AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Hypereosinophilic SyndromemRNA Cleavage and Polyadenylation FactorsReceptor, Platelet-Derived Growth Factor alphaLeukemia, Eosinophilic, AcuteBenzamidesOncogene Proteins, FusionPiperazinesPyrimidinesLymphomaChronic DiseaseEosinophilsLeukemiaLymphoma, B-CellLymphoma, Non-HodgkinLymphoma, T-CellLeukemia, Myeloid, AcuteLymphoma, Large B-Cell, DiffuseLymphoma, FollicularBurkitt LymphomaLeukemia, Lymphocytic, Chronic, B-CellLymphoma, B-Cell, Marginal ZoneLeukemia, LymphoidLeukemia, ExperimentalLymphoma, Mantle-CellLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphoma, T-Cell, Cutaneous
AcuteMyeloidEosinophiliaHypereosinophilicNeutrophilicLymphocyticEosinophilsMantle cell lymSystemicInfiltrationGranulomatosis with polyangiitisFIP1L1-PDGFRADiffuse large B-DisordersGranularGraft-versus-MyocarditisReactiveCarcinomaAsthmaSyndromePlasma cell myCutaneousBoneClinicalSubtypesCytoplasmicMyelomonocyticMutationsIdiopathic MyelofibrosisExtranodalDisease
Acute17
  • Occasionally, people with PDGFRA -associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (medlineplus.gov)
  • [ 3 ] Pathologic specimens in Loeffler endocarditis show eosinophilic myocarditis, a tendency toward endomyocardial fibrosis and clinical manifestations of thromboembolism, and acute heart failure. (medscape.com)
  • [ 10 ] Myocardial involvement is less well known and has been considered a manifestation of an acute necrotic stage of eosinophilic endomyocardial disease, as reported by Olsen and colleagues. (medscape.com)
  • Myeloproliferative disorders (MPD) with eosinophilia (or chronic eosinophilic leukemia (CEL) and sporadic cases with acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia (ALL) or lymphoma. (atlasgeneticsoncology.org)
  • 2010) and acute myeloid leukemia in 3 (Baxter et al. (atlasgeneticsoncology.org)
  • Occasionally, the FIP1L1-PDGFRA fusion can be identified in patients with acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma and sporadically in myeloid sarcoma (Metzgeroth et al. (atlasgeneticsoncology.org)
  • Acute Myeloid Leukemia (AML) In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers. (msdmanuals.com)
  • Acute myeloid leukemia (AML) with recurrent cytogenetic abnormalities. (booksca.ca)
  • ALL - Acute lymphoblastic leukemia, AML - Acute myeloid leukemia, APL - Acute promyelocytic leukemia, CLL - Chronic lymphocytic leukemia, CML - Chronic myeloid leukemia, and childhood leukemia are all types of Leukemia. (mediflam.com)
  • The responsiveness of the sweat glands may be influenced by physical conditioning or acute and chronic anxiety states. (aafp.org)
  • These factors may make your condition more likely to develop serious complications, such as blood clots, or transform into an aggressive, rapidly progressing blood cancer, such as acute myeloid leukemia (AML). (mympnteam.com)
  • The main clinical focuses of Prof. Müller-Tidow cover the treatment of acute leukemia, myelodysplastic syndrome, lymphomas, multiple myeloma. (bookinghealth.com)
  • Is most commonly associated with liver disease, acute or chronic inflammation, autoimmune disorders and certain malignancies. (thebloodproject.com)
  • It is a secondary change associated with such disorders as inflammation, bone marrow necrosis, bone marrow injury, and disorders of myeloproliferation (e.g., acute myeloid leukemia) and lymphoproliferation (e.g., lymphoma). (nih.gov)
  • Specifically, it is used for chronic myelogenous leukemia treatment (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. (theindianpharma.com)
  • These malignancies are further characterized by the maturity and differentiation of the individual cell types and are divided into acute leukemias such as acute myeloid leukemia and acute lymphoblastic leukemia and chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia. (medscape.com)
  • MRLs are derived for acute (1-14 days), intermediate (15-364 days), and chronic (365 days and longer) durations and for the oral and inhalation routes of exposure. (cdc.gov)
Myeloid10
  • Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
  • Phenotypically diverse myeloid neoplasms that include patients that have been categorized as: chronic eosinophilic leukemia (CEL)/ atypical chronic myeloid leukemia with eosinophilia in 4 (Luciano et al. (atlasgeneticsoncology.org)
  • 2010), chronic myeloid leukemia (CML) in 1 (Hild & Fonatsch. (atlasgeneticsoncology.org)
  • Interestingly, the T674I mutation that is analogous to the T315I mutation of BCR-ABL1 in chronic myeloid leukemia also confers imatinib resistance (Cools et al. (atlasgeneticsoncology.org)
  • It can also be used in cases of chronic myeloid leukemia (CML, also called chronic myelogenous leukemia) that have entered the aggressive blast phase - although kinase inhibitors have replaced chemotherapy in most of these cases. (mympnteam.com)
  • Primary myelofibrosis, also known as idiopathic myelofibrosis and agnogenic myeloid metaplasia, is a malignant disease, one of the chronic myeloproliferative neoplasms, along with polycythemia vera and essential thrombocythemia, amongst others (see table 1). (fcarreras.org)
  • Imatinib basically inhibits the proliferation and it also induces apoptosis in bcr-abl positive cell lines as well as maiden or fresh leukemic cells from the Philadelphia chromosome positive chronic myeloid leukemia. (theindianpharma.com)
  • In the Vivo, imatinib inhibits the growth of tumor of bcr-abl transfected murine myeloid cells as well as bcr-abl positive leukemia lines derived from the CML patients in the blast crisis. (theindianpharma.com)
  • Newly diagnosed adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (theindianpharma.com)
  • A 27-year-old female was admitted, in a Hematology Center, in 1997, with previous diagnosis of chronic myeloid leukemia since 1994. (bvsalud.org)
Eosinophilia8
  • They thereby continuously stimulate cell growth and proliferation and lead to the development of leukemias, lymphomas, and myelodysplastic syndromes that are commonly associated with hypereosinophilia and therefore regarded as a sub-type of clonal eosinophilia. (wikipedia.org)
  • Additionally, idiopathic eosinophilic endomyocarditis, in the absence of peripheral eosinophilia, has been reported by Priglinger et al. (medscape.com)
  • An interstitial deletion del(4)(q12q12) generating a FIP1L1-PDGFRA fusion gene is observed in diverse eosinophilia-associated hematologic disorders like hyperseosinophilic syndrome (HES), systemic mastocytosis (SM) and chronic eosinophilic leukemia (CEL). (atlasgeneticsoncology.org)
  • Marked and sustained eosinophilia eventually leads to eosinophilic infiltration and functional damage of peripheral organs, most commonly the heart, skin, lungs, or nervous system. (atlasgeneticsoncology.org)
  • Since then, there has been an accepted association of eosinophilia with hematologic malignancies such as lymphoma and leukemia. (biomedcentral.com)
  • Up to 75% of people with chronic strongyloidiasis have mild peripheral eosinophilia or elevated IgE levels. (cdc.gov)
  • We analyzed purified eosinophils from patients with IHES by next-generation whole-exome sequencing and compared DNA methylation profiles from reactive eosinophilic conditions to known clonal and suspected clonal eosinophilia. (oncotarget.com)
  • In healthy individuals, eosinophilic granulocytes (eosinophils) constitute less than five percent of all white blood cells [ 1 ], and in clinical practice blood eosinophilia is defined as an eosinophil count ≥ 0.5x10 9 /l. (oncotarget.com)
Hypereosinophilic4
Neutrophilic2
  • Therefore, neutropenia develops in severe or chronic infections because the neutrophilic demand is greater than the supply. (medscape.com)
  • Myeloproliferative neoplasms (MPN), rare types (Chronic eosinophilic leukemia, Chronic neutrophilic leukemia). (booksca.ca)
Lymphocytic10
  • G (rs1800896) Single Nucleotide Polymorphism is Not a Risk Factor of Chronic Lymphocytic Leukemia in Sudanese Population. (cdc.gov)
  • Clonal evolution in chronic lymphocytic leukemia is associated with an unmutated IGHV status and frequently leads to a combination of loss of TP53 and TP53 mutation. (cdc.gov)
  • The rs1001179 SNP and CpG methylation regulate catalase expression in chronic lymphocytic leukemia. (cdc.gov)
  • Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia. (cdc.gov)
  • Genetic Testing at Diagnosis Has Prognostic Value in Patients with Chronic Lymphocytic Leukemia including at Early Stages. (cdc.gov)
  • A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia. (cdc.gov)
  • Real-world Clinical Outcomes of First-Line Ibrutinib or Chemoimmunotherapy in Patients with Chronic Lymphocytic Leukemia by Risk Status. (cdc.gov)
  • TP53-altered chronic lymphocytic leukemia treated with firstline Bruton's tyrosine kinase inhibitor-based therapy: A retrospective analysis. (cdc.gov)
  • del(8p) and TNFRSF10B loss are associated with a poor prognosis and resistance to fludarabine in chronic lymphocytic leukemia. (cdc.gov)
  • Genetic Predictors of Ibrutinib-Related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia. (cdc.gov)
Eosinophils4
  • However, these circumstances do not account for the increased number of eosinophils in PDGFRA -associated chronic eosinophilic leukemia. (medlineplus.gov)
  • Another characteristic feature of PDGFRA -associated chronic eosinophilic leukemia is organ damage caused by the excess eosinophils. (medlineplus.gov)
  • When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in blood cell precursors, the growth of eosinophils (and occasionally other blood cells, such as neutrophils and mast cells) is poorly controlled, leading to PDGFRA -associated chronic eosinophilic leukemia. (medlineplus.gov)
  • PDGFRA-associated chronic eosinophilic leukemia is a form of blood cell cancer characterized by an elevated number of cells called eosinophils in the blood. (nih.gov)
Mantle cell lym1
Systemic2
  • Based on new data and increased understanding of disease molecular genetics, the international consensus classification (ICC) has made several changes in the diagnosis and classification of eosinophilic disorders and systemic mastocytosis. (bvsalud.org)
  • Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)
Infiltration2
  • Although eosinophilic endocardial disease has been well described, myocardial and vascular damage due to eosinophilic infiltration and degranulation is rarely diagnosed during life, as reported by Oakley et al and others. (medscape.com)
  • Duodenal aspirate is more sensitive than stool examination, and duodenal biopsy may reveal parasites in the gastric crypts, in the duodenal glands, or eosinophilic infiltration in the lamina propria. (cdc.gov)
Granulomatosis with polyangiitis1
  • May provide an important clue for less common difficult-to-diagnose conditions, such as eosinophilic granulomatosis with polyangiitis, IgG4-related disease, and Rosai-Dorfman disease. (thebloodproject.com)
FIP1L1-PDGFRA2
  • The most common genetic abnormality in PDGFRA -associated chronic eosinophilic leukemia results from a deletion of genetic material from chromosome 4 , which brings together part of the PDGFRA gene and part of the FIP1L1 gene, creating the FIP1L1-PDGFRA fusion gene. (medlineplus.gov)
  • however chronic eosinophilic leukemia with FIP1L1-PDGFRA is likely to be responsive also to dasatinib, nilotinib, sorafenib and midostaurin (PKC412) (Lierman et al. (atlasgeneticsoncology.org)
Diffuse large B-1
Disorders3
  • however the incidence rates for molecularly defined eosinophilic disorders are not known. (atlasgeneticsoncology.org)
  • Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)
  • Elevated WBC, leukocytosis, is seen in response to infection, stress, inflammatory disorders (referred to as reactive leukocytosis), or abnormal production as in leukemia. (medscape.com)
Granular1
  • [ 14 ] Gliech et al reported a dose-dependent cytotoxic effect of the eosinophilic granular proteins, inhibiting multiple enzyme systems. (medscape.com)
Graft-versus-1
  • Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
Myocarditis2
  • [ 4 ] Herzog et al and Tonnesen et al have proposed that the reason for this situation may be the rapidly fatal evolution of most cases of eosinophilic arteritis and myocarditis. (medscape.com)
  • [ 11 ] More recently, cases of isolated eosinophilic myocarditis have been reported without signs of endomyocardial involvement, with or without vasculitis. (medscape.com)
Reactive1
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Carcinoma1
  • Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinoma. (medscape.com)
Asthma2
  • Rarely, patients with chronic strongyloidiasis have complained of arthritis, cardiac arrhythmias, and signs and symptoms consistent with chronic malabsorption, duodenal obstruction, nephrotic syndrome, and recurrent asthma. (cdc.gov)
  • Hyperinfection syndrome and disseminated strongyloidiasis are most frequently associated with subclinical infection in patients receiving high-dose corticosteroids for the treatment of asthma or chronic obstructive pulmonary disease (COPD) exacerbations. (cdc.gov)
Syndrome7
  • Ghislain PD, Van Eeckhout P. Eosinophilic cellulitis of papulonodular presentation (Wells' syndrome). (medscape.com)
  • Holme SA, McHenry P. Nodular presentation of eosinophilic cellulitis (Wells' syndrome). (medscape.com)
  • Espana A, Sanz ML, Sola J, Gil P. Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5. (medscape.com)
  • Heelan K, Ryan JF, Shear NH, Egan CA. Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. (medscape.com)
  • Wells syndrome (eosinophilic cellulitis) following vaccination: Two pediatric cases with positive patch test to aluminium salts. (medscape.com)
  • In chronic strongyloidiasis and in hyperinfection syndrome the larvae are limited to the GI tract and the lungs whereas in disseminated strongyloidiasis the larvae invade numerous organs. (cdc.gov)
  • Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)
Plasma cell my1
  • Monoclonal gammopathies which do not meet the criteria of plasma cell myeloma, plasmocytoma or B-Cell lymphoma with plasmacytic differentiation. (muni.cz)
Cutaneous4
  • Chronic strongyloidiasis is generally asymptomatic, but in patients with clinical disease gastrointestinal and cutaneous manifestations are the most common. (cdc.gov)
  • Cutaneous symptoms include chronic urticaria and larva currens- a recurrent serpiginous maculopapular or urticarial rash along the buttocks, perineum, and thighs due to repeated auto-infection. (cdc.gov)
  • Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous. (bvsalud.org)
  • Lichenoid and sclerodermatous are the two main types of cutaneous chronic GVHD [14]. (bvsalud.org)
Bone3
  • All the cancers that arise in the bone marrow are known as Leukemia. (mediflam.com)
  • Treatment for Leukemia includes radiation therapy, Chemotherapy, Immunotherapy, Bone marrow transplant, etc. the treatment cost of Leukemia in India depends on the type and growth of leukemia in the body. (mediflam.com)
  • The eosinophilic proliferation was severe in peripheral blood and bone marrow, and they revealed marked dysplastic features. (karger.com)
Clinical1
  • Histological and clinical forms of the eosinophilic cellulitis]. (medscape.com)
Subtypes1
  • Please refer to our booklet, Non-Hodgkin Lymphoma, for additional subtypes ( click here ). (lls.org)
Cytoplasmic2
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
Myelomonocytic1
Mutations1
Idiopathic Myelofibrosis1
  • In humans, myelofibrosis is an abbreviated term that has been used in reference to chronic idiopathic myelofibrosis or primary myelofibrosis. (nih.gov)
Extranodal1
  • Individuals with a WAS-related disorder, particularly those who have been exposed to Epstein-Barr virus (EBV), are at increased risk of developing lymphomas, which often occur in unusual, extranodal locations including the brain, lung, or gastrointestinal tract. (beds.ac.uk)
Disease3
  • Treatment for leukemia is determined by the patient's overall health and age, the type of leukemia, the patient's response to initial treatment, and whether the disease has spread to other organs. (mediflam.com)
  • Pediatric patients with Ph+ CML in chronic phase who are newly diagnosed or whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. (theindianpharma.com)
  • Chronic graft-vs-host disease (cGVHD) is the most common complication following allogeneic BMT [10]. (bvsalud.org)