Lymphocytes receptors antigen t cell. Medical search. Frequent questions

Non-receptor tyrosine kinases regulate cell growth, proliferation, differentiation, adhesion, migration and apoptosis, and they are critical components in the regulation of the immune system. (wikipedia.org)
Comparing these transcriptional responses provides a greater understanding of the mechanisms cells use in the differentiation between types of DNA damage and the potential consequences of different sources of damage. (biomedcentral.com)
The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
In the skin, nAChRs regulate the activity of genes involved in the growth and division (proliferation), maturation (differentiation), and survival of cells. (medlineplus.gov)
Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. (medlineplus.gov)

Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
Therefore the application of immunotherapy has driven the treatment of brain tumors to the study of the response of intratumoral and systemic immune cells and cytokines to these malignancies 10 - 12 . (researchsquare.com)
CD62E is highly expressed on activated endothelial cells (IL-2, TNF-α, other cytokines can increase expression) and can also be expressed on endothelial cells in the skin, bone marrow and placenta. (biolegend.com)
1 , 2 In addition, mRNA encoding the cytokines interleukin 2 (IL-2) and granulocyte macrophage colony stimulating factor (GM-CSF) are increased at sites of disease activity, suggesting local activation of antigen specific T cells. (bmj.com)
ILCs play important roles in allergic and nonallergic inflammatory diseases due to their location at barrier surfaces within the airways, gut, and skin, and they respond to cytokines produced by activated cells in their local environment. (eur.nl)
Innate lymphoid cells contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. (eur.nl)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Apart from the tumor lysis syndrome, the only other grade 3/4 toxic effect related to chimeric antigen receptor T cells was lymphopenia. (nih.gov)

The immense diversity of the T-cell receptor (TCR) enables specific antigen recognition ( 3 , 4 ). (frontiersin.org)
There is oligoclonal expansion of lung T cells bearing certain V beta transcripts and the T cell receptor (TCR) is internalised with upregulation of TCR mRNA transcription suggesting recent occupancy by a specific antigen. (bmj.com)
Elevated levels of anti-EBV-specific antigen IgA were found in mucosal secretions of NPC patients, and this EBV-IgA-SC-mediated endocytosis may represent a physiological pathway for EBV to invade nasopharyngeal epithelial cells in vivo. (selfgrowth.com)
Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. (eur.nl)

A non-receptor tyrosine kinase (nRTK) is a cytosolic enzyme that is responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins. (wikipedia.org)
Loncastuximab tesirine-lpyl (Zynlonta™) is an antibody-drug conjugate that combines a monoclonal antibody with an alkylating (cell-killing) medication to target certain receptors or proteins in cancer cells. (oncolink.org)
Antibodies are proteins made and released by B cells against foreign pathogens. (differencebetween.net)
The cytotoxic T cells kill pathogens that are marked with particular proteins and are very specific in their action. (differencebetween.net)
A T cell varies in structure depending on what specific type it is, but all of these cells have special proteins on the cell membrane called T cell receptors. (differencebetween.net)
Over 250 crystal structures of monoclonal Fab fragments and complexes with a variety of antigens, such as peptides, steroids, cocaine, and proteins, including HIV-1, gp120 and gp41, have led to significant insights into antibody-antigen recognition, virus neutralization, and vaccine design for HIV-1. (scripps.edu)
Current projects in the Oltz Lab aim to determine the roles of transcription, chromatin states and architectural proteins in orchestrating developmental programs of the lymphoid cells that compose our innate and adaptive immune systems. (osu.edu)
After the process of deciduous root resorption, dentin proteins that have not been yet been presented to the immune system become sequestered antigens that can induce autoimmune responses and play a role in etiopathogenesis of dental resorption. (bvsalud.org)
MHC (Major Histocompatibility Complex) is a complex of proteins that constitutes an important part of the immune system, helping to reveal the presence of bacteria or a virus in cells, for example. (lu.se)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)

Therefore, we developed a novel system in which we could form and then aggregate dimers, representative of partial receptor complexes, which contained either Ig alpha alone, Ig beta alone, or the two chains together and then examine their ability to induce apoptosis in the immature B-cell line, WEHI-231. (nih.gov)
One method is to target senescent T cells which have selective apoptosis function. (hindawi.com)
It appears to induce apoptosis in malignant lymphocytes upon exposure. (medscape.com)
This agent binds CD20 on lymphocytes and induces apoptosis as well as initiating complement-mediated killing of bound cells. (medscape.com)
thus, those cells that fail to receive a signal (ie, do not recognize self) die by apoptosis or become inactive. (medscape.com)

We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. (nih.gov)
The affinity of a TCR for a given peptide epitope and the specificity of the binding are governed by the heterodimeric αβ T-cell receptors ( 2 ). (frontiersin.org)
In both TCRα and TCRβ chains, CDR3 loops have the highest sequence diversity and are the principal determinants of receptor binding specificity. (frontiersin.org)
These CAR-T cells will be evaluated for specificity, antineoplastic potential and in vivo persistence in an orthotopic model of human glioblastoma multiforme. (fapesp.br)

There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)
Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)
However, the therapeutic efficacy of CAR-T cells is still low or non-existent against solid tumors, which make up the vast majority of neoplasms. (fapesp.br)
At present, tumors related to EBV infections include epithelial tumors such as nasopharyngealcarcinoma(NPC), gastric carcinoma (GC), lymphatic hematopoietic malignant tumors such as Hodgkin's Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL), BL, pyropogy-related lymphoma (PAL) and NK/T cell lymphoma and other rare tumors (such as EBV-related smooth fibroids, neuromuscular endocrine cancer). (selfgrowth.com)
NK cells, CD8+ T cells, and γδ T cells observed in EBV-associated T/NK lymphocyte tumors are typical of EBV-infected cells and belong to the type of killer cells that attempt to kill EBV-infected B cells or epithelial cells. (selfgrowth.com)
Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)
Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
8-10 Long-lasting protective immunity relies on the efficient establishment of long-lived memory CD8 + T cells, which have the potential to eradicate primary and disseminated tumors. (lifeboat.com)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)

A specific immune response was detected in the bone marrow, accompanied by loss of normal B cells and leukemia cells that express CD19. (nih.gov)
Antigens are foreign substances that evoke an immune response. (medscape.com)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)
T lymphocytes (T cells) are pivotal in the cellular immune response ( 1 , 2 ). (frontiersin.org)
These results indicate that exposure to TDI results in an antigen-driven immune response in the nasal mucosa suggestive of allergic rhinitis. (cdc.gov)
There are several types of T cells that are made, which work together with each other and with the B cells to bring about a cellular immune response. (differencebetween.net)
The T cells are a class of lymphocytes that function in the cell-level immune response of the body. (differencebetween.net)
T cells are related to antibodies in helping in the cellular immune response. (differencebetween.net)
These lymphocytes are closely related to the T cells since they also originate in the bone marrow from stem cells and some of the T cells work in conjunction with B cells by triggering the release of antibodies during an immune response. (differencebetween.net)
The CD4+ T-lymphocyte coordinates a number of important immunologic functions, and a loss of these functions results in progressive impairment of the immune response. (cdc.gov)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)

Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
Genotoxic damage causes robust alterations to pathways associated with B cell activation and increased proliferation, suggesting that genotoxic damage initiates not only the normal B cell maturation processes but also mimics activated B cell response to antigenic agents. (biomedcentral.com)
It binds to the CD52 receptor of the lymphocytes, which slows the proliferation of leukocytes. (medscape.com)
Patients with thymoma may experience dysregulation of the lymphocyte negative and positive selection process leading to abnormal proliferation, autoimmunity, and/or immunodeficiency. (medscape.com)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)

A low dose (approximately 1.5×10(5) cells per kilogram of body weight) of autologous chimeric antigen receptor-modified T cells reinfused into a patient with refractory chronic lymphocytic leukemia (CLL) expanded to a level that was more than 1000 times as high as the initial engraftment level in vivo, with delayed development of the tumor lysis syndrome and with complete remission. (nih.gov)
Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)

In metazoans, intracellular receptors recognize these molecules. (nature.com)
Therefore, SLE is currently believed to be a T cell-driven condition and, indeed, targeting molecules expressed on T cells and their signalling pathways can be one of the potential therapeutic strategies in SLE. (hindawi.com)
The current state of clinical trials evaluating therapeutic agents which target molecules expressing on and inside T cells for the treatment of SLE will be updated. (hindawi.com)
The complete activation of T cells requires the engagement of co-stimulatory molecules whose expression is temporally segregated and whose nature of biochemical signals are complementary. (fapesp.br)
The GP42 in the complex is combined with the HLA II molecular molecules, and caused the virus cell fusion under the participation of GP85/GP25 and GP110 glycoprotein. (selfgrowth.com)
EBV-infected B cells can activate NK cells to acquire CD21 molecules through synaptic transfer, and the ectopic receptor leads to the binding of EBV to NK cells. (selfgrowth.com)
Studies have shown that EBV-infected T/NK lymphocytes often express cytotoxic molecules, such as perforin, granzyme B, and T cell intracytoplasmic antigen (TIA-1). (selfgrowth.com)
Intradermal, but not intraperitoneal vaccination, generated memory precursors expressing skin-homing molecules in circulation and Trm cells in skin. (lifeboat.com)
Many other key molecules in cellular immunology are being studied, such as non-classical or MHC homologues: for example, CD1 binds lipid, glycolipid, and lipopeptide antigens from the cell walls of microbial pathogens and the NK family of receptors recognizes classical as well as distant MHC homologues. (scripps.edu)
Studies on other pattern recognition receptors, include peptidoglycan recognition protein (PGRP), TREM-1, Toll-like receptors (TLR) have revealed how unique pathogen-associated molecules are recognized by the immune system. (scripps.edu)
Загальні відомості про імунну систему The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) must be processed into peptides and complexed with surface class II MHC molecules on professional APCs (which specialize in presenting antigens to T cells) to be recognized by CD4 helper T (Th) cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Serum from145 iGCTs patients were collected and lymphocyte subsets were analyzed by flow cytometry. (researchsquare.com)
Clinical Applications of Flow Cytometry: Quality Assurance and Immunophenotyping of Lymphocytes: Approved Guideline. (bdbiosciences.com)
Detection of CD8 alpha in Human PBMC lymphocytes by Flow Cytometry. (rndsystems.com)

Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. (hindawi.com)
This medication targets CD19 which is a b-cell lymphocyte antigen that is present in some cancers. (oncolink.org)

Following consumption of 1.2 litres of cows' milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fcγ-receptors). (karger.com)
Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
Some EBOV infections generate a cytokine storm, which hinders peripheral natural killer cells (NK) and T and B lymphocytes. (cdc.gov)
Additionally, a 11-year prospective cohort study of Japanese inhabitants linked low peripheral-blood NK cell cytotoxicity with increased cancer risk ( 12 ). (frontiersin.org)
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8-T lymphocytes. (bdbiosciences.com)
Lanier LL, Ruitenberg J, Bolhuis RL, Borst J, Phillips JH, Testi R. Structural and serological heterogeneity of gamma/delta T cell antigen receptor expression in thymus and peripheral blood. (bdbiosciences.com)
Functional and phenotypic differences between CD4+ and CD4- T cell receptor-γ δ clones from peripheral blood. (bdbiosciences.com)
Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human CD3e PE-conjugated Monoclonal Antibody (Catalog # FAB100P ) and either (A) Mouse Anti-Human CD8a Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # FAB1509R) or (B) Mouse IgG 2B Alexa Fluor 647 Isotype Control (Catalog # IC0041R ). (rndsystems.com)
Vβ11 is expressed by 0.4% to 0.9% of peripheral CD3+ cells in normal blood. (beckman.com)
Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)

Lyn is activated by stimulation of B-cell receptor, which leads to the recruitment and phosphorylation of Zap70-related nRTK, Syk. (wikipedia.org)
Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
Large plaque parapsoriasis is a chronic inflammatory disorder, and the pathophysiology has been speculated to be long-term antigen stimulation. (medscape.com)
Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)

A T cell is a type of lymphocyte that has T cell-type receptors on the plasma membrane of the cell. (differencebetween.net)

However, from the beginning of puberty after thymus degeneration, human cytomegalovirus (HCMV) persists due to the chronic activation of cytomegalovirus in humans causing repeated activation of T cells, which is considered the driving factor of human immune aging [ 9 ]. (hindawi.com)
T cells are one of the types of lymphocytes that develop in the thymus. (differencebetween.net)
T cells are a type of white blood cell called a lymphocyte, which is formed in the blood but develops further in the thymus and plays a role in the immune system. (differencebetween.net)
The initial cell that is produced moves to the thymus gland where it then differentiates into one of the types of T cells of the body. (differencebetween.net)
T cells are produced from stem cells in the bone marrow which later differentiate in the thymus. (differencebetween.net)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)

As the nomenclature and description of the disease spectrum under the descriptive term parapsoriasis evolved, the primary focus has been on the distinction of whether the disorder progresses to mycosis fungoides (MF) or cutaneous T-cell lymphoma (CTCL). (medscape.com)
The initiating cause of parapsoriasis is unknown, but the diseases likely represent different stages in a continuum of lymphoproliferative disorders from chronic dermatitis stimulated by activated T cells to frank malignancy of cutaneous T-cell lymphoma (CTCL). (medscape.com)
cutaneous exposure to antigen in atopic dermatitis may enhance the development of asthma. (cdc.gov)

Part of the HL-A molecule in the cell membrane. (wikidata.org)
Viral glycoproteins including gp350, gHgL, gB and gp42 mediate the preferential binding of EBV to B cells by interacting with the complement receptor CR2 (CD21) on the surface of B cells, and then the envelope glycoprotein gp42 and gp85/gp25 form a fusion protein triple molecule Complex. (selfgrowth.com)
This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. (beckman.com)
Here, the utility of OX40, a costimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a PET imaging biomarker to quantify and track response to immunotherapy. (aacrjournals.org)
The T-cell receptor in complex with pMHC has revealed how peptide antigens can be recognized in the context of the MHC molecule. (scripps.edu)
A lectin and cell adhesion molecule found in B-LYMPHOCYTES. (bvsalud.org)
BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. (medscape.com)
On a virus-infected host cell, the antigen is made up of an MHC molecule and attendant virus protein. (lu.se)

Our goal is to identify the key factors and pathways that endow each cell type with its signature functions, then leveraging the information to engineer better cellular therapeutics for cancer and chronic inflammatory diseases. (osu.edu)
Mediation may be (1) through engagement of immune effector cells, (2) by directly activating intracellular death-signaling pathways, and/or (3) by activation of the complement cascade. (medscape.com)

This "depot" was formed by associating the antigen with substances able to persist at the injection site, such as aluminum salts or emulsions. (mdpi.com)
When the T-lymphocyte and antigen connect, the T-cell releases substances that kill the cell. (lu.se)

The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)

Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. (elifesciences.org)
T cells recognize antigens presented to them by the major histocompatibility complex of antigen-presenting cells via the TCRs expressed on their surface. (hindawi.com)

When antigen binds to T-cell receptor, Lck becomes autophosphorylated and phosphorylates the zeta chain of the T-cell receptor, subsequently another nRTK, Zap70, binds to this T-cell receptor and then participates in downstream signaling events that mediate transcriptional activation of cytokine genes. (wikipedia.org)
Physiologic dsDNA breaks are generated in a variety of normal cellular functions, including the RAG endonuclease-mediated rearrangement of antigen receptor genes during the normal development of lymphocytes. (biomedcentral.com)
Genes involved in antigen processing/presentation, lymphocyte activation/regulation, cytokine-receptor signaling and humoral immunity were differentially regulated in TDI rhinitis. (cdc.gov)
Southern blot analysis of T-cell receptor genes from parapsoriasis does not identify a dominant clone of T cells. (medscape.com)
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes. (duke.edu)
Researchers speculate that without SLURP-1, the activity of genes controlled by nAChR signaling is altered, leading to overgrowth of skin cells or survival of cells that normally would have died. (medlineplus.gov)

Demonstration of heavy and light chain antigenic determinants on the cell-bound receptor for antigen. (wikidata.org)
These results suggest genotoxic damage may induce a unique cancer-prone phenotype and processes mimicking activated B cell response to antigenic agents, as well as the normal B cell maturation processes. (biomedcentral.com)
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)

Separation of normal and immune lymphoid cells by antigen-coated coated columns. (wikidata.org)
The term lymphoepithelioma has been used in cases in which the thymoma contains a large number of lymphoid cells. (medscape.com)

The helper T cells stimulate B cells to release antibodies, and also trigger the activity of macrophages, which literally consume foreign pathogens. (differencebetween.net)
Antibodies are chemicals that are formed and released by B cells of the body. (differencebetween.net)
Antibodies are chemicals that are formed and released from specific B cells in response to a signal from a T cell. (differencebetween.net)
The function of antibodies is to attach to antigens of pathogens, but some can also inhibit movement of pathogens, or paralyze or inhibit protein synthesis in viruses. (differencebetween.net)
T cells and antibodies are related in that certain T cells trigger the release of antibodies from B cells. (differencebetween.net)
Our major goal is to understand the interaction and neutralization of foreign antigens by the immune system through high-resolution x-ray structural studies of antibodies, Variable Lymphocyte Rectors (VLRs) and antigens in the humoral system, T-cell receptor complexes with MHC class I and class II in the cellular system, and through pattern recognition receptors, such as TLRs, in the innate immune system. (scripps.edu)
His research is aimed at understanding the cellular immune mechanisms responsible for the generation of IgG antibodies that recognize platelet antigens. (lu.se)

After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
While it is known that genotoxic agents, such as IR, activate transcriptional programs involved in maintaining the integrity of the genome, we also want to investigate whether or not the genotoxic breaks could affect lymphocyte-specific maturation transcriptional responses similar to those we observed following RAG-induced physiological DSBs. (biomedcentral.com)

Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
Our findings provide insight into the activation mechanism of this highly expanded family of plant receptors that have essential roles in hormone, developmental and innate immunity signalling. (nature.com)
NK cells, among other cells, are key effector cells of the innate immune system and play a crucial role in the antiviral response. (cdc.gov)
NK cells are now accepted to play an important role in both the adaptive and innate immune responses that govern infection, autoimmunity, and tumor immunosurveillance ( 2 , 3 ). (frontiersin.org)
Resident memory CD8 + T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. (lifeboat.com)
In platelet refractoriness, his group studies the pro-inflammatory nature of platelets responsible for adverse reactions during platelet transfusions, particularly how platelet Toll-like receptor expression modulates innate immune mechanisms. (lu.se)

Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that can transfer the phosphate group from ATP to a tyrosine residue of a protein (phosphorylation). (wikipedia.org)
Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein-protein, protein-lipid, and protein-DNA interactions. (wikipedia.org)
The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)
Her work on the T cell tyrosine kinase ITK has revealed a critical role for this TCR signaling protein in autoreactive T cell trafficking into tissues such as the pancreas and the intestine. (cuanschutz.edu)
EBV initially enters the body through the oropharyngeal mucosa and infects B cells through the binding of the viral envelope protein gp350 to CD21 on the surface of B cells. (selfgrowth.com)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
An antibody is a protein known as an immunoglobulin, which attaches to antigens or inhibits pathogen movement or protein synthesis in some way. (differencebetween.net)
An antibody is a protein called an immunoglobulin, which binds to antigens or helps stop functions of pathogens through disrupting certain processes. (differencebetween.net)
An antibody is a protein that has various chains, some of which are modified for attachment to antigens. (differencebetween.net)
I also directed the Joint Center for Structural Genomics (2000-2016) that pioneers new high throughput methodologies and technologies for protein production, structure determination and functional analysis in order to investigate the Expanding Protein Universe and the human gut microbiome and other high-value targets in the regulation of stem cells and T cells. (scripps.edu)
This protein is found in skin cells and other cells that line the surfaces and cavities of the body. (medlineplus.gov)

NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR). (thermofisher.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)

The main function of nRTKs is their involvement in signal transduction in activated T- and B-cells in the immune system. (wikipedia.org)
Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. (nature.com)

Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
The focus of Dr. Baker's research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. (cuanschutz.edu)
Small plaque parapsoriasis likely is a reactive process of predominantly CD4+ T cells. (medscape.com)
Multiple dominant clones can be detected by polymerase chain reaction (PCR) of T-cell receptor gene usage, which supports a reactive process. (medscape.com)
An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonal expanded CD4- CD8- T cells, reactive to bacterial antigens. (beckman.com)

These findings may provide insight into the mechanisms by which the BCR, and other such multimeric receptor complexes, initiate both apoptotic and proliferative responses to antigen. (nih.gov)
Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. (mdpi.com)
neoantigens that elicit T-cell responses are identified as immunogenic. (aacr.org)
Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)
Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

The secondary objective was to assess the effect of anti-OX40 on lymphocyte subsets in the tumor and blood. (bepress.com)
It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)
or from functionally distinct subsets such as CD4 and CD8 T-cells. (elifesciences.org)
11 They have been typically classified in two subsets: effector-memory (Tem) and central-memory (Tcm) CD8 + T cells. (lifeboat.com)

The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of 'fluid-phase' Fcγ-receptors found in normal human serum. (karger.com)
Anti-TCR-γ/δ is intended for in vitro diagnostic use in the identification of cells expressing TCR-γ/δ antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)

For example, specific domains that target enzymes to the cytoplasmic part of cytokine receptors (Jak family) or two domains: an integrin-binding domain and a focal adhesion-binding domain (Fak family). (wikipedia.org)
However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)

cytotoxic T cells directly kill pathogens. (differencebetween.net)
In addition, we apply our approaches to understand epigenetic mechanisms that sculpt the diverse repertoire antigen receptors required for B and T lymphocytes to recognize a veritable universe of pathogens and, the same time, allow these cells to respond rapidly to DNA damage during the assembly of B and T cell receptors. (osu.edu)

Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)

Viruses are obligate intracellular parasites - they can only reproduce within the cell of a host organism. (thesmartset.com)

The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. (elifesciences.org)

The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
[ 4 ] MG is caused by autoantibodies to postsynaptic nicotinic acetylcholine receptors (anti-AChRs) at the neuromuscular junction, causing weakness of skeletal muscles. (medscape.com)
Laboratory studies show that SLURP-1 can bind to nicotinic acetylcholine receptors (nAChRs). (medlineplus.gov)
Nicotinic acetylcholine receptors are best known for their role in chemical signaling between nerve cells, but they are also found in other tissues. (medlineplus.gov)

A set of standard tests are defined for the performance of peptide-TCR binding, including the detection of TCRs binding to a given peptide/antigen, choosing among a set of candidate peptides for a given TCR and determining whether any pair of TCR-peptide bind. (frontiersin.org)
It is expressed on cytolytic T cells and functions in conjunction with the T cell receptor in the recognition of MHC-I/peptide complexes. (rndsystems.com)
To test our hypothesis, human T cells will be modified to express a CAR.GD2 or CAR.GD2 and GITRL fused to a signal peptide for constitutive secretion. (fapesp.br)

Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)
Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)
In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
His work has ranged from exploring the mechanisms contributing to T cell effector function to investigating the role of new beta-cell autoantigens. (cuanschutz.edu)
A major focus has been understanding the role of intra-islet communication and functional sub-populations of cells in islet function, and how disruption to intra-islet communication mechanisms and changes in sub-populations occur in diabetes and may contribute to islet decline. (cuanschutz.edu)
The immune effector cell mechanisms include antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. (medscape.com)

It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. (karger.com)
However, Ig alpha, Ig beta, and most of the other receptor chains that contain ITAMs, including CD3 epsilon, CD3 gamma, TCR zeta, and Fc epsilon Rl gamma, are found as components of multimeric and heterogeneous complexes. (nih.gov)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Effector cell recruitment correlated with expression of chemokines directed towards eosinophils in TDI rhinitis and neutrophils in LPS rhinitis. (cdc.gov)

Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. (bdbiosciences.com)
After primary immunization with an immunogenic conjugate of (4-hydroxy-3-nitrophenyl)acetyl, two anatomically and phenotypically distinct populations of antibody-forming cells arise in the spleen. (duke.edu)
Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. (lifeboat.com)
Alemtuzumab is a humanized monoclonal antibody against CD52, an antigen found on B-cells, T-cells, and almost all CLL cells. (medscape.com)
Rituximab is a humanized murine monoclonal antibody against CD20, an antigen found on B-cells. (medscape.com)
Ofatumumab is an anti-CD20 human monoclonal antibody that inhibits B-cell activation in early stages. (medscape.com)
Obinutuzumab is a CD20-directed cytolytic antibody, which, upon binding to CD20, mediates B-cell lysis. (medscape.com)

Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)

Associates with the T-cell antigen receptor zeta chain. (lu.se)

We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)
Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings. (hindawi.com)
To provide the context for everybody, Australia's very first CAR T-cell therapy clinical trial was run here at Peter Mac a little over a decade ago. (health.gov.au)
CDC has revised the classification system for HIV infection to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions. (cdc.gov)
Measures of CD4+ T-lymphocytes are used to guide clinical and therapeutic management of HIV-infected persons (22). (cdc.gov)
This revision establishes mutually exclusive subgroups for which the spectrum of clinical conditions is integrated with the CD4+ T-lymphocyte count. (cdc.gov)
The revised CDC classification system for HIV-infected adolescents and adults * categorizes persons on the basis of clinical conditions associated with HIV infection and CD4+ T- lymphocyte counts. (cdc.gov)
The system is based on three ranges of CD4+ T- lymphocyte counts and three clinical categories and is represented by a matrix of nine mutually exclusive categories (Table 1). (cdc.gov)
This system replaces the classification system published in 1986, which included only clinical disease criteria and which was developed before the widespread use of CD4+ T-cell testing (1). (cdc.gov)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

Vβ11 is the human variable β11 chain of the T cell receptor. (beckman.com)

Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)
T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies. (duke.edu)
The adoptive therapy of T lymphocytes expressing chimeric antigen receptors (CAR) has demonstrated impressive results in the treatment of some hematological malignancies. (fapesp.br)
We are confident that the potential results of this project will foster the development of a new advanced cellular immunotherapy strategy for the treatment of solid GD2+ neoplasms and will pave the way to increase the antineoplastic efficiency of T-CAR cells against other malignancies. (fapesp.br)
Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)

instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)
Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)
Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)

EBV shows obvious tendency to B lymphocytes, which is easy to infect B cells and convert initial B cells into proliferative lymphocytes. (selfgrowth.com)

From the corticomedullary junction, the cells enter the medulla or circulate in the periphery to other lymphoid structures (ie, lymph nodes). (medscape.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)

T cell recognition of cell surface antigens. (wikidata.org)

Engineered cells persisted at high levels for 6 months in the blood and bone marrow and continued to express the chimeric antigen receptor. (nih.gov)
can also be expressed on endothelial cells in the skin, bone marrow and placenta. (biolegend.com)
The T cells are a type of lymphocyte that is initially created in the bone marrow from hematopoietic stem cells. (differencebetween.net)

Recently, high-throughput DNA sequencing has enabled large-scale characterization of TCR sequences, producing detailed T cell repertoire (Rep-Seq) ( 11 ). (frontiersin.org)

In man it was found that Fcγ-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. (karger.com)
Thirty-two non-receptor tyrosine kinases have been identified in human cells (EC 2.7.10.2). (wikipedia.org)
The effector capability of NK cells has been described in a wide range of viral infections, such as hepatitis B, hepatitis C (HCV), HIV, and human cytomegalovirus infection ( 7 ). (cdc.gov)
Human NK cells are phenotypically characterized by the expression of CD56 and the absence of CD3 and can be further subdivided into a CD56 bright population and a CD56 dim population. (frontiersin.org)
The development of this construction in human T lymphocytes will be an important opportunity to expand treatment possibilities within the Cell Therapy Center (project CEPID 013/08135-2) with the inclusion of solid neoplasms. (fapesp.br)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)
The avian H5N1 and swine H1N1 influenza virus HA structures have been determined as well as mutations that enhance binding to human receptors that may allow the virus to cross the species barrier into humans and be transmissible. (scripps.edu)

Mutations in the Btk gene are responsible for X-linked agammaglobulinemia, a disease characterized by the lack of mature B-cells. (wikipedia.org)
Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
I'm very proud to be the chief executive of the Sir Peter MacCallum Cancer Institute and I would like to give a very, very warm welcome to Federal Health Minister the Honourable Greg Hunt, to Australia's Chief Medical Officer Professor Brendan Murphy, to representatives of Novartis including Didier Dargent, head of International Markets for Cell and Gene Therapy at Novartis Oncology. (health.gov.au)

The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. (nih.gov)
Most of the nRTKs are localized in the cytoplasm, but some nRTKs are anchored to the cell membrane through amino-terminal modification. (wikipedia.org)
Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1). (nature.com)
3) After primary infection, EBV spreads directly across the lateral membrane to adjacent epithelial cells. (selfgrowth.com)

Oral mucosal epithelial cells are the first threshold for their invasive host cells. (selfgrowth.com)
EBV can also be transmitted from EBV-infected B cells or epithelial cells to T/NK lymphocytes by cell-to-cell infection. (selfgrowth.com)
Epithelial cells do not express CR2, and the mechanism of how EBV invades and releases from epithelial cells is not yet clear. (selfgrowth.com)
The anti-EBV antigen polymer IgA can mediate the invasion of EBV into pharyngeal epithelial cells through endocytosis, and EBV bound to IgA can invade pharyngeal epithelial cells through endocytosis mediated by secretory corpuscle (SC). (selfgrowth.com)
EBV infection of glandular epithelial cells can cause gastric cancer and bile duct cancer, and the mechanism is unclear. (selfgrowth.com)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)

Removing senescent T cells from the physiological cycle to maintain the homeostasis of memory and effector T cells is the way of replacement. (hindawi.com)
When their protective barriers are missing, hormones and cells that are present during inflammatory processes induce activation of clasts which, when unbalanced, no longer perform physiological bone remodeling and begin to provoke an immunopathological response that causes dental resorption. (bvsalud.org)
Infants suffering of cell death occurring as a series of changes from chronic illnesses, chromosomal abnor- in dying cells under several physiological malities and those on medication prior to conditions [ 6,7 ] and has been implicated enrolment were excluded from the study. (who.int)

We identified a central lymphocyte-specific transcriptional response common to both physiologic and genotoxic breaks, which includes many lymphocyte developmental processes. (biomedcentral.com)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)

The defining functional feature of NK cells remains their intrinsic ability to conduct "natural killing" of cellular targets without prior sensitization. (frontiersin.org)

Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)

First described in 1975, NK cells were initially identified as a distinct sub-population of lymphocytes by their capacity to spontaneously lyse tumor cells ( 1 ). (frontiersin.org)
For recent decades, it has been recognized that malignant tumor cells potentially induce local and systemic immunosuppression 9 . (researchsquare.com)

Anatomy38

Organisms16

Diseases7

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Health Care2

Differentiation6

Cytokines9

Chimeric antigen receptor T cells1

Specific antigen4

Proteins11

Apoptosis5

Specificity4

Tumors14

Immune response12

Proliferation7

Autologous2

Molecules14

Flow cytometry3

CD192

Peripheral10

Stimulation5

Plasma-membrane1

Thymus7

Cutaneous3

Molecule8

Pathways2

Substances2

Types of lymphocytes1

Recognize antigens2

Genes6

Antigenic3

Lymphoid cells2

Antibodies7

Maturation2

Innate9

Protein11

Inhibitory3

Signal Transduction2

Reactive5

Responses7

Subsets5

Vitro2

Cytokine2

Pathogens2

APCs2

Intracellular1

Immunoglobulin receptor1

Nicotinic4

Peptide3

Mechanisms6

Complexes3

Effector cell1

Antibody8

Dendritic3

Zeta chain1

Clinical10

Chain of the T-cell rec1

Neuromuscular junction1

Malignancies11

Immunotherapy4

Proliferative1

Lymph nodes1

Adaptive immune1

Recognition1

Bone Marrow3

Repertoire1

Human7

Gene3

Membrane4

Epithelial cells6

Physiological3

Developmental2

Targets1

Induces1

Tumor Cells2