Lymphoma refractory disease. Medical search. Frequent questions

Treatment protocols for classical Hodgkin lymphoma (HL) are provided below, including treatment for early-stage, advanced-stage, and relapsed/refractory disease. (medscape.com)
In a phase II trial reported in JAMA Oncology , Locke J. Bryan, MD , and colleagues found that the combination of pembrolizumab with ICE chemotherapy (a regimen including ifosfamide, carboplatin, and etoposide) produced a high rate of complete response in patients with relapsed or refractory classical Hodgkin lymphoma who were candidates for autologous stem cell transplantation (SCT). (ascopost.com)
The purpose of this study is to assess the safety of the investigational drug SEA-TGT in people with classical Hodgkin lymphoma that has come back or continued to grow despite treatment. (mskcc.org)
Participants must have classical Hodgkin lymphoma that has come back or continued to grow despite prior treatment. (mskcc.org)
Objectives Patients with classical Hodgkin lymphoma (cHL) relapsing after second-line therapy have a dismal prognosis and novel approaches are required for this patient group. (uni-koeln.de)
The JSH Practical Guidelines for Hematological Malignancies, 2018 expanded edition, newly adopted brentuximab vedotin, doxorubicin, vinblastine, dacarbazine(A+AVD)protocol as a standard treatment for advanced-stage classical Hodgkin lymphoma(CHL). (bvsalud.org)

[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Regimens that combine chemotherapy and radiation therapy (RT) have replaced RT alone for treatment of early-stage, favorable disease. (medscape.com)
As stated by the investigators, "To our knowledge, this is the first clinical trial designed to investigate concurrent treatment with a checkpoint inhibitor and conventional chemotherapy in relapsed or refractory classic[al] Hodgkin lymphoma in patients destined for an autologous SCT. (ascopost.com)
In the U.S. investigator-initiated multicenter study, 37 evaluable patients with relapsed or refractory disease after one or two lines of chemotherapy were enrolled between April 2017 and October 2020. (ascopost.com)
The investigators concluded, "Results suggest that the addition of pembrolizumab to ICE chemotherapy was well tolerated and highly effective in comparison with prior reports of chemotherapy-only regimens, supporting further investigation in patients with relapsed or refractory classic[al] Hodgkin lymphoma eligible for an autologous SCT. (ascopost.com)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Most people diagnosed with diffuse large B-cell lymphoma, the most common form of aggressive NHL, will be cured by initial treatment with chemotherapy. (cancer.gov)
Until recently, the only treatment with the possibility of eliminating recurrent or treatment-resistant diffuse large B-cell lymphoma was more high-dose chemotherapy, followed by an autologous stem cell transplant. (cancer.gov)
Earlier findings from the ZUMA-7 trial, which began recruiting patients in 2018, led the Food and Drug Administration (FDA) to approve axi-cel in 2022 for adults with diffuse large B-cell lymphoma that wasn't eliminated by their initial treatment or that returned within 12 months of initial chemotherapy. (cancer.gov)
While 94% of people in the axi-cel group received their CAR T cells, only 36% of those in the standard-treatment group were able to have a stem cell transplant because in most cases their disease continued to progress despite chemotherapy, Dr. Westin explained at the ASCO meeting. (cancer.gov)
High-dose chemotherapy with autologous stem-cell rescue (HDC/ASCT) is the best salvage therapy for patients with aggressive B-cell lymphomas. (cun.es)
Patients suffering from lymphoma (a type of cancer of the white blood cells called lymphocytes) have less chance of cure if they are refractory to initial chemotherapy or relapse after receiving initial chemotherapy when compared to patients who are responsive to and do not relapse following initial chemotherapy. (knowcancer.com)
However, before this can be considered most patients require chemotherapy to control the lymphoma and to determine whether the lymphoma is still sensitive to alternative types of chemotherapy (salvage chemotherapy). (knowcancer.com)
Two new chemotherapy drugs, vinorelbine and gemcitabine, have both shown encouraging efficacy against lymphoma when used alone for patients with heavily pretreated lymphoma. (knowcancer.com)
All the patients participating in this study have been diagnosed with relapsed or refractory lymphoma and have been offered treatment with vinorelbine and gemcitabine as an alternative to inpatient salvage chemotherapy. (knowcancer.com)
Chemotherapy is an option is the disease has spread beyond its origin, or if it has proven refractory on antibiotics. (lymphomainfo.net)
DYNAMO assessed the efficacy and safety of duvelisib (25 mg twice daily) as a monotherapy in 129 patients with follicular lymphoma ( n = 83), small lymphocytic lymphoma ( n = 28), or marginal zone lymphoma ( n = 18) whose disease has progressed and who are refractory to rituximab and to either chemotherapy or radioimmunotherapy. (genengnews.com)
Polivy is intended to be used in combination with Roche's Rituxan and the chemotherapy bendamustine to treat patients with relapsed/refractory diffuse large B-cell lymphoma, a relatively rare type of blood cancer. (fool.com)
Per the terms of the collaboration, Affimed will fund and conduct a Phase 1b clinical trial to evaluate the combination of Merck's anti-PD-1 therapy, KEYTRUDA (pembrolizumab), with Affimed's proprietary drug candidate AFM13 in patients with Hodgkin lymphoma whose disease has relapsed or is refractory to chemotherapy, including treatment with Adcetris (brentuximab vedotin). (drugdiscoverynews.com)
The mainstay of treatment for indolent non-Hodgkin's lymphoma is an anti-CD20 antibody rituximab in combination with chemotherapy consisting of alkylating agents, anthracyclines, antimitotic agents, or purine analogues. (esmo.org)
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is an under-recognized complication of several chemotherapy agents used as part of curative-intent therapy for Hodgkin Lymphoma (HL). (bvsalud.org)
comment the results of three large, phase III, randomized clinical trials in early-stage favorable Hodgkin Lymphoma (HL), aimed at exploring the non-inferiority of ABVD chemotherapy alone compared to combined-modality treatment with ABVD and Involved Field/Node Radiotherapy (INRT). (bvsalud.org)

I. Determine the response rate (complete and partial) in patients with relapsed or refractory Burkitt's, mantle cell or diffuse large cell non-Hodgkin's lymphoma treated with FR901228 (depsipeptide). (knowcancer.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. (newworldencyclopedia.org)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Based on these results, axi-cel is now the preferred treatment for people whose diffuse large B-cell lymphoma has recurred quickly or proven resistant to standard initial treatment, explained Christopher Melani, M.D., of NCI's Center for Cancer Research . (cancer.gov)
This combination is currently considered the standard of care for treatment-resistant or relapsed diffuse large B-cell lymphoma. (cancer.gov)
The diffuse large B-cell lymphoma (DLBCL) accounts for the majority of cases. (intechopen.com)
In addition to the approved indications, multi-center, multi-indication clinical trials are underway in the US and China with orelabrutinib as monotherapy or in combination therapies, such as first line treatment of MCD subtype of diffuse large B-cell lymphoma (DLBCL). (businesswire.com)
Despite meaningful progress in the treatment of diffuse large B-cell lymphoma, treatment options are very limited when the disease is refractory to or recurrent after multiple regimens," the company wrote in a press release. (fool.com)
Filing is based on safety and efficacy from the TRANSCEND NHL 001, which tested liso-cel in 269 patients with with relapsed/refractory large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL). (pharmaphorum.com)
Evidence-based recommendations on polatuzumab vedotin (Polivy) with rituximab, cyclophosphamide, doxorubicin and prednisolone for untreated diffuse large B-cell lymphoma in adults. (bvsalud.org)

It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ( 131 I-rituximab). (karger.com)
Although long-term follow-up and analysis of additional patients are needed, our results indicate that bispecific anti-CD19/CD20 CAR in naïve memory T cells may be safe and effective in patients with relapsed or refractory B-cell lymphomas," Ghafouri said. (aacr.org)

The ORR was 68% among the 28 patients with small lymphocytic lymphoma, the company said, but 41% among the 83 patients with follicular lymphoma, and just 33% among the 18 patients with marginal zone lymphoma. (genengnews.com)
Orelabrutinib has been also approved in China for the treatment of r/r chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and r/r mantle cell lymphoma (MCL). (businesswire.com)
On Dec. 25, 2020, orelabrutinib received conditional approval from the China National Medical Products Administration (NMPA) in two indications: the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma (SLL), and the treatment of patients with relapsed/refractory mantle cell lymphoma (MCL). (businesswire.com)
Indolent cases constitute approximately one third of all patient with non-Hodgkin's lymphoma and include follicular lymphoma, small lymphocytic lymphoma, marginal-zone lymphoma, and lymphoplasmacytic lymphoma with or without Waldenström's macroglobulinemia. (esmo.org)
Subtypes of indolent non-Hodgkin's lymphoma included follicular lymphoma (72 patients), small lymphocytic lymphoma (28), marginal-zone lymphoma (15), and lymphoplasmacytic lymphoma with or without Waldenström's macroglobulinemia (10). (esmo.org)

For more information, see Non-Hodgkin Lymphoma and Pediatric Non-Hodgkin Lymphoma . (medscape.com)
Lymphoma commonly is categorized broadly as Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL, all other types of lymphoma). (newworldencyclopedia.org)
Hodgkin lymphoma, as well as other minor groups. (newworldencyclopedia.org)
Download or order The Leukemia & Lymphoma Society's free booklet, Hodgkin Lymphoma . (schoolandyouth.org)
CAR T-cell therapy, a type of personalized immunotherapy, can help cure some people with aggressive non-Hodgkin lymphoma (NHL). (cancer.gov)
Infinity Pharmaceuticals said today it will shut down its discovery research operation and eliminate 46 jobs-21% of its workforce-following underwhelming Phase II results for its lead candidate duvelisib in refractory indolent non-Hodgkin lymphoma (iNHL). (genengnews.com)
We hoped that treatment with duvelisib as a monotherapy would have provided a larger clinical benefit for patients with advanced indolent non-Hodgkin lymphoma," Perkins stated. (genengnews.com)
Marginal zone lymphoma (MZL) is a type of non-Hodgkin lymphoma (NHL) of indolent nature originating from B cells in the marginal zones of the spleen, lymphatic tissue, and lymph nodes. (businesswire.com)
Non-Hodgkin lymphoma (NHL) is a cancer of the lymphatic system. (cancer.net)
In partnering with companies such as Affimed, we continue our efforts to bring forward new scientific breakthroughs for patients with Hodgkin lymphoma and the field of immuno-oncology overall. (drugdiscoverynews.com)
The compound is designed to treat CD30-positive malignancies, including Hodgkin lymphoma and T cell lymphoma, and it is currently in Phase 2 studies in Hodgkin lymphoma patients. (drugdiscoverynews.com)
DLBCL is the most common and aggressive type of non-Hodgkin lymphoma, and accounts for three out of every five cases. (pharmaphorum.com)
Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies of different biology and prognosis. (medscape.com)
non-Hodgkin lymphoma, other and unspecified types (C85. (who.int)

Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
Approximately one-third of patients with DLBCL relapse after receiving first-line treatment, and about 10% have refractory disease. (pharmaphorum.com)

This is the first trial in nearly 30 years to significantly improve overall survival for patients with large B-cell lymphoma that is not responding to initial treatment or has relapsed," said Dr. Jason Westin, M.D., of the University of Texas MD Anderson Cancer Center, who helped lead the study. (cancer.gov)
This landscape began to change in 2021, when the results of two large clinical trials showed that CAR T cells could improve the time that people with treatment-resistant or recurrent large B-cell lymphoma lived without their cancer getting worse. (cancer.gov)
Breyanzi (lisocabtagene maraleucel) is a CD-19 directed chimeric antigen receptor (CAR) T cell therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma (LBCL). (drugs.com)
BMS said it has filed the CAR-T therapy lisocabtagene maraleucel (liso-cel) with the FDA for relapsed or refractory large B-cell lymphoma (LBCL) after at least two prior therapies. (pharmaphorum.com)

Since Dickie first described the benefits of a gluten-free diet in the 1940s and 1950s, this diet is the standard of care for all patients with celiac disease [ 1 , 2 ]. (springer.com)
While dietary modifications are likely to remain the treatment of choice in celiac disease, the use of adjuvant corticosteroids in newly diagnosed patients is a topic that has been addressed previously. (springer.com)
Their objective was to identify whether adjuvant treatment with corticosteroids can help expedite clinical and histological recovery in patients with newly diagnosed celiac disease. (springer.com)
The use of systemic corticosteroids for severe celiac disease is not new. (springer.com)
Currently, the most common indication for the use of corticosteroids in celiac disease is the treatment of refractory symptoms. (springer.com)
There are two subtypes of refractory celiac disease: type 1 disease is characterized by normal intra-epithelial lymphocytes, whereas type 2 disease is characterized by aberrant intra-epithelial lymphocytes of clonal origin. (springer.com)
Corticosteroids, however, remain the mainstay of treatment for refractory celiac disease. (springer.com)
A second and less common indication for the use corticosteroids in celiac disease is for the treatment of life-threatening celiac crisis. (springer.com)
Evidence confirming their effectiveness in celiac disease first came from in vitro studies involving samples of intestinal mucosa in tissue culture. (springer.com)
8 ] examined intestinal enzyme activity in patients with celiac disease following in vitro exposure to gluten. (springer.com)
Despite the benefits accruing from these early studies, the use of locally active corticosteroids in celiac disease has received little attention until recently. (springer.com)
Celiac.com 06/04/2012 - Non-responsive celiac disease is very much what it sounds like: celiac disease where symptoms seem to resist treatment and continue even in the face of a gluten-free diet. (helpforibs.com)
Photo: CC--return the sunA team of researchers recently set out to look for the most likely causes of persistent symptoms in celiac disease patients on a gluten-free diet. (helpforibs.com)
Their goal for the study was to investigate all patients referred to our center with non-responsive celiac disease (NRCD), to establish a cause for their continued symptoms. (helpforibs.com)
For their study, the research team assessed all non-responsive celiac disease who were referred to their gastroenterology center over an 18-mo period. (helpforibs.com)
Overall, the team looked at 112 patients with non-responsive celiac disease. (helpforibs.com)
They determined that twelve of those did not actually have celiac disease. (helpforibs.com)
We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period. (wjgnet.com)
Twelve were found not to have celiac disease (CD). (wjgnet.com)
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. (medlineplus.gov)
Celiac disease can develop at any age after an individual starts eating foods containing gluten. (medlineplus.gov)
Abdominal pain, swelling (distention), and food intolerances are common in celiac disease. (medlineplus.gov)
Inflammation associated with celiac disease may lead to an increased risk of developing certain gastrointestinal cancers such as cancers of the small intestine or esophagus. (medlineplus.gov)
Many people with celiac disease have one or more of these varied health problems but do not have gastrointestinal symptoms. (medlineplus.gov)
This form of the condition is called nonclassic celiac disease. (medlineplus.gov)
Researchers now believe that nonclassic celiac disease is actually more common than the classic form. (medlineplus.gov)
Celiac disease often goes undiagnosed because many of its signs and symptoms are nonspecific, which means they may occur in many disorders. (medlineplus.gov)
Most people who have one or more of these nonspecific health problems do not have celiac disease. (medlineplus.gov)
On average, a diagnosis of celiac disease is not made until 6 to 10 years after symptoms begin. (medlineplus.gov)
However, people with silent celiac disease do have immune proteins in their blood (antibodies) that are common in celiac disease. (medlineplus.gov)
In a small number of cases, celiac disease does not improve with a gluten-free diet and progresses to a condition called refractory sprue. (medlineplus.gov)
Celiac disease is a common disorder. (medlineplus.gov)
The risk of developing celiac disease is increased by certain variants of the HLA-DQA1 and HLA-DQB1 genes. (medlineplus.gov)
Celiac disease is associated with an inappropriate immune response to a segment of the gluten protein called gliadin . (medlineplus.gov)
Experts share 10 pieces of best practice advice for diagnosing and treating refractory celiac disease. (gastro.org)
1. In patients believed to have celiac disease who have persistent or recurrent symptoms or signs, the initial diagnosis of celiac disease should be confirmed by review of prior diagnostic testing, including serologies, endoscopies and histologic findings. (gastro.org)
2. In patients with confirmed celiac disease with persistent or recurrent symptoms or signs (nonresponsive celiac disease), ongoing gluten ingestion should be excluded as a cause of these symptoms with serologic testing, dietitian review and detection of immunogenic peptides in stool or urine. (gastro.org)
If villous atrophy persists or the initial diagnosis of celiac disease was not confirmed, consider other causes of villous atrophy, including common variable immunodeficiency, autoimmune enteropathy, tropical sprue and medication-induced enteropathy. (gastro.org)
3. For patients with nonresponsive celiac disease, after exclusion of gluten ingestion, perform a systematic evaluation for other potential causes of symptoms, including functional bowel disorders, microscopic colitis, pancreatic insufficiency, inflammatory bowel disease, lactose or fructose intolerance and small intestinal bacterial overgrowth. (gastro.org)
4. Use flow cytometry, immunohistochemistry and T-cell receptor rearrangement studies to distinguish between subtypes of refractory celiac disease and to exclude enteropathy-associated T-cell lymphoma. (gastro.org)
Type 1 refractory celiac disease is characterized by a normal intraepithelial lymphocyte population and type 2 is defined by the presence of an aberrant, clonal intraepithelial lymphocyte population. (gastro.org)
5. Perform small bowel imaging with capsule endoscopy and computed tomography or magnetic resonance enterography to exclude enteropathy-associated T-cell lymphoma and ulcerative jejunoileitis at initial diagnosis of type 2 refractory celiac disease. (gastro.org)
6. Complete a detailed nutritional assessment with investigation of micronutrient and macronutrient deficiencies in patients diagnosed with refractory celiac disease. (gastro.org)
Celiac disease is an immunologically mediated disease in genetically susceptible people caused by intolerance to gluten, resulting in mucosal inflammation and villous atrophy, which causes malabsorption. (msdmanuals.com)
Celiac disease mainly affects people of northern European descent. (msdmanuals.com)
are at risk of developing celiac disease. (msdmanuals.com)
Celiac disease can manifest in infancy and childhood after introduction of cereals into the diet. (msdmanuals.com)

Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
It was based upon the "Revised European-American Lymphoma classification" (REAL). (newworldencyclopedia.org)
The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)

High response rates were consistent among patients with different MZL subtypes and those with negative disease prognostic factors at baseline. (businesswire.com)
Ghafouri and colleagues plan to expand their patient cohort and are also interested in evaluating the therapy in additional B-cell lymphoma subtypes. (aacr.org)
Similar response rates were observed across all subtypes of indolent non-Hodgkin's lymphoma, though the numbers were small for some categories. (esmo.org)

In the nineteenth and twentieth centuries, the affliction was called simply Hodgkin's Disease, as it was discovered by Thomas Hodgkin in 1832. (newworldencyclopedia.org)
Bcell non-Hodgkin's lymphoma is a malignant, monoclonal (arising from a single cell) proliferation of lymphocytes that is preceded by lymphadenopathy and characterized by varying, less predictable spread than Hodgkin's disease. (glutenfreeworks.com)
The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. (schoolandyouth.org)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
The earliest study was conducted by Falini and his associates3 in Italy and Germany utilizing a CD30 antibody coupled to saporin for the treatment of four patients with advanced Hodgkin's disease. (atsbio.com)

It is a non-Hodgkin's lymphoma and is sometimes referred to as extranodal marginal zone B cell lymphoma. (lymphomainfo.net)

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)

Type 2 disease has an extremely poor prognosis as it is considered a cryptic T cell lymphoma with a high rate of progression to enteropathy-associated T cell lymphoma (EATL) [ 6 ]. (springer.com)
However, results with this therapy in peripheral T-cell lymphoma (PTCL) are not well defined. (cun.es)
Refractory sprue is characterized by chronic inflammation of the gastrointestinal tract, poor absorption of nutrients, and an increased risk of developing a type of cancer of the immune cells called T-cell lymphoma. (medlineplus.gov)
For the treatment cutaneous T-cell lymphoma (CTCL), including mycosis fungoides. (pdr.net)
PHILADELPHIA - Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data presented during Week 1 of the virtual AACR Annual Meeting 2021 , held April 10-15. (aacr.org)
Patients with relapsed/refractory B-cell lymphoma tend to have a more aggressive disease trajectory and limited treatment options," said presenting author Sanaz Ghafouri, MD , a fellow of hematology and oncology at University of California Los Angeles Medical Center. (aacr.org)
Treatment of B-cell lymphoma should be individualized according to the specific histological subtype and disease stage. (dentistrytoday.com)
CT scan of a patient with a natural killer (NK)/T-cell lymphoma of the right nasal cavity and maxillary sinus. (medscape.com)

T-cell immunophenotype constitutes an unfavorable prognostic factor in aggressive non-Hodgkin's lymphomas. (cun.es)
Salvage treatment results with HDC/ASCT in PTCL are similar to those found in corresponding aggressive B-cell lymphomas. (cun.es)
Another interest lies in the identification of improved treatment strategies that incorporate radiation in the management of aggressive and refractory lymphomas. (mdanderson.org)
Our findings raise the possibility of a lasting long-term remission with bispecific CAR T-cell therapy in patients with this aggressive disease. (aacr.org)
After completion of the Run In, an aggressive lymphoma and an indolent lymphoma Dose Expansion cohort may open. (who.int)

In lymphoma, the cells in the lymphatic system grow abnormally, dividing too rapidly and growing without any order or control (Longe 2005). (newworldencyclopedia.org)
Lymphoma begins when healthy cells in the lymphatic system change and grow out of control, which may form a tumor. (cancer.net)

Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
A quarter of all extranodal lymphomas occur in the head and neck, and 8% of findings on supraclavicular fine-needle aspirate biopsy yield a diagnosis of lymphoma. (medscape.com)

NICE is unable to make a recommendation on teclistamab (Tecvayli) for treating relapsed or refractory multiple myeloma after 3 or more therapies in adults. (bvsalud.org)

Involved-site radiation therapy (ISRT) is typically recommended, because high-dose, large-field radiation therapy (LFRT) increases risk for heart disease, pulmonary dysfunction, and secondary cancers. (medscape.com)
Lymphoma is any of a diverse group of cancers that originate in lymphocytes of the lymphatic system , a secondary (but open) circulatory system in vertebrates . (newworldencyclopedia.org)
It is those cancers that originate in the lymphatic system that are referred to as lymphomas. (newworldencyclopedia.org)
Orelabrutinib is a highly selective BTK inhibitor developed by InnoCare for the treatment of cancers and autoimmune diseases. (businesswire.com)
Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)

12 months after completion of therapy) may be cured with conventional therapy, those with progressive disease or early relapse (3-12 months) are considered candidates for autologous HSCT. (nih.gov)
According to patient selection criteria, overall and disease-free survival rates after autologous HSCT are 43-95% and 31-70%, respectively. (nih.gov)
Short time to relapse and refractory disease at the time of autologous HSCT remain the most important risk factors. (nih.gov)
Data suggest that young patients with recurring disease following autologous HSCT, as well as some patients with multiple relapses and selected patients with refractory lymphoma, might benefit from allogeneic HSCT, but relapse remains the major challenge. (nih.gov)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
But in general, I do think that at first relapse we're deciding is this a patient that is going to be appropriate for an intensive salvage approach and if they have chemo-sensitive disease, consolidated with high-dose therapy autologous stem cell transplant I think most places will agree on characteristics according to the patient and the depth of response in terms of whether or not they're appropriate for consolidation. (onclive.com)
MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)

Three of these were diagnosed with intestinal lymphoma. (helpforibs.com)
Extraintestinal lymphomas (non-Hodgkin's) are malignancies that arise in peripheral lymphatic tissue outside the intestinal tract from B-cell and T-cell lymphocytes. (glutenfreeworks.com)
T cell immunity is at the center of the disease contributing to the inflammatory process through the loss of tolerance to gluten and the differentiation of HLA-DQ2 or HLA-DQ8-restricted anti-gluten inflammatory CD4 + T cells secreting pro-inflammatory cytokines and to the killing of intestinal epithelial cells by cytotoxic intraepithelial CD8 + lymphocytes. (frontiersin.org)
Coeliac disease (CeD) is a multifactorial intestinal immune-mediated disorder with autoimmune features that leads to inflammatory and destructive lesions in the proximal small intestine. (frontiersin.org)

The most obvious candidate disease is cancer and consequently the vast majority of early phase clinical studies with immunotoxins have centered on the treatment of human malignancies with the goal of eliminating cancer cells from the patient's body. (atsbio.com)

Lymphoma represents a breakdown in the intricate coordination of the lymphatic system. (newworldencyclopedia.org)
Ironically, the lymphatic system is fundamentally important for combating cancer cells-as well as foreign bodies, such as viruses and bacteria , and combating heart disease and arthritis as well. (newworldencyclopedia.org)
Because the lymphatic system is part of the body's immune system , patients with weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma. (newworldencyclopedia.org)
Cutaneous MALT lymphoma is a cancer of the lymphatic system, targeting b-cell lymphocytes . (lymphomainfo.net)
Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. (rarediseases.org)

BEIJING--( BUSINESS WIRE )--American Journal of Hematology recently published the study result of BTK (Bruton Tyrosine Kinase) inhibitor orelabrutinib in patients with relapsed or refractory (r/r) Marginal Zone Lymphoma (MZL), which investigated the efficacy and safety of orelabrutinib in r/r MZL. (businesswire.com)

Leukemia & Lymphoma. (wikipedia.org)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against cancer. (schoolandyouth.org)
The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (schoolandyouth.org)
Affimed is also advancing AFM13 with the help of the Leukemia and Lymphoma Society (LLS). (drugdiscoverynews.com)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)

CeD is characterized by an infiltration of intraepithelial lymphocytes in the proximal part of the small intestine, crypt hyperplasia and the development of villous atrophy in the latest stages of the disease. (frontiersin.org)
The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. (frontiersin.org)
Other authors, particularly when defining severe CAEBV disease, require both an elevated level of EBV in the blood as well as infiltration of tissues by EBV-positive lymphocytes ( 16 ). (frontiersin.org)

Testicular lymphoma may either represent secondary involvement by systemic disease or primary malignancy. (intechopen.com)
Regarding primary testicular lymphoma (PTL), it is a rare form of extranodal lymphoma and the most frequent malignant testicular neoplasm in men over the age of 60 years. (intechopen.com)
They excluded those with primary care refractory disease, and they could only have had 1 to 3 prior lines of therapy. (onclive.com)
Not for treating primary CNS lymphoma. (empr.com)
In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
Lymphoma is the second most common primary malignancy occurring in the head and neck. (medscape.com)

The overall response rate was impressive 57%, with a median progression-free survival of 11 months, values suggesting that the efficacy of idelalisib is similar or superior to those of other active treatment options in relapsed or refractory indolent non-Hodgkin's lymphoma. (esmo.org)

For the treatment of cutaneous manifestations of CTCL in patients who are refractory to at least 1 prior systemic therapy. (pdr.net)
MALT lymphomas attack mucosa-associated lymphoid tissue, and cutaneous MALT lymphoma specifically targets the skin, especially the second layer of skin. (lymphomainfo.net)
Cutaneous MALT lymphoma is characterized by a nodule under the skin, a bright red rash, or a lump on the skin with a mushroom-like appearance. (lymphomainfo.net)
A doctor will typically attempt to diagnose cutaneous MALT lymphoma with a biopsy of the skin lesions. (lymphomainfo.net)
There is also research linking the disease to the presence of the H. pylori bacteria and, in the particular case of the cutaneous type, B. burgdorferi , so the oncologist may also test for those, although the link with the former is less pronounced in the cutaneous type of lymphoma. (lymphomainfo.net)
Because cutaneous MALT lymphoma tends to be highly localized, it can typically be treated with radiation therapy or with surgery. (lymphomainfo.net)
Cutaneous MALT lymphoma is somewhat unique among MALT lymphomas in that it is more responsive to antibiotic treatments with may remove underlying bacterial causes. (lymphomainfo.net)
Because cutaneous MALT lymphoma is slowing growing and tends to remain highly localized, prognosis is generally positive. (lymphomainfo.net)

Although he had not taken nonsteroidal antiinflammatory drugs or aspirin, he did not respond to therapy, even with the administration of the antisecretory agent vonoprazan (20 mg), and had multiple refractory gastric ulcers diagnosed. (cdc.gov)
Because of this rapid disease progression, 57% of the participants in the standard-treatment group went on to receive CAR T-cell therapy (in most cases with axi-cel) after their disease got worse. (cancer.gov)
relapsed or refractory disease after two or more lines of systemic therapy. (drugs.com)
Relapsed/refractory after 1 line of therapy: give a single dose of 90-110×10 6 CAR-positive viable T cells (consisting of 1:1 CD8 and CD4 components), with each component supplied separately. (empr.com)
Reauthorization may be granted if the patient does not show evidence of progressive disease while on everolimus therapy. (oklahoma.gov)
Anti-CD19 CAR T-cell therapy has revolutionized the management of this disease in recent years, but it still has several limitations," she noted, explaining that approximately half of patients relapse within six months of starting the treatment due to a lack of CAR T-cell persistence and/or downregulation of the target antigen, CD19, on the tumor. (aacr.org)
Bridging therapy: For participants who are at high risk to experience disease progression during the manufacture of JNJ-90009530 drug product and before lymphodepletion, a bridging therapy is allowed at the investigator's discretion and Sponsor's approval. (who.int)

Treatment repeats every 28 days for at least 6 courses in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
Relapse means the disease comes back after a remission following treatment. (schoolandyouth.org)
Refractory means the disease has not responded to treatment. (schoolandyouth.org)
They estimate that about 55% of patients would still be alive 4 years after receiving axi-cel, compared with 46% of those who initially received the standard treatment for relapsed disease. (cancer.gov)
InnoCare is a commercial stage biopharmaceutical company committed to discovering, developing, and commercializing first-in-class and/or best-in-class drugs for the treatment of cancer and autoimmune diseases with unmet medical needs in China and worldwide. (businesswire.com)
Through research, we can identify new treatment options for digestive disease patients. (gastro.org)
The only proven effective treatment for the disease is hematopoietic stem cell transplantation. (frontiersin.org)
Progressive disease from a previous treatment. (oklahoma.gov)
The patient whose cancer did not respond to treatment had early disease progression with CD19/CD20-negative disease by day 14 after infusion. (aacr.org)
Systemic therapies may be considered for the treatment of active systemic disease. (dentistrytoday.com)
Treatment of systemic disease should be tailored to organ-specific severity using the EULAR SjS disease activity index ESSDAI definitions. (dentistrytoday.com)
Further assessment of blinatumomab treatment earlier in the course of the disease and in combination with other treatment approaches is warranted. (nih.gov)
A lymphoma specialist should perform staging and treatment. (medscape.com)
The lesions are often refractory to treatment and can last for years or decades. (cdc.gov)

Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)

Her clinical and research interests lie in improving the outcomes of patients with lymphoma. (mdanderson.org)

However, in a significant percentage of patients-especially those with advancedstage HL-the disease relapses or is refractory. (schoolandyouth.org)

Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. (frontiersin.org)
This entity is referred to as chronic active EBV (CAEBV) disease. (frontiersin.org)
Chronic active Epstein-Barr virus disease is usually defined as a chronic illness lasting at least 6 months, an increased EBV level in either the tissue or the blood, and lack of evidence of a known underlying immunodeficiency ( 15 ). (frontiersin.org)
Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)

Lymphoma may be nodal or extranodal. (medscape.com)

MALT lymphomas are relatively rare, comprising only eight percent of all b-cell lymphomas. (lymphomainfo.net)
It affects men and women equally, and there seems to be a relationship between MALT lymphomas in general and persons with autoimmune disorders, especially Sjorgren's syndrome or Hashimoto's thyroiditis. (lymphomainfo.net)

Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)

When HIV infection causes symptoms and specific disease syndromes, the disease is called AIDS. (cancer.net)
The symptoms individuals experience depends on the extent of the disease and the region of the body that is affected. (rarediseases.org)
These recommendations form a logical sequence starting with the management of the central triplet of symptoms-dryness, fatigue, and pain-followed by the management of systemic disease. (dentistrytoday.com)

Centers for Disease Control and Prevention. (cdc.gov)

The researchers used whole-exome sequencing to detect the presence of clonal hematopoiesis of indeterminate potential in peripheral blood cells and associated that discovery with coronary heart disease using samples from 4 case-control studies that together enrolled 4,726 participants with coronary heart disease and 3,529 controls. (ascopost.com)

At the end of 2021, orelabrutinib was included into National Reimbursement Drug list to benefit more lymphoma patients. (businesswire.com)

Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach. (cdc.gov)

The journal concluded that orelabrutinib demonstrated high response rates with durable disease remission and was well tolerated in patients with relapsed or refractory MZL. (businesswire.com)

The most recent chemotherapeutic agent that has been approved for use in patients with rituximab-refractory indolent non-Hodgkin's lymphoma is the alkylating agent bendamustine, but it is not currative. (esmo.org)
In this single-arm, open-label, phase II study, 125 patients with indolent non-Hodgkin's lymphomas who had not had a response to rituximab and an alkylating agent or had had a relapse within 6 months after receipt of those therapies were administered idelalisib, until the disease progressed or the patient withdrew from the study. (esmo.org)

Its use is being studied in patients with refractory lymphoproliferative diseases. (wikipedia.org)

After obtaining informed consent, we enrolled the patient in a clinical trial investigating the effects of non- H. pylori Helicobacter (NHPH) infections on intractable ulcers and gastric mucosa-associated lymphoid tissue lymphoma. (cdc.gov)
Dr. Pinnix's ultimate aspiration is to advance the clinical outcomes of patients afflicted with Hodgkin's and Non-Hodgkin's lymphoma via the minimization of normal tissue toxicity related to radiotherapy. (mdanderson.org)
Based on promising (pre-)clinical data and the favourable toxicity profile, we performed a phase II clinical trial with the JAK inhibitor ruxolitinib in patients with relapsed or refractory cHL (r/r cHL). (uni-koeln.de)

In 13 March 2014 issue of the New England Journal of Medicine , Dr Ajay Gopal of the Division of Medical Oncology, University of Washington School of Medicine, Seattle Cancer Care Alliance, USA and colleagues reported results from an international non-randomised phase II study of idelalisib monotherapy in patients with indolent non-Hodgkin's lymphoma. (esmo.org)

Despite the generally excellent prognosis of children and adolescents with Hodgkin's lymphoma (HL), approximately 15% of patients relapse. (nih.gov)
Adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia have an unfavourable prognosis. (nih.gov)

During the current outbreak, CDC has received reports of people with monkeypox who have severe manifestations of disease, including but not limited to · Atypical or persistent rash with coalescing or necrotic lesions, or both, some which have required extensive surgical debridement or amputation of an affected extremity. (cdc.gov)

Anatomy20

Organisms5

Diseases73

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology1

Phenomena and Processes30

Disciplines and Occupations1

Information Science5

Health Care16

Classical Hodgkin6

Chemotherapy27

Diffuse11

Relapsed or refractory B-cell2

Small lymphocy5

Hodgkin Lymphoma14

DLBCL2

Large B-cell lym4

Celiac disease47

European-American Lymphoma3

Subtypes3

Hodgkin's Disease6

Extranodal marginal1

Mantle4

Cell lymphoma8

Aggressive5

Cells in the lymphatic system2

Diagnosis2

Multiple myeloma1

Cancers5

Autologous7

Intestinal4

Malignancies1

Lymphatic system5

Marginal zone1

Leukemia5

Lymphocytes3

Primary6

Efficacy1

Cutaneous8

Therapy7

Treatment14

Neoplasms1

Patients with lymphoma1

Relapses1

Chronic4

Nodal1

MALT2

Prognostic1

Symptoms3

Centers for Diseas1

Peripheral1

20211

Infectious Diseases1

Remission1

Rituximab2

Lymphoproliferative1

Clinical3

Phase1

Prognosis2

Lesions1