Loading...
  • gene expression
  • Epigenetics refers to heritable changes in gene expression patterns that are not regulated by changes in the primary DNA sequence. (aacrjournals.org)
  • The most notable signature for MLL-related leukemia is the change of specific gene expression pattern. (grantome.com)
  • Among all the functional features of genome activities, dissecting the complex regulatory mechanisms controlling the precise spatial and temporal patterns of gene expression is critical for understanding developmental and cellular processes. (biomedcentral.com)
  • enzymes
  • This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process. (pubmedcentralcanada.ca)
  • complex
  • A methionine substitution at lysine-27 on histone H3 variants (H3K27M) characterizes ~80% of diffuse intrinsic pontine gliomas (DIPG) and inhibits polycomb repressive complex 2 (PRC2) in a dominant-negative fashion. (sciencemag.org)
  • or (ii) complex, requiring a coordinated pattern of movement or sound like touching, squatting, jumping. (frontiersin.org)
  • active
  • Methylation-dependent changes in the MnSOD conformation and subsequent changes in the electrostatic potential around the active site during quiescence versus proliferation could increase the accessibility of superoxide, a negatively charged substrate. (aacrjournals.org)
  • include
  • Core components include RCOR1 (CoREST) that is required for KDM1A to demethylate nucleosomal substrates ( 12, 13 ), PHF21A (BHC80) that recognizes unmethylated histone H3 lysine 4 ( 14 ), and HMG20B (BRAF35) that recognizes DNA ( 15 ). (aacrjournals.org)