• Description: A sandwich ELISA kit for detection of Lysyl tRNA Synthetase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jemsec.com)
  • Lysyl hydroxylase-2 (LH2) catalyzes the hydroxylation of telopeptidyl lysine residues on collagen, leading to the formation of stable collagen cross-links that connect collagen molecules and stabilize the extracellular matrix. (uky.edu)
  • The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. (ox.ac.uk)
  • Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. (nih.gov)
  • We further demonstrate that the procollagen lysyl hydroxylase ( PLOD1) promoter is regulated by Nkx2.5. (lu.se)
  • Mutations can exist in the genes that encode different types of collagen (eg, type I, III, or V) or collagen-modifying enzymes (eg, lysyl hydroxylase, a collagen-cleaving protease). (msdmanuals.com)
  • The Recombinant Human Lysyl Oxidase Homolog 2 Protein is derived from NS0. (fishersci.com)
  • The Recombinant Human Lysyl Oxidase Homolog 2 Protein has been validated for the following applications: Enzyme Activity. (fishersci.com)
  • Lysyl Endopeptidase Mass Spectrometry Grade is a lyophilized enzyme used for in-gel digestion of protein spots and bands. (labmark.eu)
  • Lysyl oxidase-like protein secreted from an acidophilic red alga, Cyanidium caldarium . (bvsalud.org)
  • We evaluated whether lysyl oxidase-like 2 (LOXL2), which promotes cross-linking of collagen in pathological stroma, was detectable in serum from idiopathic pulmonary fibrosis (IPF) patients, and assessed its relationship with IPF disease progression. (ersjournals.com)
  • The enzyme lysyl oxidase (LOX) is a cupper-dependent extracellular enzyme that catalyzes lysine-derived cross-links in collagen and elastin. (cun.es)
  • Increased left ventricular stiffness can be associated with excessive myocardial fibrosis and increased cross-linked collagen by the enzyme lysyl oxidase (LOX). (arizona.edu)
  • The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. (nih.gov)
  • Lysyl oxidase is an extracellular, copper dependent enzyme that initiates the covalent cross-linking of collagen and elastin. (kzoo.edu)
  • Collagen production is controlled by a family of proteins called lysyl oxidases. (survivingmesothelioma.com)
  • Interestingly, we found epithelial YT signaling to be actively involved in extracellular matrix remodeling in the fibrotic lung epithelium through modulation of lysyl oxidase expression, a collagen crosslinking enzyme. (lu.se)
  • Gjaltema, RAF & Bank, RA 2017, ' Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease ', Critical reviews in biochemistry and molecular biology , vol. 52, nr. 1, blz. (rug.nl)
  • Lysyl endopeptidase ® is a serine protease that cleaves peptide bonds at the carboxy-terminus of lysine residues with high specificity. (fujifilm.com)
  • Taking advantage of its excellent specificity, Lysyl Endopeptidase ® is used for peptide fragmentation and peptide mapping for analysis of the primary structure of proteins. (fujifilm.com)
  • Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. (nih.gov)
  • One important driver of matrix tension is lysyl oxidase-like 2 (LOXL2), an enzyme that catalyses covalent cross-linking of ECM molecules, including fibrillar collagens. (ersjournals.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lysyl Oxidase (LOX) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (antibody-tech.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Lysyl Oxidase (LOX) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (antibody-tech.com)
  • Increased lysyl oxidase activity has been reported in fibrotic diseases including hypertension, atherosclerosis, and hepatic and pulmonary fibrosis, while deficiencies oflysyl oxidase have been observed in cutis laxis, and X-linked recessively inherited disorders such as Menkes syndrome and Ehlers-Danlos syndrome subtype IX. (kzoo.edu)
  • The purpose of this study was to evaluate association profiles of lysyl oxidase-like 1 ( LOXL1 ) gene polymorphisms with pseudoexfoliation syndrome (XFS) in a Korean population. (molvis.org)
  • Another interesting facet of lysyl oxidase is that it is identical to the ras-recision gene (rrg) and possesses tumor suppressor activity. (kzoo.edu)
  • A fingerprint digest was also performed, and together with the sequence data and restriction data, allowed for the improvement of a previously made map covering the region 5' and 3' to the gene as well as the 45kb region covering the human lysyl oxidase gene. (kzoo.edu)
  • The only significant change in amino acid residues recovered from HSA before and after reaction with HDI occurred in the lysyl residues. (cdc.gov)
  • Retraction: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma. (cdc.gov)
  • Dr. Steven Gray, a thoracic oncologist from St James's Hospital, notes, "Given the significant roles of lysyl oxidases in both cancerous and fibrotic disease settings, coupled with the current development of small molecule inhibitors, it is our opinion that a strong rationale has emerged for the progression to clinical trials in mesothelioma. (survivingmesothelioma.com)
  • These lysyl oxidase inhibitors could reduce mesothelioma patients' fibrotic response. (survivingmesothelioma.com)
  • Description: Quantitative sandwich ELISA for measuring Rat Lysyl oxidase (LOX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (antibody-tech.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Lysyl Oxidase (LOX) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (antibody-tech.com)
  • A new study is looking at how a family of proteins called lysyl oxidases can help solve this problem. (survivingmesothelioma.com)
  • Lysyl oxidase-like 2 (LOXL2) has emerged as a promising therapeutic target against metastatic/invasive tumors and organ and tissue fibrosis. (ku.edu)
  • Mure, M. Oligomeric States and Hydrodynamic Properties of Lysyl Oxidase-Like 2. (ku.edu)
  • Lysyl oxidase (LOX) catalyzes the cross-linking of elastin and collagen, which is essential for the structural integrity and function of bone tissue. (nih.gov)
  • Our efforts were inspired by genetic, biochemical, and tissue evidence of reduced lysyl oxidase (LOX) activity in keratoconic corneas. (crstodayeurope.com)
  • We and others identified the impaired tolerogenic role of lysyl oxidase (LOX) and its family member, LOXL4 in macrophages apart from its role in extracellular matrix remodelling. (edu.hk)
  • The researchers are focusing on a protein in the lysyl oxidase (LOX) family. (cancer.org)
  • rs1048661 , also known as R141L, a SNP causing an amino acid change in the lysyl oxidase 1 LOXL1 gene, has been linked to exfoliation glaucoma . (snpedia.com)
  • The examination of ECM components collagen, elastin, and lysyl oxidase (LOX) family showed that the expression of type VI collagen, elastin and LOXL4 were significantly elevated in the ITGB4-deficiency mice, compared with those in normal groups. (frontiersin.org)
  • 1. Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms. (nih.gov)
  • 2. Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane. (nih.gov)
  • 3. Proteolytic processing of lysyl oxidase-like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV. (nih.gov)
  • 4. Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity. (nih.gov)
  • 5. Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin. (nih.gov)
  • 6. Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane. (nih.gov)
  • 7. The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin. (nih.gov)
  • 9. Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition. (nih.gov)
  • 11. Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2. (nih.gov)
  • 13. Human lysyl oxidase-like 2. (nih.gov)
  • 14. Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor. (nih.gov)
  • 15. Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice. (nih.gov)
  • 16. Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. (nih.gov)
  • 17. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. (nih.gov)
  • 18. Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts. (nih.gov)
  • Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA. (origene.com)
  • Copper, lysyl oxidase, and extracellular matrix protein cross-linking. (thejcdp.com)
  • Erler 등은 저 산소 상태의 세포에서 LOX(lysyl oxidase) 효소가 많이 분비되는 것을 발견하였다. (natureasia.com)
  • Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α. (chop.edu)
  • 2011) Transforming growth factor-beta induces extracellular matrix protein cross- linking lysyl oxidase (LOX) genes in human trabecular mesh- work cells. (hanspub.org)
  • The hexapeptide Hyp-Gly-Pro-Lys-Gly-Glu was synthesized as a potential substrate for collagen lysyl hydroxylase. (mcmaster.ca)
  • Heikkinen J, Toppinen T, Yeowell H, Krieg T, Steinmann B, Kivirikko KI, Myllyla R. Duplication of seven exons in the lysyl hydroxylase gene is associated with longer forms of a repetitive sequence within the gene and is a common cause for the type VI variant of Ehlers-Danlos syndrome. (medlineplus.gov)
  • This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. (prosci-inc.com)
  • Lysyl and prolyl hydroxylations are well-known post-translational modifications to animal and plant proteins with extracellular roles. (ox.ac.uk)
  • Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. (ox.ac.uk)
  • JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA splicing-related proteins. (ox.ac.uk)
  • Together with mutational studies, the structural data suggest how JMJD6 binds its lysyl residues such that it can catalyse C-5 hydroxylation rather than Nepsilon-demethylation, as for analogous enzymes. (ox.ac.uk)
  • It uses the C-carboxamide group of the glutamine residue in the peptide bond as the acyl donor, and the E-amino group of the lysyl residue in the polypeptide chain as the acyl acceptor, forming intramolecular and intermolecular E-C-(Glutamyl)-lysine isopeptide bonds, which allow protein molecules to cross-link. (cancer.org)
  • Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize primary amine substrates to reactive aldehydes. (nature.com)
  • Lysyl oxidases (LOX) are a family of copper-dependent amino oxidases for which important roles in cancer and vascular and fibrotic diseases have been proposed 1 . (nature.com)
  • 19. The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation. (nih.gov)
  • Inhibition of lysyl hydroxylase by malathion and malaoxon. (nih.gov)
  • These results support a significant role for inhibition of lysyl hydroxylase activity as causing, or contributing to, the teratogenic effects of malathion and malaoxon. (nih.gov)
  • The resulting products (des-Arg 9 -bradykinin or des-Arg 9 -lysyl-bradykinin, respectively) now react with the kinin B1 receptor (B1R), which is expressed by a variety of cell types including leukocytes and endothelial cells at sites of inflammation. (thieme-connect.de)
  • Kinetic data on the interaction of this peptide with purified chicken embryo lysyl hydroxylase showed that the hexapeptide is a moderately good substrate having Km, Vmax, and Kcat/Km values comparable to those of synthetic peptide substrates having longer chain lengths. (mcmaster.ca)
  • Maheshwari, Mani, "Role of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) and renal hemodynamics on obesity related renal damage" (2018). (marshall.edu)
  • In conjunction with data obtained earlier on lysyl hydroxylase (P. Jiang and V. S. Ananthanarayanan, 1991, J. Biol. (mcmaster.ca)