Lymphoid lineage lymphoid precursor cells. Medical search. Frequent questions

When compared to other similar chemicals, UM171 allowed for more HSC proliferation and lower apoptotic cell number compared to controls, along with a higher number in multipotential progenitors like CFU-GEMM. (wikipedia.org)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
Although similar methods have detected committed pre-B cells in mouse fetal liver, earlier progenitors with additional non-B lineage options have not been demonstrated in normal tissues. (pasteur.fr)
Analyses of CD34+ cell lines representing early myeloid, multipotential, and pre-pre-B-lymphoid progenitors indicate that precursors of both myeloid and B-lymphoid cells express PECAM-1 at high levels. (ox.ac.uk)
In the hematopoietic lineage, the transcription factors GATA-1 and GATA-2 show restricted and largely overlapping expression profiles, but GATA-2 is uniquely expressed in early hematopoietic progenitors. (elsevierpure.com)
Erythropoiesis starts in the bone marrow with lineage commitment of pluripotent myeloid progenitor cells and differentiation of these cells into immature erythroid progenitors that retain a certain proliferative capacity. (assemblymade.com)
Additionally it is unidentified at what stage during lineage diversification mesenchymal cells become completely committed toward a specific fate and whether distinct stromal cell subsets arise from single multipotent progenitors or if different precursors exists for each stromal cell type. (technologybooksindustrialprojectreports.com)
Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. (sunnybrook.ca)
Also because check donor cells had been transplanted into wild-type recipients these results support a is necessary for the standard function of HSCs progenitors and precursors as well as for terminal differentiation.10-12 a Cul4A is suggested by These results ubiquitin ligase goals a regulator of HSC function for degradation. (liveconscience.com)
Although p21Cip1-lacking mice exhibited a self-renewal defect down-regulating p21Cip1 in individual HSCs improved engraftment.2 16 Whereas analyses of p27Kip1-deficient mice indicate this gene regulates progenitors mice deficient in both p27Kip1 and MAD1 exhibited improved stem-cell function 2 17 recommending that under some circumstances p27Kip negatively regulates HSC function. (liveconscience.com)

In another study in 2014, researchers were in search of molecules to stimulate the proliferation of long-term hematopoietic stem cells (LT-HSC). (wikipedia.org)
These results suggest that UM171+SR1 together enhance proliferation of progenitor cells and suppress differentiation. (wikipedia.org)
In: 'Control of Proliferation in Animal Cells', Cold Spring Harbor Laboratory, pp. 393-410, 1974. (uni-mainz.de)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
It is due to the malignant proliferation of lymphoid precursor cells that invade the bone marrow and can spread to extramedullary sites. (bvsalud.org)
Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. (scielo.br)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
Proliferation occurs as a result of several successive cell divisions. (assemblymade.com)
MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. (sunnybrook.ca)
Although the antigen has also been associated with ribosomal RNA transcription, it is strongly linked to cell proliferation and has thus been indicated as an effective marker in grading the proliferation rate of tumors, including those of the brain, breast, cervix, and prostate. (attogene.com)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and cell survival. (medlineplus.gov)
As a result, the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells. (medlineplus.gov)

they are thus also called common myeloid progenitor cells or myeloid stem cells. (wikipedia.org)
The common myeloid progenitor (CMP) and the common lymphoid progenitor (CLP) are the first branch of cell differentiation in hematopoiesis after the hemocytoblast (hematopoietic stem cell). (wikipedia.org)
In the adjacent image, CFU-GEMM is the scientific name for the "common myeloid progenitor" that is responsible for forming all the cells of the myeloid lineages. (wikipedia.org)
This study revealed that IL-1 plays an important role in the regulation of the production of stimulatory factors that influence the progenitor cells of hematopoiesis. (wikipedia.org)
It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
In this report, we show that enriched CD34+ human hematopoietic progenitor cell populations, containing early myeloid, erythroid, and multipotential progenitor cells, are CD31+. (ox.ac.uk)
Preliminary studies show that a proportion of the PECAM-1 molecules on the lymphomyeloid/multipotential progenitor cell line, KG1, and on the monocytic cell line, U937, binds to heparin-sepharose. (ox.ac.uk)
It may also act as a homotypic adhesion molecule by interacting with PECAM-1 on bone marrow stromal macrophage-like cells and endothelial cells or on endothelial cells during stem/progenitor cell migration. (ox.ac.uk)
Thus, this molecule has the potential importance of directing both lineage commitment and trafficking of early hematopoietic progenitor cells. (ox.ac.uk)
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. (assemblymade.com)
Subsequently, these progenitor cells undergo further differentiation and maturation. (assemblymade.com)
At present it remains unclear whether FRCs originate from a common embryonic mesenchymal progenitor or AS 602801 (Bentamapimod) if different lineages of mesenchymal cells generate the FRC network. (technologybooksindustrialprojectreports.com)
Pediatric acute lymphoblastic leukemia (ALL) originates from the malignant transformation of lymphocyte progenitor cells into leukemic cells in the B-cell and T-cell lineages. (biomedcentral.com)
In RA, circulating bone marrow-derived progenitor cells were diminished, and concentrations stagnated at levels typical of those in old control subjects. (elsevierpure.com)
we evaluate the different types of come cells and progenitor cells that are potential candidates for restorative strategies in perinatal mind accidental Rabbit Polyclonal to DRP1 injuries, and sum it up recent preclinical and medical studies. (cancer8.info)
MHCII, CD80, Aire in both postnatal Ikaros−/− and WT thymi after arrival of lymphoid progenitor cells. (ucm.es)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

Three new hematology cancer protocols including Precursor and Mature Lymphoid Malignancies, Myeloid and Mixed / Ambiguous Neoplasms, and Plasma Cell Malignancies. (cap.org)
The 2016 World Health Organization (WHO) classification of lymphoid neoplasms incorporates genetic data, clinical features, cell morphology, and immunophenotype, all of which have important implications for disease prognosis and management. (msdmanuals.com)
Myeloid neoplasms always concern bone marrow cell lineage and are related to hematopoietic cells. (assemblymade.com)
As a pan-T-cell marker, CD2 staining is used for recognizing practically all normal T-cells, but may be deleted in some T-cell neoplasms. (attogene.com)
Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)

A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
We now understand that adaptive immunity is the purview of a second set of leukocytes, T and B lymphocytes, which are responsible not only for antibody production but also for the generation of T cells that can directly identify and kill host cells infected by pathogens (e.g., viruses). (aacrjournals.org)
20. Melchers, F.: Biochemical characterization of immunoglobulin-producing B-lymphocytes at different stages of their differentiation.In: 'Regulation of Growth and Differentiated Function in Eukaryotic Cells,' eds. (uni-mainz.de)
LYMPHOCYTES (B and T cells) derive continuously from the same multipotential stem cells that produce myeloid cells, including erythrocytes, granulocytes and macrophages. (pasteur.fr)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
and (b) cell-mediated immunity, mediated by sensitized lymphocytes. (brainkart.com)
These are the organs in which precursor lymphocytes proliferate, develop, and differ-entiate from lymphoid stem cells to become immunologically competent cells. (brainkart.com)
After acquiring immu-nological competency, the lymphocytes migrate to secondary lymphoid organs to induce appropriate immune response on exposure to antigens. (brainkart.com)
It consists mainly of ( a ) cortical thymocytes, theimmunologically immature T lymphocytes, and ( b ) a small number of macrophages and plasma cells. (brainkart.com)
Bone marrow is the site for prolifera-tion of stem cells and for the origin of pre-B cells and their matu-ration to become immunoglobulin-producing lymphocytes. (brainkart.com)
B lymphocytes develop their B-cell receptors (BCRs) by DNA rearrangement. (brainkart.com)
The B lymphocytes are transformed into plasma cells and secrete antibodies. (brainkart.com)
In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
Supplementary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. (technologybooksindustrialprojectreports.com)
A slow clearance of leukemic cells by the initial course of chemotherapy, as measured by the morphologic analysis of peripheral blood or bone marrow smears 1 to 3 weeks from diagnosis, predicts a higher risk of relapse, but can be inaccurate because ALL blast cells are remarkably similar in appearance to bone marrow lymphoid precursors (alias hematogones) and, in some instances, to mature lymphocytes. (ashpublications.org)
The first demonstration that bone marrow samples apparently devoid of ALL cells may, in fact, contain measurable levels of leukemia (ie, "minimal residual disease" or MRD) was provided soon after the advent of polyclonal antisera against leukocyte antigens: combinations of cell markers were used to distinguish T-lineage ALL cells from normal immature and mature lymphocytes by immunofluorescence microscopy. (ashpublications.org)
Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (thermofisher.com)
Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Cell cycle phase distribution of nuclear DN Aof head kidney cells were determined by flow cytometry. (caluniv.ac.in)
The flow cytometry analysis of the head kidney cells of both the species according to their Forward scatter (size) and Side scatter (granularity) properties revealed two distinct populations corresponding to small agranular and large granular cells. (caluniv.ac.in)
The percentage distribution of such cells by flow cytometry corroborated with the observation under light microscopy. (caluniv.ac.in)
Assays based on polymerase chain reaction or flow cytometry can detect one ALL cell among 10,000 to 100,000 normal cells in clinical samples. (ashpublications.org)
When lymphoid leukemia is suspected in cats, the diagnostic process often involves peripheral blood assessment, including complete blood count (CBC) with differential count, flow cytometry (FC) analysis, and polymerase chain reaction (PCR) for antigen receptor rearrangement (PARR). (e-jvc.org)
Recommended Dilution: Flow Cytometry: Use 10ul to label 10e6 cells. (biosave.com)

Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm. (atlasgeneticsoncology.org)
2001 thus indicating that different signaling molecules and cell types may be required for proper FRC differentiation in different lymphoid organs. (technologybooksindustrialprojectreports.com)
2011 Thus a full understanding of the ontogeny and function of the stromal microenvironment still requires that we uncover the genetic and transcriptional programs underlying mesenchymal cell differentiation and elucidate the molecular repertoire that characterize each stromal subsets during normal and pathological conditions. (technologybooksindustrialprojectreports.com)
TGF-β affects development and differentiation of human natural killer cell subsets. (sunnybrook.ca)
HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation. (sunnybrook.ca)
Cluster of differentiation 2 (CD2) is a useful early T-cell lineage restricted antigen that is present in T-cell differentiation. (attogene.com)
Cluster of differentiation 44 (CD44) is a glycoprotein receptor for hyaluronic acid, which plays a fundamental role in cellular adhesion, stromal binding, migration, and cell-cell interactions. (attogene.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
This initiates cortex-medulla differentiation inducing expression of medullary genes in the apically differentiating cells and of cortical genes in the non-apically differentiating cells, which will definitely differentiate in wt and postnatal Ikaros−/− mice. (ucm.es)
Therefore, the thymus development is based on a branching morphogenesis and tubulogenesis developmental pattern: FoxN1 expression in the thymic primordium inhibits tubulogenesis and induces the expression of genes involved in TEC differentiation, which culminates with the expression of functional cell markers, i.e. (ucm.es)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)

The cellular or innate immune system was first described by the pathologist Elie Metchnikoff who recognized the existence of cells in the blood and tissues whose role was to identify, capture, and destroy invading pathogens. (aacrjournals.org)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
The immune system is organized into several special tissues, which are col-lectively termed lymphoid or immune tissues . (brainkart.com)
The tissues that have evolved to a high degree of specificity of function are termed lymphoid organs . (brainkart.com)
However, clear evidence for functional NK cell subsets exists in humans and the presence of NK cells in the thymus and immature NK cells in the liver suggests specific functions for NK cells in the tissues. (scielo.br)
Conventional lineage DCs generally differentiate into myeloid DCs which originally come from tissues, such as epithelial or interstitial DCs. (biomedcentral.com)

The lymphoid organs, based on their function, are classified into central (primary) and peripheral (secondary) lymphoid organs. (brainkart.com)

In current terminology, CFU-S refers to the pluripotent stem cells that can differentiate into all types of blood cells. (wikipedia.org)
A mast cell is a type of granulocyte which is derived from myeloid stem cells. (proprofs.com)
Mast cells are derived from pluripotent stem cells, which have the ability to differentiate into various cell types. (proprofs.com)
Pluripotent stem cells are found in the bone marrow and can give rise to different blood cell lineages including mast cells. (proprofs.com)
Tri- and bipotential myeloid intermediates between the multipotential stem cells and later unipotential cells have been identified using clonal methods in culture. (pasteur.fr)
Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. (atlasgeneticsoncology.org)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Red bone marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. (assemblymade.com)
Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. (sunnybrook.ca)
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
Of the 2 p27Kip1 may end up being targeted for degradation with a Cul4A-ubiquitin ligase in erythroblasts12 and in nonhematopoietic cells 18 therefore p27Kip1 overexpression Bardoxolone methyl in Cul4A -haploinsufficient stem cells might impair engraftment and self-renewal. (liveconscience.com)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

The cells are characterized by expressing the cell surface markers CD33, CD34 and HLA-DR. These surface markers are proteins on the surface that are unique to specific cells and certain maturation periods, allowing researchers to differentiate between two different cells as well as what stage the cell is found in its developmental progression. (wikipedia.org)
We have identified a bifurcation of human B cell maturation from the T1 stage forming IgM hi and IgM lo developmental trajectories. (lu.se)
The developmental branching points between several lymphoid and myeloid lineages are still controversial, and little is known about how their diversification is induced. (scielo.br)
Next, an overview of several current models of hematopoietic lineage trees to identify developmental branching points between the lymphoid and myeloid cell compartments is discussed. (scielo.br)
Results Eleven types of hematopoietic precursors and mature cells in erythroid and lymphoid lineage at different developmental stages were identified and documented through cytological description and morphometry in head kidneys of both the species. (caluniv.ac.in)
Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. (sunnybrook.ca)

There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)

8. Melchers, F.: Biosynthesis, transport and secretion of immunoglobulin in plasma cells. (uni-mainz.de)
11. Melchers, F.: Synthesis, transport and secretion of immunoglobulin in lymphoid cells. (uni-mainz.de)
Their dual potential and unrearranged immunoglobulin loci place the precursors before exclusive B-lineage commitment in the haematopoietic hierarchy. (pasteur.fr)
Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
ALL cells can be recognized by their clonal rearrangement of immunoglobulin and T-cell receptor genes, expression of gene fusions, and leukemia-associated immunophenotypes. (ashpublications.org)
During B-cell development, the V, D, and J segments of the immunoglobulin genes are rearranged, with deletion and random insertion of nucleotides at the junctional sites, generating a unique gene sequence for each cell and its progeny. (ashpublications.org)
Because ALL cells arise from the oncogenic transformation of a single lymphoid precursor, they have clonal antigen-receptor (immunoglobulin and/or T-cell receptor) gene rearrangements in most cases, which can be used to distinguish ALL cells from normal lymphoid cells (expressing gene rearrangements with different sequences) and nonlymphoid cells (lacking the rearrangements). (ashpublications.org)
The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Cell needs to figure it out (macrophage and DC through their PRR recognizes PAMP). (freezingblue.com)

Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
In the majority of the former cases, GATA-2 mRNA expression and the expression of CD34 and c-kit antigens on leukemic cells were demonstrated. (elsevierpure.com)
Non-B, non-T cell lymphoproliferative diseases are characterized by the absence of B-cell or T-cell-specific antigens and instead express common lymphocyte antigens. (e-jvc.org)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

Where are erythroid precursors found in the bone marrow? (assemblymade.com)

A single molecular weight species was generally observed with enriched membrane preparations, whereas two PECAM-1 molecules were present in whole-cell lysates of cell lines and the CD34+ bone marrow cell subset. (ox.ac.uk)

IgM hi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgM lo branch and are selectively recruited into gut-associated lymphoid tissue. (lu.se)
branch and are selectively recruited into gut-associated lymphoid tissue. (lu.se)
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)
Lymphoid organs include the gut-associated lymphoid tis-sues-tonsils, Peyer's patches, and appendix-as well as aggre-gates of lymphoid tissue in the submucosal spaces of the respiratory and genitourinary tracts. (brainkart.com)
Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors. (atlasgeneticsoncology.org)
lymphoid tissue stromal organizer cells. (technologybooksindustrialprojectreports.com)
Tissue imprint technique and haematopoietic efficiency determination method we re employed for qualitative and quantitative analysis of haematopoietic cells. (caluniv.ac.in)
Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)

[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. (atlasgeneticsoncology.org)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)

Central or primary lymphoid organs are the major sites for lymphopoiesis. (brainkart.com)
These organs have the ability to produce pro-genitor cells of the lymphocytic lineage. (brainkart.com)
The primary lymphoid organs include thymus and bone marrow. (brainkart.com)
In addition these CD86 findings also showed that PDGFRβ+ perivascular cells from non-lymphoid organs have the capacity to differentiate into FDCs and in vivo thus suggesting that this cell population may be the source of AS 602801 (Bentamapimod) FDC in tertiary lymphoid organ formation (Krautler et al. (technologybooksindustrialprojectreports.com)
Central to these results is the idea that connections between lymphoid and mesenchymal cells are necessary for the introduction of supplementary lymphoid organs. (technologybooksindustrialprojectreports.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

These findings suggest that down-regulation of GATA-2 and expression of GATA-3 are important events for the commitment of cells to lymphoid and T cell lineage, respectively. (elsevierpure.com)
The expression profiles of GATA factors in leukemic cells are generally consistent with those in their normal counterparts, and thus provide a useful tool to determine the lineage commitment of unclassified leukemia. (elsevierpure.com)
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. (sunnybrook.ca)
Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes. (sunnybrook.ca)
The mechanisms that determine the commitment of thymic epithelial precursors to the two major thymic epithelial cell lineages, cTECs and mTECs, remain unknown. (ucm.es)

Since CD2 is present in most precursor and mature T-cell leukemias and lymphomas, it is useful in the evaluation of lymphoid malignancies. (attogene.com)

The somatic mutation occurs initially in a single cell, which continues to grow and divide, producing a group of cells with the same mutation (a clonal population). (medlineplus.gov)

These cells play a crucial role in the immune system by releasing inflammatory substances, such as histamine, in response to allergens or pathogens. (proprofs.com)
These cells, including macrophages and neutrophils, were found to provide a rapid response to virtually all pathogens and to initiate inflammation at sites of local infection. (aacrjournals.org)
NK cells coordinate tumor immunosurveillance and the immune response against pathogens. (scielo.br)
It helps the effector cells by marking pathogen with molecular flags and also attack pathogens. (freezingblue.com)

Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Occasionally, people with PDGFRA -associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (medlineplus.gov)
Posttransplant cyclophosphamide versus antithymocyte globulin in patients with acute lymphoblastic leukemia treated with allogeneic hematopoietic cell transplantation from matched unrelated donors. (cdc.gov)
Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population. (cdc.gov)

show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
Anti-Hairy Cell Leukemia stains various B-cells in the follicular mantle zone and virtually all cases of hairy cell leukemia. (attogene.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
RUNX1-positive leukemia cells in preclinical models. (lu.se)
Immunophenotypes of lymphoid leukemia in cats have been reported. (e-jvc.org)
Compared to studies of non-B, non-T leukemia in human ALL ( 6 , 9 ), there is limited research available on non-B, non-T cell-origin lymphocytic leukemia in veterinary medicine. (e-jvc.org)
Some people with PDGFRA -associated chronic eosinophilic leukemia have an increased number of other types of white blood cells, such as neutrophils or mast cells. (medlineplus.gov)
When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in blood cell precursors, the growth of eosinophils (and occasionally other blood cells, such as neutrophils and mast cells) is poorly controlled, leading to PDGFRA -associated chronic eosinophilic leukemia. (medlineplus.gov)

Human ILC precursors contain populations of KLRG1 + ILCs biased towards the ILC2 lineage and NKp46 + ILCs biased towards the ILC3 lineage. (silverchair.com)
Simultaneous staining of C57BL/6 spleen cells with PK136 and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells. (thermofisher.com)
Fibrotic livers are characterized by an inflammatory microenvironment that is composed of various immunologically active cells, including liver-resident populations (e.g. (mdpi.com)

The erythroid lineage was dominant over all other lineages with relatively less storage forms and more young and mature eiythrocyte population which was about 55.73% and 47.74% of the whole haematopoietic components studied in Gaira gotyla gotyla and Garra annandalei, respectively. (caluniv.ac.in)

Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling. (sunnybrook.ca)
A Mg 2+ -dependent mechanism regulates proximal T cell receptor signaling by modulating ITK activity through a low-affinity Mg 2+ binding pocket in the catalytic domain. (silverchair.com)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
The PDGFRA gene provides instructions for making a receptor protein that is found in the cell membrane of certain cell types. (medlineplus.gov)

Like thymic selection during T-cell maturation, a selection process within the bone marrow eliminates B cells with self-reactive antibody receptors. (brainkart.com)
The genes encoding the components of the T-cell receptors undergo a similar process in T-cell precursors. (ashpublications.org)
Proliferative burst, cell cycle dynamics, and induction of lineage-restricted receptors were tested in purified CD34+ HPCs after stimulation with early hematopoietins. (elsevierpure.com)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)

This round shape is characteristic of mast cells and helps to differentiate them from other types of cells. (proprofs.com)
B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. (lu.se)
Immature B cells proliferate and differentiate within the bone marrow. (brainkart.com)
There is normally ongoing issue on whether MSCs and HSCs can trans-differentiate into non-hematopoietic or non- mesenchymal lineages such as sensory [24]. (cancer8.info)
Lymphoid lineage DCs primarily differentiate into plasmacytoid DCs and occupy approximately 0.5% of peripheral blood mononuclear cells (PBMCs) in humans [ 2 ], but the cell population percentage is unclear in horses. (biomedcentral.com)

What is erythroid lineage? (assemblymade.com)

The high level of expression of PECAM-1 on CD34+ cells suggests that this glycoprotein may function as a heterotypic adhesion molecule, possibly mediating multipotential, myeloid, and early-B-lymphoid precursor cell interactions with stromal cells and extracellular matrix molecules via heparan sulfate proteoglycans. (ox.ac.uk)
Stromal cells within the bone marrow interact directly with the B cells and secrete various cytokines that are required for the development of B cells. (brainkart.com)
The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)

On the peripheral blood smear examination, medium to large lymphoblastic cells with moderate amounts of basophilic cytoplasm were observed in up to 70% of peripheral leukocytes. (e-jvc.org)

Although NK precursors and immature NK cells have been identified in mice and humans, the precise sites where NK cell maturation take place are not yet fully defined. (scielo.br)
Definition: A immature or mature cell in the lineage leading to and including erythrocytes. (assemblymade.com)

The complete blood cell count revealed severe non-regenerative anemia, lymphocytic leukocytosis, neutropenia, and thrombocytopenia. (e-jvc.org)
The leukogram also showed remarkable lymphocytic leukocytosis, with a lymphocyte count of 41,600 cells/μL (reference interval: 920-6,880 cells/μL), a total white blood cell counts of 45,570 cells/μL (reference interval: 2,870-17,020 cells/μL) and a neutrophil count of 140 cells/μL (reference interval: 2,300-10,290 cells/μL). (e-jvc.org)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
Erythroid precursors at various stages of maturation. (assemblymade.com)
During maturation, hemoglobin appears in the cell, and the nucleus becomes progressively smaller. (assemblymade.com)
Cell cycle analysis and erythropoietic efficiency of head kidney also revealed significantly high maturation rate of developing blood cells in Garra gotyla gotyla than Garra annandalei. (caluniv.ac.in)

Lineage progression from T1 cells to MZBs via an IgM hi trajectory is identified by pseudotime analysis of scRNA-sequencing data. (lu.se)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
It has also been demonstrated that there is a positive correlation between tumor progression and increased expression of CD44v, a high molecular weight CD44 isoform that has been described in epithelial cells. (attogene.com)

Understanding the paradoxical importance of dendritic cells in immunity and tolerance will inform the development of successful cancer immunotherapies. (aacrjournals.org)
Lymphoid cells concerned with humoral immunity. (lookformedical.com)
Vaccine strategies that concentrate on stimulating T cell immunity will at best generate reactive and persisting T cell responses that can suppress virus without preventing infection, limiting or preventing the damage the virus cause. (scielo.br)
Dendritic cells (DCs) are critical initiators of innate immunity and orchestrate the later and more specific adaptive immunity. (refine.bio)
Dietary Mg 2+ deprivation in mice impairs T cell activation and T cell-mediated immunity against influenza. (silverchair.com)

Basophils, lymphoid cells, and megakaryocytes are not direct precursors of mast cells. (proprofs.com)

Given their central role in controlling the immune response in patients with cancer, DCs are emerging as a critical cell type that must be considered as we come to understand basic cancer immunobiology. (aacrjournals.org)

Three-color flow-cytometric analyses also show that normal human bone marrow CD31+ CD34+ subsets coexpress myeloid (CD33) or B-lymphoid (CD19, CD10) markers. (ox.ac.uk)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)

Given the expression of CD44 in a wide range of cancers, the most practical application of CD44 immunostaining is its use in discriminating between urothelial transitional cell carcinoma in situ from non-neoplastic changes in the urothelium. (attogene.com)

Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
A Cul4A-ubiquitin ligase goals HoxA9 for degradation in myeloid cells however in HSCs HoxA9 promotes function.11 19 non-e of the various other Cul4A targets recognized so far offers known HSC regulatory functions. (liveconscience.com)
HSCs are able of distinguishing into the several myeloid and lymphoid lineages while MSCs maturate to the several mesodermal lineages including adipocytes, osteoblasts and fibroblasts. (cancer8.info)

The stroma of the organ is composed of dendritic cells, epithelial cells, and macrophages (Fig. 16-1). (brainkart.com)
In addition, the cortex contains two subpopulations of epithelial cells, the epithelial nurse cells and the cortical epithelial cells, which form a network within the cortex. (brainkart.com)
The concentric rings of squamous epithelial cells known as Hassall's corpuscles are found exclusively in the medulla. (brainkart.com)
E-cadherin is an intercellular adhesion molecule present in epithelial cells. (attogene.com)
surface lined with mucus secreting epithelial cells in organ systems that open to the environment. (freezingblue.com)

The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes. (ox.ac.uk)
Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
There are many subsets of DCs with different phenotypes derived from either conventional or lymphoid lineages. (biomedcentral.com)

In contrast, BMSCs are capable of differentiating into mesenchymal lineages such as osteoblasts, chondrocytes, adipocytes, and even neurons and astrocytes [ 12 ]. (hindawi.com)

T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
We used microarrays to detail the global program of gene expression underlying the acquisition of Docetaxel resistance in prostate cancer cells. (refine.bio)

We report the characterization and purification of fetal liver cells that generate clones containing both macrophages and B cells, identified biochemically and morphologically. (pasteur.fr)
In mammals, T cells mature in thymus and B cells in fetal liver and bone marrow. (brainkart.com)
HEBAlt enhances the T-cell potential of fetal myeloid-biased precursors. (sunnybrook.ca)

In: 'Regulation of the Immune System: Genes and the Cells in which They Function,' Vol. VI, eds. (uni-mainz.de)
Context-dependent regulation of hematopoietic lineage choice by HEBAlt. (sunnybrook.ca)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
The construction of this cell line is the first promising step in the regulation of GAL secretion from hTERT-immortalized BMSCs, and the potential application of this system may provide a stem cell-based research platform for pain. (hindawi.com)
Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. (thermofisher.com)

Human MC were initially divided into three subsets based on the cell surface expression of CD14 and CD16, and recently classified based on CD40 expression ( 2 - 5 ). (frontiersin.org)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
It also stains some high grade B-cell lymphomas. (attogene.com)

A latest research demonstrated that a small percentage of perivascular cells in the human brain are MSCs [44, 45]. (cancer8.info)

Genomic signatures and prognosis of advanced stage Chinese pediatric T cell lymphoblastic lymphoma by whole exome sequencing. (cdc.gov)

Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
It has long been appreciated that the innate and adaptive arms of the immune system must be coordinated, but it was not until the discovery of dendritic cells (DC) by Ralph Steinman at The Rockefeller University in the early 1980s that we truly understood conceptually how the immune system functions as a coherent unit. (aacrjournals.org)
Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways. (refine.bio)
Genome-wide analysis of alternative splicing during dendritic cell response to a bacterial challenge. (refine.bio)
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)

90% leukemic cells. (aacrjournals.org)
Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)

In the suitable moderate, these cells start showing the early oligodendrocytic family tree indicators PDGFR and NG2 and possess lately been proven to become mature oligodendrocytes in vivo [48]. (cancer8.info)

Anatomy70

Organisms24

Diseases2

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Progenitors10

Proliferation14

Progenitor19

Neoplasms5

Lymphocytes25

Flow Cytometry6

Differentiation12

Tissues6

Secondary lymphoid organs1

Stem cells14

Developmental6

Hematopoietic stem2

Immunoglobulin8

Macrophage2

Antigens6

Found in the bone ma1

Bone marrow cell1

Tissue14

Antigen-receptor1

Malignant5

Organs6

Commitment5

Malignancies1

Clonal1

Pathogens4

Acute6

Leukemia8

Populations3

Haematopoietic1

Receptor5

Receptors4

Differentiate5

Erythroid lineage1

Stromal8

Peripheral1

Immature2

Lymphocytic2

Maturation4

Progression3

Immunity5

Basophils1

Immune response1

Markers3

Neoplastic1

HSCs3

Epithelial cells5

Phenotypes3

Osteoblasts1

Gene expression2

Fetal3

Regulation5

Subsets1

Lymphomas2

Perivascular cells1

Lymphoblastic1

Dendritic5

Leukemic2

Vivo1