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  • Lymphocytes
  • Huleatt JW, Lefrancois L: Anti-gen-driven induction of CD11 c on intestinal lymphocytes and CD8 + T cells in vivo. (springer.com)
  • We now propose a clinical trial to test whether donor lymphocytes infusion (DLI) using TK-transduced cells permits to induce a graft-versus-tumor (GVT) effect for treatment of relapse after HSCT, while GVHD can be controlled by GCV treatment. (bioportfolio.com)
  • 1,2 A myeloid derived precursor 3 gives rise to immature circulating blood DC which enter the tissues and after interacting with antigen migrate to the T lymphocyte dependent areas of lymph nodes, where they deliver stimulatory signals to responding T lymphocytes. (springer.com)
  • 9 The DC series also includes a lymphoid precursor derived cell 10 a subset of which, in the mouse, has an inhibiting effect on responding T lymphocytes. (springer.com)
  • Jak1 loss of function is also associated with profound abnormalities in the B cell compartment caused by a block in differentiation at the pro-B/pre-B cell transition step, resulting in a deficit in the production of mature B lymphocytes ( 10 ). (rupress.org)
  • However, when both factors are eliminated simultaneously a block is uncovered at the transition between pre-B and immature B cells, indicating that these proteins exert a critical function in developing B lymphocytes. (nih.gov)
  • This finding raises questions about the co-expression of T- and B-cell markers in the development of lymphocytes, benign as well as malignant, and alerts pathologists to a potential problem in diagnosis. (ox.ac.uk)
  • Chromosome aberrations do not persist in the lymphocytes or bone marrow cells of mice irradiated in utero or soon after birth. (rerf.jp)
  • Genes
  • Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics remain unknown. (fujita-hu.ac.jp)
  • Leukemic cells with mutated JAK1 alleles shared a gene expression signature characterized by transcriptional up-regulation of genes positively controlled by JAK signaling. (rupress.org)
  • We identified genes whose expression is deregulated in the pre-B cell compartment of these mice. (nih.gov)
  • Acute
  • Leukemia, acute lymphoblastic (ALL): A subtype of acute leukemia, a cancer of the white blood cells. (nih.gov)
  • The incidence of MEF2D fusions overall was 2.4% among consecutive precursor B-cell acute lymphoblastic leukemia patients enrolled onto a single clinical trial. (fujita-hu.ac.jp)
  • Mutations of PHF6, recurrent in T-cell acute lymphoblastic leukemia, also showed an unexpectedly high frequency (50%) in these patients. (fujita-hu.ac.jp)
  • Our observations indicate that MEF2D fusions comprise a distinct subgroup of precursor B-cell acute lymphoblastic leukemia with a characteristic immunophenotype and gene expression signature, associated with distinct clinical features. (fujita-hu.ac.jp)
  • cytokine
  • In the present study, the results of in vitro Ab neutralization, immunoadsorption, and cytokine reconstitution experiments, combined with preliminary m.w. determination, suggest that the pre-pro-B cell growth-stimulating factor (PPBSF) in CM from our culture system ( 21 ) is a bimolecular complex of IL-7 and an as yet unidentified cofactor, the latter of which is produced by BM stromal cells from IL-7 (−/−) mice. (jimmunol.org)
  • subgroup
  • Among them, JAK1 plays an essential and nonredundant role in mediating biological responses induced by a specific subgroup of cytokines controlling lymphoid cell precursor development ( 10 ). (rupress.org)
  • pediatric patients
  • The efficacy of Sprycel tablets in combination with chemotherapy was evaluated in a single cohort of the Phase 2, multicenter, single-arm CA180-372 study, which included 78 pediatric patients with newly diagnosed B-cell precursor Ph+ ALL. (businesswire.com)
  • immature
  • Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. (hindawi.com)
  • Again, we found a dramatic reduction in the frequency of cells expressing high levels of both the Vγ5TCR and CD45RB (Figures 5A-5C), which resulted in a skewing in the mature:immature DETC ratio in Tnfrsf11a−/− mice (1:100) as compared to WT littermate controls (1:3) (Figure 5D). (nih.gov)
  • Mice with a hematopoietic cell-specific deletion of G9a ( Vav.G9a −/− mice) have a severe reduction in ILC2s in peripheral sites, associated with impaired development of immature ILC2s in the bone marrow. (rupress.org)
  • In mice deficient for Aiolos and OBF-1, the numbers of immature B cells are reduced, small pre-BII cells are increased and a significant impairment in immunoglobulin light chain DNA rearrangement is observed. (nih.gov)
  • abnormalities
  • The identification of leukemic clones with unrelated DJ rearrangements and the presence of cytogenetic abnormalities on lineage negative cells strongly suggest the participation of primitive cells. (hindawi.com)
  • The abnormalities that result are termed 'chromosome aberrations' and may be visualized at mitosis when cells divide. (rerf.jp)
  • lymphocyte
  • In this study our hypothesis is that infusion of donor lymphocyte immune cells from the subject's bone marrow donor will activate the subject's immune system to attack their cancer. (bioportfolio.com)
  • The goal of this clinical research study is to learn if giving donor lymphocyte cells and SGI-110 will help control AML and MDS. (bioportfolio.com)
  • Primary Objectives: This a pilot project to determine the feasibility of the preemptive CD8+ depleted T-cell donor lymphocyte infusion (DLI) in: - Reducing the incidence of graf. (bioportfolio.com)
  • Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. (bioportfolio.com)
  • Mice
  • To test this hypothesis in preclinical settings, we have previously developed several experimental models of GVHD using TK+ T-cells in mice. (bioportfolio.com)
  • Loss of Rank Impacts Invariant Vγ5+ Dendritic Epidermal T Cells(A and B) Epidermal sheets from WT and Tnfrsf11a−/− neonatal mice were analyzed by flow cytometry for CD3+ T cells (A), together with expression of the Vγ5TCR (B).(C) Frequency of CD3+Vγ5+ DETCs in WT (white bars) and Tnfrsf11a−/− (black bars) neonatal epidermis. (nih.gov)
  • In addition, analysis of neonatal epidermal preparations showed that Tnfrsf11a−/− mice have a dramatic reduction in the frequency of total epidermal CD3+ T cells (Figure 6A), as well as a disproportionate reduction in those expressing the Vγ5TCR (Figures 6B and 6C). (nih.gov)
  • Mice lacking either of these factors have a largely normal early B cell development. (nih.gov)
  • Bone marrow cells from wild type, single- and double-mutant mice were stained for B220 together with surface pre-BCR (left panels) or intracellular surrogate light chain (λ5, right panels). (nih.gov)
  • The combined expression data from pooled large and small pre-BII cells demonstrated strikingly elevated levels of VpreB1, 2 and λ5 mRNA in Aiolos single- and Aiolos/OBF-1 double-mutant mice. (nih.gov)
  • In line with this lack of requirement for Aire in the expression of Skint1, comparison of the neonatal epidermis of Aire−/− and WT mice showed no changes in the frequency of epidermal CD3+ cells (Figure 7B), including those expressing Vγ5+ (Figures 7C and 7D). (nih.gov)
  • regulation
  • Interestingly, we have recently shown that mouse epidermal LCs, expressing neither CD8 nor leukocyte function-associated antigen 1 (LFA-1), underwent a maturation-induced CD8/LFA-1 up-regulation on migration to the lymph nodes (LNs), 9 suggesting that LCs belong to the CD8 + lymphoid DC category. (bloodjournal.org)
  • LILRB 1-5 transduce signals via ITIMs that recruit phosphatase SHP-1, SHP-2, or SHIP, leading to negative regulation of immune cell activation. (utsouthwestern.edu)
  • immunoglobulin
  • In vitro studies show that BLyS increases B cell number, Ig production, antigen-specific immunoglobulin response, and induces production of secretory IgA. (bioportfolio.com)
  • B-cells collected from patients with Common Variable Immune Deficiency show evidence for BLyS binding to B cells and enhanced immunoglobulin secretion. (bioportfolio.com)
  • 2014). Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. (springer.com)
  • proliferate
  • The results show that, although rIL-7 and IL-7 (−/−) CM each can maintain the viability of freshly harvested pre-pro-B cells in vitro, neither induces them to proliferate and/or differentiate, even in the presence of recombinant stem cell factor (rSCF) and/or recombinant insulin-like growth factor (rIGF). (jimmunol.org)
  • transcriptional
  • Interestingly, a number of quiescence-associated transcription factors were elevated, including the transcriptional repressor Gfi-1, which was highly expressed in primitive CD34 + cells. (hindawi.com)
  • The chromatin regulator Aiolos and the transcriptional coactivator OBF-1 have been implicated in regulating aspects of B cell maturation and activation. (nih.gov)
  • developmental
  • Moreover, the understanding of the mechanisms that damage the earliest steps of the lymphoid developmental program in ALL is incomplete, and the existence of specialized cancer stem cells is still a debate [ 8 ]. (hindawi.com)
  • Identification
  • Rosewald H-R, Dessing M, Dvor-ak AM, Galli SJ: Identification of a committed precursor for the mast cell lineage. (springer.com)
  • Single cell transcriptomics is critical for understanding cellular heterogeneity and identification of novel cell types. (bioportfolio.com)
  • Egner W, McKenzie JL, Smith SM, Beard MEJ, Hart DNJ: Identification of potent mixed leucocyte reaction-stimulatory cells in human bone marrow. (springer.com)
  • Currently available antibodies against CD79a, in particular JCB117, allow the identification of B cells, and hence B lymphoblastic disease, in paraffin-embedded material. (ox.ac.uk)
  • Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). (jimmunol.org)
  • leukemia cells
  • Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. (nih.gov)
  • We further elucidated unique signaling downstream of a representative ITIM-containing receptor in leukemia cells. (utsouthwestern.edu)
  • intestine
  • Specifically, metabolites from the commensal microbiota such as short-chain fatty acids have been identified to maintain tolerogenic conditions in the intestine, e.g., promoting regulatory T cells and down-modulating pro-inflammatory signaling pathways. (springer.com)
  • epidermal
  • The present study shows that mouse lymphoid-committed CD4 low precursors, with the capacity to generate T cells, B cells, CD8 + lymphoid DCs, and natural killer cells, 2 6 also generate epidermal LCs on intravenous transfer, supporting the view that LCs belong to the lymphoid lineage. (bloodjournal.org)
  • B and C) Epidermal preparations from WT and Aire−/− neonates were analyzed by flow cyometry for the presence of CD3+ T cells (B), together with antibodies to the Vγ5TCR (C).(D) Frequency of CD3+Vγ5+ DETCs in WT (white bars) and Aire−/− (black bars) neonates. (nih.gov)