AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
LymphomaLymphoma, B-CellLymphoma, T-CellLymphoma, Non-HodgkinBurkitt LymphomaLymphoma, Large B-Cell, DiffuseLeukemia, B-CellLymphoma, FollicularB-LymphocytesLymphoma, B-Cell, Marginal ZoneMultiple MyelomaNeoplasms, Plasma CellAntigens, CD20Lymphoma, Mantle-CellLymphoma, T-Cell, CutaneousChromosomes, Human, Pair 14LeukemiaTranslocation, GeneticTumor Cells, CulturedLeukemia, LymphoidCell Line, TumorLymphoma, Large-Cell, AnaplasticLeukemia, Lymphocytic, Chronic, B-CellLeukemia, Plasma CellNeoplasms, Germ Cell and EmbryonalLymphoma, AIDS-RelatedAntibodies, MonoclonalLymphoma, T-Cell, PeripheralHodgkin DiseaseLeukemia, T-CellAntineoplastic AgentsLymphoproliferative DisordersImmunoglobulin Heavy ChainsPlasmacytomaT-LymphocytesApoptosisGenes, ImmunoglobulinAntigens, CD19Flow CytometryAntigens, NeoplasmTesticular NeoplasmsLeukemia L5178Mice, SCIDGene Expression Regulation, NeoplasticHerpesvirus 4, HumanAntibodies, Monoclonal, Murine-DerivedHematologic NeoplasmsBone MarrowCell Transformation, NeoplasticLymphoma, Large-Cell, ImmunoblasticAntigens, SurfaceAntigens, CD30PhenotypeVincristineMolecular Sequence DataSignal TransductionPrednisoneNeoplasmsDoxorubicinThymus NeoplasmsCyclophosphamideChromosomes, Human, Pair 18Antineoplastic Combined Chemotherapy ProtocolsImmunophenotypingCell LinePrognosisImmunohistochemistryLymphoma, Extranodal NK-T-CellMice, TransgenicProto-Oncogene Proteins c-bcl-2Neoplasm ProteinsGene RearrangementTreatment OutcomeLymph NodesDNA, NeoplasmRetrospective StudiesReed-Sternberg CellsEpstein-Barr Virus InfectionsCell DifferentiationSkin NeoplasmsEpstein-Barr Virus Nuclear AntigensReceptors, Antigen, B-CellTumor Markers, BiologicalHerpesvirus 8, HumanBase SequencePolymerase Chain ReactionGenes, mycEye NeoplasmsFatal OutcomeCombined Modality TherapyProto-Oncogene Proteins c-bcl-6Sialic Acid Binding Ig-like Lectin 2Proto-Oncogene Proteins c-mycGenes, bcl-2Cell SurvivalNeoplasms, Second PrimaryNeoplasms, ExperimentalSurvival RateCentral Nervous System NeoplasmsBiopsy
Multiple MyelomaCutaneous T-cell lHematologic MalignanciesMalignantFollicularHematological MalignanciesCancersDiagnosisRelapsed or refractoryDiffusePrognosisDLBCLLymphocytesChronicExtranodalSmall lymphocyLeukemia and lymphomaClinicallyReceptorLymphoblasticPediatricMantle cell lymphoma trTherapiesAnaplasticAccount for 10ChemotherapyLeukemias and lymphomasCancerInducesInternal malignancyChimeric antigenBone marrowPatientsMyelomaMutationsTumor cellsEtiologySystemic diseaseHodgkin LymphomaAggressiveHematopoietic stem cellManifestationsSubtypesClinicalPeripheralGastric lymphomaSecondaryLeukaemiaPrognosticImmatureGene expressionCytotoxicImmunotherapy
Multiple Myeloma8
Cutaneous T-cell l3
  • Less common subtypes of mature T-cell lymphoma include cutaneous T-cell lymphoma, adult T-cell leukaemia/lymphoma, enteropathy-type T-cell lymphoma, nasal NK/T-cell lymphoma, hepatosplenic gamma-delta T-cell lymphoma, etc. (wikipedia.org)
  • Symptoms specific to subtypes include diffuse lymphadenopathy and hepatosplenomegaly in AITL, and swellings in skin in cutaneous T-cell lymphoma. (wikipedia.org)
  • Hydroa-like cutaneous T-cell lymphoma (hydroa-like CTCL) is an unusual pediatric malignancy with a poor prognosis. (nih.gov)
Hematologic Malignancies4
  • This series of interactive webinars will provide clinicians across the care spectrum treating hematologic malignancies with a foundational understanding of genomics, current applications and advances, and practical strategies to apply these findings to treating patients. (schoolandyouth.org)
  • Session: Hematologic Malignancies-Leukemia, Myelodysplastic Syndromes, and Allotransplant. (businesswire.com)
  • Session: Hematologic Malignancies-Lymphoma and Chronic Lymphocytic Leukemia. (businesswire.com)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
Malignant20
  • Lymphomas are malignant neoplasms of lymphoid lineage. (medscape.com)
  • In contrast, non-Hodgkin lymphoma is best regarded as a systemic disease, because of the unique anatomy of the lymphoid system and because of the physiology of lymphoid cells, which tend to migrate whether they are normal or malignant. (medscape.com)
  • Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
  • CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)
  • Many investigators have suggested that both lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) may be part of one clinical spectrum of a single malignant lymphoproliferative disorder . (medscape.com)
  • Wide excision of the primary tumour bed following histological confirmation of melanoma, appendageal carcinoma, malignant connective tissue or merkel cell carcinoma of the skin may be claimed using item 31371, 31372, 31373, 31374, 31375 or 31376, depending on the location of the malignancy and the size of the excision diameter. (health.gov.au)
  • And if some of those cells are malignant, that can affect the test results - acting as a kind of unasked-for cancer screening. (npr.org)
  • The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
  • Malignant blast cells (i.e. diffuse large B-cell lymphoma) are fast-growing and result in aggressive disease, whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. (oncolink.org)
  • MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
  • The contributors review the normal functions of hematopoietic stem cells-the precursors to white blood cells-and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. (cshlpress.com)
  • Through these multiple actions, BTK helps to direct malignant B-cells to lymphoid tissues, thus allowing access to a microenvironment necessary for survival. (jnj.com)
  • Regarding primary testicular lymphoma (PTL), it is a rare form of extranodal lymphoma and the most frequent malignant testicular neoplasm in men over the age of 60 years. (intechopen.com)
  • Aho R, Ecfor T: Pathogenesis of primary central nervous lymphoma: invasion of malignant lymphoid cells into and within the brain parenchyma. (karger.com)
  • Kuhn D, Buchfelder M: Intrasellar malignant lymphoma developing within pituitary adenoma. (karger.com)
  • In malignant B cells of ABC lymphomas, these receptors provide crucial signals that promote tumor cell survival. (nih.gov)
  • Hypercalcemia is a paraneoplastic syndrome that occurs secondary to malignant cell production of a parathyroid hormone-related peptide (PTH-rp). (vin.com)
  • Very severe infiltration may cause myelophthisis (crowding out of normal marrow elements by malignant cells) and may be manifested as peripheral cytopenias and lymphoid leukemia. (vin.com)
  • Incidence of primary large bowel lymphomas comprises only 0.2-0.6% of large bowel malignant tumors ( 3 ). (frontiersin.org)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
Follicular8
  • It is characterised by systemic disorders, polymorphous lymphoid infiltrate and a significant increase in proliferation of follicular dendritic cells and high endothelial venules. (wikipedia.org)
  • It originates from follicular T helper (TFH) cells, which is important in maintaining immune response. (wikipedia.org)
  • Participants with follicular lymphoma (FL) must have received at least 2 lines of systemic therapy and have high-risk disease. (survivornet.com)
  • The t(14;18) translocation (characteristic for follicular lymphoma but also common in other types) results in activation of the BCL-2 gene and suppression of apoptosis. (oncolink.org)
  • Important types include follicular lymphoma and small lymphocytic lymphoma . (oncolink.org)
  • In dogs, high grade (large cell type effacing normal node architecture) histologic subtypes are reported to be more responsive to therapy than low grade (follicular growth within the node) subtypes. (vin.com)
  • 376 (91%) patients had mature B cell malignancy, nearly half MALT lymphoma (n = 197), followed by DLBCL (n = 67), nodal MZL lymphoma (n = 29), CLL/SLL (n = 19) and follicular lymphoma (n = 17). (lu.se)
  • This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Hematological Malignancies7
  • The overall goal of this mechanism is to enhance the development of innovative strategies for the treatment, diagnosis or prevention of hematological malignancies. (lls.org)
  • Hematological malignancies are the kinds of cancer affecting blood, bone marrow and lymph nodes. (medgadget.com)
  • OBJECTIVE: To characterize 414 patients with primary SS who developed hematological malignancies and to analyze how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. (lu.se)
  • Hematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. (lu.se)
  • RESULTS: There were 414 patients (355 women, mean age 57 years) with hematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). (lu.se)
  • CONCLUSION: In the largest reported study of hematological malignancies complicating primary SS, we confirm the overwhelming predominance of B cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. (lu.se)
  • Our study aimed to report the management of hematological malignancies at the Centre National d'Oncologie Médicale et de Radiothérapie Alassane Ouattara (CNRAO). (bvsalud.org)
Cancers9
  • This therapy is most advanced in blood cancers, specifically B-cell lymphomas and leukemias, with multiple FDA approved CAR T-cells treatments targeting the CD19 protein now available. (lls.org)
  • Nature Medicine Oct 2020) documented a high overall response rate in patients with relapsed B-cell cancers. (lls.org)
  • Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
  • Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
  • Direct sequencing of hematopoietic cancers identified gain-of-function mutations of EZH2, the gene encoding the enzymatic subunit of Polycomb Repressive Complex-2 PRC2, among 10 germ-center B-cell lymphomas. (dtic.mil)
  • During this funding period, we have made significant progress in testing our central hypothesis is that, overexpression of PHF19 confers oncogenicity to lymphoma by either enhancing enzymatic activities or chromatin association of PRC2 complexes in addition, we have evaluated the pan PRC2 inhibitor as a novel means for blockade of unwanted PRC2 hyperactivities among blood cancers including B-cell malignancies. (dtic.mil)
  • Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
  • Diffuse large B-cell lymphomas (DLBCL), which were studied in this trial, are aggressive cancers that grow rapidly and represent 30 percent to 40 percent of newly diagnosed lymphomas. (nih.gov)
  • An interesting statistical association exists between high birth weight and the subsequent risk of childhood cancers, including non-Hodgkin lymphoma. (medscape.com)
Diagnosis16
  • Diagnosis of CD19-positive relapsed or refractory (R/R) B-cell Non-Hodgkin's Lymphoma (NHL). (survivornet.com)
  • 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
  • The appearance of paraneoplastic AN usually coincides with the presence of malignancy, but it can precede or follow the diagnosis of cancer and thus may signal a relapse in patients with a history of cancer. (medscape.com)
  • Fine-needle aspirate is sufficient for lymphoma diagnosis but rarely adequate for subtyping, thus excisional or incisional biopsy is considered mandatory[5]. (oncolink.org)
  • To understand a diagnosis of mantle cell lymphoma, it is helpful to briefly consider where in the body it develops. (moffitt.org)
  • If a diagnosis of mantle cell lymphoma is confirmed, the doctor will determine what stage the cancer is in. (moffitt.org)
  • Large, monomorphic, multinucleated neoplastic cells containing abundant cytoplasm and scattered pleomorphic cells were also noted, leading to the diagnosis of tibial plasmablastic lymphoma. (hindawi.com)
  • Biopsy was conducted from the right tibia at a primary care hospital in Larkana four months prior to presenting at Indus Hospital, and histopathological analysis confirmed a diagnosis of plasmablastic lymphoma. (hindawi.com)
  • The differential diagnosis includes other cutaneous lymphomas, particularly the cutaneous nasal type T/natural killer-cell lymphoma, mycosis fungoides, precursor T-cell lymphoblastic lymphoma, nonspecific peripheral T-cell lymphoma, cutaneous anaplastic large cell lymphoma, and subcutaneous panniculitic T-cell lymphoma. (nih.gov)
  • As cytomorphological appearance was consistent with anaplastic carcinoma in ultrasonography-guided aspiration biopsies of thyroid nodule and lymphadenopathy, immunohistochemical staining was performed for differential diagnosis of lymphoma. (endocrine-abstracts.org)
  • According to Revised European American Classification of Lymphoid Neoplasms, the diagnosis was diffuse large B-cell lymphoma. (endocrine-abstracts.org)
  • We introduce the case in order to emphasize that infiltration of diffuse large B-cell lymphoma should be recalled with instantaneous enlargement of nodules known to be benign previously, and when cytological specimen is uncertain, immunohistochemical staining should be performed for differential diagnosis. (endocrine-abstracts.org)
  • The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
  • Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
  • Therefore, doctors should maintain high suspicion of this malignancy for early diagnosis at an early stage clinically. (frontiersin.org)
  • There were significant differences in age at diagnosis (younger in MALT, older in CLL/SLL), predominant clinical presentation (glandular enlargement in MALT lymphoma, peripheral lymphadenopathy in nodal MZL and FL, constitutional symptoms in DLBCL, incidental diagnosis in CLL/SLL), therapeutic response (higher in MALT lymphoma, lower in DLBCL) and survival (better in MALT, nodal MZL and FL, worse in DLBCL). (lu.se)
Relapsed or refractory4
  • ELiPSE-1 is a Phase 1, multi-center, dose-finding study to evaluate the safety, pharmacokinetics, and preliminary efficacy of CNTY-101 in participants with relapsed or refractory cluster of differentiation (CD)19-positive B-cell malignancies. (survivornet.com)
  • These rigorously collected, patient-level, long-term follow-up data provide reassurance that bendamustine or bendamustine plus rituximab is associated with efficacy and safety for patients with relapsed or refractory indolent non-Hodgkin lymphoma. (ox.ac.uk)
  • In February 2013 , FDA granted Breakthrough Therapy Designations for ibrutinib as a monotherapy for two B-cell malignancies: in patients with relapsed or refractory Mantle cell lymphoma (MCL) who have received prior therapy, and in patients with Waldenström's macroglobulinemia (WM). (jnj.com)
  • It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ( 131 I-rituximab). (karger.com)
Diffuse6
  • The diffuse large B-cell lymphoma (DLBCL) accounts for the majority of cases. (intechopen.com)
  • Initially considered a variation of diffuse large B-cell lymphoma (DLBCL), PBL was later classified as a distinctive mature B-cell lymphoma and separated from the class of DLBCL by WHO [ 1 ]. (hindawi.com)
  • Plasmablastic lymphoma was first reported in 1997, when a series of sixteen diffuse large B-cell lymphomas with unique immunohistochemistry were presented in HIV-positive patients with predominant involvement of the oral cavity [ 3 ]. (hindawi.com)
  • Diffuse large B-cell lymphoma cells showing CD20 involvement were seen in cytological specimens. (endocrine-abstracts.org)
  • While normal thyrocytes were detected in thyroid gland, atypical lymphoid cells showing diffuse infiltration in thyroid tissue were observed in the nodule, which were stained diffuse, strongly positive for CD20 and BcL and negative for CD45 RO. (endocrine-abstracts.org)
  • Diffuse large B-cell lymphoma is the most common histologic subtype of NHL, with ENKTL of the large bowel being less frequent ( 4 ). (frontiersin.org)
Prognosis5
  • Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
  • The belief that T-cell lymphomas have a worse prognosis than B-cell lymphomas remains controversial. (oncolink.org)
  • The T cell form of lymphoma is less responsive the therapy, and has a worse long term prognosis than B cell lymphoma. (vin.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
  • Two cases of oral manifestations of Burkitt's lymphoma are described on the right jaw in young patients, which had different clinical evolution and prognosis. (bvsalud.org)
DLBCL3
  • DLBCL originates from B cells, which play a crucial role in the body's immune response. (nih.gov)
  • The activated B-cell (ABC) subtype of DLBCL accounts for approximately 40 percent of cases and has the poorest clinical outcome with current therapy. (nih.gov)
  • Remissions were also observed in patients with non-ABC DLBCL, suggesting a broader role for the B-cell receptor pathway in this type of lymphoma. (nih.gov)
Lymphocytes8
Chronic5
  • Ibrutinib has been granted Breakthrough Therapy Designation as a monotherapy in the treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma with deletion of the short arm of chromosome 17 (del17p). (jnj.com)
  • Recent genetic studies have revealed that chronic activity of receptors that sit on the surface of B cells play an important role in the progression of ABC lymphomas. (nih.gov)
  • The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia. (who.int)
  • In addition, an M component may be detected in other lymphoid malignancies like chronic lymphocytic leukemia, any B- or T- cell lymphomas, breast cancer, colon cancer, cirrhosis, sarcoidosis, and other autoimmune disorders. (medscape.com)
  • Liver disease, autoimmune disease, chronic viral or bacterial infections and various malignancies may cause a polyclonal rise in the gamma fraction (see Table 2 below). (medscape.com)
Extranodal4
  • Childhood non-Hodgkin lymphoma generally manifests as bulky extramedullary (usually extranodal) disease with or without demonstrable dissemination. (medscape.com)
  • Liu JK, Sayama C, Chin SS, Couldwell WT: Extranodal NK/T-cell lymphoma presenting as a pituitary mass. (karger.com)
  • Extranodal NK/T cell lymphoma is a rare non-Hodgkin lymphoma mainly involving the upper aerodigestive tract, even rarer is primary extranasal disease involving the intestine. (frontiersin.org)
  • Extranodal NK/T cell lymphoma nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma (NHL). (frontiersin.org)
Small lymphocy2
  • n = 73), grade 3 FL (n = 23), small lymphocytic lymphoma (n = 20), marginal zone lymphoma (n = 15), mantle cell lymphoma (n = 9), transformed lymphomas (n = 5), lymphoplasmacytic lymphoma (n = 2) and not reported (n = 2). (ox.ac.uk)
  • 5] Small Lymphocytic Lymphoma (SLL) is a slow-growing lymphoma in which too many immature white blood cells cause lymph nodes to become larger than normal. (jnj.com)
Leukemia and lymphoma4
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. (cshlpress.com)
  • MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma. (cshlpress.com)
  • In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. (cshlpress.com)
  • Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)
Clinically5
  • Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is a group of biologically and clinically heterogeneous lymphomas that do not fit into the other subtypes of mature T-cell lymphoma. (wikipedia.org)
  • Broadly classified as either Hodgkin disease (Hodgkin's disease) or as non-Hodgkin lymphoma, lymphomas are clinically, pathologically, and biologically distinct (see the image below). (medscape.com)
  • Therefore, these entities (acute lymphoblastic leukemia and lymphoblastic lymphoma) are best considered in terms of a spectrum ranging from clinically localized disease to overt leukemia. (medscape.com)
  • The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
Receptor13
  • Chimeric Antigen Receptor (CAR) modified T-cells are an exciting new form of immunotherapy that involves the genetic modification of one's own T-cells to redirect them against proteins on cancer cells. (lls.org)
  • It can be recognized by a constant expression of the tumour receptor necrosis factor CD30, a membrane protein expressed by activated T and B cells, in the cancer cells. (wikipedia.org)
  • Participants with aggressive NHL must have received at least 2 lines of systemic therapy (if not intended for transplant, have already undergone or be unwilling or unable to undergo chimeric antigen receptor [CAR] T-cell therapy to be eligible), or at least 3 lines of systemic therapy. (survivornet.com)
  • Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
  • Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
  • Rates of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) from Center for International Blood and Marrow Transplant Research (CIBMTR) Data on U.S. Subjects (SUBJ) with Lymphoma Following Chimeric Antigen Receptor T Cell (CAR-T) Therapy (Abstract #7528. (businesswire.com)
  • Translocations are thought to occur during normal gene rearrangements (Ig, T-cell receptor). (oncolink.org)
  • T-cell receptor gamma (TCRgamma) displayed monoclonal-type rearrangement in four cases studied. (nih.gov)
  • Over one-fifth of ABC tumors have mutations that alter the activity of the B-cell receptor. (nih.gov)
  • Based on these findings, researchers looked for ways to target B-cell receptor signaling therapeutically. (nih.gov)
  • This research identified the enzyme Bruton's tyrosine kinase (BTK) as a key element in the B-cell receptor pathway that is required to maintain the survival of ABC lymphoma cells. (nih.gov)
  • Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • The Food and Drug Administration (FDA) has received reports of T-cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies such as idecabtagene vicleucel injection. (medlineplus.gov)
Lymphoblastic12
  • Massive mediastinal T-lymphoblastic lymphoma. (medscape.com)
  • Particularly in the case of lymphoblastic diseases, the distinction between non-Hodgkin lymphoma and acute leukemia is arbitrary. (medscape.com)
  • Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
  • however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
  • Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common in children and young adults. (medscape.com)
  • Lymphoblastic lymphoma is aggressive and progresses rapidly, presenting as stage IV disease in more than 70% of patients (see Staging). (medscape.com)
  • Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
  • Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
  • In the United States, lymphoblastic lymphoma is relatively rare, comprising only 2% of all non-Hodgkin lymphomas (NHLs). (medscape.com)
  • T-lymphoblastic lymphoma (T-LBL) accounts for 25-30% of childhood NHL and is closely related to T-lymphoblastic leukemia (T-ALL). (medscape.com)
  • The estimated overall incidence of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma in Europe is 1.28 per 100 000 individuals annually, with significant age-related variations (0.53 at 45-54 years, ∼1.0 at 55-74 years and 1.45 at 75-99 years). (medscape.com)
Pediatric4
  • Since the late 1960s, treatment outcomes for pediatric patients with non-Hodgkin lymphoma have steadily improved. (medscape.com)
  • Exposure to air pollution may increase the risk of pediatric non-Hodgkin lymphoma. (medscape.com)
  • Finally, we present an overview of ALCL, one of the more rare pediatric malignancies. (cancernetwork.com)
  • Burkitt's lymphoma is one of the fastest growing malignancies in the pediatric population. (bvsalud.org)
Mantle cell lymphoma tr1
Therapies9
  • Data from these studies will advance CAR T-cell therapies for lymphoma patients. (lls.org)
  • Newer therapies that target immunologic and biologic aspects of the lymphoma are still under development but beginning to appear in the clinical arena. (medscape.com)
  • Participants with marginal zone lymphoma (MZL) must have received at least 2 prior systemic therapies. (survivornet.com)
  • Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)
  • In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
  • This SCOR paves the way for therapies that harness the body's own cell death machinery, called apoptosis, the normal process that causes impaired cells to self-destruct. (lls.org)
  • Mice treated with the other therapies or left untreated, on the other hand, continued to show tumor cells present," Wahl explained. (worldhealth.net)
  • These results illustrate how an understanding of the molecular machinery inside a cancer cell can lead to new therapies which can kill tumor cells while sparing normal cells, thus greatly reducing toxicities for patients," said Staudt. (nih.gov)
  • T Cell Therapies. (texaschildrens.org)
Anaplastic10
  • Its common subtypes include angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma not otherwise specified. (wikipedia.org)
  • The common subtypes are angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma not otherwise specified. (wikipedia.org)
  • Anaplastic large cell lymphoma (ALCL) is a subtype of mature T-cell lymphoma involving T-cells or natural killer (NK) cells, representing 12% of patients. (wikipedia.org)
  • It is further divided into two subtypes, ALK positive (ALK+) and ALK negative (ALK-), based on whether they express anaplastic lymphoma kinase or not. (wikipedia.org)
  • B-cell LCLs and anaplastic (usually T-cell) LCLs (ie, Ki-1+ lymphomas) have come to be viewed as distinct entities. (medscape.com)
  • Ultimately, however, anaplastic large cell lymphoma (ALCL) was diagnosed. (cancernetwork.com)
  • Oncological causes were then investigated, and ultimately, anaplastic large cell lymphoma was diagnosed. (cancernetwork.com)
  • There are no established risk factors for anaplastic large cell lymphoma. (wikidoc.org)
  • 2016). "Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma" . (wikidoc.org)
  • 2017). "Cytological diagnostic features of late breast implant seromas: From reactive to anaplastic large cell lymphoma" . (wikidoc.org)
Account for 102
  • Mature T-cell lymphomas account for 10% to 15% of all lymphomas and is more common in Asia than in Europe and America. (wikipedia.org)
  • Additionally,Leukemia is diagnosed 10 times more often in adults than children.New cases of leukemia, lymphoma and myeloma are expected to account for 10 percent of the estimated 1,762,450 new cancer cases diagnosed in the US in 2019. (medgadget.com)
Chemotherapy5
  • Chemotherapy, drugs, autologous stem cell treatment and extracorporeal photopheresis are treatment options. (wikipedia.org)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • The standard of care for many non-Hodgkin lymphoma patients involves chemotherapy and immunotherapy targeting the CD20 protein, which is highly expressed on most non-Hodgkin lymphoma cells. (worldhealth.net)
  • Consequently, we proceeded with salvage chemotherapy followed by autologous stem cell transplantation. (karger.com)
  • Adoptive T-Cell Transfer and Chemotherapy in the First-Line Treatment of Metastatic And/or Locally Recurrent Nasopharyngeal Carcinoma. (texaschildrens.org)
Leukemias and lymphomas1
  • REAL/WHO- [6] - classification includes leukemias and lymphomas, with 3 categories based on lineage and morphology (Hodgkin, B cell, and T/NK cell). (oncolink.org)
Cancer32
  • The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
  • For patient education information, see the Cancer Center , as well as Lymphoma (Hodgkin's Disease and Non-Hodgkin's Lymphoma) and Cancer of the Mouth and Throat . (medscape.com)
  • Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)
  • CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
  • In fact, this test sent her on a medical odyssey, one that shows the promise - and challenges - of blood tests that can potentially zero in on DNA released by cancer cells. (npr.org)
  • We are working to understand why and how it is that if cells in the body don't die when they should, cancer is able to develop," Dr. Strasser said. (lls.org)
  • When the process goes awry, cancer cells do not die as readily. (lls.org)
  • Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
  • Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
  • In the study , researchers labeled ofatumumab, a recently developed anti-CD20 fully human antibody, with 177 Lu, a widely used therapeutic radioisotope that can kill cancer cells. (worldhealth.net)
  • One of many types of cancer that can develop in the lymphatic system, mantle cell lymphoma is a rare form of non-Hodgkin lymphoma, affecting only about one in 200,000 Americans annually. (moffitt.org)
  • The term "lymphoma" refers to cancer of the body's lymphatic system, a network of tissues and organs that produce white blood cells to fight off infections and other diseases. (moffitt.org)
  • As with other forms of cancer, lymphoma is a malignancy caused by abnormal cell growth. (moffitt.org)
  • In the case of mantle cell lymphoma, the cancer starts in the outer edge of a lymph node follicle, an area known as the mantle zone. (moffitt.org)
  • When uncontrolled, the cancer cells can spread, or metastasize, to other parts of the body, where they can interfere with normal cell activity and cause serious damage. (moffitt.org)
  • For a biopsy, a small tissue sample is removed and analyzed under a microscope to determine whether cancer cells are present. (moffitt.org)
  • For patients who are diagnosed with a less aggressive form of mantle cell lymphoma, physicians may recommend a short period of "watchful waiting"-or monitoring the cancer progression before starting active treatment. (moffitt.org)
  • Nationally known for his research in the field of breast oncology, Dr. Wicha has been a major leader in the science of cancer stem cells. (stanford.edu)
  • His lab was part of the team that first discovered stem cells in breast cancer, the first described in any human solid tumor. (stanford.edu)
  • Subsequently his laboratory identified a number of cancer stem cell markers and developed in vitro and mouse models to isolate and characterize these cells, models which have been widely utilized in the field. (stanford.edu)
  • This work has directly led to development of several clinical trials aimed at targeting breast cancer stem cells. (stanford.edu)
  • In 2015, Dr. Wicha stepped down as the Cancer Center director enabling him to devote his full efforts to cancer stem cell research. (stanford.edu)
  • In 2016, he was awarded an R35- Outstanding Investigator award from the National Cancer Institute to support his research in cancer stem cells. (stanford.edu)
  • Using T cell-specific Atm-knockout models, as well as allogeneic transplantation experiments, we pinpoint impaired immune surveillance as a contributor to cancer predisposition and development. (nih.gov)
  • And I want that high level view, but I also want to hear how the cells are manipulated to recognize and fight cancer cells. (uhhospitals.org)
  • Lymphomas are the fifth most common form of cancer. (nih.gov)
  • A better understanding of the changes in cancer cells is leading us to what we hope will be more effective treatment strategies tailored to the genetic profile of each patient's cancer. (nih.gov)
  • Researchers at Texas Children's Cancer Center are undertaking a ground breaking clinical trial to train patient's own immune system to kill nasopharyngeal cancer cells. (texaschildrens.org)
  • O-GlcNAcylation of STAT5 could be required for nutrient sensing and metabolism of cancer cells. (nature.com)
  • 16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)
  • It works by causing the body's immune system (a group of cells, tissues, and organs that protects the body from attack by bacteria, viruses, cancer cells, and other substances that cause disease) to fight the cancer cells. (medlineplus.gov)
  • South Africa (SA)'s high levels of environmental contamination of mine tailings from uranium and its decay products, coupled with remarkably short distances between mine tailings and residential areas, raise concern about whether there is an association between environmental uranium exposure and risk of cancer, including haematological malignancies. (bvsalud.org)
Induces2
  • Here, we show that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induces tumor regression. (nih.gov)
  • Fleming WH, Murphy PR, Murphy LJ, Hatton TW, Matusik RJ, Friesen NG: Human growth hormone induces and maintains cmyc gene expression in Nb2 lymphoma cells. (karger.com)
Internal malignancy2
  • or a cutaneous metastasis from an internal malignancy. (health.gov.au)
  • A wide range of cutaneous signs may be related to internal malignancy. (medscape.com)
Chimeric antigen1
  • One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
Bone marrow7
  • Mature T-cell lymphoma, also called peripheral T-cell lymphoma, is a group of rare, aggressive lymphomas that develop from mature white blood cells and originate from lymphoid tissues outside of the bone marrow. (wikipedia.org)
  • Adequate bone marrow function (unless involvement of bone marrow by lymphoma) defined as AGC greater than 1500 and platelet count greater than 100,000. (knowcancer.com)
  • Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
  • Histopathology of the right tibial lesion was reviewed at IHHN, revealing sheets and aggregates of neoplastic cells replacing bone marrow interspersed with sclerotic bony fragments. (hindawi.com)
  • To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca. (karger.com)
  • It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
  • Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)
Patients21
  • The objective of this proposal is to improve bispecific anti-CD20/anti-CD19 CAR T-cell activity and persistence by understanding impact of cell manufacturing parameters on final engineered CAR-T product and determining resistance mechanisms in relapsing patients. (lls.org)
  • For those with relapsed aggressive B-cell lymphoma, anti-CD19 CAR T-cell therapy can achieve a long-term remission in 30-40% of patients. (lls.org)
  • Despite effectiveness, most patients still fail to respond or relapse after administration of CAR T-cells. (lls.org)
  • From this trial we plan to analyze the starting material used to make the CAR T-cells, the final product before infusion, and blood samples from the patients after administration to understand differences among long-term responders and non-responders. (lls.org)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • Angioimmunoblastic T-cell lymphoma (AITL) is a fast-growing form of mature T-cell lymphoma, accounting for 18.5% of patients. (wikipedia.org)
  • It is the most common subtype, representing 25.9% of mature T-cell lymphoma patients. (wikipedia.org)
  • Mature T-cell lymphoma is fast-growing and patients are usually diagnosed at later stage. (wikipedia.org)
  • About 30% of PTCL-NOS patients exhibit EBV-infected cancerous T cells, leading to the classification of Epstein-Barr virus-associated peripheral T cell lymphoma not otherwise specified. (wikipedia.org)
  • Patients who have AN associated with malignancies also have skin changes involving the scalp, areolae, and eyelids. (medscape.com)
  • Ibrutinib continues to demonstrate promise for patients living with B-cell malignancies, and we are pleased that the FDA has recognized its potential for people living with CLL and the del17p mutation," said Peter F. Lebowitz, M.D., Ph.D., Global Oncology Therapeutic Area Head, Janssen. (jnj.com)
  • Scientists have identified a characteristic shared by most patients with this type of lymphoma: a genetic abnormality affecting certain chromosomes. (moffitt.org)
  • Because patients with this type of lymphoma often display no symptoms or have symptoms that are similar to those of other health conditions, mantle cell lymphoma is often diagnosed in its late stages. (moffitt.org)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • We further find a reduced T cell abundance in B cell lymphomas from Atm-defective mice and A-T patients. (nih.gov)
  • Altogether, our data indicate that T cell-specific restoration of ATM activity or allogeneic hematopoietic stem cell transplantation may prevent lymphomagenesis in A-T patients. (nih.gov)
  • Baumgartner JE, Rachlin JR, Beckstead JH, Meeker TC, Levy RM, Wara WM, Rosenblum ML: Primary central nervous system lymphomas: natural history and response to radiation therapy in 55 patients with acquired immunodeficiency syndrome. (karger.com)
  • A Phase II Study Evaluating the Safety and Efficacy of an Adenovirus-ΔLMP1-LMP2 Transduced Dendritic Cell Vaccine in Patients with Advanced Metastatic Nasopharyngeal Carcinoma. (texaschildrens.org)
  • Adoptive Transfer of EBV-Specific T Cells Results in Sustained Clinical Responses in Patients with Locoregional Nasopharyngeal Carcinoma. (texaschildrens.org)
  • Patients with unusual bladder malignancies and a rare cause of splenomegaly. (bvsalud.org)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
Myeloma1
  • The team is now testing multiple new approaches to boost apoptosis in other leukemias, as well as lymphoma and myeloma. (lls.org)
Mutations6
  • Some subtypes of mature T-cell lymphoma may be associated with viral exposure as well as gene mutations. (wikipedia.org)
  • Mature T-cell lymphoma can be associated with viral exposure and gene mutations. (wikipedia.org)
  • Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, that have up to now not been investigated thoroughly for common oncogenic mutations. (techblessing.com)
  • Knockdown of NRAS by siRNA induced apoptosis in mutant Hut78 cells however, not in CTCL cell lines missing RAS mutations. (techblessing.com)
  • Somatic mutations that are located in many malignancies, including digestive tract carcinoma, melanoma, or pancreatic malignancy, occur almost specifically in BRAF, KRAS, or NRAS isoforms.9C11 Standard mutations affect glycine 12 (G12), glycine 13 (G13), or glutamine 61 (Q61) and maintain RAS within an turned on form. (techblessing.com)
  • FHL is an autosomal recessive disease caused by several mutations in the NK/T-cell cytotoxic pathway. (medscape.com)
Tumor cells6
  • We hypothesized that targeting multiple antigens on tumor cells could be a more effective approach to minimize tumor antigen escape. (lls.org)
  • Nevertheless, in tumor cells, mutated TCS ERK 11e (VX-11e) (oncogenic) RAS preferentially promotes success and proliferation. (techblessing.com)
  • A single dose of the radioimmunotherapy, [ 177 Lu]Lu-ofatumumab, was found to quickly eliminate tumor cells and extend the life of mice injected with cancerous cells for more than 221 days (the trial endpoint), compared to fewer than 60 days for other treatments and just 19 days in untreated control mice. (worldhealth.net)
  • May be normal, or may reveal abnormalities related to organ infiltration (i.e., elevated liver enzymes) or production of substances by the tumor cells. (vin.com)
  • Hyperproteinemia is a rare finding, and is secondary to protein production by tumor cells. (vin.com)
  • GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
Etiology2
  • In industrialized countries, most individuals with non-Hodgkin lymphoma have no known etiology or association. (medscape.com)
  • The epidemiologic association between non-Hodgkin lymphoma and certain paternal occupations (eg, those that increase contact with other individuals) suggests a possible infective etiology for childhood non-Hodgkin lymphoma. (medscape.com)
Systemic disease1
  • Testicular lymphoma may either represent secondary involvement by systemic disease or primary malignancy. (intechopen.com)
Hodgkin Lymphoma14
  • Mature T-cell lymphoma is under the category of non-Hodgkin lymphoma. (wikipedia.org)
  • In certain individuals with non-Hodgkin lymphoma, surgical resection and radiation therapy are also key components of definitive treatment. (medscape.com)
  • Epidemiologic data suggest that certain human leukocyte antigen (HLA) types, and even certain blood types, may increase or decrease the likelihood of developing non-Hodgkin lymphoma. (medscape.com)
  • the case for its involvement in childhood non-Hodgkin lymphoma is less compelling than the case for adults, but this is still under investigation. (medscape.com)
  • Hvidtfeldt et al observed an association between residential exposure to fine atmospheric particulate matter, including black carbon, and the development of non-Hodgkin lymphoma in children. (medscape.com)
  • Despite the long history of bendamustine as treatment for indolent non-Hodgkin lymphoma, long-term efficacy and toxicity data are minimal. (ox.ac.uk)
  • Non-Hodgkin lymphoma is a common blood malignancy. (worldhealth.net)
  • They then determined the in vitro characteristics of [ 177 Lu]Lu-ofatumumab, estimated human dosimetry, and evaluated its therapeutic effectiveness for non-Hodgkin lymphoma in a mouse model. (worldhealth.net)
  • The excellent therapeutic results in this animal model of human B cell lymphoma suggest that this curative treatment should be tested in humans with non-Hodgkin lymphoma," noted Wahl. (worldhealth.net)
  • In fact, it is a subtype of B-cell non-Hodgkin lymphoma . (moffitt.org)
  • As with other types of non-Hodgkin lymphoma, mantle cell lymphoma can also cause lymph node enlargement in the elbows, shoulders and armpits as well as the chest, stomach and groin areas. (moffitt.org)
  • Plasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. (hindawi.com)
  • ABSTRACT In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). (who.int)
  • Among 41 cases of non-Hodgkin lymphoma, 12 (29.27%) benefited from the R-CHOP protocol and full response was observed in 46.34% of them. (bvsalud.org)
Aggressive1
Hematopoietic stem cell1
  • The report also includes clinical guidance for adults who have received 7-valent PCV (PCV7) only and adults who are hematopoietic stem cell transplant recipients. (cdc.gov)
Manifestations1
  • The African, or endemic, variant usually involves the maxilla and other facial bones, while head and neck manifestations in sporadic Burkitt's lymphoma are rare. (bvsalud.org)
Subtypes4
  • There are many different subtypes under mature T-cell lymphoma, each being considered as a separate disease due to specific clinical features. (wikipedia.org)
  • Signs and symptoms of mature T-cell lymphoma vary among different subtypes, sometimes even among individuals under the same subtype. (wikipedia.org)
  • However, important advances have been made in understanding that this disease is comprised of at least three molecular subtypes, each derived from B cells at unique stages in their development. (nih.gov)
  • It is a high-grade B-cell non-Hodgkin's lymphoma with endemic, sporadic and human immunodeficiency-associated subtypes. (bvsalud.org)
Clinical2
  • Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
  • Primary lymphoma of the pituitary: an emerging clinical entity. (karger.com)
Peripheral2
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • Hematologic neoplasms are abnormal and anarchic proliferations of hematopoietic cells with a medullary or peripheral starting point. (bvsalud.org)
Gastric lymphoma1
  • There is a well-characterized association of gastric lymphoma with Helicobacter pylori infection. (oncolink.org)
Secondary1
  • HLH has been traditionally divided into a primary form, which typically manifests in children with documented genetic abnormalities of the cytotoxic function of NK cells and T cells, and a secondary form that tends to occur at older ages in the setting of an associated condition, such as infection and malignancy, without an identifiable genetic abnormality. (medscape.com)
Leukaemia2
  • Mature T-cell lymphoma can be associated with exposure to Epstein-Barr virus (EBV) or human T-cell leukaemia virus 1 (HTLV-1). (wikipedia.org)
  • However, the vaccine is contraindicated in those with The live oral polio vaccine (OPV) is a trivalent vaccine containing suspensions of primary immune deficiency disease or suppressed immune response from types 1, 2 and 3 attenuated poliomyelitis viruses (Sabin strains) prepared in medication, leukaemia, lymphoma or generalized malignancy. (who.int)
Prognostic1
  • Greater than 50% infiltration of lymphoma within the marrow is a poor prognostic factor. (vin.com)
Immature2
  • This condition arises from immature T cells in more than 80% of cases and immature B cells in the remainder of cases. (medscape.com)
  • Canine lymphoma is usually a malignancy of immature cells (lymphoblasts). (vin.com)
Gene expression1
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
Cytotoxic5
  • Deoxycoformycin(DCF)/Pentostatin is a T-cell cytotoxic drug with previously reported responses in lymphoid malignancies but larger studies are needed. (knowcancer.com)
  • Binding of a tumor antigen via the scFv activates the T cell in a major histocompatibility-independent manner which leads to a cytotoxic response [ 3 ]. (nature.com)
  • The lymphoma cells displayed T-cell cytotoxic phenotype. (nih.gov)
  • It is an invasive lymphoma derived from NK cells or cytotoxic T cells, which is related to Epstein-Barr virus infection. (frontiersin.org)
  • [ 2 ] HLH is caused by a defect in inflammatory signals that results in uncontrolled hypercytokinemia, usually in a setting of congenital or acquired defective natural killer (NK)/T-cell function in the cytotoxic pathway. (medscape.com)
Immunotherapy3