Autologous stem cell transLymphomaLymph nodesLymphocytesMucosa-associOrgansBiopsySpleenDonorEngraftmentChemotherapyTherapyRecipientsGvHDClinicalTumorsOrgan transplantationTumor cellsHematopoiesisFormed in the body'sTreatment of malignantTherapeuticImmune systemLiverEffect on bone marrowDiseasesMalignantEmbryonicPatient'sLymphomasPatientsCancer immunotherapyProgenitorMalignanciesCord bloodMorbidity and mortaDisordersHaematopoieticMyeloidLeukemiaMetastatic renal cell carcHematopoietic systemRenalPotentiallyPeripheral bloodBloodCellularComplicationsLymphoproliferative
Autologous stem cell trans2
- In early 1987 Slavin introduced the concept of cancer immunotherapy using donor lymphocytes infusion (DLI) for the treatment and prevention of recurrent disease and pioneered the use of adaptive allogeneic cell-mediated immunotherapy and cytokine-activated lymphocytes for both treatment and prevention of relapse following allogeneic and autologous stem cell transplantation for hematologic malignancies and solid tumors. (wikipedia.org)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Lymphoma57
- The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
- These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
- Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
- Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
- Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
- it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
- Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
- Hata M, Kaneko A, Tomita N, Inoue T: Severe retinopathy following radiation therapy with a moderate dose for orbital mucosa-associated lymphoid tissue lymphoma. (ycuhri.com)
- Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
- MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
- Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
- The NCCN guideline for PTLD, which is integrated into the larger B-cell lymphoma guideline, provides the following algorithm to diagnose the disorder with steps categorized as either "essential" or "useful under certain circumstances. (medscape.com)
- We present an unusual case of monomorphic T cell PTLD with features of angioimmunoblastic T cell lymphoma in an 8-year-old heart transplant patient, presenting with cranial nerve palsy. (karger.com)
- Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ: Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. (karger.com)
- Miyazaki K, Masuya M, Yamaguchi M, Isaka S, Nakase K, Kobayashi T, Nakamura S, Shiku H: Angioimmunoblastic T-cell lymphoma occurring four months after autologous peripheral blood stem cell transplantation with high-dose chemotherapy for follicular lymphoma. (karger.com)
- de Leval L, Gisselbrecht C, Gaulard P: Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. (karger.com)
- Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
- Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
- Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
- Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
- Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
- Lymphoma b cell. (lookformedical.com)
- B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
- Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
- Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
- Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
- A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
- Time trends in risk and risk determinants of non-hodgkin lymphoma in solid organ transplant recipients. (medscape.com)
- Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk. (medscape.com)
- For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)
- [9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
- T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
- We determined the risk of late morbidity and mortality after autologous blood or marrow transplantation (BMT) for lymphoma performed before age 40. (bvsalud.org)
- Mantle cell lymphoma a very rare disease is cancer that is a subtype of B-cell non-Hodgkin lymphomas (NHLs) that affects certain cells of the immune system. (gilmorehealth.com)
- Mantle cell lymphoma is a form of non-Hodgkin's lymphoma. (gilmorehealth.com)
- In the case of mantle cell lymphoma, it is the B lymphocytes (B Cells) that are responsible for producing antibodies. (gilmorehealth.com)
- Mantle cell lymphoma progresses slowly and can take years before it is diagnosed. (gilmorehealth.com)
- Mantle cell lymphoma has a genetic origin. (gilmorehealth.com)
- However, the diagnosis of mantle cell lymphoma usually needs to be confirmed by blood tests, imaging studies, and biopsy (taking a tissue sample). (gilmorehealth.com)
- Mantle cell lymphoma affects different parts of the body, such as lymph nodes, bone marrow, spleen, and blood. (gilmorehealth.com)
- Who is at risk for mantle cell lymphoma? (gilmorehealth.com)
- Mantle cell lymphoma is a rare disease. (gilmorehealth.com)
- Mantle cell lymphoma is most common after the age of 60. (gilmorehealth.com)
- How is mantle cell lymphoma treated? (gilmorehealth.com)
- In rare cases of limited mantle cell lymphoma, treatment consists only of regular medical supervision. (gilmorehealth.com)
- If the mantle cell lymphoma is localized, radiotherapy may be offered. (gilmorehealth.com)
- Because Mantle cell lymphoma goes undetected for many years its treatment is usually delayed because of the late diagnosis. (gilmorehealth.com)
- Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. (medscape.com)
- Rook AH, Yoo EK, Grossman DJ, Kao DM, Fox FE, Niu Z. Use of biological response modifiers in the treatment of cutaneous T-cell lymphoma. (medscape.com)
- Emerging new therapies for cutaneous T-cell lymphoma. (medscape.com)
- Novel treatment approaches for cutaneous T-cell lymphoma. (medscape.com)
- Herrmann JJ, Roenigk HH Jr, Hönigsmann H. Ultraviolet radiation for treatment of cutaneous T-cell lymphoma. (medscape.com)
- Cutaneous T cell lymphoma: update of treatment. (medscape.com)
- Sinha AA, Heald P. Advances in the management of cutaneous T-cell lymphoma. (medscape.com)
- Topical treatment of early cutaneous T-cell lymphoma. (medscape.com)
- Russell-Jones R. Extracorporeal photopheresis in cutaneous T-cell lymphoma. (medscape.com)
- Epidemiology and clinical manifestations of cutaneous T-cell lymphoma. (medscape.com)
Lymph nodes9
- These can occur in lymph nodes or in sites such as the gastrointestinal tract or the inner eyelids, where these tumors are referred to as mucosa-associated lymphoid tissue (MALT) lymphomas. (dana-farber.org)
- img class='aligncenter' src='https://scx1.b-cdn.net/csz/news/800a/2023/pitt-study-reframes-un.jpg' alt='Pitt study reframes understanding of graft-versus-host disease' title='A new model of graft-versus-host-disease (GVHD): Early post transplant (left side), GVHD is initiated by progenitor T cells that seed affected tissues from the spleen and lymph nodes via the blood. (awebfind.biz)
- According to a widely held theory, GVHD is maintained by T cells that continually migrate from secondary lymphoid organs throughout the body-including the spleen and lymph nodes-to affected tissues via the blood. (awebfind.biz)
- Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
- Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
- Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. (biomedcentral.com)
- To investigate the role of SDF-1 in recirculation and homing in vivo we have developed a model in which human peripheral lymph nodes (huPLN) are transplanted into SCID mice. (biomedcentral.com)
- A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (lookformedical.com)
- [4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
Lymphocytes18
- Slavin pioneered the use of immunotherapy mediated by allogeneic donor lymphocytes and innovative methods for stem cell transplantation for the cure of hematological malignancies and solid tumors, and using hematopoietic stem cells for induction of transplantation tolerance to bone marrow and donor allografts. (wikipedia.org)
- In CLL, the bone marrow makes abnormal lymphocytes (a type of white blood cell). (medlineplus.gov)
- Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
- Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
- Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
- Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
- A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
- They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
- A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
- A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
- In post-natal life, SDF-1 is widely expressed and is induced in chronically inflamed tissues such as psoriatic skin and the rheumatoid synovium, but has also been implicated in the migration of lymphocytes to lymphoid organs. (biomedcentral.com)
- Other authors, particularly when defining severe CAEBV disease, require both an elevated level of EBV in the blood as well as infiltration of tissues by EBV-positive lymphocytes ( 16 ). (frontiersin.org)
- Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. (lookformedical.com)
- Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
- Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
- Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
- Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
- Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
Mucosa-associ1
- They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)
Organs12
- Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
- Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
- In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
- This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
- [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
- This model provides a powerful tool to investigate the pathways involved in cell-migration into lymphoid organs and potentially to target them for therapeutic purposes. (biomedcentral.com)
- These fatty materials are stored naturally in the body's cells, organs, and tissues. (nih.gov)
- Both solid organs and bone marrow Bone marrow The soft tissue filling the cavities of bones. (lecturio.com)
Biopsy1
- Diagnosis requires demonstration of peripheral normocytic anemia and a normocellular bone marrow biopsy with absence of erythroid precursors. (msdmanuals.com)
Spleen4
- Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
- Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
- Recognizing MAS variants and the important anatomical considerations around macrophage perivascular topography in the marrow, liver and spleen allows for a novel evaluation of other states associated with hypercytokinaemia. (nature.com)
- [2] [9] Enlargement of the spleen and low red blood cells ( anemia ) may also occur. (wikipedia.org)
Donor11
- New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies. (awebfind.biz)
- Published today in Immunity , the study showed in a mouse model that GVHD, which often affects the skin, gut and liver, is maintained by donor T cells that seed those tissues soon after transplant and not by the continual recruitment of T cells from the blood as previously thought. (awebfind.biz)
- While often lifesaving for patients with leukemia and other blood disorders, the treatment also comes with a risk of developing GVHD, a life-threatening disease that occurs when donor alloreactive T cells attack the recipient's healthy tissues. (awebfind.biz)
- A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
- It is well recognized from adult stem cell studies that the growth of transplanted bone marrow is generated from the hematopoietic ("blood-forming") stem and progenitor cells provided by the donor bone marrow. (ca.gov)
- Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
- a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
- Here, we report the clinical case of an 18-month-old boy diagnosed with Wiskott-Aldrich syndrome, who did not have an HLA-matched related or unrelated donor and was treated successfully with a hematopoietic stem cell transplant (HSCT) from a haploidentical family donor. (bvsalud.org)
- Currently, at month 32 post-transplant, the patient has hematological and immune reconstitution and complete donor chimerism without evidence of GvHD. (bvsalud.org)
Engraftment7
- V. Cellular and molecular assessment of TMLI effect on bone marrow environment and TMLI effect on the engraftment and disease relapse. (survivornet.com)
- Heredity explicit chimerism studies are regularly acquired at a few time guides after nonmyeloablative hematopoietic cell transplantation toward evaluate the rhythm and level of engraftment, and to screen join dismissal. (scitechnol.com)
- Fragmented contributor engraftment was available just in the fringe blood T cells in a little level of patients. (scitechnol.com)
- NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
- Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
- Interest of study of lymphocyte phosphoglucomutase (PGM) and adenylatokinase (AK) in the early demonstration of Bone Marrow Engraftment. (cellsilab.com)
- Prior to infusion of the CAR-modified immune cells, lymphodepletion is performed in most therapeutic settings to allow efficient cell engraftment [ 10 ]. (nature.com)
Chemotherapy6
- These observations that confirmed the therapeutic benefits of cell therapy led to the development of new concepts for the treatment of hematologic malignancies and solid tumors focusing on utilizing well-tolerated non-myeloablative stem cell transplantation as a platform for cell therapy of cancer targeting killer cells against chemotherapy-resistant malignant cells. (wikipedia.org)
- Using procedures developed by Slavin and his team, treatment of cancer is based on bright rather than aggressive treatment with conventional chemotherapy, which is associated with immediate and late procedure-related toxicity and mortality, aiming at selective elimination of all malignant cells including cancer stem cells. (wikipedia.org)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
- The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
- Immunotherapy is usually combined with chemotherapy, which relies on the use of chemicals to kill cancer cells. (gilmorehealth.com)
Therapy21
- Baxter International recognized the potential of cell therapy and signed an agreement which resulted in significant investment with Slavin at Hadassah Medical Center for further development of new approaches based on cell therapy for the treatment of cancer, autoimmune diseases, and organ transplantation based on new methods for regulation rather than non-specific suppression of the immune system. (wikipedia.org)
- This study changes the paradigm of how people think about GVHD," said co-senior author Warren Shlomchik, M.D., director of the Hematopoietic Stem Cell Transplant and Cell Therapy program at UPMC Hillman Cancer Center and professor of medicine and immunology at the University of Pittsburgh School of Medicine. (awebfind.biz)
- Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells. (medlineplus.gov)
- Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
- The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
- Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
- This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases. (biomedcentral.com)
- Stem cell (SC) therapy is not a new concept. (biomedcentral.com)
- It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
- It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
- Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)
- Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
- Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
- The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)
- An autologous CAR-T or NK cell therapy comprises several steps as shown in Fig. 1 . (nature.com)
- The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
- Conversely, at the other boundary, immune hypersensitivity with gain of immune function in MHC class II-associated sJIA-AOSD and with chimeric antigen receptor (CAR) T cell therapy also triggers MAS. (nature.com)
- Supportive therapy, including transfusions of the cells that are deficient (ie, red blood cells [RBCs], platelets), and treatment of infections are the main treatments. (medscape.com)
- With the wider use of non-myeloablative (reduced-intensity) transplant therapy, various atypical presentations can occur, representing a diagnostic challenge. (bvsalud.org)
- The spectrum of cutaneous T-cell lymphomas: new insights into biology and therapy. (medscape.com)
Recipients6
- It provides important mechanistic detail about what's going on in the tissues affected by GVHD, which could ultimately inform the development of better therapeutics and lead to better outcomes for stem cell recipients. (awebfind.biz)
- Stem cell recipients are typically treated with immunosuppressants to prevent and treat GVHD. (awebfind.biz)
- [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
- ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
- Posttransplant lymphoproliferative disorders (PTLD) are a potentially life-threatening complication of immunosuppression in transplant recipients. (karger.com)
- One-third of hematopoietic cell transplantation recipients develop acute eruption classically described as folliculocentric, maculopapular, or morbilliform, in contrast to the more common chronic presentations of sclerotic, poikilodermic, or lichenoid dermatitides. (bvsalud.org)
GvHD16
- In the later phases of GVHD (right side), hoodia diet drink costco the disease is maintained locally in the tissues by these long-lived progenitor cells, which differentiate into disease-causing cells. (awebfind.biz)
- In the new study, Shlomchik, lead author Faruk Sacirbegovic, Ph.D., research assistant professor of surgery at Pitt, and their team investigated the two hypotheses for how GVHD is sustained in tissues. (awebfind.biz)
- The researchers developed a system to track alloreactive T cells in a mouse model of GVHD by labelling individual cells with unique tags to create different T cell "flavors. (awebfind.biz)
- The analysis showed that each tissue affected by GVHD had unique T cell populations with varying frequencies of each T cell flavor. (awebfind.biz)
- We think that progenitor T cells are long-lived in target tissues and are critical for maintaining GVHD," said Sacirbegovic. (awebfind.biz)
- The findings also suggest that treating GVHD in the tissues themselves would be effective-although targeting tissues beyond the skin remains a challenge. (awebfind.biz)
- With better ways to minimize the risk of GVHD after stem cell transplantation, the procedure could become more widely used to treat a broader range of diseases, including blood disorders such as sickle cell anemia and autoimmune diseases such as lupus and multiple sclerosis. (awebfind.biz)
- As opposed to the aggravated circumstance in GVHD, when communication happens between enacted APC and benefactor T cells, the tissue harm brought about by myeloablative alloSCT brings about dermal enrollment of HLA class II-positive tissue fixing macrophages coinciding with expanded quantities of patient and contributor determined T cells, however without indications of explicit connection and commencement of a safe reaction. (scitechnol.com)
- GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
- The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
- GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
- In contrast to organ/tissue transplant associated GvHD, the incidence of TA-GvHD is increased with HLA matching (first-degree or close relatives). (wikipedia.org)
- The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
- Neither pre-transplant clinical characteristics nor transplant characteristics are reliably predictive of GvHD outcomes. (cryostem.org)
- Graft-versus-host disease (GvHD) prophylaxis included post-transplant cyclophosphamide (PT-Cy). (bvsalud.org)
- Skin is commonly affected by graft versus host disease (GVHD), a complication of bone marrow transplantation (BMT). (bvsalud.org)
Clinical12
- In 1975-1978, Slavin trained in clinical immunology/rheumatology at the Division of Immunology, Stanford University School of Medicine and later on in 1978, trained in clinical bone marrow transplantation under the late E.D. Thomas at the Fred Hutchinson Cancer Research Center in Seattle, Washington. (wikipedia.org)
- RIC or NST made it possible to apply much safer curative stem cell transplantation for every patient in need with no lower or upper age restriction, including patients with less than optimal clinical conditions that would not be eligible for the standard myeloablative stem cell transplantation. (wikipedia.org)
- It is thus essential when designing clinical approaches that use tissues or cells derived from human embryonic stem cells (hESC), to specifically target the production of stem and progenitors that will survive, proliferate and differentiate normally after transplantation. (ca.gov)
- In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
- However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)
- Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
- Diagnosis of EBV-PTLD must be based on clinical presentation plus detection of EBV by an appropriate method in a specimen from involved tissue. (medscape.com)
- In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
- Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
- OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
- Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
- Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Tumors5
- LCDD is categorized as a monoclonal immunoglobulin deposition disease in the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues. (medscape.com)
- The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
- B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
- Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
- The most common indications for the application of the method include, among others, primary (meningioma, glioma) and secondary tumors of the brain (metastatic), pituitary adenoma, acoustic neuromas, early stage inoperative lung cancer, prostate cancer and single metastasis to the lung, liver, or the bone. (gov.pl)
Organ transplantation3
- Blaes AH, Morrison VA: Post-transplant lymphoproliferative disorders following solid-organ transplantation. (karger.com)
- Yang F, Li Y, Braylan R, Hunger SP, Yang LJ: Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation. (karger.com)
- Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)
Tumor cells3
- Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
- Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
- CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Hematopoiesis6
- Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
- The researchers used whole-exome sequencing to detect the presence of clonal hematopoiesis of indeterminate potential in peripheral blood cells and associated that discovery with coronary heart disease using samples from 4 case-control studies that together enrolled 4,726 participants with coronary heart disease and 3,529 controls. (ascopost.com)
- In the after-math of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow (BM) transplanted into irradiated mice produced hematopoiesis [ 1 ]. (biomedcentral.com)
- In experimental settings, the ability of human HSCs to reconstitute hematopoiesis is measured by transplantation into genetically immunocompromised mice (e.g. (stemcell.com)
- This bone marrow film (400× magnification) demonstrates an almost complete replacement of normal hematopoiesis by blasts in a refractory anemia with an excess of blasts in transformation. (medscape.com)
- To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
Formed in the body's1
- White blood cells formed in the body's lymphoid tissue. (lookformedical.com)
Treatment of malignant2
- As such, innovative reduced intensity conditioning (RIC) or non-myeloablative stem cell transplantation (NST) was pioneered by Slavin for safer stem cell transplantation for the treatment of malignant and life-threatening non-malignant disorders correctable by using stem cells and post-transplant immunotherapy if indicated for all patients in need. (wikipedia.org)
- Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
Therapeutic6
- Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
- Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
- In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
- So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
- The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
- Organ transplantations have become the therapeutic option of choice for many individuals with end-stage organ failure. (lecturio.com)
Immune system10
- Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
- First, we have identified some of the key genetic differences in the way blood is formed from hESC that may be particularly important in the formation of the lymphoid cells of the immune system. (ca.gov)
- During the next year of funding, we will continue to study the hEMP and other blood progenitors with the ultimate goal of learning how to improve production of the lymphoid immune system from hESC. (ca.gov)
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
- Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
- Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
- Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)
- Tolerance Tolerance Pharmacokinetics and Pharmacodynamics of the transplanted organ by the immune system Immune system The body's defense mechanism against foreign organisms or substances and deviant native cells. (lecturio.com)
- In other words, it is a form of cancer of the lymphatic system that affects cells of the immune system, i.e. certain cells involved in the body's defense. (gilmorehealth.com)
- Its aim is to stimulate the body's immune system to prevent cancer cells from developing. (gilmorehealth.com)
Liver2
- The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
- These patients may develop transfusion-induced iron overload and can incur significant damage of the liver, heart, pancreas, and other tissues. (medscape.com)
Effect on bone marrow2
- Longitudinal and spatial assessment of TMLI effect on bone marrow environment. (survivornet.com)
- The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
Diseases7
- The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)
- Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
- Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
- WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
- A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
- Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
- A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. (nature.com)
Malignant2
- CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)
- Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Embryonic6
- We have called this primitive population "embryonic mesoderm progenitor" (EMP) cells as they have the potential to make many if not all the cells of the mesoderm germ layer. (ca.gov)
- Several investigations [ 5 - 7 ] have been carried out with isolated embryonic, fetal, and adult SCs in a well-defined culture microenvironment to define the sequential steps and intracellular pathways that are involved in their differentiation into the specific cell lineages. (biomedcentral.com)
- Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells. (biomedcentral.com)
- The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
- WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
- SDF-1 (CXCL12), a CXC chemokine, has a primary role in signalling the recruitment of haematopoietic stem-cell precursors to the bone marrow during embryonic development. (biomedcentral.com)
Patient's4
- I. Characterize minimal residual disease from bone marrow aspirates and investigate the possible association between TMLI-based regimen and patient's disease status. (survivornet.com)
- First, T or NK cells are isolated from patient's or donor's blood. (nature.com)
- The goal is to replace cells that are prematurely undergoing apoptosis in the patient's bone marrow. (medscape.com)
- For locations with considerable respiratory mobility, the system keeps track of the patient's breathing and the moving tumor, closely following the lesion and avoiding irradiation of the surrounding healthy tissue. (gov.pl)
Lymphomas10
- However, there are several slow growing B-cell lymphomas that occur in this young age group. (dana-farber.org)
- There are also rare T-cell lymphomas that are more frequently seen in adults but occasionally occur in children. (dana-farber.org)
- Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
- The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
- Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
- The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
- Diffuse large cell lymphomas and their mimics. (llu.edu)
- B-cell lymphomas. (llu.edu)
- Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases. (medscape.com)
- Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
Patients27
- [ 10 ] Approximately 50-60% of patients with LCDD have associated multiple myeloma and 17% have monoclonal gammopathy of unknown significance (MGUS) or no evidence of neoplastic plasma cell proliferation. (medscape.com)
- The approach for diagnosis with LCDD should be the same as for patients with plasma cell dyscrasias. (medscape.com)
- This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
- TRANSPLANT: Patients undergo hematopoietic cell transplantation on day 0. (survivornet.com)
- Long haul resistant recuperation in more seasoned patients given hematopoietic cell transplantation after non-myeloablative molding remains ineffectively comprehended. (scitechnol.com)
- The perception that late resistance in more established patients primarily relies upon mature T cells contained in the unite has significant ramifications since it proposes that drawn out safe capacity after HCT may be impacted by procedures of in vitro or in vivo T cell consumption of the join in these patients. (scitechnol.com)
- In this review, a review examination was performed to survey the transfer result of grown up patients with ALL who had chimerism investigations of unfractionated BM cells or fringe blood subsets performed roughly 80 days after transplantation. (scitechnol.com)
- These patients got unmanipulated, myeloablative transfers utilizing either HLA indistinguishable or HLA jumbled, related or inconsequential contributor undeveloped cells. (scitechnol.com)
- Aoki J, Tsubokura M, Kakihana K, Oshikawa G, Kobayashi T, Doki N, Sakamaki H, Ohashi K: The predictive value for pulmonary infection by area over the neutrophil curve (D-index) in patients who underwent reduced intensity hematopoietic stem cell transplantation. (ycuhri.com)
- Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
- Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
- En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
- T cell PTLD is rare, particularly in pediatric patients. (karger.com)
- Autologous bone marrow transplantation for acute leukemia: Results and prognostic factors in 90 consecutive patients. (cellsilab.com)
- Guidelines for transfusion in patients with MDS and bone marrow failure are as follows. (medscape.com)
- PATIENTS: Nineteen children with cutaneous findings in the first 4 weeks of life and subsequently diagnosed with LCH based on compatible tissue histologic analysis, confirmed by electron microscopy and/or immunohistochemical analysis. (thedoctorsdoctor.com)
- Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
- Patients with CAEBV in the United States most often present with disease involving B or T cells, while in Asia, the disease usually involves T or NK cells. (frontiersin.org)
- These patients are unable to control EBV infection and have infiltration of tissues by EBV positive T, NK, or less often B cells. (frontiersin.org)
- Some patients with CAEBV have been reported to have impaired NK cell ( 8 ) or T cell activity ( 9 - 13 ) against EBV-infected cells. (frontiersin.org)
- In addition, reduced numbers of EBV-specific T cells have been described in patients with CAEBV disease ( 10 ). (frontiersin.org)
- Unlike healthy persons with infectious mononucleosis, patients with CAEBV disease often have low numbers of EBV-specific CD8 cells ( 10 ). (frontiersin.org)
- A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)
- Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
- Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
- Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
- Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
Cancer immunotherapy2
- Upon returning to Jerusalem, he opened the first Bone Marrow Transplantation Center at the Hadassah University Hospital, which was later recognized as Israel's National Bone Marrow Transplantation and & Cancer Immunotherapy Center. (wikipedia.org)
- Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
Progenitor16
- Led by co-senior author Thomas Höfer, Ph.D., division head of the German Cancer Research Center and professor of theoretical systems biology at the University of Heidelberg, the team used mathematical models to predict that progenitor T cells seed out into recipient tissues early after transplant, differentiating there into disease-causing cells. (awebfind.biz)
- Now that we know the identity of progenitor cells, we might be able to prevent them forming early post-transplant or target them directly after they've formed," said Shlomchik. (awebfind.biz)
- We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
- All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. (biomedcentral.com)
- A progenitor cell is a biological cell that, like an SC, has a tendency to differentiate into a specific type of cell but is already more specific than an SC and is pushed to differentiate into its 'target' cell. (biomedcentral.com)
- The most important difference between SCs and progenitor cells is that SCs can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. (biomedcentral.com)
- Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
- Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
- The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
- Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
- CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
- Transplanted tissue may be cells (e.g., hematopoietic stem cells Hematopoietic stem cells Progenitor cells from which all blood cells derived. (lecturio.com)
- B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
- As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
- These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
- Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Malignancies1
- Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study. (medscape.com)
Cord blood5
- However, it has become apparent more recently that the types of blood cells that hESC can produce under current conditions are more limited functionally than those found in bone marrow or cord blood. (ca.gov)
- In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)
- 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
- With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
- Successful cord blood transplantation for mycosis fungoides. (medscape.com)
Morbidity and morta1
- The acute or fulminant form of the disease (aGvHD) is normally observed within the first 10 to 100 days post-transplant, [9] [10] and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
Disorders6
- More recently, he's been working on the use of multi-potent mesenchymal stem cells (MSCs) in regenerative medicine for the treatment of neurological, systemic, and orthopedic disorders. (wikipedia.org)
- The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. (biomedcentral.com)
- Morovic A, Jaffe ES, Raffeld M, Schrager JA: Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. (karger.com)
- Draoua HY, Tsao L, Mancini DM, Addonizio LJ, Bhagat G, Alobeid B: T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience. (karger.com)
- Post-transplant lymphoproliferative disorders. (llu.edu)
- 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
Haematopoietic2
- Swerdlow SH, International Agency for Research on Cancer, World Health Organization: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (karger.com)
- The distinct MAS phenotype that arises with hypercytokinaemia can be explained by activation of macrophages that are closely juxtaposed to sinusoids that permit direct phagocytic access to haematopoietic lineage cells. (nature.com)
Myeloid1
- increased risk of myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML) and T-cell acute lymphoblastic leukaemia (T-ALL). (eviq.org.au)
Leukemia5
- Leukemia is a term for cancers of the blood cells. (medlineplus.gov)
- Leukemia starts in blood-forming tissues such as the bone marrow. (medlineplus.gov)
- When you have leukemia, your bone marrow makes large numbers of abnormal cells. (medlineplus.gov)
- Flow cytometry tests, which check for leukemia cells and identify which type of leukemia it is. (medlineplus.gov)
- The goals of treatment are to slow the growth of the leukemia cells and to give you long periods of remission. (medlineplus.gov)
Metastatic renal cell carc1
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Hematopoietic system3
- HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
- HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
- Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Renal4
- Similarly, it opens a new path for the treatment and repair of damaged renal cells. (biomedcentral.com)
- So, the research on renal tissue repair and regeneration has ignited a new field of study that focuses on various regenerative options. (biomedcentral.com)
- Because in order to avoid renal injury, the recovery of affected cells is as significant as preventing its progression towards end stage renal disease [ 1 ]. (biomedcentral.com)
- E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
Potentially1
- SCs can potentially be used for both neuroprotection and cell replacement. (biomedcentral.com)
Peripheral blood5
- Automatic classification of abnormal peripheral blood cells. (cellsilab.com)
- They are found primarily in the bone marrow and also in small numbers in the peripheral blood. (lecturio.com)
- These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
- FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
- At day +30, the peripheral blood-nucleated cell chimerism was 100% and the WAS protein had a normal expression. (bvsalud.org)
Blood29
- Allogeneic stem cell transplantation involves infusion of stem cells from a healthy donor's blood or bone marrow to a recipient. (awebfind.biz)
- However, a different model posits that the disease is maintained locally by T cells in the tissues with little input from the blood. (awebfind.biz)
- If tissues were constantly getting T cells from circulating blood, then the frequencies of T cell flavors in each tissue should become more and more alike over time-but we didn't see that. (awebfind.biz)
- After the initial seeding phase, the disease is mostly sustained within the tissue itself without a lot of input from new T cells in the blood. (awebfind.biz)
- Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. (medlineplus.gov)
- This problem most often happens with white blood cells. (medlineplus.gov)
- These abnormal cells build up in your bone marrow and blood. (medlineplus.gov)
- They crowd out the healthy blood cells and make it hard for your cells and blood to do their work. (medlineplus.gov)
- The abnormal cells can also spread outside the blood to other parts of the body. (medlineplus.gov)
- The tests can be done on blood, bone marrow, or other tissue. (medlineplus.gov)
- We and others have shown that blood cells can be generated from hESC. (ca.gov)
- Third, we have developed a way to express genes in hESC and hEMP to try and improve how these cells produce blood. (ca.gov)
- Biol Blood Marrow Transplant, 20(12): 2029-2033, 2014. (ycuhri.com)
- Biol Blood Marrow Transplant, 20(5): 684-689, 2014. (ycuhri.com)
- New research line in automatic blood cell digital image classification. (cellsilab.com)
- Are other atypical white blood cells an asset to address complications? (cryostem.org)
- mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)
- Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lecturio.com)
- EBV is present in circulating B cells, and the level of EBV DNA is elevated in the blood for the first month of the illness. (frontiersin.org)
- Chronic active Epstein-Barr virus disease is usually defined as a chronic illness lasting at least 6 months, an increased EBV level in either the tissue or the blood, and lack of evidence of a known underlying immunodeficiency ( 15 ). (frontiersin.org)
- [4] These cells do not function well and crowd out healthy blood cells . (wikipedia.org)
- [17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
- These immature cells help to produce healthy blood and lymphoid cells. (gilmorehealth.com)
- Acquired pure red blood cell aplasia is a disorder of erythroid precursors that results in an isolated normocytic anemia. (msdmanuals.com)
- White blood cells and platelets are not affected. (msdmanuals.com)
- Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (msdmanuals.com)
- Pure red blood cell (RBC) aplasia is most often due to an inappropriate immune response causing suppression of erythropoiesis. (msdmanuals.com)
- The onset of pure red blood cell anemia usually is insidious, often occurring over weeks or months. (msdmanuals.com)
- Pure RBC aplasia manifests with a normocytic anemia but normal white blood cell and platelet counts. (msdmanuals.com)
Cellular4
- this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
- Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
- It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
- In addition, some evidence suggests that iron overload in the bone marrow adds to the cellular early apoptosis contributed by the microenvironment. (medscape.com)
Complications1
- 6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
Lymphoproliferative1
- Lundell R, Elenitoba-Johnson KS, Lim MS: T-cell posttransplant lymphoproliferative disorder occurring in a pediatric solid-organ transplant patient. (karger.com)