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  • cytokines
  • In univariate analyses of factors mediating bone destruction, levels of cytokines that selectively induce and maintain the Th17 phenotype tightly correlated with the extent of bone disease in myeloma. (bloodjournal.org)
  • skeletal
  • osteoblast, T cell, Wnt-10b, CD40 ligand, MR1, bone formation, rheumatoid arthritis Rheumatology key messages Due to the immuno-skeletal interface, pharmacological manipulation of immune functions can drive skeletal changes, including stimulation of bone anabolism. (deepdyve.com)
  • The appendicular skeletal section of our skeleton has 126 bones. (sciencekids.co.nz)
  • Our teeth form part of the skeletal system, but are not counted as bones. (sciencekids.co.nz)
  • There are a number of skeletal disorders, osteoporosis is a bone disease that increases the chance of fractures, scoliosis is a curvature of the spine, while arthritis is an inflammatory disease that damages joints. (sciencekids.co.nz)
  • Significant dimorphism between the sexes and bone compartments adds to the complexity of the skeletal findings. (springer.com)
  • The web portal presents a bone-centric view appropriate for the skeletal biologist/clinician to organize and understand the large number of genes that can influence skeletal health. (springer.com)
  • Osteoporosis is a skeletal disorder characterized by a generalized increase in bone fragility resulting in fracture of the hip, spine, or wrist. (medsci.org)
  • marrow derived
  • This case report aims at highlighting the different effects on subchondral bone regeneration of two different biomaterials in the same patient, in addition to bone marrow derived cell transplantation (BMDCT) in ankle. (hindawi.com)
  • Regenerative techniques, like autologous chondrocyte implantation (ACI) and bone marrow derived cell transplantation (BMDCT), have been developed in order to heal the lesions through hyaline cartilage [ 4 , 5 ]. (hindawi.com)
  • Immunity
  • The involvement of an elevated and specific lymphocyte response suggests an adaptive (macrophage recruiting) immunity response to metallic implant debris rather than an innate (nonspecific) immune response. (biomedcentral.com)
  • Methods
  • Methods Female C57BL6 mice were treated with MR1 and BMD was quantified by dual energy X-ray absorptiometry and indices of trabecular bone structure were quantified by micro-CT. (deepdyve.com)
  • axial skeleton
  • Therapeutic targeting of the CD40L pathway may indeed have unforeseen consequences for the skeleton, but may also constitute a novel strategy to promote bone formation to ameliorate osteoporotic bone loss and reduce fracture risk in the axial skeleton. (deepdyve.com)
  • The axial skeleton part of the human skeleton has 80 bones. (sciencekids.co.nz)
  • Bone lesions associated with multiple myeloma include discrete radiolucent lytic areas (punched-out appearance) or diffuse osteopenia and commonly affect the axial skeleton and long bones. (animalmedcenter.com)
  • osteoporosis
  • Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. (medsci.org)
  • We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women with osteoporosis or osteopenia, 16 young women with osteopenia, and 43 healthy women without osteoporosis or osteopenia. (medsci.org)
  • An increased serum level of AGEs was associated with impaired bone formation and was a risk factor for the development of osteoporosis. (medsci.org)
  • Bone microdamage, including linear microcracks or diffuse damage, can be found in patients with osteoporosis and exhibits an age-related variation [ 3 ]. (medsci.org)
  • Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. (biomedcentral.com)
  • flow cytometry
  • The clonality of the circulating B lymphocytes needs to be confirmed by flow cytometry. (high-kick.ru)
  • Orthogonal validation of immunophenotyping using mass cytometry demonstrated a strong correlation with flow cytometry. (jci.org)
  • Serum
  • Serum biochemical markers were used to evaluate bone turnover and formation indices by histomorphometry. (deepdyve.com)
  • traumatic
  • Osteochondral lesions of the talus (OLT) are defects of the joint surface affecting the cartilage and the subchondral bone [ 1 ], mainly due to traumatic etiology. (hindawi.com)
  • ligand
  • Pharmacological suppression of CD40 ligand signalling in healthy mice causes a bone anabolic response. (deepdyve.com)
  • Cell
  • Bone marrow and stem cell transplants are an alternative option in patients who do not respond to chemotherapy. (news-medical.net)
  • There has recently been much work directed towards describing functionally distinct classes of lymphocytes and charting their ontogeny from a multipotential stem cell in the bone marrow. (springer.com)
  • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction," Journal of Experimental Medicine , vol. 203, no. 12, pp. 2673-2682, 2006. (hindawi.com)
  • Donor lymphocyte infusion (DLI) has a significant role in relapsed patients with chronic myelogenous leukemia (CML) after stem cell transplant. (medscape.com)
  • As CD40L blockade has been reported to promote T cell anergy and CD40L inhibitors thus have the potential to stimulate bone formation, we investigated the effect of pharmacological CD40L suppression by MR1 antibody on physiological bone turnover, BMD and trabecular and cortical bone structure in healthy mice. (deepdyve.com)
  • Direct comparison of techniques revealed discrepancy in the quantification of T lymphocyte and natural killer cell populations. (jci.org)
  • Lymphocytes are a kind of white blood cell (WBC). (verywell.com)
  • patients
  • Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates," Journal of Clinical Oncology , vol. 27, no. 10, pp. 1564-1571, 2009. (hindawi.com)
  • Here we demonstrate the critical role of interleukin-17-producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients. (bloodjournal.org)
  • As yet no data are available on the presence and prevalence of low bone mass density (BMD) in NCWS patients. (beds.ac.uk)
  • The aim of the present study was to evaluate bone density and metabolism in patients with microscopic colitis. (biomedcentral.com)
  • Low bone mass was measured in 57.14% patients with microscopic colitis. (biomedcentral.com)
  • cartilage
  • Another type of tissue called cartilage covers each bone joint surface area to prevent the bones rubbing. (sciencekids.co.nz)
  • In this case, DBM and the collagen membrane were demonstrated to be good biomaterials to restore subchondral bone: this is a critical step towards the regeneration of a healthy hyaline cartilage. (hindawi.com)
  • Many treatments have been proposed in order to solve symptomatology and restore bone and cartilage but most of all have showed remarkable limits, mostly related to technical demanding procedures, iatrogenic morbidity, and generation of nonadequate fibrocartilage [ 4 ]. (hindawi.com)
  • Among these procedures, the demineralized bone matrix (DBM) addition was demonstrated to be osteoinductive [ 6 ], while a collagen membrane has been shown to regenerate cartilage and bone [ 7 ]. (hindawi.com)
  • muscle or ligament
  • 2. A circumscribed, rounded, solid elevation on the skin, mucous membrane, surface of an organ, or the surface of a bone, the latter giving attachment to a muscle or ligament. (thefreedictionary.com)
  • Blood
  • Irradiated Donor Leukocytes Promote Engraftment of Allogeneic Bone Marrow in Major Histocompatibility Complex Mismatched Recipients Without Causing Graft-Versus-Host Disease", Blood, vol. 94, No. 9, Nov. 1, 1999: pp.3222-3233. (patentgenius.com)
  • Too few lymphocytes in the blood is called lymphopenia. (verywell.com)
  • So, lymphocytes, a type of WBC, fall into this "not common but not rare" sort of category in the blood stream. (verywell.com)
  • dense
  • The majority of human bones have a dense, strong outer layer, followed by a spongy part full of air for lightness, while the middle contains a soft, flexible, tissue substance called bone marrow. (sciencekids.co.nz)
  • disease
  • Cataloging the relative severity of each variant is the first step towards compiling the dataset necessary to appreciate the full polygenic basis of degenerative bone disease. (springer.com)
  • Lymphocytes are important in health and disease, and this article will begin to explore how. (verywell.com)
  • However, only 50% of dogs have radiographic evidence of bone disease. (animalmedcenter.com)
  • Low bone mass is frequent in microscopic colitis, and alterations to bone metabolism are similar to those present in Crohn's disease. (biomedcentral.com)
  • mice
  • In this study, we examined the effect of MR1, a CD40L neutralizing antibody, on physiological bone remodelling in healthy mice. (deepdyve.com)
  • Exogenous IL-33 administration increased EoMs in both the bone marrow and the periphery in wild-type and IL-33-deficient, but not ST2-deficient, mice. (jimmunol.org)