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  • thymic lymphoma
  • E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4 − CD8 − ) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. (jimmunol.org)
  • encodes
  • Thirteen years later, it was shown that the oncogene transduced by this virus encodes a serine/threonine protein kinase (AKT) (also known as PKB), which harbors an N-terminal regulatory domain (now known as the PH domain) and exhibits a high degree of homology with the kinases PKC and PKA ( 2 - 5 ). (sciencemag.org)
  • The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. (asm.org)
  • In one example, the gag gene from Friend Leukemia Virus encodes an H-2D d -restricted CTL target on the leukemia cell line, FBL-3 [ 22 ]. (pubmedcentralcanada.ca)
  • viral
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • This indicates that some human cells express a protein on their surface that acts as a receptor for MCF viruses and allows MCF viral entry. (umassmed.edu)
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Exclusive involvement of H-2Db or H-2Kd product in the interaction between killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas. (histrecmed.fr)
  • Becker S., Fenyo E. M., Klein E. The «natural killer» cell in the mouse does not require H - 2 homology and is not directed against type or group - specific antigens of murine С viral proteins. (medkursor.ru)
  • Rous Sarco
  • Bandyopadhyay A. K. Partial purification and characterization of DNA polymerases from a Rous sarcoma virus - transformed rat cell line. (medkursor.ru)
  • Billeter M. A., Coffin J. M., Joho R. Mapping of the genome of prague rous sarcoma virus В. (medkursor.ru)
  • Genome
  • The virus integrates into the cellular genome and inserts its DNA near or within genes, which leads to various outcomes: (i) The insertion site is too far away from a protooncogene and thus does not activate it. (biomedcentral.com)
  • tumor cells
  • Brugge J. S., Purchio A. F., Erikson R. L. The distribution of virus - specific RNA in RSV - induced hamster tumor cells. (medkursor.ru)
  • Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. (frontiersin.org)
  • Therapy in an intracerebral murine glioma model, using bacillus calmette-guerin, neuraminidase-treated tumor cells, and 1-(2- -chloroethyl)-3-cyclohexyl-1-nitrosourea. (jax.org)
  • vivo
  • Flow microfluorimetric analysis of sensitive and resistant leukemia l1210 following 1-beta-d- -arabinofuranosylcytosine in vivo. (jax.org)
  • genes
  • Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. (asm.org)
  • Structures of herpes simplex virus type 1 genes required for replication of virus DNA. (asm.org)
  • Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression. (asm.org)
  • nucleotide sequence
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Strains
  • Biologic, serologic, and molecular characterization of several HIV-1 and HIV-2 strains has revealed their extensive heterogeneity and how viruses can evolve differently in the same individual in the immune system, bowel, and the brain. (ucsf.edu)
  • tumour viruses
  • He postulated that RNA tumour viruses made DNA copies which then integrated into host chromosomal DNA, analogous to integration of prophage in bacteria. (royalsocietypublishing.org)
  • Indeed, germ-line integration has not yet been described for DNA tumour viruses, although we now know that it occasionally occurs with human herpesvirus 6 [ 9 , 10 ]. (royalsocietypublishing.org)
  • Barbacid M., Stephenson J. R., Aaronson S. A. Gag Gene of mammalian type - С RNA tumour viruses. (medkursor.ru)
  • gene
  • A replication competent MCF virus containing a bacterial amber suppressor tRNA gene ( supF ) was used to investigate the changes in the enhancer region following injection of MCF containing one enhancer in the LTR. (umassmed.edu)
  • Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants. (asm.org)
  • Benjamin T. L. Tumor viruses and cellular gene expression. (medkursor.ru)
  • replication
  • To address this issue, primary and immortalized human cells were tested for their ability to be infected by MCF packaged defective vectors as well as replication competent MCF virus. (umassmed.edu)
  • In addition, I show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication. (umassmed.edu)
  • Levy
  • Research in the Levy laboratory is directed at understanding the interaction of viruses and the immune system in microbial pathogenesis. (ucsf.edu)
  • infection
  • Biegeleisen K., Rush M. G. Association of herpes simples virus type I DNA with host chromosomal DNA during productive infection. (medkursor.ru)
  • simian
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Beth E., Cikes M., Schloen L. Interspecies species- and type - specific determinants of human papovaviruses (JC and BK) and of simian virus 40. (medkursor.ru)
  • protein
  • Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1. (asm.org)
  • pathogenic
  • Most strongly pathogenic MCF viruses have a duplication of the enhancer element found in the LTR. (umassmed.edu)
  • These data suggest that the injected virus is not pathogenic unless the enhancer region is altered. (umassmed.edu)
  • human
  • It was only in 1976 that a virologist named Harald zur Hausen identified the human papillomavirus, one of the first viruses known to lead to human cancer. (smithsonianmag.com)
  • Human T-Lymphotropic Virus. (ucsf.edu)
  • locus
  • Indeed, 80% of the translocations in Burkitt's lymphoma juxtapose MYC to the immunoglobulin heavy chain locus, with MYC being overexpressed as a consequence. (biomedcentral.com)