AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Myeloproliferative DisordersMyelodysplastic SyndromesMyelodysplastic-Myeloproliferative DiseasesAnemia, RefractoryLeukemia, Myelomonocytic, ChronicThrombocytosisAnemia, SideroblasticPolycythemia VeraJanus Kinase 2Primary MyelofibrosisThrombocythemia, EssentialLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAnemia, Refractory, with Excess of BlastsLeukemia, Myelomonocytic, JuvenileLeukemia, Myeloid, AcuteLymphomaBone MarrowSplenomegalyHematopoiesis, ExtramedullaryFusion Proteins, bcr-ablReceptors, ThrombopoietinHematopoietic Stem CellsOncogene Proteins, FusionLeukocytosisGenes, ablSyndromeBone Marrow CellsSTAT5 Transcription FactorLeukemia, MyeloidBone Marrow TransplantationMutationfms-Like Tyrosine Kinase 3Chromosomes, Human, Pair 5LeukemiaLymphoma, Non-HodgkinLymphoma, B-CellCell Transformation, NeoplasticGene Expression Regulation, LeukemicTranslocation, GeneticHematopoiesisLymphoma, T-CellKaryotypingAzacitidineChromosome AberrationsMyeloid CellsPreleukemiaMonosomyBenzamidesLymphoma, Large B-Cell, DiffuseTreatment OutcomeLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativePrognosisThalidomidePyrimidinesChromosomes, Human, Pair 7Mutation, MissenseRetroviridaeFlow CytometryPiperazinesLymphoma, FollicularBone Marrow NeoplasmsDisease Models, AnimalMice, Inbred C57BLBone Marrow DiseasesPancytopeniaAcute DiseaseAnemia, AplasticSignal TransductionReceptors, ErythropoietinCytogenetic AnalysisProto-Oncogene ProteinsBlast CrisisChromosome DeletionProtein-Tyrosine KinasesCell ProliferationHematopoietic Stem Cell TransplantationPhenotypeBurkitt LymphomaRetrospective StudiesTransduction, GeneticMegakaryocytesPostoperative ComplicationsMice, KnockoutCytogeneticsChromosomes, Human, Pair 8Hematologic NeoplasmsAntigens, CD34Granulocyte Precursor CellsTrisomySurvival AnalysisNeoplasms, Second PrimaryLymphoma, B-Cell, Marginal ZoneAntimetabolites, AntineoplasticDown SyndromeGranulocytesChromosomes, Human, Pair 20ErythropoietinBone Marrow ExaminationBlood Cell CountDisease Progression
NeoplasmsDisordersPrimary MyelofibrosisGraft-versus-HodgkinMyelomaMantle Cell LymMyeloidLeukemia and lymphomaFollicular LymphomaMyelofibrosisDisorderMALIGNANCIESAggressive LymphomaMPNsChemotherapyThrombohemorrhagic eventsParasitic DiseasesPulmonaryPatientsNeoplasticAllogeneicInfectious complicationsClinicalTransplantationSymptomsLymphocyteHodgkin'sSickle Cell DiMutationCoagulationHypereosinophilic SyndromeSplenomegalyTreatmentLymph nodesPlateletHematologicAnemiaSignificantly
Neoplasms9
  • A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
  • Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by a proliferation of normally developed (nondysplastic) multipotent hematopoietic stem cells from the myeloid cell line . (amboss.com)
  • A recent review examined the current evidence regarding risk factors, molecular characterization, and treatment options for myeloproliferative neoplasms. (ajmc.com)
  • Myeloproliferative neoplasms (MPNs) represent a heterogenous group of disorders of the hematopoietic stem cell, with a high risk of evolution into acute myeloid leukemia (AML). (ajmc.com)
  • Iurlo A, Cattaneo D, Gianelli U. Blast transformation in myeloproliferative neoplasms: risk factors, biological findings, and targeted therapeutic options [published online April 13, 2019]. (ajmc.com)
  • To aid diagnose bone marrow disorders called as myeloproliferative neoplasms (MPNs) in which the bone marrow creates too many of one or more types of blood cells. (metropolisindia.com)
  • The bone marrow disorders caused JAK2 mutations are known as myeloproliferative neoplasms (MPNs) in which the bone marrow produces way too many WBCs, RBCs and Platelets. (metropolisindia.com)
  • JAK2 mutation was positive, which led to myeloproliferative neoplasms being considered as the differential diagnosis. (bvsalud.org)
  • This case report emphasizes that physicians should consider myeloproliferative neoplasms as part of their differential diagnosis when presented with EHPVT. (bvsalud.org)
Disorders7
  • He is co-director of the Georgetown University Medical Center Adult Hemophilia Treatment Center and has particular clinical and research interest in bleeding and clotting disorders, bone failure and aplastic anemia, leukemia, and genetic syndromes of cancer predisposition. (medstarhealth.org)
  • Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
  • The Department of Gastroenterology and Hepatology treats diseases occurring in gastrointestinal tracts, such as the esophagus, stomach, duodenum, small intestine, and large intestine, and deals with disorders involving the liver, biliary tract, or pancreas. (keio.ac.jp)
  • The Department of Endocrinology, Metabolism and Nephrology provides the following medical services: In the field of kidney disease, we diagnose, treat and prevent the progression of various (chronic) kidney disorders, such as diabetic nephropathy, nephrosclerosis, and renal dysfunction associated with autoimmune disease. (keio.ac.jp)
  • We also have specialty outpatient clinics for patients with stroke, Parkinson disease, dementia, headache, neuroimmunological diseases, multiple sclerosis, or spasmodic disorders requiring Botox injection treatment, all of which are directed by staff members with expertise in each of these fields. (keio.ac.jp)
  • They make the patient susceptible to suffer hemorrhagic processes, such as: abundant periods, nosebleeds, or frequent bruising, which can be due to congenital diseases, such as von Willebrand's Disease, hemophilia, platelet disorders, kidney or liver disease, or disorders affecting other organs. (bloodcellbarcelona.com)
  • If left untreated, these disorders result in a progressive disease with neurological and psychomotor obstruction, skeletal abnormalities, and life-threatening cardiac and pulmonary complications. (bethematchclinical.org)
Primary Myelofibrosis1
Graft-versus-2
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • Correlate incidence and severity of graft-versus-host disease with relapse and survival in patients treated with this regimen. (bioseek.eu)
Hodgkin10
  • Hodgkin disease. (lookformedical.com)
  • Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
  • The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Vivimusta (bendamustine hydrochloride injection) is an alkylating drug indicated for treatment of patients with chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. (rxlist.com)
  • The dose of Vivimusta for indolent B-cell non-Hodgkin lymphoma (NHL) is 120 mg/m2 infused intravenously over 20 minutes on Days 1 and 2 of a 21-day cycle, up to 8 cycles. (rxlist.com)
  • non-Hodgkin lymphoma, other and unspecified types (C85. (who.int)
  • Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease. (unicatt.it)
  • 100%), and multiple myeloma (97%) demonstrated the highest rates of detectable antibody, while patients with chronic lymphocytic leukemia (62%) and non-Hodgkin lymphoma (low-grade: 60%, high-grade: 74%) had the lowest rates. (hematologyadvisor.com)
  • Indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. (nih.gov)
Myeloma1
Mantle Cell Lym1
Myeloid3
  • These are diseases in which bone marrow hematopoietic stem cells produce more mature elements than normal: leukocytes (chronic myeloid leukemia), red blood cells or erythrocytes (polycythemia vera) and platelets (essential thrombocythemia). (bloodcellbarcelona.com)
  • The clinical signs of leukemia in dogs can vary depending on the type of leukemia (lymphoid or myeloid) and the extent of the disease. (thevetexpert.com)
  • However, long-term follow-up and X-linked clonality studies indicate that at least some patients with hypereosinophilic syndrome have an underlying clonal myeloid malignancy or a clonal or phenotypically abnormal T-cell population, suggesting a true secondary process. (medscape.com)
Leukemia and lymphoma2
Follicular Lymphoma2
Myelofibrosis2
  • Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
  • 3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
Disorder5
  • Eosinophilic fasciitis (EF), also called Shulman syndrome, is a rare, localized fibrosing disorder of the fascia. (medscape.com)
  • 3. Name the 4 major classes of myeloproliferative disorder. (missionforvisionusa.org)
  • Patients with very high platelet counts may be tested for acquired von Willebrand disease, a blood disorder that can impair normal blood clotting and cause major bleeding. (lls.org)
  • Hypereosinophilic syndrome (HES) is a myeloproliferative disorder (MPD) characterized by persistent eosinophilia that is associated with damage to multiple organs. (medscape.com)
  • Initial investigations revealed iron deficiency anaemia accompanied by a significantly elevated platelet count, prompting suspicion of an underlying myeloproliferative neoplastic disorder. (bvsalud.org)
MALIGNANCIES1
  • Other Malignancies: Pre-malignant and malignant diseases have been reported. (nih.gov)
Aggressive Lymphoma3
  • Members of our consultant team are involved in international reference groups that drive treatment trends for aggressive lymphoma and have been leaders in clinical and bench-top research. (petermac.org)
  • You can refer directly to the aggressive lymphoma team by contacting the individuals listed on this page. (petermac.org)
  • The Aggressive Lymphoma Service is part of Clinical Haematology we have formed with the Royal Melbourne Hospital. (petermac.org)
MPNs3
  • Less common MPNs, which are not associated with the driver mutations, include chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia , and myeloproliferative neoplasm , unclassifiable. (amboss.com)
  • Treatments for all MPNs primarily focus on the prevention of known complications (e.g., thrombohemorrhagic events ) and the alleviation of symptoms with combinations of medications and/or procedures including platelet inhibitors , cytoreduction , phlebotomy , targeted therapy , transfusions of blood products , and splenectomy . (amboss.com)
  • Conventional antileukemic therapy has limited efficacy in patients with BCR-ABL1 -negative MPNs in accelerated or blast phase of the disease. (ajmc.com)
Chemotherapy3
  • Some people have a history of exposure to chemotherapy (especially alkylating agents such as melphalan, cyclophosphamide, busulfan, and chlorambucil) or radiation (therapeutic or accidental), or both (e.g., at the time of stem cell transplantation for another disease). (wikipedia.org)
  • Currently, stem cell therapy is the best option, but it first requires intensive chemotherapy to reduce the disease burden to become eligible. (ajmc.com)
  • Suppress myeloproliferative activity with chemotherapy (hydroxyurea) in all patients older than 50 years. (medscape.com)
Thrombohemorrhagic events1
  • The major causes of morbidity and mortality are usually thrombohemorrhagic events and less frequently infectious complications, and/or transformation to blast phase, often termed secondary AML or blast-phase MPN (MPN-BP). (ajmc.com)
Parasitic Diseases2
  • certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
  • Worldwide, parasitic diseases are the most common cause, whereas in developed countries, allergic diseases are the most common cause. (medscape.com)
Pulmonary2
  • The Department of Pulmonary Medicine provides high-quality medical care for patients with lung diseases or respiratory symptoms, such as COPD (chronic obstructive pulmonary disease), bronchial asthma, respiratory infection, interstitial pneumonia, lung cancer, and sleep apnea syndrome. (keio.ac.jp)
  • 6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
Patients19
  • These cancers can wreak havoc on the immune system, leaving patients defenseless against illness or disease. (marijuanadoctors.com)
  • Patients with cancer need to feel revitalized and well-rested to battle their symptoms and the disease. (marijuanadoctors.com)
  • Provide evidence-based, patient-centered clinical and laboratory training and education in order to deliver care of the highest standards to patients with hematological diseases in Oman. (gov.om)
  • Our department provides individually tailored medical care that not only diagnoses and treats respiratory disease, but also supports patients' rehabilitation to diagnose and treat lung cancer, we hold joint conferences with the Department of General Thoracic Surgery, Department of Radiology, and Department of Diagnostic Pathology. (keio.ac.jp)
  • Using high-level techniques, the Department of Cardiology provides medical services for patients with various cardiovascular diseases, such as angina pectoris, myocardial infarction, arrhythmia, valvular heart disease, cardiomyopathy, heart failure, and congenital heart disease. (keio.ac.jp)
  • Our motto is to provide comprehensive care not only to treat diseases of patients, but also to support their lives. (keio.ac.jp)
  • We treat patients with neurologic diseases through contemporary and leading-edge approaches. (keio.ac.jp)
  • [ 9 ] Pathologic specimens from patients with eosinophilic fasciitis demonstrate increased numbers of eosinophils, especially early in the disease course. (medscape.com)
  • 5 4 In addition to increased disease-related morbidity, MF results in early death with the median survival of affected patients being approximately 6 years. (haematologica.org)
  • We retrospectively analyzed 34 patients with PNH disease between 2016 and 2018, who were on eculizumab treatment and who presented with respiratory symptoms and were subsequently tested for 10 respiratory viruses (influenza A, influenza B, parainfluenza, respiratory syncytial virus, adenovirus, rhinovirus, and human metapneumovirus). (bvsalud.org)
  • Further study is needed to identify other mutations that may cause the disease in these patients. (lls.org)
  • The literature now favors the view that cases of idiopathic hypereosinophilic syndrome with FIP1L1 indeed represent chronic eosinophilic leukemia, because these patients have a molecular genetic abnormality, specifically an FIP1L1-PDGFRA fusion gene. (medscape.com)
  • In addition, some patients with hypereosinophilic syndrome present with features typical of MPDs, such as hepatosplenomegaly, the presence of leukocyte precursors in the peripheral blood, increased alkaline phosphatase level, chromosomal abnormalities, and reticulin fibrosis. (medscape.com)
  • NCT04422470 ) is an ongoing observational study in adult patients with malignant and non-malignant hematological diseases and COVID-19 in Russia. (hematologyadvisor.com)
  • Low post-disease antibody immunity to SARS-CoV-2 and cases of re-infection may justify vaccination of these patients and warrant further research. (hematologyadvisor.com)
  • A study of HCT in 217 patients with Hurler syndrome found that preservation of cognitive function at the time of transplant and younger age at transplantation were major predictors for superior post-transplant cognitive development. (bethematchclinical.org)
  • Our guidelines highlight disease categories that include patients at risk for disease progression and who should be referred for a consultation for transplantation. (bethematchclinical.org)
  • Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study. (bethematchclinical.org)
  • Our mission is to support our patients through this challenging time in their lives and provide the highest quality of care and the best outcomes for their lymphoma. (petermac.org)
Neoplastic1
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Allogeneic1
Infectious complications1
  • These diseases are characterized by the presence of low levels of immunoglobulins, either one or several, which in many cases leads to an increase in the vulnerability to infectious complications. (bloodcellbarcelona.com)
Clinical7
  • The Department of Hematology, Oncology, Adult and Pediatric Rheumatology at the University Hospital Heidelberg offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. (bookinghealth.com)
  • The available literature has generated a broader clinical image of the condition, but fascial thickening in the setting of eosinophilia, elevated erythrocyte sedimentation rate, and hypergammaglobulinemia remain critical elements of the syndrome. (medscape.com)
  • Each chapter has a strict chapter format that includes the indications and contraindications for each procedure, a list of equipment and drugs, a step-by-step illustration-focused how-to, a list of possible post-procedural complications, and bullet-pointed clinical pearls and pitfalls. (nshealth.ca)
  • This is a group of diseases with varied clinical evolution and prognosis that are produced to abnormalitiers in the functioning of the hematopoietic stem cells that produce less mature elements in peripheral blood, with a defective function. (bloodcellbarcelona.com)
  • Amongst them we can distinguish chronic lymphocytic leukemia, in which there is an increase in leukocytes and lymphocytes in peripheral blood and lymphomas, which are diseases of the lymph nodes with different histologies, clinical behavior and course and requiring very different treatment modalities. (bloodcellbarcelona.com)
  • We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease. (metropolisindia.com)
  • The service provides a thorough clinical trials program covering the spectrum of the diseases we treat and has been successful in translating discoveries from the research bench to the clinic. (petermac.org)
Transplantation1
  • The National Marrow Donor Program® (NMDP)/Be The Match® and the American Society for Transplantation and Cellular Therapy (ASTCT) have jointly developed guidelines for transplant consultation and referral timing based on disease characteristics. (bethematchclinical.org)
Symptoms2
  • MF is characterized by variable degrees of cytopenias, a leukoerythroblastic blood picture, and extramedullary hematopoiesis resulting in progressive splenomegaly and debilitating disease-related constitutional symptoms, compromising quality of life. (haematologica.org)
  • Additionally, some dogs with leukemia may only show noticeable symptoms once the disease progresses. (thevetexpert.com)
Lymphocyte1
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Hodgkin's2
  • An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
Sickle Cell Di1
  • Two posters set to be presented at the 65th American Society of Hematology Annual Meeting & Exposition met their primary and secondary end points regarding exagamglogene autotemcel therapy for sickle cell disease and β-thalassemia. (ajmc.com)
Mutation1
  • The prevalence of such a mutation is 0.4% in unselected cases of eosinophilia, but it can be as high as 12-88% in cohorts that meet the World Health Organization (WHO) criteria for idiopathic hypereosinophilic syndrome, particularly those with features of MPD (increased levels of tryptase and mast cells in the bone marrow). (medscape.com)
Coagulation1
Hypereosinophilic Syndrome3
  • However, due to advances in the diagnostic techniques, secondary causes of eosinophilia can be identified in a proportion of cases that would have otherwise been classified as idiopathic hypereosinophilic syndrome. (medscape.com)
  • The differential diagnosis (see DDx) of hypereosinophilic syndrome includes other causes of eosinophilia,[1, 9, 10, 11] which may be classified as familial or acquired. (medscape.com)
  • 15] In addition, there are documented cases of acute transformation to either AML or granulocytic sarcoma in some cases of hypereosinophilic syndrome after an interval as long as 24 years. (medscape.com)
Splenomegaly1
  • Fever, weight loss and splenomegaly should point to a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) rather than pure myelodysplastic process. (wikipedia.org)
Treatment3
  • The evidence for many of these agents is anecdotal, and there is no general consensus regarding the best agent for treatment of steroid-resistant disease or cases refractory to steroid withdrawal. (medscape.com)
  • Experts from Penn Medicine's Endocrine Disease team discuss the management of Thyroid Nodules and address critical decision making points along this patient-centered pathway of treatment. (pennmedicine.org)
  • The treatment of a disease or condition by several different means simultaneously or sequentially. (lookformedical.com)
Lymph nodes1
  • A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (lookformedical.com)
Platelet1
Hematologic1
Anemia1
  • Children with Down syndrome are susceptible to MDS, and a family history may indicate a hereditary form of sideroblastic anemia or Fanconi anemia. (wikipedia.org)
Significantly2