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  • enzyme
  • When cGMP binds to the allosteric GAF-B domain of the PDE, it causes conformational change in the protein structure leading to higher enzyme activity. (wikipedia.org)
  • This invention provides various combinations of enzyme replacement therapy, gene therapy, and small molecule therapy for the treatment of lysosomal storage diseases. (google.com)
  • More specifically, the invention relates to various combinations of enzyme replacement therapy, gene therapy, and small molecule therapy for the treatment of lysosomal storage diseases. (google.com)
  • Generally, the activity of a single lysosomal hydrolytic enzyme is reduced or lacking altogether, usually due to inheritance of an autosomal recessive mutation. (google.com)
  • UniProtKB
  • Washington DC, USA ---------------------------------------------------------------------------- Description: Human chromosome 4: entries, gene names and cross-references to MIM Name: humchr04.txt Release: 2018_11 of 05-Dec-2018 ---------------------------------------------------------------------------- This documents lists all the human protein sequence entries whose genes are known to be encoded on chromosome 4 in this release of UniProtKB/Swiss-Prot. (uniprot.org)
  • Washington DC, USA ---------------------------------------------------------------------------- Description: Human chromosome 9: entries, gene names and cross-references to MIM Name: humchr09.txt Release: 2018_01 of 31-Jan-2018 ---------------------------------------------------------------------------- This documents lists all the human protein sequence entries whose genes are known to be encoded on chromosome 9 in this release of UniProtKB/Swiss-Prot. (uniprot.org)
  • glutathione
  • While the compound N -arachidonoyl maleimide (NAM) inhibits MAGL, NAM is not selective due to its chemically reactive maleimide functional group , which can also react with other thiol -containing small molecules and proteins (e.g., glutathione ). (ipfs.io)
  • kinase
  • One well-studied pathway is the mitogen-activated protein (MAP) kinase HOG1, the cascade of which initiates a temporary cell cycle arrest in response to osmotic stress, allowing the fungus to adapt and repair damaged cell wall structures. (asm.org)
  • Dedicator of Cytokinesis 2 -- Hiroshi Nishihara -- Domain Protein -- Dopamine and Adenosine 3',5'-Monophosphate-Regulated Phosphoprotein, 32 kDa -- Dopamine and cAMP-Regulated Phosphoprotein -- Dopamine- and cAMP-Regulated Phosphoprotein, Mr32 kDa -- Double-Stranded RNA-Activated Protein Kinase -- Down Syndrome Candidate Region 1 (DSCR1) -- Down Syndrome Critical Region 1 (DSCR1) -- Drag1. (opal-libraries.org)
  • Sequence
  • Glucose-6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with glucose-6-phosphatase-α. (wikipedia.org)
  • Exchange Regulating Factor) -- NimO (Aspergillus) -- NINAC (p174, p132) -- NIPK -- NK Receptor / Bin Xu, Mesfin Gewe, Kathryn Finton and Roland K. Strong -- NKG2D / Michael T. McCarthy and Christopher A. O'Callaghan -- NKp46 / Simona Sivori -- NLS (Nuclear Localization Sequence) -- NMT -- NMT (N-Myristoyltransferase) / Sujeet Kumar, Ponniah Selvakumar, Jonathan R. Dimmock and Rajendra K. Sharma -- Nociceptin Opioid Receptor -- Non-Lysosomal Cysteine Protease. (opal-libraries.org)
  • transmembrane
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (nih.gov)
  • Molecule
  • Glycerol-3-phosphate is first acylated with acyl-coenzyme A (acyl-CoA) to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. (hmdb.ca)
  • novel
  • 3. Miyazawa, S., Furuta, S. and Hashimoto, T. Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators. (qmul.ac.uk)
  • insulin
  • The discovery of restriction enzymes allows DNA to be manipulated, leading to the development of recombinant DNA technology that has many applications, for example, allowing the large scale production of proteins such as human insulin used by diabetics. (metal-invest.pl)
  • gene
  • Gene deletion studies and reverse pharmacology have provided evidence that many of the biological effects of S1P are mediated via five specific G protein-coupled receptors (GPCRs), now designated S1P 1-5 ( Fig. 3 ). (aspetjournals.org)
  • Monoacylglycerol lipase , also known as MAG lipase, MAGL , MGL or MGLL is a protein that, in humans, is encoded by the MGLL gene . (ipfs.io)
  • nicotinamide
  • Adenosine diphosphate ribosylation of histone and nonhistone chromosomal proteins with oxidized nicotinamide adenine dinucleotide and 2'-deoxynicotinamide adenine dinucleotide using nuclei isolated from rat liver and HeLa cells. (docphin.com)
  • pathway
  • βγ-complex of heterotrimeric G-proteins , as in a minor pathway of growth hormone release by growth hormone-releasing hormone . (readtiger.com)
  • yield
  • Two molecules of acyl-CoA are esterified to glycerol-3-phosphate to yield 1,2-diacylglycerol phosphate (also known as phosphatidic acid). (hmdb.ca)