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  • Genes
  • Interestingly, the p202 protein inhibits cell cycle progression in part through up-regulation of p21 CIP1 expression, by decreasing phosphorylation of Rb, and through inhibition of E2F-mediated transcription of growth-promoting genes ( 22 , 23 ). (aacrjournals.org)
  • The results of this report demonstrate that the transferred inducible expression system is a powerful tool for analyzing the function of ASFV genes. (asm.org)
  • Viral
  • Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus. (patentgenius.com)
  • At 4 days post-transfection, aliquots of each supernatant were inoculated onto vertebrate (BHK-21 and Vero) and mosquito (C6/36) cells which were then assayed for evidence of viral infection by reverse transcription-PCR, Western blot and plaque assay. (biomedcentral.com)
  • cellular
  • Here we use topological analysis of sRNA targets in terms of protein-protein interaction and transcription-regulatory networks in Escherichia coli to shed light on the global correlation between sRNA regulation and cellular control networks. (biomedcentral.com)
  • To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. (jove.com)
  • Increased expression of the IFI16 protein, a positive modulator of p53-mediated transcription, in normal old human diploid fibroblasts (HDF) is associated with cellular senescence-mediated cell growth arrest. (aacrjournals.org)
  • p53 is a transcription factor, which is activated in cells in response to certain stimuli, such as DNA damage, hypoxia, oxidative stress, or other cellular stress ( 16 - 18 ). (aacrjournals.org)
  • trigger
  • 2. The method of claim 1 wherein the fully processed RNAi trigger molecules are incorporated into a micro RNA (miRNA). (patentgenius.com)
  • small
  • PRRSV is a small, enveloped RNA virus belonging to the genus Arterivirus in the family Arteriviridae of the order Nidovirales ( 33 ). (asm.org)
  • found
  • As was found for the protein-protein interaction network, the targets that are regulated by the same sRNA also tend to be closely knit within the transcription-regulatory network (larger density, p-val = 0.036), and inward interactions between them are greater than the outward interactions (higher in-degree ratio, p-val = 0.023). (biomedcentral.com)
  • Which of these nitrogenous bases is found only in RNA? (cram.com)
  • Targets
  • In protein-protein interaction network, sRNA targets tend to occupy more central positions (higher closeness centrality, p-val = 0.022) and more cliquish (larger clustering coefficient, p-val = 0.037). (biomedcentral.com)
  • Namely, the sRNA targets show close interaction and forms a closely knit network module for both the protein-protein interaction and the transcription-regulatory networks. (biomedcentral.com)
  • In addition, in the transcription-regulatory network, sRNA targets act as "multiplexor", accepting regulatory control from multiple sources and acting accordingly. (biomedcentral.com)
  • approximately
  • 4. The method of claim 1, wherein the RNAi triggers target approximately 3.5, 2.1, 2, 4, or 0.7 kilo base pair RNAs of the HBV, or any subset thereof. (patentgenius.com)