• LMG was thought to be a manifestation of three or four different diseases: the well-characterized disease of granulomatosis with polyangiitis, the ill-defined disorders of polymorphic reticulosis or mid-line malignant reticulosis, and an incompletely defined form of non-Hodgkin lymphoma. (wikipedia.org)
  • Subsequent studies found that the cells infiltrating the midline tissues in cases of lethal midline granuloma that were not clearly diagnosed as granulomatosis with polyangiitis were: a) infected by the Epstein-Barr virus and b) consisted of malignant lymphocytes, usually NK cells or, rarely, cytotoxic T cells. (wikipedia.org)
  • Since cases of LMG that were manifestations of granulomatosis with polyangiitis, a vascular inflammatory but not malignant disease, the term lethal midline granuloma is considered confusing and obsolete. (wikipedia.org)
  • This syndrome can be manifested in several diseases including the nasal type of EXTRANODAL NK-T-CELL LYMPHOMA and GRANULOMATOSIS WITH POLYANGIITIS . (nih.gov)
  • In some patients, the common causative lesions are Wegener's granulomatosis, sarcoidosis, conventional Sino-nasal diffuse large B cell, and lymphomas carcinomas. (openpr.com)
  • 19. NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen. (nih.gov)
  • The disease is therefore now regarded as a NK/T cell malignancy, is grouped with other Epstein-Barr virus-associated lymphoproliferative diseases and is classified by the World Health Organization (2017 update) as a manifestation of the well-defined disease, extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT). (wikipedia.org)
  • ENKTCL-NT is a rare type of lymphoma that commonly involves the nasal cavity, oral cavity, and/or pharynx but less commonly can also involve the eye, larynx, lung, gastrointestinal tract, skin, and various other tissues. (wikipedia.org)
  • GPA localized to the upper respiratory tract should be distinguished from primary nasal natural killer/T-cell lymphoma (lethal midline granuloma) before immunosuppressive therapies are initiated, especially if an oral-nasal fistula is present and/or mass is appreciated. (medscape.com)
  • 2. A case of CD30+ nasal natural killer/T-cell lymphoma. (nih.gov)
  • 6. Extra-nasal NK/T-cell lymphoma: A rare case with a rarer presentation. (nih.gov)
  • 7. CD56-positive (nasal-type T/NK cell) lymphoma arising on the skin. (nih.gov)
  • 9. Nodal presentation of nasal-type NK/T-cell lymphoma. (nih.gov)
  • 12. [Nasal NK/T lymphoma. (nih.gov)
  • 15. Clinicopathological features of CD56+ nasal-type T/natural killer cell lymphomas with lobular panniculitis. (nih.gov)
  • 16. Vision-threatening complications of nasal T/NK lymphoma. (nih.gov)
  • 18. Extranodal natural killer/T-cell lymphoma, nasal-type. (nih.gov)
  • Este síndrome puede manifestarse en varias enfermedades, entre las que se incluyen la forma nasal del LINFOMA EXTRAGANGLIONAR DE CÉLULAS T-NK y la GRANULOMATOSIS CON POLIANGEÍTIS. (bvsalud.org)
  • Natural killer cells are cytotoxic in nature and are able to kill their targets cells by two different mechanisms: as antibody dependent cell-mediated cytotoxicity (ADCC) and as simple natural killer activity of these cells. (openpr.com)
  • In vivo delivery of TK-NTR and administration of prodrugs led to the effective killing of both targeted cells and surrounding tumor cells via TK-NTR-mediated conversion of co-delivered prodrugs into active cytotoxic agents. (regenerativemedicine.net)
  • Patients presenting with highly localized midline facial disease fit the historical definition of lethal midline granuloma. (wikipedia.org)
  • Destructive midline facial lesions have conventionally been referred to as lethal midline granuloma. (openpr.com)
  • A condition that is characterized by inflammation, ulceration, and perforation of the nose and the PALATE with progressive destruction of midline facial structures. (nih.gov)
  • 1. An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis. (nih.gov)
  • 13. Extranodal NK/T-cell Lymphoma Mimicking Granulomatous Myositis. (nih.gov)
  • Natural killer cells play an important role in stem-cell transplantation in therapies involving such cells activating endogenous natural killer cells and may transfer exogenous cells through adoptive cell therapy (ACT) and hematopoietic stem cell transplantation (HSCT). (openpr.com)
  • According to National Center for Biotechnology Information, U.S. National Library of Medicine, in 2014, such therapies are less effective in eliminating cancer stem cells as revealed by various studies. (openpr.com)
  • Lethal midline granuloma (LMG) is an historical term for a condition in which necrotic and highly destructive lesions develop progressively in the middle of the face, principally the nose and palate. (wikipedia.org)
  • However, among patients from Asia and South America, such lesions often show atypical lymphoid cells. (openpr.com)
  • Methylation status of retinoic acid receptor beta2 promoter and global DNA in esophageal squamous cell carcinoma. (kmu.edu.tw)
  • Though natural killer cells are demonstrated to be critical elements in the early immune response to a large variety of intracellular pathogens, they are used in clinical applications for treating lymphomas and other disorders. (openpr.com)
  • The immediate response in the clinical abnormalities is to favor growth in adoption rate of the natural killer cells, which in turn is expected to support the growth of the natural killer cells market in the near future. (openpr.com)
  • 17. [Angiocentric T/NK cell lymphoma: a special clinical-pathological entity of lethal midline granuloma. (nih.gov)
  • AB - The clinical observation of an oral pulse granuloma allows to detail the clinical and pathological characteristics of this lesion. (nih.gov)
  • Such receptor engages its ligand when a natural killer cell encounters any normal cell that leads to generation of signal triggered, which in turn stimulates the natural killer cells to carry out its process. (openpr.com)
  • For instance, R&D Systems offer a wide range of reagents for culturing natural killer cells and investigating natural killer cell and tumor cell interactions and various other components such as recombinant proteins, blocking/neutralization antibodies, fluorochrome-conjugated antibodies and ELISA Kits. (openpr.com)
  • The global natural killer cells market is highly competitive and fragmented, though companies are investing of specific therapy using natural killer cell products to be used in immune-oncology to treat cancer and other tumors. (openpr.com)
  • 3. Aggressive T/natural killer cell lymphoma presenting as testicular tumor. (nih.gov)
  • 5. T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases. (nih.gov)
  • These results suggest that MC delivery via microvesicles can mediate gene transfer to an extent that enables effective prodrug conversion and tumor cell death such that it comprises a promising approach to cancer therapy. (regenerativemedicine.net)
  • Killer cell also work through another approach of direct recognition of pathogen derived structures on the surface of the infected cell. (openpr.com)
  • c-kit gene encodes a receptor tyrosine kinase, which plays a crucial role in proliferation and differentiation of hematopoietic stem cells. (nih.gov)
  • Cancer starts when cells in the body begin to grow out of control. (cancer.org)
  • Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells. (kmu.edu.tw)
  • Natural killer cells are a form of granular lymphocytes of varying sizes that play an important role in innate immunity in the human body. (openpr.com)
  • They typically constitute of around 10% of total blood lymphocytes as compared to around 70% and 20% of T cells and B cells, respectively. (openpr.com)
  • Mutations of p53, K-ras, c-kit, and beta-catenin gene were examined in 100 cases of sinonasal NK/T-cell lymphoma (NKTCL) from Korea and Japan. (nih.gov)
  • 10. [Aggressive NK cell leukemia/lymphoma: an autopsy case]. (nih.gov)
  • Studies have also been carried to express the vitality of natural killer cells' response against infected cells by various intracellular bacteria such as Listeria, Salmonella and Legionella in humans. (openpr.com)
  • Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan. (nih.gov)
  • 14. Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. (nih.gov)
  • We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)
  • Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)
  • Furthermore, lectin-like receptors are one of two complex families of membrane receptors that recognize carbohydrates expressed on all cells. (openpr.com)
  • Recent advancements have proven the exclusive role of killer cells in the innate immune response to microbial pathogens. (openpr.com)
  • In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)
  • Their specific attaching ability and ability to discard stressed cells are fueling adoption of natural cells therapy, which is projected to support growth of the natural killer cells market over the forecast period. (openpr.com)