• Here, we confirm regulation of ALDH1A1 transcription by TLX1 and show that ALDH1A1 can profoundly perturb murine hematopoiesis by promoting myeloid differentiation at the expense of lymphopoiesis. (edu.au)
  • Alterations in the expression of E2A, Pax-5, and STAT5 may affect multiple stages of B cell development, contribute to reduced B lymphopoiesis, and preface changes in the "read-out" of the BCR repertoire during murine senescence. (elsevier.com)
  • Unlike IL-1β, which inhibits B lymphopoiesis by acting on early lymphoid progenitors, S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inflammatory molecules, including IL-1β. (jimmunol.org)
  • We suggest that inflammaging contributes to a decline of B lymphopoiesis in aged individuals, and furthermore, that MDSCs and IL-1 provide therapeutic targets for restoration of B lymphopoiesis in aged and obese individuals. (jimmunol.org)
  • Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). (wikipedia.org)
  • Lymphopoiesis is now usually used interchangeably with the term "lymphocytopoiesis" - the making of lymphocytes - but other sources may distinguish between the two, stating that "lymphopoiesis" additionally refers to creating lymphatic tissue, while "lymphocytopoiesis" refers only to the creation of cells in that tissue. (wikipedia.org)
  • In the case of mammals such as humans, lymphopoiesis begins with limited passive provision by the mother of lymphocytes and substantial immunoglobulin G that cross the placenta and enter the fetus to provide some protection against pathogens, and also leukocytes that come from breast milk and enter circulation via the digestive tract. (wikipedia.org)
  • Lymphopoiesis is the formation of lymphocytes, which start from their first committed progenitor cells, lymphoblasts. (news-medical.net)
  • The formation of lymphocytes is known as lymphopoiesis . (wikipedia.org)
  • We demonstrate that mutant animals develop an age-dependent, macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, as well as profound defects in lymphopoiesis. (bloodjournal.org)
  • CONCLUSION: These results indicate that canonical Wnt signaling is involved in human BM B lymphopoiesis where it acts as a negative regulator of cell proliferation in a direct or stroma dependent manner. (biomedsearch.com)
  • Regulation of microRNA expression and abundance during lymphopoiesis. (semanticscholar.org)
  • Our data demonstrate a cell-extrinsic defect of B cell development in a progeroid mouse model and a critical role for lamin A in the regulation of NF-κB signaling and cytokines that are essential for lymphopoiesis. (biomedcentral.com)
  • mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. (nih.gov)
  • The results indicate that p53 is actively involved as an apoptosis inducer at an early quality control checkpoint in B lymphopoiesis. (hku.hk)
  • In addition, trypanosomes are able to weaken the immune system by inducing B cell apoptosis (cell death) and the degradation of B cell lymphopoiesis. (wikipedia.org)
  • Lymphopoiesis continues throughout life and so progenitor cells and their parent stem cells must always be present. (wikipedia.org)
  • In this study, we characterized rabbit BM after the arrest of B lymphopoiesis and found a dramatic increase in fat, increased CD11b + myeloid cells, and upregulated expression of the inflammatory molecules, IL-1β and S100A9, by the myeloid cells. (jimmunol.org)
  • We suggest that fat provides an inflammatory microenvironment in the BM and promotes/activates myeloid cells to produce inflammatory molecules such as IL-1β and S100A9, which negatively regulate B lymphopoiesis. (jimmunol.org)
  • Human induced pluripotent stem cells are capable of B-cell lymphopoiesis. (nextbio.com)
  • Interestingly, regions of de novo DNA methylation in B cells overlap with an intronic antisense transcription unit that is differently regulated during lymphopoiesis. (embopress.org)
  • Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis. (stembook.org)
  • A birthday for B cells: Lymphopoiesis II, a scientific symposium honoring Max Cooper. (duke.edu)
  • Here we analyze how caseins can exert numerous hematopoietic and immunomodulatory actions, their role in granulopoiesis, monocytopoiesis, and lymphopoiesis from the early stages of postnatal development seemingly throughout life, and we wonder if casein could be useful to fight pathogens resistant to antibiotics, inducing a strong immune response in immunosuppressed patients, or even be a prophylactic strategy to prevent infections. (intechopen.com)
  • The partial loss of or loss of function of any white blood cell type is a serious health matter and lymphopoiesis is absolutely necessary for life. (wikipedia.org)
  • The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. (semanticscholar.org)
  • Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis. (jimmunol.org)
  • The subsequent description of patients with T − B + NK + SCID resulting from an IL-7Rα chain mutation confirmed that IL-7 is essential for human T cell lymphopoiesis. (jimmunol.org)
  • In the spleen, T. brucei induces extramedullary B lymphopoiesis as evidenced by significant increases in HSC-LMPP, CLP, pre-pro-B, pro-B and pre-B cell populations. (prolekare.cz)
  • EZH2 also has critical roles in stem cell maintenance and cell lineage determination, such as osteogenesis, myogenesis, lymphopoiesis and hematopoiesis. (wikipedia.org)
  • In this review, we discuss the impairment of B lymphopoiesis during old age in the context of mechanisms at the molecular level responsible for the handling and turnover of these key transcriptional proteins. (elsevier.com)
  • To examine the role of chromatin structure in this process we studied epigenetic silencing of c‐fms during B‐lymphopoiesis. (embopress.org)
  • citation needed] (See Lymphopoiesis#Labeling lymphopoiesis) CD135 is a proto-oncogene, meaning that mutations of this protein can lead to cancer. (wikipedia.org)