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  • primary cutaneous
  • Diseases formerly designated as reticulosis or reticulosarcomatosis are currently classified according to the World Health Organization (WHO)/European Organization for Research and Treatment of Cancer (EORTC) classification (WHO-EORTC classification) for primary cutaneous lymphomas and the WHO classification. (medscape.com)
  • tumor cells
  • Three researchers who are recipients of a collaborative grant from the Samuel Waxman Cancer Research Foundation have developed a new type of drug designed to kill non-Hodgkin lymphoma tumor cells. (redorbit.com)
  • ONC201 is a small molecule that induces p53-independent cell death in tumor cells while sparing normal cells through a number of putative mechanisms, including inactivation of the pro-survival kinases Akt and ERK. (bloodjournal.org)
  • It helps the cancer to grow unimpeded-for example, by activating genes for immune checkpoint ligands that protect tumor cells from the body's built-in defense system. (ehealthweek2010.org)
  • malignant
  • An unusual feature of this form of lymphoma is that only a small proportion of the tumor mass is made up of malignant cells. (ehealthweek2010.org)
  • Identify gene expression patterns in malignant T cells that can be used to diagnose cutaneous T-cell lymphoma. (clinicaltrials.gov)
  • Determine the patterns of gene expression that distinguish normal skin-homing T cells from malignant T cells. (clinicaltrials.gov)
  • Malignant T cells from blood or skin are then isolated and patterns of gene expression in the malignant T cells are compared to those in normal skin-homing T cells from healthy donors using a 'gene chip' (Lymphochip). (clinicaltrials.gov)
  • Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in sensitive cells and may be suitable for novel anti-cancer therapies aimed at inducing apoptosis via the activation of TRAIL receptors on malignant cells. (nih.gov)
  • lymph
  • In time, the cancerous cells turn into lymph node tumors. (reference.com)
  • The symptoms of non-Hodgkin's lymphoma include swollen lymph nodes, abdominal pain, fatigue, fever and weight loss, according to the Mayo Clinic. (reference.com)
  • findings
  • The researchers, who published their findings in the April issue of Cancer Cell, have identified a drug that targets an oncogene known as BCL6. (redorbit.com)
  • Findings published in today's issue of Cancer Cell show that an experimental compound designed by a team of researchers from Weill Cornell Medical College, the University of Maryland and the Ontario Cancer Center at the University of Toronto may effectively block the cancer-causing actions of BCL6 by attaching to a critical "hot spot" on its surface, thus killing off the cancer cells. (scienceblog.com)
  • Abstract
  • Lymphoma in pregnancy: excellent fetal outcomes and maternal survival in a large multicenter analysis," Blood , vol. 118, Abstract 94, 2011. (hindawi.com)
  • proteins
  • Using high-resolution 2-dimensional gel electrophoresis to separate proteins from cells labeled in vivo with either [ 32 P]phosphate or [ 35 S]methionine, the tumor promoter 12- O -tetradecanoylphorbol-13-acetate (TPA) was shown to stimulate phosphorylation of at least 18 proteins in a subline of S49 mouse lymphoma cells deficient in cyclic AMP-dependent protein kinase. (aacrjournals.org)
  • Treatment of cells with phospholipase C mimicked TPA in stimulating phosphorylation of some of these substrate proteins, thereby suggesting possible involvement of protein kinase C, the calcium-activated phospholipid-dependent protein kinase. (aacrjournals.org)
  • Melnick
  • This means that if given as a therapeutic agent, the compound would be unlikely to have ill-effects on healthy normal cells, and therefore would not be expected to have significant side effects," explains Dr. Melnick. (scienceblog.com)
  • Dr. Melnick is among the physician-scientists supported by the Leukemia and Lymphoma Society's (LLS) Scholar Award Program. (scienceblog.com)
  • Kaposi's
  • Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). (nih.gov)
  • Using co-crystal structural analysis, Lee and her colleagues found a tight, "belt-type" interaction between HAUSP and a viral protein that causes Kaposi's sarcoma and lymphoma . (phys.org)
  • Variants
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • The small and lympho-histiocytic variants display a marked variability of the neoplastic cell size that ranges from small to large. (hindawi.com)