AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Lymphomabeta 2-Glycoprotein IAntibodiesLymphoma, B-CellLymphoma, Non-HodgkinAntibody SpecificityLymphoma, T-CellAntiphospholipid SyndromeAntibodies, AnticardiolipinLymphoma, Large B-Cell, DiffuseAntibodies, MonoclonalLymphoma, FollicularAntibodies, ViralAntibodies, BacterialScleroderma, SystemicAutoantibodiesBurkitt LymphomaAntibodies, AntiphospholipidAntibody FormationLymphoma, B-Cell, Marginal ZoneDNA Topoisomerases, Type IHuman T-lymphotropic virus 2Antibody AffinityLupus Coagulation InhibitorDeltaretrovirus InfectionsAntibodies, NeutralizingEpitopesAntibodies, AntinuclearLymphoma, Mantle-CellFluorescent Antibody TechniqueGlycoproteinsLymphoma, T-Cell, CutaneousCross ReactionsHTLV-I InfectionsLymphoma, T-Cell, PeripheralLymphoma, AIDS-RelatedLymphoma, Large-Cell, AnaplasticEnzyme-Linked Immunosorbent AssayImmunoglobulin GDeltaretrovirusAntigen-Antibody ReactionsImmunoglobulin MDeltaretrovirus AntibodiesAntibodies, Anti-IdiotypicBinding Sites, AntibodyQ FeverLupus Erythematosus, SystemicCoxiella burnetiiHuman T-lymphotropic virus 1Molecular Sequence DataHodgkin DiseaseParaneoplastic SyndromesAntibodies, NeoplasmHIV AntibodiesAmino Acid SequenceIsoantibodiesAntibodies, ProtozoanAntibodies, Monoclonal, Murine-DerivedRNA Polymerase ILymphoma, Large-Cell, ImmunoblasticCardiolipinsHistocompatibility Antigens Class IB-LymphocytesImmunoblottingAutoantigensHuman T-lymphotropic virus 3VincristineT-LymphocytesAntigens, CD20Cell LineImmunohistochemistryCells, CulturedAntibodies, BispecificAntibodies, FungalMice, Inbred BALB CImmunoenzyme TechniquesNeutralization TestsPrednisoneSimian T-lymphotropic virus 1Single-Chain AntibodiesBase SequenceLeukemiaAntibodies, BlockingTranslocation, GeneticPolymerase Chain ReactionCyclophosphamideSkinLymphoma, Extranodal NK-T-CellAntigens, SurfaceBlotting, WesternImmunoglobulin Fab FragmentsAntigen-Antibody ComplexBlood DonorsAntigens, ViralHerpesvirus 4, HumanThrombosisDoxorubicinMycosis FungoidesAntibodies, HeterophileImmunoglobulin Heavy Chains
ATLLMonoclonal antibodyAdultCutaneous T-cell lAnaplastic large ceAntigensTropical spastic parHodgkinInfectionLymph nodesSpecific antibodiesAntigenPrimary cutaneousProviralLymphocytesRecombinantPathogen typeRituximabPathogenesisRetrovirusesLymphoidMillion people are infectedDiagnosisCell leukaemiaFollicular lymphomaClinicalManifestationsViralForm of lymphomaTypes of lymphomaAggressiveSeroprevalenceAssaysCytotoxicDiffuseDLBCLPrevalence amongLymphotropic virusLymphaticMalignantSynthesisELISAVirusPolymerase chain reHistiocyticTypeAsymptomaticHodgkin'sHumanOriginatesSerumTransfusionProteinsInfectionsEndemicPregnant womenEpidemiologyVivo
ATLL11
  • InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL). (wikipedia.org)
  • In Brazil, between lymphoma (ATLL) development in approximately 1-5% of 800,000 and 2.5 million individuals are infected with HTLV- infected children4. (bvsalud.org)
  • Introduction Individual T-cell leukemia/lymphoma pathogen type 1 (HTLV-1) may be the etiologic agent of the rare but intense hematopoietic malignancy of T cells, specified adult T-cell leukemia/lymphoma (ATLL), and a intensifying myelopathy thought as HTLV-1Cassociated myelopathy/exotic spastic paraparesis (HAM/TSP). (estme.org)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare mature T-cell malignancy first described in Japan in 1977 [ 1 ]. (oncotarget.com)
  • The causative agent of ATLL has been identified as the human T cell lymphotropic virus type 1 (HTLV-1) [ 2 - 4 ], which is endemic to Japan, the Caribbean islands, Central and South America, and parts of sub-Saharan Africa [ 5 ]. (oncotarget.com)
  • ATLL develops in approximately 5% of HTLV-1 infected individuals who acquire the virus via vertical transmission [ 5 ]. (oncotarget.com)
  • The pathogenesis of ATLL in HTLV-1-infected individuals may differ from one population to another. (oncotarget.com)
  • Six months before, the patient was diagnosed with stage IV human T-lymphotropic virus type 1 (HTLV-1)-associated adult T cell lymphoma (ATLL). (the-rheumatologist.org)
  • Mutations in TET2 , encoding one of the TET members responsible for the conversion of DNA cytosine methylation to hydroxymethylation (5-hmc), have been recently described in Human T-lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (oncotarget.com)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
Monoclonal antibody9
  • In fact, this type of antigen was the target of the first monoclonal antibody therapy for a malignancy (B-cell lymphoma) in 1982. (oncolink.org)
  • This multicenter, randomized phase 3 study evaluated the efficacy and safety of 0.3 mg/kg intravenous mogamulizumab, a monoclonal antibody targeting-CC chemokine receptor 4, every 12 weeks in HAM/TSP patients. (bvsalud.org)
  • The JUN recombinant monoclonal antibody is prepared using a combination of protein technology and DNA recombinant technology. (cusabio.com)
  • The JUN recombinant monoclonal antibody is then purified from the supernatant of the cell culture through affinity chromatography. (cusabio.com)
  • To develop a fresh therapeutic monoclonal Antibody (mAb) for Hodgkin lymphoma (HL), we immunized a BALB/c mouse with live HL cell lines, alternating between two HL cell lines. (rawveronica.com)
  • In consistent with the promising therapeutic effect of monoclonal antibody mogamulizumab, targeting another GPCR CCR4, in treating aggressive HTLV-1-driven adult T-cell leukemia-lymphoma, pre-clinical study demonstrated that CCR1 blockade not only directly killed tumor cells, but also enhanced cytotoxic cell expansion irrespective of molecular subtypes or LME categories. (bioengineer.org)
  • A monoclonal antibody, which helps to reduce the number of B cells in circulation. (medicalnewstoday.com)
  • We developed a monoclonal antibody (5D2) to FTC and demonstrated its high specificity and physiologically relevant linear range of detection in a competitive enzyme immunoassay (EIA). (cdc.gov)
  • Thus, this monoclonal antibody is a key reagent that will enable simple and low-cost lateral flow assays and EIAs for adherence monitoring. (cdc.gov)
Adult9
  • however, about 1 in 20 people will develop adult T-cell leukemia/lymphoma or HTLV-1 associated myelopathy (a chronic nervous system disease). (meridianbioscience.com)
  • Screening of sera from the adult populations of some USSR regions for antibodies to the human T-cell leukemia virus type I (HTLV-I)]. Vopr Virusol. (cdc.gov)
  • Patients with comorbidities including adult T-cell leukemia-lymphoma and cerebrovascular disease were excluded. (bvsalud.org)
  • In addition, adult T-cell leukemia (ATL) is certainly a extremely intense type of malignancy triggered by T-cell alteration activated by individual T-lymphotropic pathogen type 1 (HTLV-1) infections [6]. (rawveronica.com)
  • HTLV-1, the first human retrovirus identified, causes adult T cell leukemia. (meassociation.org.uk)
  • Oncogenic transformation of CD4 + T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. (ashpublications.org)
  • In search of novel biomarkers with relevance to oncogenesis, we identified the tumor marker and actin-bundling protein Fascin (FSCN1) to be specifically and strongly up-regulated in both HTLV-1-transformed and adult T-cell leukemia/lymphoma patient-derived CD4 + T cells. (ashpublications.org)
  • HTLV-1 may be the etiological agent of adult T-cell leukemia/lymphoma (ATL), an extremely ASP9521 intense T-cell malignancy (evaluated in guide 43). (arcticcirclescotland.com)
  • Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers. (shengsci.com)
Cutaneous T-cell l2
Anaplastic large ce1
Antigens4
Tropical spastic par4
  • Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neurodegenerative disease. (bvsalud.org)
  • Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. (edu.pe)
  • The pathogen is certainly connected with lymphocyte-mediated inflammatory illnesses also, such HTLV-1-linked myelopathy-tropical spastic paraparesis (16, 24, 27). (arcticcirclescotland.com)
  • p13II mRNA is certainly expressed in a variety of HTLV-1-contaminated cell lines isolated from scientific sufferers of ATL and HTLV-1-linked myelopathy-tropical spastic paraparesis (5, 36), and circulating cytotoxic lymphocytes particular to ORF II items (i.e., p13II and p30II) have already been discovered both in HTLV-1-contaminated ATL sufferers and in asymptomatic people (34). (arcticcirclescotland.com)
Hodgkin15
Infection15
  • HTLV-1 infection is usually diagnosed by serology assays detection of HTLV-1 specific IgG or IgM antibodies. (meridianbioscience.com)
  • Clinical impact of HTLV-1 infection in Spain: implications for public health and mandatory screening. (cdc.gov)
  • Natural killer T-cell lymphoma (NKTCL) is an aggressive lymphoid neoplasm in close association with EBV infection and thus represents a disease model to study EBV-induced lymphomagenesis. (bioengineer.org)
  • The clinical manifestations of HTLV-III/LAV infection may be directly attributable to infection with this virus or the result of secondary conditions occurring as a consequence of immune dysfunction caused by the underlying infection with HTLV-III/LAV. (cdc.gov)
  • Because persons with less specific or milder manifestations of HTLV-III/LAV infection may be important in transmitting the virus, estimates of the number of such persons are of value. (cdc.gov)
  • Vertical transmission is a relevant concern in Brazil, as the blotting (WB) and/or polymerase chain reaction (PCR) assays prevalence of HTLV-1 infection in pregnant women ranges from as a confirmatory step. (bvsalud.org)
  • A recent study evaluated the performance of commercially available serological screening tests for HTLV-1 infection in Brazil, i.e. (bvsalud.org)
  • We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. (edu.pe)
  • Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (edu.pe)
  • On the other hand, zero of six rabbits inoculated with 729.ACH.p13 cells didn't create viral infection, whereas six of six rabbits inoculated with wild-type HTLV-1-expressing cells (729.ACH) were contaminated seeing that measured by antibody replies, proviral fill, and HTLV-1 p19 matrix antigen creation from former mate vivo-cultured PBMC. (arcticcirclescotland.com)
  • HTLV-4 had previously only been identified in one person living in southern Cameroon, and the origin of the infection was unable to be traced. (pasteur.fr)
  • For example, people with HTLV-I (Human T-Lymphotrophic virus) infection may have Hodgkin's lymphoma more than others. (leukeemia.ee)
  • These findings have important implications in defining the epidemiological patterns of HTLV-1 infection in Nigeria. (e-cep.org)
  • The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. (e-cep.org)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Lymph nodes5
  • They may originate primarily in the lymph nodes (nodal lymphomas) or in lymphoid tissue connected to mucouses, skin or other structures (extranodal lymphomas). (scielo.br)
  • Another example is "primary mediastinal B-cell lymphoma" which often occurs in younger patients and grows rapidly in the chest (mediastinum) Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, or groin, which is caused by enlarged lymph nodes. (lymphomaindia.com)
  • These neoplasms usually originate in lymph nodes or lymphatic tissue in other sites (extranodal lymphoma), and can be localized or widespread at the time of diagnosis. (mhmedical.com)
  • Therefore, Hodgkin's lymphoma spreads to other lymph nodes of the body. (leukeemia.ee)
  • Those navigating the lymphoma journey frequently grapple with telling symptoms like swollen lymph nodes, persistent fatigue, and nocturnal sweats. (preventiveprimary.com)
Specific antibodies1
  • HTLV-1 proviral load (PVL) in It is highly important to implement an accurate and cost- the blood and/or CSF is also useful in establishing diagnosis effective strategy for laboratory diagnosis and systematically and, when combined with other tests, such as evaluation of evaluate the performance of both screening assays and intrathecal synthesis of HTLV-1 specific antibodies, may also aid confirmatory testing. (bvsalud.org)
Antigen3
  • In certain lymphomas, the immunoglobulin antigen that the lymphoid cell is supposed to be producing becomes mutated, and hence a potential target for vaccines. (oncolink.org)
  • Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
  • Most important aspect of therapy is anti CD20 antibody, the Rituximab, which is a kind of immunotherapy or targeted therapy and attacks the CD20 antigen on the cancer cells. (lymphomaindia.com)
Primary cutaneous4
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
Proviral5
  • Secondary endpoints were changes in HTLV-1 proviral load, 10-m timed walk, cerebrospinal fluid (CSF) neopterin levels, and safety. (bvsalud.org)
  • However, the mogamulizumab arm showed a significant decrease in HTLV-1 proviral load (- 59.39 ± 29.91% vs. placebo 2.32 ± 36.31%) and CSF neopterin (p (bvsalud.org)
  • The baseline OMDS pattern and the 60-80% HTLV-1 proviral load reduction were sustained through the open-label and extension treatment periods. (bvsalud.org)
  • Positive cases were confirmed by Western Blot and HTLV-1 proviral load. (edu.pe)
  • Although initial research reported that HTLV-1 ORF II was dispensable for viral infections in vitro (15, 37), disruption of pX ORF II within an HTLV-1 proviral clone that blocks appearance of full-length p30II by itself or both p30II and p13II significantly decreased viral infectivity and web host humoral response in rabbits (2, 39). (arcticcirclescotland.com)
Lymphocytes11
  • Nevertheless, during the program of repeated inoculations with cancerous cells, mouse lymphocytes generate antibodies against the cancerous human being cells. (rawveronica.com)
  • patients will be excluded as AIDS cases if they have a negative result on testing for serum antibody to HTLV-III/LAV, have no other type of HTLV-III/LAV test with a positive result, and do not have a low number of T-helper lymphocytes or a low ratio of T-helper to T-suppressor lymphocytes. (cdc.gov)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Diffuse large B cell lymphoma (diffuse LBCL or DLBCL) is a cancer that affects white blood cells called B cell lymphocytes. (medicalnewstoday.com)
  • A fast-growing cancer of the antibody-producing lymphocytes. (lab-ally.com)
  • The root mechanisms where HTLV-1 establishes a continual infections and transforms lymphocytes continues HDAC9 to be extensively looked into but incompletely grasped. (arcticcirclescotland.com)
  • Predicated on the lengthy amount of and the reduced percentage of people ASP9521 who develop ATL latency, transformation of contaminated lymphocytes is thought to be initiated through the induction of mobile genes and modifications in mobile activation and loss of life pathways by HTLV-1 protein (18, 35). (arcticcirclescotland.com)
  • Latest research reveal a substantial function for HTLV-1 accessories proteins in the entire lifestyle routine of HTLV-1, particularly through the early stage from the viral infections of lymphocytes (evaluated in sources 12, 28, and 32). (arcticcirclescotland.com)
  • Lymphomas are a heterogeneous group of malignancies that originate from neoplastic transformation of lymphocytes that have undergone mutations that confer growth and survival advantages compared to their normal cellular counterparts. (mhmedical.com)
  • B-cell Lymphoma, often seen as the more prevalent sibling, originates from the diligent B lymphocytes that produce antibodies. (preventiveprimary.com)
  • In contrast, T-cell Lymphoma comes from the T lymphocytes, cells that are always on guard to combat those unwelcome infected cells and bolster our immune defenses. (preventiveprimary.com)
Recombinant1
  • The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). (edu.pe)
Pathogen type1
  • Individual T-lymphotropic pathogen type 1 (HTLV-1) is certainly classified being a complicated retrovirus and an associate from the genus as well as the 3 lengthy terminal do it again that encodes the regulatory proteins Taxes and Rex, aswell as several non-structural accessories proteins, p12I, p27I, p13II, and p30II (12, 16, 28, 30). (arcticcirclescotland.com)
Rituximab1
  • Additionally, many new treatments called monoclonal antibodies have been successfully used ( rituximab ( Rituxan ) for B-cell lymphomas, ofatumumab (Arzerra) for NHL, Ocrelizumab is in clinical trials). (rxwiki.com)
Pathogenesis1
  • This suggests that Fascin up-regulation by Tax contributes to the development of HTLV-1-associated pathogenesis. (ashpublications.org)
Retroviruses5
  • Retroviruses are found in a wide range of mammals, and they can contribute to the development of cancers, such as leukemia or lymphoma, as well as neurological diseases. (meassociation.org.uk)
  • Scientists from the unité d'Epidémiologie et physiopathologie des virus oncogènes (Institut Pasteur/CNRS), directed by Antoine Gessain, are working on a group of RNA viruses known as HTLV retroviruses. (pasteur.fr)
  • Scientists from the Institut Pasteur and the CNRS, working in cooperation with the International Center for Medical Research in Franceville, Gabon (the CIRMF) and the Pasteur Center in Cameroon, set about identifying HTLV retroviruses in people at risk of contact with non-human primates. (pasteur.fr)
  • Work now needs to be done to identify diseases that may be caused by the HTLV-3 and HTLV-4 retroviruses. (pasteur.fr)
  • Similar to other retroviruses, HTLV-1 evolves either through accumulation of point mutations or recombination. (biomedcentral.com)
Lymphoid3
  • the current case definition, a histologically confirmed diagnosis of chronic lymphoid interstitial pneumonitis in a child (under 13 years of age) will be considered indicative of AIDS unless test(s) for HTLV-III/LAV are negative. (cdc.gov)
  • Lymphoma is a malign neoplasia resulting from the proliferation of cells from the lymphoid system, which has a varying potential for organic aggression. (scielo.br)
  • Lymphocytic leukemias, plasmocytomas, Hodgkin's lymphoma and non Hodgkin's lymphomas stem from this lymphoid lineage. (scielo.br)
Million people are infected2
  • More than 20 million people are infected by HTLV 1&2 worldwide, and West Africa is considered a highly endemic area [ 23 ]. (biomedcentral.com)
  • At least 5 to 10 million people are infected with HTLV-1 worldwide. (biomedcentral.com)
Diagnosis3
  • Quick advancements have been made in the diagnosis and treatment of the disease and Hodgkin's lymphoma is cured in ca 80% of patients. (leukeemia.ee)
  • To confirm the diagnosis, other cells and characteristics typical of Hodgkin's lymphoma must be found in the proximity of the lymph node containing Reed-Sternberg cells. (leukeemia.ee)
  • Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. (medscape.com)
Cell leukaemia1
  • Screening for human T cell leukaemia/lymphoma virus among blood donors in Sweden: cost effectiveness analysis. (cdc.gov)
Follicular lymphoma1
  • Follicular lymphoma (FL), a B-cell lymphoma, is the most common indolent (slow-growing) form of NHL, accounting for approximately 20 percent to 30 percent of all NHLs. (lymphomaindia.com)
Clinical6
  • performed multi-omics analysis on 112 patients with NKTCL, integrating genomic (WGS), transcriptomic (RNA-seq and scRNA-seq) with mass spectrometry (MS)-based proteomics, depicted the lymphoma microenvironment (LME) at single-cell resolution and defined 3 different LME categories, namely immune-inflamed, -deficient, and -desert, corresponding to distinct setpoints of cancer-immunity cycle during EBV-host interactions and predicting clinical prognosis in the era of asparaginase-based targeted therapy. (bioengineer.org)
  • The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)
  • The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
  • The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. (shengsci.com)
  • This study aimed to conduct a pooled estimate of HTLV-1 prevalence among pregnant women in Nigeria to quantify its clinical burden and public health implications. (e-cep.org)
  • Antibody-based testing for emtricitabine (FTC), a critical component of pre-exposure prophylaxis and antiretroviral therapy would provide low-cost detection for clinical monitoring to improve adherence. (cdc.gov)
Manifestations2
  • Other manifestations of HTLV-III/LAV infections than those currently proposed to be reported are less specific and less likely to be consistently reported nationally. (cdc.gov)
  • The patient had been diagnosed with RA four years earlier, with manifestations of bilateral hand symptoms along with high titer rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies. (the-rheumatologist.org)
Viral7
  • 2 , 3 Tax activates viral transcription through the HTLV-1 long terminal repeat and induces cellular genes through signaling pathways, including nuclear factor-κB (NF-κB), serum response factor/activator protein 1, and cyclic-AMP response element-binding protein (CREB). (ashpublications.org)
  • The treatment of HTLV-1+ lymphoma T-cells with either oleandrin or a N. oleander extract did not significantly inhibit viral replication or the release of p19Gag-containing particles into the culture supernatants. (longdom.org)
  • Unlike HIV-1, extracellular HTLV-1 particles are poorly infectious and viral transmission typically occurs via direct intercellular interactions across a virological synapse. (longdom.org)
  • Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). (biomedcentral.com)
  • People who have often had certain viral infections may develop Hodgkin's lymphoma. (leukeemia.ee)
  • HTLV-1 exhibits a remarkable genetic stability, however, viral strains have been classified in several genotypes and subgroups, which often mirror the geographic origin of the viral strain. (biomedcentral.com)
  • Until now, no viral genotype or subgroup is associated with a specific HTLV-1-associated disease. (biomedcentral.com)
Form of lymphoma2
  • Approximately 30-40 % of patients with FL will eventually transform to a more aggressive form of lymphoma like Diffuse Large B Cell Lymphoma and may require intensive chemotherapy followed by autologous stem cell transplantation. (lymphomaindia.com)
  • Recent data from the Leukemia and Lymphoma Society report that there are currently over 628,000 people in the United States living with some form of lymphoma. (rxwiki.com)
Types of lymphoma1
  • Prognosis for the various types of lymphoma vary depending on type and stage of advancement. (rxwiki.com)
Aggressive1
Seroprevalence2
  • This study aimed to assess the seroprevalence and correlates of HBV, HCV, HDV, and HTLV 1&2 antibodies among MSM in Ouagadougou, Burkina Faso. (biomedcentral.com)
  • This study aimed to assess the seroprevalence and correlates of hepatitis B, C and D virus and anti-HTLV 1&2 antibodies among MSM, a high-risk population in Burkina Faso. (biomedcentral.com)
Assays1
  • We therefore investigated whether oleandrin or a N. oleander extract could inhibit virus transmission from a GFP-expressing HTLV-1+ lymphoma T-cell-line to huPBMCs in co-culture assays. (longdom.org)
Cytotoxic1
  • As a result, we recognized an anti-pan HLA course II mAb with a immediate cytotoxic impact on lymphoma/leukemia cells, including HL, NHL, and advanced ATL cells. (rawveronica.com)
Diffuse1
  • Diffuse large B-cell lymphoma (DLBCL) is the most common form of NHL, accounting for more than 30 percent of newly diagnosed cases. (lymphomaindia.com)
DLBCL2
  • For example, DLBCL that only affects the brain is called "primary central nervous system lymphoma" and is treated differently than DLBCL that affects areas outside of the brain. (lymphomaindia.com)
  • Most patients with DLBCL are adults, although this lymphoma is sometimes seen in children. (lymphomaindia.com)
Prevalence among1
  • This study shows that HBV, HCV and HTLV 1&2 prevalence among MSM in Burkina is high and suggests that comprehensive STI prevention and sexual health education services for this group are needed. (biomedcentral.com)
Lymphotropic virus5
  • Human T-cell lymphotropic virus-1 (HTLV-1) is part of a group of viruses, including HTLV-I, -II, and -III (also known as HIV-1 and HIV-2). (meridianbioscience.com)
  • Since the 1982 definition was published, human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has been recognized as the cause of AIDS. (cdc.gov)
  • Interest is increasing in human T-cell lymphotropic virus type-1 (HTLV-1) transmission due to its adverse health impacts. (e-cep.org)
  • Human T-cell lymphotropic virus (HTLV) and its subtypes were estimated to have infected 5-10 million people worldwide [ 1 - 3 ]. (e-cep.org)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Lymphatic1
  • Hodgkin's lymphoma may also spread to other regions and other organs outside the lymphatic system. (leukeemia.ee)
Malignant3
  • CCR1, highly expressed on EBV-positive lymphoma cells, regulated EBV DNA replications and gene expression, as well as malignant transformation. (bioengineer.org)
  • A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
  • Accurate clinicopathologic recognition is crucial, particularly because KFD can be mistaken for malignant lymphoma. (medscape.com)
Synthesis3
  • Encouragingly, a more recently developed serological to evaluate intrathecal synthesis of specific and total antibodies, confirmatory assay (INNO-LIA, HTLV-I/II) yielded results for which represent specific inflammatory process markers in the most samples considered indeterminate or untypeable under CNS10. (bvsalud.org)
  • Stimulation of antibody synthesis induced by surgical trauma in rats. (shengsci.com)
  • The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. (shengsci.com)
ELISA1
  • Rigorous verification of this antibody is conducted to ensure its accuracy, and it can be utilized for detecting human JUN protein in ELISA, WB, and IHC experiments. (cusabio.com)
Virus18
  • These include hepatitis C virus, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus (HTLV). (medscape.com)
  • The group analyzed 589 prostate tumor samples for the presence of the virus and tested blood samples from 146 prostate cancer patients for antibodies to the virus and found no evidence of the virus or of antibodies to the virus. (meassociation.org.uk)
  • We therefore tested whether oleandrin or an extract from N. oleander could also inhibit the infectivity of the human T-cell leukemia virus type-1 (HTLV-1) -a related enveloped retrovirus and emerging tropical infectious agent. (longdom.org)
  • Our data will be the first to point the fact that HTLV-1 mitochondrion-localizing proteins p13II comes with an important biological function through the early stage of virus infections in vivo. (arcticcirclescotland.com)
  • Scientists from the Institut Pasteur and the CNRS have identified two new strains of the HTLV-4 virus in two hunters who were bitten by gorillas in Gabon. (pasteur.fr)
  • There are four types of HTLV virus (types 1 to 4). (pasteur.fr)
  • The HTLV-3 virus has only been observed in a small number of people in Cameroon living in close contact with infected non-human primates. (pasteur.fr)
  • By using molecular screening to examine blood samples from 300 people who had been bitten by monkeys in Central Africa, they were able to identify the HTLV-4 virus - previously only observed in Cameroon - in two individuals in Gabon. (pasteur.fr)
  • The scientists also discovered that one of the two new strains is divergent from the previously known strain of HTLV-4, highlighting the genetic diversity of this human virus. (pasteur.fr)
  • Although most lymphomas arise without an evident cause, human T-cell leukemia/lymphoma virus I (HTLV-1), Epstein-Barr virus, hepatitis C virus , and human herpes virus-8 infections, as well as infections with the bacteria Helicobacter pylori and, perhaps, Chlamydophila psittaci , either are established as causal (e.g. (mhmedical.com)
  • HTLV-1) or have very strong associations with lymphoma incidence (hepatitis C virus) , suggesting their role in causation. (mhmedical.com)
  • HIV is permissive by inducing severe immunodeficiency and setting the stage for an Epstein-Barr virus -induced or human herpes virus-8 -induced lymphoma. (mhmedical.com)
  • Human T cell leukemia virus (HTLV-1) is an oncoretrovirus that infects at least 10 million people worldwide. (biomedcentral.com)
  • Molecular studies point to a fairly low evolution rate of HTLV-1 (between 5.6E−7 and 1.5E−6 substitutions/site/year), supposedly because the virus persists within the host via clonal expansion (instead of new infectious cycles that use reverse transcriptase). (biomedcentral.com)
  • HTLV-1 is a member of the Retroviridae family, the Orthoretrovirinae subfamily and the Deltaretrovirus genus, which includes bovine leukemia virus (BLV) and T-lymphotropic viruses infecting primates (PTLV). (biomedcentral.com)
  • Hepatitis C virus: Some studies have found an increased risk of lymphoma in people with hepatitis C virus. (rxwiki.com)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • Les examens ont été réalisés au Centre d'Infectiologie Charles Mérieux (CICM) de Bamako avec le dépistage du génome des virus responsables de la Dengue, de la fièvre de la Vallée du Rift, et du Zika à l'aide de la technique de la RT-PCR en temps réel. (bvsalud.org)
Polymerase chain re1
  • Strategies Appearance antibodies and plasmids The pME18S p12ISL appearance plasmid continues to be described previously.19 p12I and its own mutants had been generated by polymerase chain reaction (PCR) or with the QuickChange Site-Directed Mutagenesis Kit (Stratagene, La Jolla, CA) using site-specific mutagenic oligonucleotides following manufacturer's instructions. (estme.org)
Histiocytic1
  • 2 Their average frequency is 0.3/100,000 inhabitants yearly, with 65% T-cell, 25% B-cell and 10% true histiocytic lymphomas or rare cell types. (scielo.br)
Type6
  • Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. (scielo.br)
  • A individual 729 B-cell range that expresses a molecular clone of HTLV-1 mutated to selectively ablate p13II appearance (729.ACH.p13) was produced and compared for infectivity with 729 B cells expressing the wild-type molecular clone (729.ACH). (arcticcirclescotland.com)
  • In 2 to 8% of cases, HTLV type 1 results in severe forms of leukemia/lymphoma or neuromyelopathy. (pasteur.fr)
  • Hodgkin's lymphoma has been studied more than any other type of lymphoma. (leukeemia.ee)
  • Treatment is dependent on many factors, most importantly the type of lymphoma diagnosed, followed by the stage of the cancer, the patient's age and health status, and how symptoms have affected the body. (rxwiki.com)
  • While each type of lymphoma has its own prognosis, it is generally a very treatable illness, with over 80% of patients diagnosed early being alive after five years. (rxwiki.com)
Asymptomatic2
  • Milder disease associated with HTLV-III/LAV infections and asymptomatic infections may be reportable in some states and cities but will not be nationally reportable. (cdc.gov)
  • Although most HTLV-1-infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. (e-cep.org)
Hodgkin's11
  • The non Hodgkin's lymphomas comprise a neoplasia group derived from lymphocyte clones in their different evolutive stages. (scielo.br)
  • Unlike other lymphomas, Hodgkin's lymphoma spreads from one lymph node region to another. (leukeemia.ee)
  • Most Hodgkin's lymphoma patients have abnormal cells called Reed-Sternberg cells. (leukeemia.ee)
  • The presence of only these cells doesn't mean that the person has Hodgkin's lymphoma. (leukeemia.ee)
  • Doctors are often not able to explain why one person develops Hodgkin's lymphoma and another one doesn't. (leukeemia.ee)
  • It is known that lymphoma doesn't occur accidentally and that Hodgkin's lymphoma is not infectious. (leukeemia.ee)
  • Scientists have found several possible risk factors promoting the development of Hodgkin's lymphoma. (leukeemia.ee)
  • According to some studies, Hodgkin's lymphoma occurs somewhat more often in persons who have a family history of lymphoma, but this risk is very small. (leukeemia.ee)
  • It is important to understand that even if you have some of the mentioned risk factors, it does not mean that you will become ill with Hodgkin's lymphoma. (leukeemia.ee)
  • How common is Hodgkin's lymphoma? (leukeemia.ee)
  • Hodgkin's lymphoma is not a very common cancer. (leukeemia.ee)
Human4
  • TfR1 as a potential new target in cases of human leukemia & lymphoma. (wikipedia.org)
  • Human anti-F(ab')2 antibodies show preferential reactivity for F(ab')2 molecules bearing lambda light chains. (nih.gov)
  • The second human retrovirus, HTLV-2 has not been associated with any disease. (meassociation.org.uk)
  • If the evidence obtained substantiates its novelty, additional goals will include exploring in depth its biology and molecular genetics and establishing its possible relationship to human disease, especially chronic fatigue immune deficiency syndrome (CFIDS), leukemia, and lymphoma. (ncf-net.org)
Originates1
Serum1
  • Serum specimens obtained were tested for the presence of HBV, HCV, HDV and HTLV-1&2 infections. (biomedcentral.com)
Transfusion2
  • Accordingly, public education campaigns highlighting transfusion, in 1993, the Brazilian Ministry of Health (BMoH) transmission and prevention forms should be established, e.g., implemented mandatory HTLV screening in blood banks condom use during sexual intercourse. (bvsalud.org)
  • HTLV-1 transmission occurs through sexual intercourse, prolonged breast-feeding, or blood transfusion. (biomedcentral.com)
Proteins2
Infections3
  • Collectively, these observations indicate a definite function for p13II in HTLV-1 infections and a potential function in HTLV-1-mediated lymphocyte change. (arcticcirclescotland.com)
  • In this scholarly study, we motivated the functional need for HTLV-1 p13II in the establishment of infections within a rabbit model. (arcticcirclescotland.com)
  • Certain infections:Having certain types of infections increases the risk of developing lymphoma. (rxwiki.com)
Endemic2
  • The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. (edu.pe)
  • They also suggest the presence of HTLV-endemic clusters near low-endemic areas, even within the same geopolitical zones. (e-cep.org)
Pregnant women1
  • Brazilian populations have been performed in specific groups, restricted breastfeeding in mothers infected with HTLV-1 and such as blood donors or pregnant women, and the prevalence HTLV-2 (DAB/CAB23, 2009, BMoH). (bvsalud.org)
Epidemiology1
  • In Sub-Saharan Africa, very few data exist on hepatitis B, C, and D as well as on HTLV 1&2 epidemiology among MSM. (biomedcentral.com)
Vivo1
  • Significantly, we found a higher frequency of hereditary mutations in the ORF-I of provirus from HTLV-1Cinfected people leading to ER retention of p12I, recommending an important function for p12I features in the ER in vivo. (estme.org)