• The characteristics of predominant expression of CD8(+)T cells, depletion of CD4(+)CD25(high) cells, and a shift to a T(H)1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain. (nih.gov)
  • We found a negative correlation between urinary F and percentage of CD4(+)CD25(+) Treg cells (r? (fluoridealert.org)
  • The skin biopsies demonstrated T-cell lymphoproliferative disorder with the atypical infiltrate positive for CD3, CD5, CD25 and CD30. (appliedradiationoncology.com)
  • CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. (thermofisher.com)
  • CD25 plays a role in lymphocyte differentiating and activation/proliferation. (thermofisher.com)
  • CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
  • Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)
  • In the current study, we have investigated the influence of imatinib mesylate on CD4 + CD25 + FoxP3 + regulatory T cells (Treg), a critical population of lymphocytes that contributes to peripheral tolerance. (arizona.edu)
  • Regulatory T cells (Tregs) play a critical role in maintaining immune modulation and are present in normal peripheral blood in low numbers (5 to 10% of CD4+ T cells or 1 to 2% of total lymphocytes). (bdbiosciences.com)
  • The B cells that are present, though a small percentage of the total lymphocytes, have no abnormal markers. (labce.com)
  • Consistent with the 1993 revised classification system, CDC has also expanded the AIDS surveillance case definition to include all HIV-infected persons who have less than 200 CD4+ T-lymphocytes/uL, or a CD4+ T-lymphocyte percentage of total lymphocytes of less than 14. (cdc.gov)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • High serum iron was associated with elevated levels of Th 2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. (scirp.org)
  • The present prospective study, carried out over fifteen years, describes the pattern of natural course of disease progression in a group of ART naive male professional blood donors with asymptomatic HIV-1 infection in relation to serum iron status, viral load, peripheral CD4 + T lymphocyte count, serum levels of cytokines and immune activation markers viz. (scirp.org)
  • We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients. (cttjournal.com)
  • CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. (pasteur.fr)
  • The unbalanced secretion of cytokines from inclusion criteria were: standard serological their lymphocytes [ 5,6 ]. (who.int)
  • Stimulated recovery of leukocyte, lymphocytes, and NK cells counts were observed in mice pre-treated with Vitamin c . (biomedgrid.com)
  • Total leukocyte and lymphocyte counts diminished after 6 months of DMF therapy. (neurology.org)
  • 0.0001), whereas CD4 + T cell counts decreased by 39.2% ( p = 0.0006). (neurology.org)
  • A majority of CD8 + T cell counts, but not CD4 + T cell counts, were below the LLN even when total lymphocyte counts were greater than 500 cells/μL. (neurology.org)
  • Like Fumaderm, a fumaric acid ester (FAE) preparation of DMF and monoethyl fumarate used to treat psoriasis, DMF therapy in MS reduces peripheral blood lymphocyte counts. (neurology.org)
  • Due to the concern of potential immune suppression with DMF, we obtained lymphocyte subset counts before initiating DMF therapy in patients with MS and monitored them during treatment. (neurology.org)
  • The CD4 cell counts were obtained by using the Becton Dickinson MultiTEST reagent in TrueCOUNT tubes (Becton Dickinson Immunocytometry Systems, San Jose, CA). Comparison of this method with CD4 counts calculated from CBC absolute lymph counts from fresh whole blood X CD4% from the frozen whole blood resulted in a correlation coefficient of 0.9872. (cdc.gov)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • Hematologic analysis revealed markedly increased peripheral leukocyte counts in DRCC treated animals between day 20th and 60th following transplantation, whereas red blood cell and platelet counts did not differ between groups. (aaps1921.org)
  • Differential counts confirmed regenerative effect of DRCC on both the lymphocyte and polymorphonuclear cell lineages. (aaps1921.org)
  • T-lymphocyte counts, with special emphasis and stunted children has not changed dra- on the effect of nutritional rehabilitation. (who.int)
  • As a result, antiretroviral therapy should be considered for all persons with CD4+ T-lymphocyte counts of less than 500/uL, and prophylaxis against Pneumocystis carinii pneumonia (PCP), the most common serious opportunistic infection diagnosed in men and women with AIDS, is recommended for all persons with CD4+ T-lymphocyte counts of less than 200/uL and for persons who have had prior episodes of PCP. (cdc.gov)
  • The revised CDC classification system for HIV-infected adolescents and adults * categorizes persons on the basis of clinical conditions associated with HIV infection and CD4+ T- lymphocyte counts. (cdc.gov)
  • The system is based on three ranges of CD4+ T- lymphocyte counts and three clinical categories and is represented by a matrix of nine mutually exclusive categories (Table 1). (cdc.gov)
  • To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
  • Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
  • Homozygous mutant animals had abnormal peripheral blood lymphocytes, specifically decreased CD8-positive T cell and NK cell numbers and an increase in CD4-positive T cells. (wikipedia.org)
  • Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • The CD8α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopuplation of mature T-lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). (bdbiosciences.com)
  • HIV-1 may infect thymic precursor cells destined to become CD4 and CD8 lymphocytes and contribute to the numerical decline in both subsets on disease progression. (ox.ac.uk)
  • To investigate the relationship between CD8 activation and infection by HIV-1 in vivo, activated subsets of CD8 lymphocytes in peripheral blood mononuclear cells (PBMCs) of HIV-seropositive individuals were investigated for CD4 expression and HIV infection. (ox.ac.uk)
  • CD4(+) and CD4(-) CD8 lymphocytes, CD4 lymphocytes, other T cells, and non-T cells were purified using paramagnetic beads, and proviral sequences were quantified by PCR using primers from the long terminal repeat region. (ox.ac.uk)
  • Frequencies of activated CD8 lymphocytes were higher in HIV-infected study subjects than in seronegative controls, and they frequently coexpressed CD4 (mean frequencies on CD69(+), CD71(+), and HLA class II(+) cells of 23, 37, and 8%, respectively, compared with 1 to 2% for nonactivated CD8 lymphocytes). (ox.ac.uk)
  • After administration of Vitamin c , enhanced CD4 and CD8 cells, numbers of NK cells and CD4 and CD8 cells in mice were found and lymphocytes numbers was higher than in irradiated control group. (biomedgrid.com)
  • Hematopoietic cells and peripheral blood cells are known to be sensitive to radiation, and low doses of radiation can cause damage. (biomedgrid.com)
  • This disproportionate reduction of CD8 + T cells relative to CD4 + T cells was significant ( p = 0.007) and was reflected by a 35.5% increase in the CD4/CD8 ratio ( p = 0.007). (neurology.org)
  • Subsets of peripheral blood leukocytes and lymphocytes are differentially affected by DMF treatment of MS. Reduction of CD8 + T cells is more pronounced than that of CD4 + T cells. (neurology.org)
  • Coexpression of CD4 and CD8 on peripheral blood T cells and lamina propria T cells in inflammatory bowel disease by two colour immunofluorescence and flow cytometric analysis. (ox.ac.uk)
  • Both the absolute number and the proportion of peripheral blood CD4+, CD8+ cells in inflammatory bowel disease were small but significantly increased compared with those in normal control subjects. (ox.ac.uk)
  • These CD4, CD8 positive cells were large and granular. (ox.ac.uk)
  • Thus the increased number of peripheral blood CD4+, CD8+ cells in inflammatory bowel disease suggests that chronic immune activation occurs not only in the active state of the disease but also in remission. (ox.ac.uk)
  • The proportion of CD4+, CD8+ cells in the lamina propria was greater than in peripheral blood in normal subjects, suggesting chronic immune stimulation of the local immune system. (ox.ac.uk)
  • Description: Cryopreserved vial (30 x 10^6 cells) of freshly isolated primary human peripheral blood mononuclear cells (PBMCs) from a healthy donor, isolated from leukapheresis / apheresis samples using Ficoll gradient. (neomero.org)
  • Therefore, there is good representation of both T helper and cytotoxic T cells (a neoplastic process could have predominantly one or the other or dual positive CD4 and CD8). (labce.com)
  • Most lymphocytes in this sample are T cells, which are also normal. (labce.com)
  • Although the aberrant activation of the T cell response observed in pSS has partially been explained by the interaction of T lymphocytes both with the ductal epithelium and the infiltrating B cells via costimulatory molecules (i.e. (biomedcentral.com)
  • This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha. (cusabio.com)
  • Peripheral blood mononuclear cells (PBMC) were isolated and the level and function of Treg cells was analyzed by flow cytometry and cell proliferation assays. (fluoridealert.org)
  • The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils. (exbio.cz)
  • We evaluated, by immunohistochemistry, the intratumoral (t) and peripheral stroma (p) infiltration by CD45, CD3, CD4, CD8, CCR7, FoxP3 or PD-1-positive cells on tumor samples taken at the diagnosis (d) and relapse times (R). We correlated these variables with patients' biochemical progression free survival (bPFS), post-radiotherapy progression free survival (PFS), and overall survival (OS). (unime.it)
  • Substantial changes in the rate of TIL subsets were found between the first and the second biopsy with progressive increase in CD4, CCR7, FoxP3, PD-1+ cells. (unime.it)
  • Concordant with these findings, significantly increased percentages of CD3 + CD4 + IL-17 + and CD3 + CD4 + IL-17 + IFN-γ + cells were present in RA BM in comparison to OA BM samples. (biomedcentral.com)
  • Few cells were positive for CD20. (appliedradiationoncology.com)
  • This procedure allows CDC to determine the distribution of CD4 cells in a random sample of HIV-positive individuals. (cdc.gov)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • Therefore, we developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. (nature.com)
  • γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
  • In initial experiments using activated peripheral blood mononuclear cells, each analogue compound demonstrated marked antiviral activity against two R5 HIV isolates. (unige.ch)
  • Similarly, preincubation of LC with each analogue was able to block LC-mediated infection of cocultured CD4(+) T cells. (unige.ch)
  • We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. (nature.com)
  • Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. (thermofisher.com)
  • Evaluation of CD3, CD4, CD8a, CD45RA, CD90 and CD11b/c positive cells by flow cytometry as well as PCR assessment of donor-specific chimerism are currently in progress. (aaps1921.org)
  • Suppressive as well as stimulating effects of this drug on CD4 + and CD8 + T lymphocytes or dendritic cells have been reported. (arizona.edu)
  • It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells. (lookformedical.com)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
  • CD4 helper T-cells which alert the immune the studied infants were from low socio- system to an attack by a pathogen and the economic status families according to the CD8 suppressor T-cells which destroy cells classification of Park and Park [11]. (who.int)
  • CD4 and CD8 T lymphocytes directly target biliary epithelial cells. (msdmanuals.com)
  • Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability. (nih.gov)
  • The specific targeting of responding CD8 lymphocytes may provide a functional explanation for the previously observed impairment of cytotoxic T-lymphocyte (CTL) function disproportionate to their numerical decline in AIDS and for the deletion of specific clones of CTLs responding to HIV antigens. (ox.ac.uk)
  • infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. (lookformedical.com)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • The LSM 12.125 antibody reacts with the canine form of the 56 kDa transmembrane glycoprotein, CD4, present on the T-helper/inducer subset of normal canine donor peripheral blood lymphocytes. (bdbiosciences.com)
  • A low ratio of CD4+ (helper) any chromosomal or hereditary disorder lymphocytes relative to CD8+ (suppressor) that caused the malnutrition. (who.int)
  • Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoclonal antibodies and multiparameter flow cytometry, we investigated the coexpression of CD4 and CD8 antigens on peripheral blood lymphocytes and lamina propria lymphocytes of patients with ulcerative colitis and Crohn's disease and normal control subjects. (ox.ac.uk)
  • Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)
  • HuT 78, HT, CEMx174) and in primary human and nonhuman primate peripheral blood leukocyte cultures (13). (cdc.gov)
  • Activated CD8 lymphocytes were identified by expression of CD69, CD71, and the human leukocyte antigen (HLA) class II, the beta-chain of CD8, and the RO isoform of CD45. (ox.ac.uk)
  • Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)
  • Five coexpressed genes (CD4, CD53, EVI2B, PLEK, and SASH3) were identified as tumor purity coexpressed genes that negatively correlated with tumor purity. (hindawi.com)
  • Tumor microenvironment possesses complexity because of a mixture of growth-promoting and inhibiting growth factors, nutrients, chemokines, and other noncancer types, which interact with each other and associate with tumor growth, disease progression, drug resistance, and especially, infiltrating T lymphocytes and tumor growth [ 2 ]. (hindawi.com)
  • Tumor immunologic microenvironment is strongly involved in tumor progression and the presence of tumor infiltrating lymphocytes (TIL) with different phenotypes has been demonstrated to be of prognostic relevance in different malignancies. (unime.it)
  • A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). (scirp.org)
  • The distribution on lymphocytes for canine is similar to that found for both human and monkey, with the majority of CD4-positive lymphocytes being CD8-negative and lacking reactivity with antibodies to B- or NK-cell markers. (bdbiosciences.com)
  • T lymphocytes were analyzed for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral blood and labial gland biopsies. (biomedcentral.com)
  • In rhesus monkeys and other susceptible nonhuman primate species (e.g. pig-tailed macaque, crab-eating macaque), SIV infection leads to a chronic wasting disease syndrome with depletion of CD4 (T4) lymphocytes and lymphadenopathy. (cdc.gov)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • The differential was peripheral T-cell lymphoma, adult T-cell leukemia/lymphoma and sezary syndrome. (appliedradiationoncology.com)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
  • Because the factors in the coexpression network often participate in similar biological processes, we found that CD4, CD53, EVI2B, PLEK, and SASH3 were most related to positive regulation of cytokine production and interleukin−2 production through functional enrichment. (hindawi.com)
  • The phenotypes of both lymphocyte populations were very heterogeneous. (nih.gov)
  • To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. (nih.gov)
  • Reconstitution of CD3, CD4, CD8a, CD45RA, CD90 and CD11b/c positive cell populations was assessed by flow cytometry and donor specific chimerism was detected by PCR. (aaps1921.org)
  • Recent thymic emigrants represented 12% of the total T-lymphocyte population. (frontiersin.org)
  • All enrolled thymic lymphocytes is widely accepted as infants were breastfed in addition to receiv- an indicator of the depression of thymus- ing some traditional foods, according to dependent immune competence associated their age. (who.int)
  • The CD4+ T-lymphocyte coordinates a number of important immunologic functions, and a loss of these functions results in progressive impairment of the immune response. (cdc.gov)
  • Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. (ox.ac.uk)
  • There is increasing evidence that CD8 lymphocytes may represent targets for infection by human immunodeficiency virus type 1 (HIV-1) in vivo whose destruction may contribute to the loss of immune function underlying AIDS. (ox.ac.uk)
  • There is also evidence for the induction of CD4 expression and susceptibility to infection by HIV-1 of CD8 lymphocytes activated in vitro. (ox.ac.uk)
  • Combined, these findings provide evidence that antigenic stimulation of CD8 lymphocytes in vivo induces CD4 expression that renders them susceptible to HIV infection and destruction. (ox.ac.uk)
  • CDC has revised the classification system for HIV infection to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions. (cdc.gov)
  • The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
  • The classification system for HIV infection among adolescents and adults has been revised to include the CD4+ T-lymphocyte count as a marker for HIV-related immunosuppression. (cdc.gov)
  • During the process of HIV infection, samples by enzyme-linked immunosorbent multiple opportunistic infections occur, assay (ELISA) test and a single positive with TB being the most important. (who.int)
  • It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. (exbio.cz)
  • Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. (lookformedical.com)
  • We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4 T lymphocytes from healthy donors, multiple sclerosis, and type 1 diabetes patients. (pasteur.fr)
  • We also found a positive correlation between autophagy enhancement and the increased salivary gland expression of IL-21 and IL-23, providing a further link between innate and adaptive immune responses in pSS. (biomedcentral.com)
  • In particular, we found that CD28-activated RelA/NF-κB induces the expression of IL-6 that, in a positive feedback loop, mediates the activation and nuclear translocation of tyrosine phosphorylated STAT3 (pSTAT3). (pasteur.fr)
  • Lymphocyte proliferative responses to phytohemagglutinin were normal. (frontiersin.org)
  • Other studies have shown a strong association between the development of life-threatening opportunistic illnesses and the absolute number (per microliter of blood) or percentage of CD4+ T- lymphocytes (14-21). (cdc.gov)
  • The Dog T Lymphocyte Cocktail is a three-color reagent cocktail designed to identify dog T lymphocytes by direct immunofluorescence staining with flow cytometric analysis. (bdbiosciences.com)
  • The LSM 8.358 antibody reacts with a CD3-like T-cell receptor-associated cell-surface antigen found on thymocytes and peripheral T lymphocytes. (bdbiosciences.com)
  • Peripheral blood lymphocytes activated with phytohaemagglutinin showed appreciably increased coexpression of CD4+, CD8+. (ox.ac.uk)
  • This is a normal peripheral blood lymphocyte population with no indication of a neoplastic process. (labce.com)
  • Imatinib mesylate (Gleevec, STI571), a selective inhibitor of a restricted number of tyrosine kinases, has been effectively used for the treatment of Philadelphia chromosome-positive leukemias and gastrointestinal stromal tumors. (arizona.edu)
  • These findings suggest that CD4 + T lymphocyte autophagy could play a key role in pSS pathogenesis. (biomedcentral.com)
  • Our findings reveal a novel mechanism by which human CD28 may amplify IL-17A expression in human T lymphocytes and provide biological bases for immunotherapeutic approaches targeting CD28-associated class 1A PI3K to dampen IL-17A-mediated inflammatory response in autoimmune/inflammatory disorders. (pasteur.fr)
  • Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD294/CRTH2 (BM16) purified antibody (concentration in sample 5,0 μg/ml, GAR APC) and anti-human CD4 (MEM-241) Pacific Blue™ antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
  • In addition to HIV antibody testing in NHANES, whole-blood samples were collected and stored for future CD4 testing once the HIV status of the sample was known. (cdc.gov)
  • Whole EDTA anti-coagulated blood stored at -70°C from the 31 HIV antibody-positive participants from NHANES 1999-2004 and 34 age-matched controls were used. (cdc.gov)
  • SIV appears to be primarily tropic for CD4 (T4)-positive leukocytes and has not been successfully propagated in B-lymphocyte cell lines (e.g. (cdc.gov)
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
  • Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. (biomedcentral.com)
  • Her hemoglobin was 13g/dL, white blood count was 33500/μL and lymphocyte count was 20500/μL. (appliedradiationoncology.com)
  • This revision establishes mutually exclusive subgroups for which the spectrum of clinical conditions is integrated with the CD4+ T-lymphocyte count. (cdc.gov)
  • Measures of CD4+ T-lymphocytes are used to guide clinical and therapeutic management of HIV-infected persons (22). (cdc.gov)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
  • Three-color analysis of the expression of CD3, CD4, and CD8 on lysed canine whole blood. (bdbiosciences.com)
  • The level of CD4 expression of the double-positive population approached that of mature CD4 lymphocytes. (ox.ac.uk)
  • CD4 in the canine is also present on monocytes and granulocytes, but in higher numbers than what is seen for human. (bdbiosciences.com)
  • 6. Previous history of demyelinating or inflammatory diseases of the central (CNS) or peripheral (PNS) nervous system. (who.int)
  • 1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)