CytokinesCytotoxicProliferationHumansDendritic cellsPopulationsConsists of two subunitsPeripheralAntigensBlastogenesisVitroSecreteSolubleAntiviralMacrophageInhibitsReceptorMutationsImmuneReceptorsPhenotypesCellsInflammatoryProductionAntigenSecretionTuberculosisSTAT1GeneActivityELISAInfectionHumanReactionsPatientsAlphaReleaseMajorResponseInfluenceHostNumbersSingle
Cytokines4
- supplied by OMIM] The interferons (IFN)s are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties. (wikipedia.org)
- It is also known that an effective response against Pb depends on both TCD4 and TCD8 lymphocyte activation in the presence of ideal concentrations of Th1 inflammatory cytokines [ 12 - 14 ]. (hindawi.com)
- MIP-3a is upregulated by inflammatory cytokines such Tumor Necrosis Factor Alpha (TNFα) and Interferon Gamma (IFNγ) while being strongly down regulated by IL-10. (quanterix.com)
- Th1-type lymphocytes that secrete cytokines, such as interferon-gamma and soluble IL-2 receptor, are possible inducers of granuloma formation. (medscape.com)
Cytotoxic4
- Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability. (nih.gov)
- blockade of receptors by itself or in mixture can recovery cytotoxic Compact disc8 T lymphocyte proliferation, cytokine creation, or cytolytic activity (25, 30,C42). (exposed-skin-care.net)
- Some studies have PP121 centered on the appearance, impact, and blockade of inhibitory receptors on cytotoxic Compact disc8 T lymphocytes, much less is well known about the impact of inhibitory receptors on Compact disc4 T cell function. (exposed-skin-care.net)
- IL-2 enhances lymphocyte proliferation and cytotoxic activity and upregulates production of IFN-gamma. (medscape.com)
Proliferation3
- Mercury at 1.5 ppm increased the PHA and LPS stimulation indices for T and B lymphocytes, respectively reflecting the observed decrease in basal splenocyte proliferation in mercury -treated mice. (cdc.gov)
- Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. (jci.org)
- Results showed that histamine reduces the proliferation of myelin autoreactive T lymphocytes and the production of interferon-gamma, a crucial cytokine involved in brain inflammation and demyelination. (disabled-world.com)
Humans3
- Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. (wikipedia.org)
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
- [ 21 ] This condition has revealed the importance of IFN-gamma in the control of mycobacterial disease in humans. (medscape.com)
Dendritic cells5
- In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
- Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
- The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
- MIP-3α serves as a strong chemoattractant for both lymphocytes and dendritic cells. (quanterix.com)
- IL12 is a cytokine secreted by phagocytes and dendritic cells and that induces interferon-gamma production by natural-killer and T lymphocytes. (lu.se)
Populations3
- To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. (nih.gov)
- The phenotypes of both lymphocyte populations were very heterogeneous. (nih.gov)
- Change in immunological status (CD4 and CD8 lymphocyte populations) compared with baseline values (before therapy). (who.int)
Consists of two subunits1
- The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits, IFNAR1 (α-subunit) and IFNAR2 (β-subunit). (wikipedia.org)
Peripheral5
- To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
- Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
- Peripheral blood lymphocytes showed more potentially valuable behavioral characteristics than TILs. (nih.gov)
- Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)
- MIP-3α is expressed in many tissues with the highest levels of expression found primarily in the liver, the lymph nodes and on peripheral blood lymphocytes. (quanterix.com)
Antigens5
- Produced by lymphocytes activated by specific antigens or mitogens. (joplink.net)
- We compared the frequencies of gamma interferon (IFN-gamma)-secreting T cells specific for five region of difference 1 (RD1)-encoded antigens and one DosR-encoded antigen in 205 individuals either with active disease (n = 167), whose immune responses had failed to contain the bacillus, or with remotely acquired latent infection (n = 38), who had successfully achieved immune control, and a further 149 individuals with recently acquired asymptomatic infection. (birmingham.ac.uk)
- When subjects with an IFN-gamma enzyme-linked immunospot (ELISpot) assay response to one or more RD1-encoded antigens were analyzed, T cells from subjects with active disease recognized more pools of peptides from these antigens than T cells from subjects with nonrecent latent infection (P = 0.002). (birmingham.ac.uk)
- Secretory / excretory antigens stimulate production of antibody from B lymphocytes and eosinophil stimulation promoter from T lymphocytes. (slideshare.net)
- Individuals infected with M. tuberculosis complex organisms ( M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti ) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)
Blastogenesis2
- Single-cell splenocyte cultures were used to determine the effects of mercury treatment on mitogen-induced lymphocyte blastogenesis. (cdc.gov)
- It is used to study damage and mutations in DNA as well as lymphocyte blastogenesis and interferon-gamma production. (goldbio.com)
Vitro3
- Kinetics of in vitro response to interferon gamma inducers. (google.it)
- A study was conducted to ascertain the relationship between the in vitro gamma interferon (IFN-gamma) release test and cutaneous reactions to statins. (accessdermatology.com)
- IL-4 stimulated IgE production in vitro in B-cells of healthy donors and of children with atopic dermatitis, but had only a marginal effect on the high basal level of IgE production by lymphocytes from adult patients with atopic dermatitis. (medicaljournals.se)
Secrete1
- Even if performance specifications of QFT are of great interest (specificity of 99% and sensitivity of 84%) [ 3 ], some patients remain with an "indeterminate result" because of failed positive control corresponding to the incapacity of lymphocytes to secrete interferon (IFN)-γ after 24 h of stimulation by phytohemagglutinin A (PHA). (ersjournals.com)
Soluble1
- The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
Antiviral3
- IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. (joplink.net)
- It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (joplink.net)
- METHODS: We investigated the ability of cytomegalovirus-specific T cells, directly isolated from donor leucapheresates on the basis of interferon γ secretion, to restore antiviral immunity in a group of 25 patients following related-donor transplantation in a single-arm phase I-II study. (ox.ac.uk)
Macrophage3
- Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms. (jci.org)
- This study demonstrated how the target lymphocyte itself can modulate macrophage apo E production. (jci.org)
- As observed in other systemic mycoses, the most relevant response against PCM is cellular immunity mediated by interferon- (IFN-) γ during macrophage activation [ 8 - 10 ]. (hindawi.com)
Inhibits2
- Tac is a newly developed calcineurin inhibitor that inhibits the transcription of interleukin-2 and interferon-gamma in T lymphocytes, similar to the mechanism of CsA. (hindawi.com)
- Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
Receptor5
- The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
- Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
- The human interferon-gamma receptor. (wikidoc.org)
- In addition to OPG, the stimulation of osteoclastic bone resorption by RANKL is opposed by activation of the gamma interferon receptor (INFR) by gamma interferon (INF) production by activated lymphocytes and by the peptide hormone, calcitonin. (endotext.org)
- It is associated in some cases with IFN-gamma receptor ligand-binding deficiency, which is a recently identified autosomal recessive inherited disorder. (medscape.com)
Mutations1
- Genetic inactivation of the machinery or re-introduction of ANKRD52 frequent patient mutations dampens the JAK-STAT-interferon-γ signaling and antigen presentation in cancer cells, largely by abolishing miR-155-targeted silencing of suppressor of cytokine signaling 1 (SOCS1). (nature.com)
Immune1
- The aims of this study were to investigate the effect of mercury on immune parameters, such as hematology, lymphocyte phenotypes and cytokine gene expression. (cdc.gov)
Receptors1
- Antigen + MHC receptors on CTL permit specific binding to infected lymphocytes. (slideshare.net)
Phenotypes1
- Oral exposure to inorganic mercury alters T-lymphocyte phenotypes and cytokine gene expression in BALB/C Mice. (cdc.gov)
Cells9
- The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. (jci.org)
- Our adaptive immunity, also called acquired immunity, is composed of lymphocyte cells that are triggered when a specific pathogen enters the body. (squareonepublishers.com)
- Using a mouse model of MS, researchers generated MS-causing T lymphocytes and then treated these cells with histamine or the two other molecules. (disabled-world.com)
- The Journal of Leukocyte Biology (www.jleukbio.org) publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. (disabled-world.com)
- Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
- The target cell dose of 1 × 10(4) CD3(+) T cells/kg of recipient weight contained a median of 2840 cytomegalovirus-specific CD4(+) cells/kg and 630 cytomegalovirus-specific CD8(+) cells/kg, with a median purity of 43.9% interferon γ-secreting cells. (ox.ac.uk)
- Tim-3 provides been proven to make a difference for the era of gamma interferon (IFN-)-secreting Compact disc4 T cells in the placing of severe and HCV infections. (exposed-skin-care.net)
- [ 8 ] Host immunity seems to play a major role because a low CD4 + lymphocyte count (fewer than 100 cells/μL for adults and age-appropriate decreases in children) is associated with an increased frequency of disseminated MAC disease. (medscape.com)
- CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
Inflammatory2
- For example, patients with chronic inflammatory conditions (high neutrophil to lymphocyte ratio) have been described as more likely to have indeterminate QFT than healthy subjects [ 6 ]. (ersjournals.com)
- Social behavior and neuronal connectivity in rodents have been shown to be shaped by the prototypical T lymphocyte-derived pro-inflammatory cytokine Interferon-gamma (IFNγ). (biorxiv.org)
Production3
- Furthermore TILs showed increased interleukin-4 expression whereas in PBLs, interferon-gamma production predominated. (nih.gov)
- The influence of interferon-gamma and interleukin-4 on IgE production in B lymphocytes of patients with atopic dermatitis. (medicaljournals.se)
- The regulation of IgE production in B lymphocytes of patients with atopic dermatitis by interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) was studied. (medicaljournals.se)
Antigen2
- MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes. (wikipedia.org)
- Type 4 hypersensitivity: antigen stimulates T lymphocytes to produce interferon gamma. (slideshare.net)
Secretion1
- Possible cross-talk occurs between eosinophils and Th2-type lymphocytes in CSS via the secretion of IL-25, a potent Th2-response enhancer, by the eosinophils themselves. (medscape.com)
Tuberculosis1
- Our results suggest that RD1-specific IFN-gamma-secreting T-cell frequencies correlate with the presence of disease rather than with protective immunity in M. tuberculosis-infected individuals and do not distinguish recently acquired asymptomatic infection from remotely acquired latent infection. (birmingham.ac.uk)
STAT11
- In addition, canonical type I IFN signalling may activate STAT1 homodimers that bind to interferon-gamma-activating factor (GAF), which also translocates to the nucleus and activates transcription of IFN-stimulated genes. (wikipedia.org)
Gene1
- The virus-induced expression of IFNA/IFNB genes is primarily controlled at the gene transcription level, by the interferon regulatory factors (IRFs) and IFN-stimulated genes. (wikipedia.org)
Activity2
- This pattern may occur with insufficient lymphocytes, reduced lymphocyte activity due to prolonged specimen transport or improper specimen handling, including filling/mixing of the blood tubes, or inability of the patient's lymphocytes to generate IFN-γ. (cdc.gov)
- It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. (bvsalud.org)
ELISA1
- Interleukin (IL)-4 and interferon-γ (IFN-γ) were measured by ELISA and IL-2 was detected by a bioassay. (karger.com)
Infection1
- et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
Human1
- Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
Reactions1
- Lymphocytes from 20 patients with suspected drug-induced cutaneous reactions were incubated with or without the drugs. (accessdermatology.com)
Patients2
- A possible criterion for selection of patients for interferon therapy. (medicaljournals.se)
- Les IFN et les IL-10 étaient signi cativement élevés chez ceux qui présentaient une néphropathie diabétique (ND) et une maladie rénale en phase terminale (MRPT) par rapport aux témoins et aux patients diabétiques sans ND. (who.int)
Alpha1
- In early 2021, three variants B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) were identified as variants of concern (VOC 1 ). (nature.com)
Release1
- Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. (google.it)
Major1
- The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. (bvsalud.org)
Response1
- In strict respect of pre-analytical procedures, the response to PHA relies on the functional integrity of lymphocytes, which can be altered in various clinical contexts. (ersjournals.com)
Influence1
- interferon , interleukins) that influence the specialization and migration of T-lymphocytes throughout the body. (digitalnaturopath.com)
Host1
- [ 15 , 16 ] CD4 + lymphocytes but not CD8 + or gamma delta+ lymphocytes are required for host protection against MAC and dissemination through the intestinal route. (medscape.com)
Numbers2
- both CD4+ and CD8+ single positive lymphocyte numbers were decreased. (cdc.gov)
- With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
Single1
- The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)