Lymphocytes provided cytokines. Medical search. Frequent questions

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. (antikoerper-online.de)
Inhalation of OPA for 3 days resulted in a concentration-dependent increase in lymphocyte proliferation, mainly B lymphocytes, in the draining lymph nodes. (cdc.gov)
We further functionally demonstrate that MDSCs isolated from mouse neuroblastoma have immunosuppressive properties, impairing the proliferation of T lymphocytes.ConclusionsOur study demonstrates that neuroblastoma tumors have an immunocompromised microenvironment characterized by dysfunctional T cells and accumulation of immunosuppressive cells. (curie.fr)
IL-15 vector-transduced T cells showed continued proliferation after cytokine withdrawal and resistance to apoptosis while retaining specific Ag recognition. (johnshopkins.edu)
Th0-lymphocytes synthesize IL-2, which stimulates proliferation of B-cells. (romj.org)
25-HC also highly inhibited bacterial lipopolysaccharide (LPS)-activated inflammation and limited mitogen-stimulated proliferation in major monkey lymphocytes. (iassist2012.org)
We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)
Closely monitor such recipients following transplantation and provide appropriate antiviral therapy (agents that prevent viral proliferation or antibodies directed against a specific virus). (medscape.com)

In addition, IL-4 and IL-13 inhibit the production of proinflammatory cytokines by macrophages, and IL-10 produced by Th0-, Th2-cells and macrophages reduces the synthesis of cytokines, Th1-lymphocytes [2-4]. (romj.org)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
CH25H manifestation was interferon-dependent and induced by SIV disease in monkey-derived PBMC and macrophages cells, and 25-HC inhibited SIV disease both in permissive cell lines and major monkey lymphocytes. (iassist2012.org)
Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. (who.int)
Familial hemophagocytic lymphohistiocytosis is a disorder in which the immune system produces too many activated immune cells (lymphocytes) called T cells, natural killer cells, B cells, and macrophages (histiocytes). (medlineplus.gov)

Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
The immune-related gene signature effectively predicts the survival and immune infiltration of breast cancer patients and is expected to provide more effective immunotherapy targets for the prognosis prediction of breast cancer. (techscience.com)
Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)
Mice were exposed to OPA vapor and airway and lymph nodes were examined for cytokine gene expression and alterations in lymphocyte populations. (cdc.gov)
Rincon, who joined the UVM faculty in 1996, is a nationally and internationally recognized expert in the field of cytokine gene regulation and MAP kinases in T lymphocyte function, as well as in the role of Interleukin-6 (IL-6) in a variety of immune functions in diseases, including asthma, rheumatoid arthritis, and cancer. (uvm.edu)
T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. (ancell.com)
Other than directly administering the cytokines, another method involves introducing the gene that codes for the cytokine into a viral vector. (oncolink.org)

Previous results from two proficiency panels of intracellular cytokine staining (ICS) from the Cancer Immunotherapy Consortium and panels from the National Institute of Allergy and Infectious Disease and the Association for Cancer Immunotherapy highlight the variability across laboratories in reported % CD8+ or % CD4+ cytokine-positive cells. (nih.gov)
Figure4A)4A) and stained for intracellular cytokines staining (ICS) assay as described in Methods. (iassist2012.org)
The current and upcoming biological agents are primarily aimed at neutralizing circulating and cell-bound pro-inflammatory cytokines, interfering in the interaction of antigen-presenting and T-lymphocytes, eliminating circulating B-lymphocytes or by interfering with the intracellular signaling mechanisms of immuno-competent cells that lead to inflammation. (dovepress.com)

the TB2 tube contains an additional set of peptides targeted to the induction of CMI responses from CD8+ cytotoxic T lymphocytes. (cdc.gov)

Predicted to enable cytokine activity and type I interferon receptor binding activity. (nih.gov)
first focus on transcription factors and other parameters, such as cytokine receptor signaling. (scielo.br)
Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (antikoerper-online.de)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement (7). (ancell.com)
Like other cytokine receptors, this receptor likely has a multimeric structure. (utsouthwestern.edu)
Here, decreasing stimulation via the B-cell receptor by aging T-lymphocytes makes a difference. (medscape.com)
As Dörner emphasized, these cells are not under the command of the B-cell receptor and are independent of the cytokine BAFF (B-cell activating factor). (medscape.com)

The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
We studied the role and application of cytokines in vaccines and cancer immunotherapy. (cancer.gov)
IL-15 is a common γ-chain cytokine that has been shown to be more active than IL-2 in several murine cancer immunotherapy models. (johnshopkins.edu)
Although T lymphocytes do not produce IL-15, murine lymphocytes carrying an IL-15 transgene demonstrated superior antitumor activity in the immunotherapy of B16 melanoma. (johnshopkins.edu)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
This scholarly study provides insights into improving vaccination and immunotherapy regimes against HIV-1 infection. (iassist2012.org)

The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
This collection of short reviews by experts in the field provides a complete overview of microbial superantigens, an unusual family of proteins that form an abnormal linkage between the major histocompatibility complex class II antigens and specific T-cell repertoire Vβ families. (cdc.gov)
LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Ly-6 antigens were inducible on 2E8 and 1A9 cells, but the lymphocytes were otherwise arrested in differentiation. (elsevierpure.com)
However, extremely strong immune responses have been generated using a "boost" to the immune system, provided by viruses that encode antigens similar to the target. (oncolink.org)
Individuals infected with M. tuberculosis complex organisms (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)
has no memory of the encounters, does not remember specific foreign antigens, and does not provide any ongoing protection against future infection. (msdmanuals.com)

The normal replication and differentiation of pre-B cells is probably regulated by complex interactions with multiple cytokines and matrix components of the marrow microenvironment. (elsevierpure.com)

RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
This increased Th1 cytokine expression is driven by interleukin-12 (IL-12)/IL-23 and tumor necrosis factor-like 1A (TL1A) production by antigen-presenting cells, resulting in Tbet expression by CD4+ T cells. (nih.gov)
The nature of the formation of secondary immunodeficiency states after ethanol poisoning and, therefore, the methods of correction of immune status depend on the characteristics of antigen-presenting cells lesions, populations of T-lymphocytes, B-cells [1, 3]. (romj.org)
Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)

In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. (pasteur.fr)
HUMORAL IMMUNITYHumoral or antibody-mediated immunity is associated with B-lymphocyte cells. (referat.ru)
The role of the immune system is to provide immunity, that ment process ( WHO, 2006 ). (cdc.gov)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)

Consistently, T cells from patients are characterized by features of exhaustion, expressing inhibitory receptors and showing low expression of effector cytokines. (curie.fr)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)

They are useful for determining the molecular requirements for pre-B replication, for studying the stromal cells that supply those factors, and for delineating the final sequence of differentiation events as newly formed lymphocytes prepare to exit the bone marrow. (elsevierpure.com)
They are released more often from the bone marrow, produce more cytokines, and essentially contribute to inflamm-aging. (medscape.com)

While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
In 1997, Professor Eric Vivier set up a laboratory specialised in the functional exploration of NK lymphocytes in Conception Hospital in Marseille. (univ-mrs.fr)
We established standard physical (phenotypical) and functional (cytotoxic activity, production of cytokines) values of T and NK lymphocytes and provided this battery of tests to clinicians. (univ-mrs.fr)
The efficiency of lymphocyte growth at limiting dilution varied substantially on different stromal-cell clones and may reflect functional heterogeneity of stromal cells. (elsevierpure.com)
HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
HHcy reinforced inflammatory feature in Ly6C high MC and strengthened lymphocytes functional adaptation in Ly6C low MC. (frontiersin.org)
But, all these treatments fail to provide a promising functional outcome or decrease mortality. (karger.com)

Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)

The amount of white bloodstream cells (WBC) (A), percentage (displayed with % worth) of lymphocytes (B), neutrophils (C), and monocytes (D) are demonstrated, respectively. (iassist2012.org)

An increase in circulating leukocyte subsets such as CD8⁺ T cells and CD56loCD16⁺ natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. (researchgate.net)

Enhanced understanding of the rheumatoid arthritis (RA) pathophysiology and the role of cytokines has enabled the development of innovative biological agents in the last 10 years that target specific parts of the immune response. (dovepress.com)

Murine and human studies have demonstrated an increased expression of T-helper 1 (Th1) cytokines by lamina propria lymphocytes. (nih.gov)
A novel potential application for cancer is DNA-delivered immunotherapies, based on the development of efficient expression vectors for cytokines and other immunomodulators. (cancer.gov)
Expression of Th2 (IL-4, IL-5, and IL-13) and anti/proinflammatory (IL-10, TNFa, and IL-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa. (cdc.gov)
Thus, we sought to investigate the biological impact of constitutive IL-15 expression by human lymphocytes. (johnshopkins.edu)
ILC1 consists of NK cells and other interferon-g producing innate lymphocytes characterized by expression of the transcription factors T-bet and/Eomes. (pasteur.fr)
6). Lung tissue, bronchoalveolar lavage fluid (BALF) and plasma were analyzed for cellular inflammation, cytokines, immunoglobulin E and heme oxygenase-1 (HO-1) expression. (cdc.gov)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)

1994). The nature of lymphocyte stimulation will determine which class of immunoglobulin will be produced (Waller & Renwick, 1994). (referat.ru)

Using mice lacking the DNA hydroxymethylase TET2, we showed the requirement for TET2 in optimal production of hallmark cytokines by ILC3s and interleukin-17A (IL-17A) by inflammatory ILC2s. (stanford.edu)
To inves- inflammatory cytokines and the timing of their production support tigate the interplay of proinflammatory and anti-inflammatory cyto- an immunologic response appropriate to the amount of Ag and kines in human granulomatous disease, we evaluated the ability of duration of exposure. (cdc.gov)
ance in the timing or production of these cytokines, resulting in IL-10 is a key inhibitory cytokine in the inflammatory response tissue damage and disease. (cdc.gov)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

Five stromal-cell-dependent lymphocyte clones are described that correspond to late pre-B or early B-cell stages of differentiation. (elsevierpure.com)

These genes provide instructions for making proteins that help destroy or deactivate lymphocytes that are no longer needed. (medlineplus.gov)
By controlling the number of activated lymphocytes, these genes help regulate immune system function. (medlineplus.gov)

Frequencies of practical Compact disc8+ T cell populations secreting IFN-, IL-2, or TNF- cytokine only (B), aswell as dual TNF-/IL-2 cytokines (C) or IFN-/IL-2 (D) are demonstrated. (iassist2012.org)

STAT3, STAT1, and NF-κB physically interacted upon the cytokine stimulation. (bvsalud.org)

Immunosuppressants and immunomodulators will be differentiated between and a selection of new and often experimental drugs belonging to each category will be provided. (referat.ru)

4) innate immune cells, including immature dendritic cells (DCs), natural killer (NK) cells, and T cells, as well as (5) their cytokines and (6) chemokines. (wikipedia.org)
In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
This led to high variability in the reported percentage of cytokine-positive cells and consequently in response detection in Phase I. However, variability was dramatically reduced when all laboratories used the same gating strategy (Phase II). (nih.gov)
Recommendations are provided for the (1) placement of the cytokine-positive gate, (2) identification of CD4+ CD8+ double-positive T cells, (3) placement of lymphocyte gate, (4) inclusion of dim cells, (5) gate uniformity, and 6) proper adjustment of the biexponential scaling. (nih.gov)
Our work provides a new and precious data resource to better understand the neuroblastoma ecosystem and suggest novel therapeutic strategies, targeting both tumor cells and components of the microenvironment. (curie.fr)
In experiments in non-inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose - 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL-2, IL-4, IL-10 in blood, increases concentration of IL-6, reduces an interrelation IFNγ/IL-4 in comparison with the control, suppresses of immune responses, which displays the greater lesion of Th1-cells in comparison with Th2-lymphosytes. (romj.org)
Besides, they secrete plenty of cytokines produced by Th1-, Th2-cells (and other cells), except for IL-12. (romj.org)
Tumors derived from this clone were infiltrated by stromal cells and lymphocytes taken from the tumors' retained characteristics of the original clone. (elsevierpure.com)
Cloned lymphocyte lines that are dependent on stromal cells should continue to be important tools for molecular definition of those interactions. (elsevierpure.com)
A) A complete of 500,000 cells were processed and obtained using FlowJo software to investigate the cytokine-expressing T lymphocytes. (iassist2012.org)
The cells associated with this system, T Lymphocytes (T-cells), begin as the same stem cells as B-Lymphocytes (B-cells). (kemin.com)
Recently, additional innate lymphocytes have been discovered named innate lymphoid cells (ILCs) in both humans and mice ( 1-8 ). (pasteur.fr)
ILC3 includes several phenotypically distinct cells that express and require the transcription factor RORgt in order to produce notably the cytokines IL-17 and IL-22. (pasteur.fr)
Our results found that PBC stimulated a greater change in numbers of CD16 + NK cells and CD8 + T cells in comparison to CWI, suggesting a larger catecholamine response after PBC could result in a morepronounced mobilisation of lymphocytes than CWI. (researchgate.net)
This provides the first evidence for the effect of PBC exposure on redistribution of immune cells. (researchgate.net)
Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like. (bvsalud.org)
Proinflammatory cytokine-induced cancer cell invasiveness is mediated by a STAT3-regulated mechanism in colorectal cancer cells. (bvsalud.org)
This may also provide oncologists with targets for vaccines against cancer cells. (oncolink.org)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

A related focus area was the study of the biology and clinical applications of cytokines in vaccines and immunotherapies for cancer. (cancer.gov)
Amongst many others I must mention in particular Jackie Fletcher, the founder of JABS, whose services to all victims of vaccines merits a special mention apart from the excellent briefing notes which she and David Thrower have provided. (whale.to)

In addition, they provide synthesis of B-lymphocytes (plasmacytes) IgM and IgG2a [4]. (romj.org)
Contact (skin) allergic reactions associated with Th1-lymphocyte function, and respiratory allergic reactions associated with the activity of Th2-lymphocytes (the synthesis of IgE) [1, 3, 4]. (romj.org)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)

In recent years, many studies focus on the mechanism of secondary inflammation that can cause brain edema and this may provide new therapy targets for ICH [ 7 ]. (karger.com)
Likewise, dexamethasone can reduce cerebral cell apoptosis and inhibit inflammation [ 10 ,] and deferoxamine (DFX) provides new therapy target [ 11 ]. (karger.com)

One unusual lymphocyte clone (2E8) was propagated for more than 1 year in IL-7 alone and was selectively responsive to that cytokine. (elsevierpure.com)
Strikingly, 25-HC advertised SIV-specific IFN-producing mobile responses, but selectively suppressed proinflammatory Compact disc4+ T lymphocytes secreting TNF- and IL-2 cytokines in vaccinated mice. (iassist2012.org)

IL-15-transduced lymphocytes remained viable for up to 180 days in the absence of exogenous cytokine. (johnshopkins.edu)

Furthermore, Aclacinomycin A 25-HC got no significant immunosuppressive results on cytotoxic Compact disc8+ T lymphocytes or antibody-producing B lymphocytes. (iassist2012.org)

The study aimed to evaluate the immune responses that reflect the function of Th1- and Th2-lymphocytes, and cytokine profile (concentration of IFN-γ, IL-2, IL-4, IL-6 and IL-10 in blood) in the chronic ethanol intoxication. (romj.org)
All these mechanisms are non-specific, anti-microbial agents which work in conjunction with adaptive immune responses to provide a more effective system (Downie et. (referat.ru)

Our results showed that ME49Δ cdpk3 vaccination triggered a strong immune response marked by significantly elevated proinflammatory cytokine levels, such as IFN-γ, IL-12, and TNF-α, and increased the percentage of CD4 + and CD8 + T-lymphocytes. (nature.com)

Most lymphocyte clones were similar to uncloned lymphocytes from Whitlock-Witte cultures in that they responded only transiently to interleukin-7 (IL-7) and then died, unless maintained on a stromal-cell clone. (elsevierpure.com)
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. (utsouthwestern.edu)
In the periphery, we have identified a process we call inflamm-aging, where the cytokines interferon-γ, interleukin (IL)-10, and IL-17 play a predominant role. (medscape.com)

Active TB, in turn, may hasten the evolution of HIV-related disease, possibly through mechanisms involving increased cytokine production and accelerated HIV replication (6,7). (cdc.gov)

ILC2 secrete 'T H 2-like' cytokines under the control of the transcription factors GATA-3 and RORa. (pasteur.fr)

ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)

CDC has used both the results of discussions at this meeting and a review of published literature to prepare this updated report, which provides recommendations concerning the use of anergy testing for HIV-infected persons in the United States. (cdc.gov)

An unnumbered section after the first chapter contains high-quality color plate illustrations, which collectively provide outstanding visual support for several chapters. (cdc.gov)

This linkage leads to the nonspecific activation of large numbers of regulatory T lymphocytes, producing cytokine storms that can have a variety of serious clinical consequences. (cdc.gov)
This provides novel evidence on the use of PBC as a recovery treatment and may also have applicability in other clinical settings involving the recovery of damaged skeletal muscle. (researchgate.net)

The pulp contains the blood vessels, the nerves, and connective tissue inside a tooth and provides the tooth's blood and nutrients. (wikipedia.org)

A secondary challenge of mice with OPA resulted in a dramatic increase in the population of B lymphocytes expressing IgE. (cdc.gov)
These findings provide evidence that OPA has the potential to cause respiratory sensitization in mice. (cdc.gov)
Most of the lymphocyte clones were not tumorigenic in immunodeficient mice. (elsevierpure.com)
Ly6C high MC expressed higher levels of macrophage (MΦ) markers, whereas, Ly6C low MC highly expressed lymphocyte markers in both mice. (frontiersin.org)

A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
This recognition process involves the generation and secretion of the cytokine, IFN-γ. (cdc.gov)

These findings provide a powerful resource for studying innate lymphocyte epigenetic regulation and decode the regulatory logic governing their identity. (stanford.edu)

In the formation of allergic and anaphylactic reactions are also involved lymphocytes of Th1-and Th2-type. (romj.org)
Lymphokines are cytokines, regulators of the immune reactions which are produced by lymphocytes. (referat.ru)

Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes. (stanford.edu)

Hypothermic stress as a result of exposure to cold environments and cold water has been shown to increase circulating catecholamine concentration and subsequently influence lymphocyte mobilisation (Jansky et al. (researchgate.net)

Svistunov AA, Zabrodsky PF, Lim VG, Grishin VA. Changes in Th1- and Th2-lymphocytes function and cytokine profile in a chronic ethanol intoxication. (romj.org)
Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)

Our discovery that CD32a+ CD4 T lymphocytes harbor the elusive HIV-1 reservoir is a crucial step towards specific targeting and elimination of this HIV-1 reservoir. (europa.eu)

Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
Moreover, cIAPs are required for CD137 signaling toward the NF-?B and MAPK pathways and for costimulation of human and mouse T lymphocytes. (unav.edu)

The greatest impact could come from a new vaccine, and recent technological advances have provided the basis for new vaccine development. (cdc.gov)

Activated human CD4 + and CD8 + human lymphocytes expressed IL-15Rα and produced high levels of cytokine upon retroviral transduction with the IL-15 vector. (johnshopkins.edu)

Anatomy57

Organisms12

Diseases12

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation12

Macrophages5

Gene7

Intracellular3

Cytotoxic T lymphocyt1

Receptor9

Immunotherapy6

Antigens8

Multiple cytokines1

Proinflammatory cytokines1

Antigen4

Immunity5

Receptors2

Bone marrow2

Functional8

Infiltration1

Monocytes1

Subsets1

Rheumatoid arthritis1

Expression7

Immunoglobulin1

Inflammatory4

Differentiation1

Genes2

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Stimulation1

Immunomodulators1

Cells21

Vaccines2

Synthesis3

Inflammation2

Selectively2

Exogenous1

Immunosuppressive1

Immune responses2

Percentage1

Interleukin3

Mechanisms1

Secrete1

Abstract1

Anergy1

Collectively1

Clinical2

Tissue1

Mice4

Involves2

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