Soylu M., Kılıç B., Paydaş S., Canataroğlu H. Human T-Lymphotrophic virus type-I antibodies in uveitis and leukemia patients in Southern Turkey. (acibademfamicord.com)
Murine3
12. Combination effect of navelbine (vinorelbine ditartrate) with cisplatin against murine P388 leukemia and human lung carcinoma xenografts in mice. (nih.gov)
The cell inhibition activities of several Annonaceous acetogenins, covering the three major structural classes of bis-adjacent, bis-non-adjacent, and single tetrahydrofuran (THF) ring compounds and their respective ketolactone rearrangement products, were tested in an in vitro disk diffusion assay against three murine (P388, PO3, and M17/Adr) and two human (H8 and H125) cancerous cell lines as well as a non-cancerous immortalized rat GI epithelial cell line (I18). (cancer.org)
Using a Topo I-deficient murine B lymphoma-derived subclone (P388-45/C) selected for its resistance to high dosage of the antitumor drug camptothecin, we show that Topo I depletion results in the hypophosphorylation of SR proteins and impairs exonic splicing enhancer (ESE)-dependent but not constitutive splicing. (hal.science)
19961
Leukemia is a malignant transformation of hematopoietic cells which produces an abnormal leukemic clone of cells suppressing the production of normal blood cellular components ( Duhrsen and Hossfeld, 1996 ). (japsonline.com)
Lymphocytic2
No carcinogenicity data were found, but one anticarcinogenicity study showed that trigonelline exhibited anticarcinogenic activity toward P-388 lymphocytic leukemia in mice. (nih.gov)
14. Results of a clinical phase I dose-escalation study of cytarabine in combination with fixed-dose vinorelbine, paclitaxel, etoposide and cisplatin for the treatment of relapsed/refractory lymphoma. (nih.gov)
Assay2
Trigonelline was not mutagenic at concentrations up to 7,400 µg/plate (54 µmol/plate) in the L5178Y TK+/- mouse lymphoma mutation assay, with and without metabolic activation. (nih.gov)
It was negative in the Ames assay but induced mutations and micronuclei in mouse L5178Y lymphoma and chromosome aberrations and sister- chromatid exchange in Chinese hamster ovary cells. (nih.gov)
Acute2
Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies that arise from clonal proliferation of immature lymphoid cells in the bone marrow, peripheral blood and other organs. (nih.gov)
Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) is associated with treatment failure in acute myeloid leukemia (AML) and other malignancies. (aacrjournals.org)
Diverse1
Causes of leukemia are diverse and they could be familial, infectious, physical, or chemical depending on the cell type and the individual variations from one patient to another ( Pui, 1995 ). (japsonline.com)