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  • organs
  • In this Review, the authors discuss 2D and 3D approaches to recreate key cell-level, tissue-level and organ-level immune functionalities of primary, secondary and tertiary lymphoid organs. (nature.com)
  • This study found that sialylation of prions is enhanced upon their colonization of secondary lymphoid organs, via extracellular host sialylation machinery. (pnas.org)
  • Here we show that the sialylation status of the infectious, disease-associated state of the prion protein (PrP Sc ) changes with colonization of secondary lymphoid organs (SLOs). (pnas.org)
  • Not only does PrP Sc colonize secondary lymphoid organs (SLOs), the germinal centers of spleen and lymph nodes offer suitable environments for replicating PrP Sc autonomously from the CNS ( 8 ⇓ ⇓ - 11 ). (pnas.org)
  • In the B-cell lineage, tolerant self-reactive cells persist in the peripheral lymphoid organs of transgenic mice expressing lysozyme and anti-lysozyme immunoglobulin genes, but are eliminated in similar transgenic mice expressing anti-major histocompatibility complex immunoglobulin genes. (nih.gov)
  • In mouse, NK cells have been detected in various lymphoid and non-lymphoid organs, while in humans the current knowledge of NK cell distribution at steady state is mainly restricted to lymphoid tissues. (frontiersin.org)
  • Whether the production of IL-17 and IL-22 influences the architecture of secondary lymphoid organs (SLOs) and contributes to host defense will be important issues to examine in the future. (rupress.org)
  • GALT
  • Below these epithelial cells the gut-associated lymphoid tissues (GALT), organized in Peyer's patches, cryptopatches, and isolated l- phoid follicles, as well as isolated, dispersed single cells in the epithelial layer (intraepithelial lymphocytes) and lamina propria, are composed of T l- phocytes, B lymphocytes, Ig-secreting plasma cells, and antigen-presenting cells such as dendritic cells. (waterstones.com)
  • The results suggest that location, shape and density of lymphoid cells of GALT in Barbus sharpeyi have considerable species differences. (vin.com)
  • bone marrow
  • Results: An enriched or enhanced expression in one or more of the lymphohematopoietic tissues, compared to other tissue-types, was seen for 693 out of 20,050 genes, and the highest levels of expression were found in bone marrow for neutrophilic and erythrocytic genes. (diva-portal.org)
  • NALT
  • Debertin AS, Tschernig T, Tönjes H, Kleemann WJ, Tröger HD, Pabst R (2003) Nasal-associated lymphoid tissue (NALT): frequency and localization in young children. (springer.com)
  • progenitors
  • In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression of the transcriptional repressor Id2 and the nuclear hormone receptor retinoic acid-related orphan receptor γ t (RORγt). (rupress.org)
  • antigens
  • The roles of the M cells include absorption, transport, processing, and presentation of antigens to subepithelial lymphoid cells. (medscape.com)
  • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. (nih.gov)
  • characterization
  • The Human Protein Atlas project aims to systematically map the human gene and protein expression landscape in a multitude of normal healthy tissues as well as cancers, enabling the characterization of both housekeeping genes and genes that display a tissue-specific expression pattern. (diva-portal.org)
  • antibodies
  • lymphoid tissue ( lim -foid) n. a tissue responsible for the production of lymphocytes and antibodies. (encyclopedia.com)
  • In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. (diva-portal.org)
  • However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. (diva-portal.org)
  • ocular
  • Influence of the eye-associated lymphoid tissue (EALT) on inflammatory ocular surface disease. (acronymattic.com)
  • A two-photon microscope equipped with a near infrared femtosecond-laser and a fluorescence-lifetime detector is used for ex-vivo analysis of unfixed and unstained ocular tissue with additional application of fluorescent microspheres to demonstrate transepithelial particle transport. (arvojournals.org)
  • Immunohistochemical
  • The results constitute lists of genes with enriched or enhanced expression in the four lymphohematopoietic tissues, exemplified also on protein level with immunohistochemical images. (diva-portal.org)
  • main
  • The results showed that the lymphoid tissue is present in two different types and in two areas of intestinal bulb and main intestine of Barbus sharpeyi . (vin.com)
  • normal
  • The results confirm and extend the conclusion, derived from previous investigations on normal animals, that the lysosomes of lymphoid tissues form two and possibly three, distinct populations. (rupress.org)