)
  • For first time in history, a patient has been given a new trachea made from a synthetic scaffold seeded with his own stem cells in Harvard Bioscience's bioreactor. (globenewswire.com)
  • Now that our bioreactor has proven it can be used to seed a patient's cells onto a synthetic (i.e., manmade) scaffold, patients will not need to wait for a suitable donor trachea to become available. (globenewswire.com)
  • Since no suitable donor windpipe was available, the transplantation of the synthetic tissue-engineered trachea was performed as the last possible option for the patient, referred by Professor Tomas Gudbjartsson of Landspitali University Hospital (Iceland) who was also part of the surgical team. (regenerativemedicine.net)
  • One of the harshest critics of Macchiarini's 'method', Professor Pierre Delaere of the Catholic University of Leuven, told Elliott: "If I had the option of a synthetic trachea or a firing squad, I'd choose the last option because it would be the least painful form of execution. (przekroj.org)
  • In 2008, Italian surgeon Paolo Macchiarini garnered worldwide attention when he claimed to have transplanted a trachea he had grown from stem cells in the lab and had affixed to a synthetic skeleton. (ctpublic.org)
  • There is no doubt that the use of synthetic tracheas has been negligent and that it has entailed a deliberate risk-taking of a serious nature," the Swedish probe said. (gearsofbiz.com)
  • According to CNN , Macchiarini pushed science limits three years ago when he created an artificial windpipe combining donor tissue and the patient's stem cells. (collegenews.com)
  • To make the new airway, the doctors took a donor windpipe, or trachea, from a patient who had recently died. (bbc.co.uk)
  • With the sequence to the fact Macchiarini has also told BBC "I am now thinking to use this technique for treating a nine month old child of Korea, who was born along with a malformed trachea or windpipe. (healthdoctrine.com)
  • And in 2008, members of a team that included Dr. Macchiarini said they had given a patient a new windpipe made partly from her own cells, and partly from "scaffolding" material taken from a cadaver. (plasticsurgeryinflorida.com)
  • When the tumor reached about six centimeters in length it almost completely blocked the trachea, or windpipe, making it hard for the patient to breathe. (plasticsurgeryinflorida.com)
  • With the patient on the surgery table, Dr. Macchiarini and colleagues then added chemicals to the stem cells, persuading them to differentiate into tissue-such as bony cells-that make up the windpipe. (plasticsurgeryinflorida.com)
  • Dr. Paolo Macchiarini, a professor of regenerative medicine at Stockholm's Karolinska University Hospital where the procedure took place, described the process saying, "Stem cells from the own patient were growing inside and outside. (collegenews.com)
  • He was condemned to die," said Paolo Macchiarini, a professor of regenerative surgery who carried out the procedure at Sweden's Karolinska University Hospital. (plasticsurgeryinflorida.com)
  • The surgeon gained worldwide fame in 2011 by carrying out the world's first graft of an artificial plastic trachea, which was to be colonized by the patients' stem cells. (thelocal.se)
  • The Karolinska Institute may reopen its investigation into the work of artificial trachea researcher Paolo Macchiarini based on stories presented in a Swedish documentary series. (the-scientist.com)
  • However, the Paolo Macchiarini scandal involving the artificial implanted tracheas has probably made many people reconsider their views. (lu.se)
  • The whistle-blowers were concerned that Macchiarini may have distorted the facts about his operations with artificial tracheas when he presented them in scientific journals. (thelocal.com)
  • This Swiss-born Italian had developed an innovative method of implanting an artificial trachea. (przekroj.org)
  • Using adult stem cells from her bone marrow, the team created a scaffold and grew the new trachea. (science20.com)
  • Then they used strong chemicals and enzymes to wash away all of the cells from the donor trachea, leaving only a tissue scaffold made of the fibrous protein collagen. (bbc.co.uk)
  • 3 Donor trachea "scaffold" coated with stem cells from the patient's hip bone marrow. (bbc.co.uk)
  • Professor Macchiarini led an international team including Prof. Alexander Seifalian from University College in London, England, who designed and built the nanocomposite tracheal scaffold, and Harvard Bioscience, who produced a specifically designed bioreactor used to seed the scaffold with the patient's own stem cells. (globenewswire.com)
  • Paolo Macchiarini (born 22 August 1958) is a Swiss-born Italian thoracic surgeon and former regenerative medicine researcher who became known for research fraud and manipulative behavior. (wikipedia.org)
  • On the basis of the Kuban Medical University, Italian surgeon Paolo Macchiarini is deploying a laboratory of regenerative medicine as part of the development of a megagrant. (vechnayamolodost.ru)
  • David Green, President of Harvard Bioscience, commented, "We congratulate Professor Macchiarini and the entire scientific and surgical team on achieving this landmark in the history of regenerative medicine. (globenewswire.com)
  • Later in 2010, Macchiarini was appointed as a visiting professor at the Karolinska Institute (KI) in Stockholm and as a part-time position as surgeon at the affiliated university hospital. (wikipedia.org)
  • Italian surgeon Paolo Macchiarini. (thelocal.se)
  • A seventh patient of Italian surgeon Paolo Macchiarini, who was fired from a Swedish university over accusations of misconduct, has died. (thelocal.se)
  • Then the 9-hour operation was led by Dr. Paolo Macchiarini of the Karolinska Institute in Stockholm, the world's foremost surgeon in this area. (science20.com)
  • Footage of scandalous surgeon Paolo Macchiarini regenerative surgery transplanted trachea to patients in Russia and Europe. (tvdata.tv)
  • Italian surgeon Paolo Macchiarini has been judged to have committed research misconduct by the Swedish organisation in charge of reviewing research, the Central Ethical Review Board (CEPN). (thelocal.com)
  • Karolinska Institutet postulates that new pivotal evidence of scientific misconduct on the part of Dr Macchiarini et al. (sjukhuslakaren.se)
  • Prof Hamsten, along with the leadership of Karolinska Institutet and Karolinska University Hospital, freed Dr Macchiarini of suspicion of research misconduct in the face of an insurmountable body of evidence. (sjukhuslakaren.se)
  • The operation was performed on June 9, 2011 at Karolinska University Hospital in Huddinge, Stockholm, by Professor Paolo Macchiarini of Karolinska University Hospital and Karolinska Institutet, and colleagues. (globenewswire.com)
  • Some surgeons have temporarily tried transplanting tracheas into people's arms and letting them develop a new network of blood vessels before moving them to the throat. (ctpublic.org)
  • He realized that just a few blood vessels, about the diameter of spaghetti, could provide an adequate blood supply to the trachea. (ctpublic.org)
  • Hannah's parents, Darryl Warren and Lee Young-mi, said they had read about Macchiarini's work but could not afford the cost at Karolinska, so Dr. Mark Holterman got a Catholic hospital, Children's Hospital of Illinois, to waive the cost and they even brought in Macchiarini to lead the operation. (science20.com)
  • The CEPN will next make an assessment of Macchiarini's research articles on the trachea operations carried out at Karolinska. (thelocal.com)
  • Hannah's parents had read about Dr. Paolo Macchiarini's success using stem-cell based tracheas but couldn't afford to pay for the operation at his center, the Karolinska Institute in Stockholm. (aknottedlife.com)
  • Dr. Paolo Macchiarini, whose looks have drawn comparisons to George Clooney, entered their lives like an answer to their most heartfelt prayers. (flipboard.com)
  • The level of fuss raised at the Kuban Medical University by the arrival of Professor Paolo Macchiarini is such that it is immediately clear: the future has come here suddenly. (vechnayamolodost.ru)
  • Journalist Benita Alexander is swept off her feet by a dashing Italian doctor, Paolo Macchiarini, while filming a documentary about his miraculous surgeries. (aarp.org)
  • The second time he met the family in tears and they told him "we don't know what to do, our daughter is a prisoner in the hospital" and asked him to contact Dr. Paolo Macchiarini, which he promised to do when he gets back to Illinois. (blogspot.com)
  • The leadership of the Karolinska Institute, Sweden's most important medical centre, would certainly be pleased that they had managed to recruit Dr Paolo Macchiarini. (przekroj.org)
  • This above surgery has performed at the Karolinska University Hospital under the honorable guidance of an Italian Professor Paolo Macchiarini. (healthdoctrine.com)
  • Prosecutor Jennie Nordin said it can't be proven that Dr. Paolo Macchiarini would be guilty of either causing another's death or causing bodily harm, so he is no longer a suspect. (gearsofbiz.com)
  • Given that many procedures involve inserting a needle into the trachea without direct visualization of the tracheal wall, concerns have been raised over the needle punctures through the cartilaginous rings as compared to the space between them may result in fractured cartilage and post-tracheostomy airway complications. (bvsalud.org)
  • Previously, our bioreactor had been used to seed a patient's stem cells onto a donor trachea, so treatment was limited by the supply of donor organs. (globenewswire.com)
  • Cetir was the victim of two failed surgeries as her trachea was first badly damaged during treatment in Turkey before she received surgery in Stockholm. (thelocal.se)
  • Also in October, Sweden's Expert Group on Scientific Misconduct found evidence of research fraud by Macchiarini and his co-authors in six papers and called for them to be retracted. (wikipedia.org)
  • To now be contacted by Prof Carlstedt-Duke, one of the main authors of last years decision to free Dr Macchiarini, asking for more evidence of research fraud is just plain absurd. (sjukhuslakaren.se)
  • Urban Lendahl [sv], the secretary of the Nobel Committee for Physiology or Medicine, resigned in February 2016, owing to his involvement in recruiting Macchiarini to KI. (wikipedia.org)
  • was Deputy Editor-in-Chief of "Przekrój" Magazine and Przekroj.pl in 2016-2018 and Editor-in-Chief of "Przekrój" Magazine, Przekroj.pl and Przekroj.pl/en in 2019-2020. (przekroj.org)
  • Macchiarini was fired from Sweden's prestigious Karolinska Institute in March 2016 for breaching medical ethics after being accused of falsifying his resume and misrepresenting his work. (gearsofbiz.com)
  • After being dismissed from KI, Macchiarini worked at the Kazan Federal University in Russia until that institution terminated his project in April 2017, effectively firing him. (wikipedia.org)
  • Macchiarini obtained degree certificates-a masters in organ and tissue transplantation dated 1994 and a doctorate in the same dated 1997-from University of Franche-Comté in France. (wikipedia.org)
  • Moreover, Scientist at the University College London were performed a 3D scan on Andemariam Teklesenbet Beyene, a 36 years old African patient and with the help of the images they were now being able to craft a suitable and perfect copy of Beyene's trachea as well as out of glass the two main bronchi. (healthdoctrine.com)
  • After a one-year medico-legal investigation, the Swedish Prosecution Authority announced in October 2017 that Macchiarini had been negligent in four of the five cases investigated due to the use of devices and procedures not supported by evidence, but that a crime could not be proven because the patients might have died under any other treatment given. (wikipedia.org)
  • Primary tracheal resection with direct end-to-end anastomosis after release of the surrounding anatomical structures is insufficient when the length of trachea resected is greater than 50% in adults or 30% in children. (ersjournals.com)
  • Inhibition to tracheal surgery before 1960 was explained by difficulties related to perioperative ventilation, the poor healing capacity of cartilage and, finally, the "2-cm Belsey rule" stipulating that it was not possible to remove more than 2 cm of the trachea with primary reconstruction [ 1 ]. (biomedcentral.com)
  • Last year no amount of evidence was sufficient to pronounce Dr Macchiarini guilty. (sjukhuslakaren.se)
  • The CEPN concluded that Macchiarini and a number of the co-authors of the article were guilty of research misconduct. (thelocal.com)
  • Surgical sciences professor at Uppsala University Bengt Gerdin last year presented a report to the Karolinska Institute (KI) where he claimed that Macchiarini had been guilty of research misconduct in his work. (thelocal.com)
  • Shortly afterwards KI's vice chancellor, Anders Hamsten [sv], who in 2015 had cleared Macchiarini of misconduct, also resigned. (wikipedia.org)
  • Prof Hamsten certainly stated that he had "almost completely misjudged" Dr Macchiarini (5) but we cannot accept that Prof Hamsten consciously relied on the prejudiced opinion of several Professors including Lendahl, Tsai-Felländer, Cardell, Carlstedt-Duke, Kuylenstierna and Hermanson. (sjukhuslakaren.se)
  • Accusations of research misconduct were first levelled at Macchiarini in 2014, when four doctors at Karolinska University Hospital reported him to then KI president Anders Hamsten. (thelocal.com)
  • The trachea came from a cadaver, and was stripped of its cells and seeded with cells taken from Castillo's bone marrow. (wikipedia.org)
  • Dr. Macchiarini had good reason to feel emboldened: He had successfully transplanted cadaver-based windpipes in 10 patients. (plasticsurgeryinflorida.com)
  • The trachea, the tube that connects the voice box and enters both lungs, was then immersed in a solution that contained the patient's stem cells. (collegenews.com)
  • Macchiarini operated on eight patients between 2011 and 2014, three of them at the prestigious Stockholm-based Karolinska Institute, which selects the winners of the Nobel Prize in medicine. (thelocal.se)
  • The head of the board is not sure what has caused the surge, but states that it could be a result of the press coverage of the Macchiarini* affair that is encouraging other whistleblowers to come forward. (blogspot.com)
  • Dr. Macchiarini has had no involvement in this project on any level, in any way, at any time. (blogspot.com)
  • Macchiarini obtained his medical degree (equivalent to MD) at the Medical School of the University of Pisa (UniPi) in 1986 and a Master of Surgery in 1991. (wikipedia.org)
  • Professor Macchiarini focuses his efforts in thoracic surgery - operations in the chest area, more specifically- on the trachea. (vechnayamolodost.ru)
  • UC Davis issued a press release saying Macchiarini served as an advisor and assisted in the surgery. (blogspot.com)
  • Hannah had her surgery on April 9th, not only receiving a new trachea, but an operation on her esophagus as well, and then was breathing through a tracheostomy tube. (blogspot.com)
  • I was intubated too long so the trachea was damaged," she says, "so I went through surgery after surgery trying to repair it. (ctpublic.org)
  • In summary, using mobilization procedures, current surgical techniques permit the resection of approximately half of the adult trachea with reconstruction by primary anastomosis [ 3 ]. (biomedcentral.com)
  • Macchiarini himself admits that the university, despite having a solid clinical base, is "not big enough" for such a level of research, and in order to achieve significant results in two years, "it is necessary to accelerate very much," the professor warns with icy calm. (vechnayamolodost.ru)
  • By using Ms Castillo's own cells the doctors were able to trick her body into thinking the donated trachea was part of it, thus avoiding rejection. (bbc.co.uk)
  • And with no signs of rejection four months on, Professor Macchiarini says the future chance of rejection is practically zero. (bbc.co.uk)
  • So Dr. Mark Holterman helped the family arrange to have the procedure at his Peoria hospital, bringing in Macchiarini to lead the operation. (aknottedlife.com)
  • At the time of our submission for an appeal for an investigation of scientific misconduct by Dr Macchiarini on August 18, 2014 (1) it became obvious that more than the seven articles that we had analyzed contained manipulated data, but because of time constraints we had to limit the scope of that report. (sjukhuslakaren.se)
  • As of 2023, Macchiarini has had nine of his research papers retracted, four others have received an expression of concern, and three others have been corrected. (wikipedia.org)
  • The Macchiarini saga and its California connections offer a peek into the global nature of stem cell research and how scientists must rely on the integrity of others thousands of miles away -- as well as the sometimes agonizingly slow search for cures. (blogspot.com)
  • One of the four doctors who first reported Macchiarini for research misconduct in 2014 said he had been waiting for the CEPN's opinion. (thelocal.com)
  • In March, Macchiarini was acquitted of charges of research misconduct by KI's ethics council. (thelocal.com)
  • What compelled him to press forward was he realized the field's seminal research paper about complex blood supply to the trachea was just plain wrong. (ctpublic.org)
  • The Drosophila trachea is an interconnected network of epithelial tubes, which delivers gases throughout the entire organism. (bvsalud.org)
  • It would of course be inappropriate to discuss her earlier medical condition and treatment," Macchiarini said in a written comment to Swedish public broadcaster SVT. (thelocal.se)