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  • endosomal
  • Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane. (wikipedia.org)
  • This so-called "fusion peptide" acts like a molecular grappling hook by inserting itself into the endosomal membrane and locking on. (wikipedia.org)
  • Then, when the rest of the HA molecule refolds into a new structure (which is more stable at the lower pH), it "retracts the grappling hook" and pulls the endosomal membrane right up next to the virus particle's own membrane, causing the two to fuse together. (wikipedia.org)
  • antigen
  • Antigen 'cleaning' and VSG recycling-VSG is efficiently recycled through the trypanosome flagellar pocket, allowing antibodies to be 'cleaned' from VSG before re-incorporation back into the cellular membrane. (wikipedia.org)
  • compartment
  • Lysosomes are considered to be a terminal degradative compartment of the endocytic pathway, into which transport is mostly unidirectional. (nih.gov)
  • secretory
  • Cytotoxic T lymphocytes (CTL) kill virally infected and tumourigenic cells via the regulated secretion of specialised secretory lysosomes. (bl.uk)
  • These secretory lysosomes contain cytolytic effector molecules, such as perforin and granzymes, which are able to induce apoptosis in target cells. (bl.uk)
  • CTL from the new HPS2 patients show reduced cytotoxicity, which is shown here to be due to impaired secretory lysosome polarisation towards the IS. (bl.uk)
  • Further investigation of these results will help to shed light on the mechanisms involved in secretory lysosome polarisation in CTL. (bl.uk)
  • Cells
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • Metastatic cancer cells often express a high density of sialic acid-rich glycoproteins. (wikipedia.org)
  • 2010) triple positive T cells, αβTCRlowCD4+CD8+ within the spaces formed by the interlocking of the membrane. (wikipedia.org)
  • It is responsible for binding the virus to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. (wikipedia.org)
  • Neutralizing antibodies against flu have been found to act by two different mechanisms, mirroring the dual functions of hemagglutinin: Inhibition of attachment to target cells Inhibition of membrane fusion (entry) Most commonly, antibodies against hemagglutinin act by inhibiting attachment. (wikipedia.org)
  • The first proposal that the membranes within cells form a single system that exchanges material between its components was by Morré and Mollenhauer in 1974. (wikipedia.org)
  • SCARB2
  • Mutations in SCARB2 have also been shown to cause Gaucher disease and myoclonic epilepsy, as LIMP-2 is critical for the proper sorting and targeting of glucocerebrosidase enzyme (the enzyme deficient in Gaucher disease) to lysosomes. (wikipedia.org)