Lymphoid antigen specificity after mouse cd4 gene mice after antigen. Medical search. Frequent questions

Lymphocytes are of the lymphoid (rather than the myeloid or erythroid) lineage of blood cells. (wikipedia.org)
citation needed] Mature lymphocytes are a critical part of the immune system that (with the exception of memory B and T cells) have short lives measured in days or weeks and must be continuously generated throughout life by cell division and differentiation from cells such as common lymphoid progenitors (CLPs) in mice. (wikipedia.org)
Examples of such cells are CFUs (Colony-forming units - referred to as such because of their ability to form colonies in vitro in artificial media) such as CFU-T. In mice, transplantation of a single pHSC cell can reconstitute a sub-lethally irradiated host (i.e. a mouse that has been irradiated so that all leukocytes are killed) with all these lineages of cells, including all types of lymphocytes via CLPs. (wikipedia.org)
Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (bioskinrevive.com)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
CD4 + T lymphocytes have featured prominently because the genetic elements most strongly associated with RA susceptibility or severity are encoded within the MHC class II region (discussed in this issue in the chapters by H McDevitt, and G Sønderstrup). (biomedcentral.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
Our discovery that CD32a+ CD4 T lymphocytes harbor the elusive HIV-1 reservoir is a crucial step towards specific targeting and elimination of this HIV-1 reservoir. (europa.eu)

the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). (thermofisher.com)
There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)

Currently many stem or progenitor cell therapies including T cell receptor (TCR) or chimeric antigen receptor (CAR) focusing on epitopes indicated on malignant cells are under development for medical translation (17C20). (bioskinrevive.com)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
There remains an urgent need for the noninvasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor functionality. (snmjournals.org)
The specificity of T-cells is determined by the T-cell receptor (TCR), a heterodimer of alpha and beta protein chains. (elifesciences.org)
A keystone of the antigen-specific immune response is the T-cell receptor (TCR)/CD3 complex. (biomedcentral.com)

Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Current vaccine strategies against influenza focus on Antigen-specific ligation of T-cell receptors induces generating robust antibody responses. (cdc.gov)
Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
The binding of specific T cell receptors (TCR) to major histocompatibility complex (MHC)/antigen complexes on cancer cells induces the TCR/CD3-mediated signal transduction pathway and stimulates the release of specific toxins (perforin and granzyme) for cancer elimination [ 6 , 7 ]. (biomedcentral.com)
Chimeric antigen receptors (CARs) endow T cells with antigen-specific recognition, activation, and proliferation independent of major histocompatibility complex ( 1 - 3 ). (snmjournals.org)

Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)

ImmunoPET takes benefit of the beautiful specificity and affinity of antibodies or antibody fragments as well as the awareness of Family pet (1C3). (bioskinrevive.com)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Similarly, since spermatozoa are not self and isoantigens to females, if they are exposed repeatedly to sperm antigens by coitus, it is not surprising that isoimmunity to sperm antigens could be induced and develop antisperm antibodies (ASA) in females. (benthamscience.com)
Recombinant adeno-associated viruses (AAV) are one of the leading vectors for gene therapy applications that deliver gene-editing enzymes, antibodies, and RNA interference molecules to eliminate viral reservoirs that fuel persistent infections. (biomedcentral.com)
Here we find that allogeneic tumour rejection is initiated in mice by naturally occurring tumour-binding IgG antibodies, which enable dendritic cells (DCs) to internalize tumour antigens and subsequently activate tumour-reactive T cells. (bioxcell.com)

It was only natural to ask where these two great classes of cells arose, and after much work two cell types with some strong stem cell properties were isolated and defined - CMP, the common myeloid progenitor and CLP, the common lymphoid progenitor for mice. (wikipedia.org)
These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. (nature.com)
In contrast with CD10, CD19 and CD20 antigen, CD22 antigen is still present on lymphoplasmacytoid cells but is dininished on the fully mature plasma cells. (bioskinrevive.com)
Reporter gene monitoring of T cells permits longitudinal monitoring, do it again indication and monitoring amplification because of cell department, but it needs the transfection of cells with exogenous DNA as well as the advancement of non-immunogenic reporters for translation (14, 15). (bioskinrevive.com)
From here, the antigen is slowly released and provided to immune cells over an extended period of time. (mdpi.com)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
METHODS: In this observational study, pathogen-specific T cells were quantified in blood samples of 55 patients with PFP and 23 healthy controls after stimulation with antigens from varicella-zoster virus (VZV), herpes-simplex viruses (HSV) or borrelia. (bvsalud.org)
Although the quantity and general phenotypical characteristics of antigen-specific T cells did not differ either, expression of CTLA-4 and Ki67 was highly increased in VZV-specific T cells of 9 PFP patients, of which 5 showed typical signs of cutaneous zoster. (bvsalud.org)
One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
The strong association between specific alleles encoded within the MHC class II region and the development of rheumatoid arthritis (RA) has provided the best evidence to date that CD4 + T cells play a role in the pathogenesis of this chronic inflammatory disease. (biomedcentral.com)
However, the unusual phenotype of synovial T cells, including their profound proliferative hyporesponsiveness to TCR ligation, has challenged the notion that T-cell effector responses are driven by cognate cartilage antigens in inflamed synovial joints. (biomedcentral.com)
However, the results of detailed phenotypic and functional analyses of chronically activated T cells derived from inflamed joints are difficult to reconcile with traditional models of cartilage-antigen-driven inflammatory disease in patients with RA. (biomedcentral.com)
There is now good evidence that there exists a coordinated programme of molecular events initiated at the outset of T-cell differentiation that leads to the generation of CD4 + Th effector cells [ 1 ]. (biomedcentral.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
We review the literature express CD8 and induce apoptosis of cells on which they on the role of CD4+ and CD8+ T cell-mediated immunity in recognize foreign antigens presented by MHC class I mol- influenza infection and the available data on the role of ecules, providing a defense against intracellular pathogens these responses in protection from highly pathogenic such as viruses. (cdc.gov)
Influenza-specific CD8+ T cells recognize multiple of reagents and genetically modified mouse models has viral epitopes on target cells and antigen-presenting cells. (cdc.gov)
Emerging evidence indicates that findings from from PR8 that are processed to generate peptides recog- mouse studies are pertinent to immunopathology in human nized by influenza-specific CD8+ T cells. (cdc.gov)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
However, the commercial production of cancer-specific T cells is often hampered by laborious cell culture procedures, the concern of retrovirus-based gene transfection, or insufficient T cell purity. (biomedcentral.com)
Notably, the BsAb-armed T cells did not cause obvious cytokine release syndrome or tissue toxicity in SCID mice bearing human tumors. (biomedcentral.com)
However, most effector T cells generated using these established cultivation methods lack cancer specificity [ 8 ]. (biomedcentral.com)
However, the gene transfer technology used in current CAR T cells primarily depends on retrovirus or lentivirus systems, which will randomly insert the CAR gene into the T cell genome and may pose a potential carcinogenic risk [ 19 , 20 ]. (biomedcentral.com)
Mice with a conditional deletion of FURIN in their myeloid cells (LysMCre- fur (fl/fl) ) were healthy and showed unchanged proportions of neutrophils and macrophages. (oncotarget.com)
If the blood-testes barrier, which isolates germ cells from the contact with local immune system, is impaired by some reasons, autoimmunity to sperm antigens could be induced and results in the development of autoimmune orchitis. (benthamscience.com)
c production of replication incompetent AAV vectors via transient plasmid transfection into 293 producer cells that express adenovirus type 5 E1 genes. (biomedcentral.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Lymphoid cells concerned with humoral immunity. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Either systemic administration of DCs loaded with allogeneic-IgG-coated tumour cells or intratumoral injection of allogeneic IgG in combination with DC stimuli induced potent T-cell-mediated antitumour immune responses, resulting in tumour eradication in mouse models of melanoma, pancreas, lung and breast cancer. (bioxcell.com)
T cells from these patients responded vigorously to autologous tumour antigens after culture with allogeneic-IgG-loaded DCs, recapitulating our findings in mice. (bioxcell.com)
Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
Naive CD4+ T cells (those that have not encountered any antigens before) recovered from these mice 36 hours post-anti-MHC administration showed decreased responsiveness to the antigen pigeon cytochrome C peptide, as determined by Zap-70 phosphorylation , proliferation, and Interleukin-2 production. (wikidoc.org)
2002) demonstrated that self-MHC recognition (which, if too strong may contribute to autoimmune disease) maintains the responsiveness of CD4+ T cells when foreign antigens are absent. (wikidoc.org)
Clonal Deletion theory , proposed by Burnet , according to which self-reactive lymphoid cells are destroyed during the development of the immune system in an individual. (wikidoc.org)
HTLV-I infected CD4 + T-cells lines usually progress towards a CD3 - or CD3 low phenotype. (biomedcentral.com)
It is currently thought that tumors develop from a persistently infected T-cell reservoir, which can be amplified by cytokine-induced activation leading to viral gene expression, cellular proliferation and survival of some expanded cells. (biomedcentral.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Immunological tolerance to developmental sperm antigens is not induced in males, because spermatogenesis begins first in the testis on puberty, much after the establishment of tolerance to self-antigens. (benthamscience.com)
The misconception that an individual's immune system is totally incapable of recognising self antigens is not new. (wikidoc.org)
Now, it is accepted that autoimmune responses are vital to the development and functioning of vertebrate immune systems, and central to the development of immunological tolerance to self-antigens. (wikidoc.org)

Second, autoimmunity is likely to have a role in allowing a rapid immune response in the early stages of an infection when the availability of foreign antigens limits the response (i.e., when there are few pathogens present). (wikidoc.org)

Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. (thermofisher.com)
Applications Tested: This eBio17B7 antibody has been tested by intracellular staining and flow cytometric analysis of restimulated, Th17-polarized mouse splenocytes using the Intracellular Fixation and Permeabilization Buffer Set (cat. (thermofisher.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
C57BL/6 mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.25 µg of Rat IgG2b kappa Isotype Control, Super Bright 600 (Product # 63-4031-82) (left) or 0.25 µg of CD3 Monoclonal Antibody, Super Bright 600 (right). (thermofisher.com)
Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. (thermofisher.com)
Applications Tested: This 17A2 antibody has been tested by flow cytometric analysis of mouse splenocytes. (thermofisher.com)
The RA3.3A1/6.1 monoclonal antibody reacts with mouse B220 also known as CD45R. (bioxcell.com)
The first US Food and Drug Administration-approved immunotherapy for type 1 diabetes, the anti-CD3 antibody teplizumab, delays symptomatic type 1 diabetes onset by 2-3 years [ 4 ], opening the door for the future clinical application of antigen-specific approaches with potentially superior immunoregulatory properties [ 5 ]. (springer.com)
DOTA antibody reporter 1 (DAbR1) comprises a single-chain fragment of the antilanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid ( S )-2-(4-acrylamidobenzyl)-DOTA (AABD). (snmjournals.org)
2002) injected an anti- MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2 b ) to temporarily prevent CD4+ T cell-MHC interaction. (wikidoc.org)

Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)

citation needed] Observations on research going back well over 100 years had elucidated the two great classes of WBCs - myeloid and lymphoid - and great advances in medicine and science have resulted from these studies. (wikipedia.org)
But science is an additive game, and it was eventually found these progenitors were not unique, and further that the two great families of myeloid and lymphoid were not disjoint, but rather two partially interwoven family trees. (wikipedia.org)

Disruption in lymphopoiesis can lead to a number of lymphoproliferative disorders, such as lymphomas and lymphoid leukemias. (wikipedia.org)
CD22 antigen is present in the most B-cell leukemias and lymphomas but not T-cell leukemias. (bioskinrevive.com)
Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)

in vivo in the spleen and lymph nodes of crazy type mice, with specificity confirmed through in vivo obstructing and depletion studies. (bioskinrevive.com)

Mouse models of influenza A virus pneumonia provide to heterologous viral strains. (cdc.gov)
a genome organization of wild type AAV2 depicting its ssDNA genome and the 7 viral RNAs expressed from 2 genes Rep (Black boxes) and Cap (Grey boxes) and via the p5, p19 or p40 promoters. (biomedcentral.com)
Viral gene expression has been implicated in the disruption of various normal cellular processes, including activation, growth, and apoptosis, the latter allowing accumulation of abnormalities leading to cellular transformation. (biomedcentral.com)
We decided to investigate the mechanisms responsible for the loss of CD3 expression, its kinetics and its timely relationship with viral gene expression. (biomedcentral.com)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

A genome-wide gene expression analysis revealed the overexpression of several pro-inflammatory genes in resting FURIN-deficient macrophages. (oncotarget.com)

Subsequently, a murine model of HSC transplantation shown successful in vivo detection of T cell repopulation at 2, 4, and 8 weeks post-HSC transplant using the 89Zr-radiolabeled anti-CD4 and -CD8 cDbs. (bioskinrevive.com)

METHODS: Cell subsets in TNBC tissues were obtained through scRNA-seq, followed by screening differentially expressed genes in TN-BCSCs and B.C.s (CD44+ and CD24-) and predicting the transcription factor regulated by CHI3L1. (bvsalud.org)

An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)

Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
On the basis of these data, it is proposed that T-cell survival and effector responses are driven by antigen-independent, cytokine-dependent mechanisms, and that therapeutic strategies that seek to restore T-cell homeostasis rather than further depress T-cell function should be explored in the future. (biomedcentral.com)

We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

If confirmed in larger studies, antigen-specific immune-phenotyping may have the potential to improve specificity of the clinical diagnosis. (bvsalud.org)
The success of AAV as a gene delivery vector is due to several characteristics, including its nonpathogenic nature, its good safety profile, and its ease of production to clinical grade. (biomedcentral.com)
So far, the approved AAV-based drugs and most clinical trials utilizing AAV vectors aim to supplement a defective gene with a new, working copy [ 3 ], but many studies have investigated AAV for the delivery of non-self therapeutic genes. (biomedcentral.com)
The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)

A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)

Bottom line These recently created -Compact disc8 and anti-CD4 immunoPET reagents signify a robust reference to monitor T cell extension, book and localization engraftment protocols. (bioskinrevive.com)

The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. (mdpi.com)

A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)

Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)

The proposed Th1-Tr1 switch appears to bridge two stable, self-reinforcing immune states, pro- and anti-inflammatory, each with a characteristic gene regulatory network. (frontiersin.org)

The ic mice had developed lymphoma. (who.int)

Our analyses revealed a markedly greater number of transcriptome alterations associated with Eos maturation (1199 genes) than with Eos-lineage commitment (490 genes), highlighting the greater transcriptional investment necessary for differentiation. (bioxcell.com)

Associations of natural variation in the cd163 and other candidate genes on host response of nursery pigs to PRRSV infection. (usda.gov)
response to influenza infection has been well characterized in C57BL/6 (B6,H2b) mice. (cdc.gov)
In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection. (biomedcentral.com)

To identify regulators of homeostatic eosinophilopoiesis in mice, we took a global approach to identify genome-wide transcriptome and epigenome changes that occur during homeostasis at critical developmental stages, including Eos-lineage commitment and lineage maturation. (bioxcell.com)

Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)

Thus, over the past few decades, extensive efforts to optimize AAV vectors for gene therapy applications have focused on capsid engineering with approaches such as directed evolution and rational design. (biomedcentral.com)

Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)

What pathways are this gene/protein implicaed in? (cancer-genetics.org)

Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
To measure cellular influx, mice were injected with 100 μg GlyAg and 1:4 SCC and at various time points, peritoneal lavage was performed with 1 mL of sterile PBS. (mek-signaling.com)

The HKx31 and PR8 strains share 6 internal genes derived response. (cdc.gov)

Immunohistopathological studies of pancreases from individuals with type 1 diabetes are generally compatible with these observations made in mice (see references below) but have exposed additional phenomena peculiar to the natural history of the disease in humans. (springer.com)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)

In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)

The identification of Pathogen-Associated Molecular Patterns (PAMPs) has greatly advanced our understanding of how adjuvants work beyond the simple concept of extended antigen release and has accelerated the development of novel adjuvants. (mdpi.com)
7 Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic, RIKEN BioResource Center, Tsukuba, Japan. (jci.org)

Anatomy21

Organisms11

Diseases2

Chemicals and Drugs154

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Health Care2

Lymphocytes11

Cytotoxic T-lymphocyte associat2

Receptor7

Receptors5

Secondary lymphoid organs1

Antibodies5

Cells46

Self-antigens3

Foreign antigens1

Antibody10

Tumors3

Myeloid2

Lymphomas5

Immunosuppressive1

Lymph nodes1

Viral5

Tumour1

Macrophages1

Vivo1

Tissues1

Humoral1

Effector2

Disruption1

Clinical4

Mechanisms1

Reagents1

Responses1

Tissue3

Lymphoproliferative1

Inflammatory1

Lymphoma1

Differentiation1

Infection3

Maturation1

Recognize1

Approaches1

Transplant1

Pathways1

Cellular2

Response1

Type2

SCID1

Species2

Development2