• CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
  • The mouse monoclonal antibody HI30 recognizes an extracellular epitope on all isoforms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. (exbio.cz)
  • Mouse monoclonal to CD45.4AA9 reacts with CD45, a 180-220 kDa leukocyte common antigen (LCA). (woofahs.com)
  • CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mouse, is member C of the class 1 (receptor-like) protein tyrosine phosphatase family (PTPRC) (1, 2). (rndsystems.com)
  • It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. (biolegend.com)
  • It is an exon 5 splice variant of the tyrosine phosphatase CD45. (biolegend.com)
  • The CD45 antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signalling in lymphocytes. (ox.ac.uk)
  • Summary CD45, the leucocyte common antigen, is a haematopoietic cell specific tyrosine phosphatase. (ox.ac.uk)
  • PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. (ximbio.com)
  • PTPRC/CD45: Protein Tyrosine Phosphatase Receptor Type C, CD45 antigen. (ox.ac.uk)
  • Recent findings suggest that one of the key events is the exclusion of the large receptor-type tyrosine phosphatase CD45, from close contacts formed at sites of T-cell/APC interaction. (ox.ac.uk)
  • CD45 is an abundant transmembrane tyrosine phosphatase, expressed on all leukocytes, and is required for efficient lymphocyte signaling. (aston.ac.uk)
  • The CD45 antibody recognizes a 180- to 220-kDa human leucocyte antigen that is a member of the leucocyte common antigen (LCA) family. (bdbiosciences.com)
  • The non-restricted CD45, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. (beckman.com)
  • Biopsy specimens showed a proliferation of atypical lymphoid cells, and on immunohistochemistry, these were diffusely and strongly positive for lymphocyte common antigen (CD45) and CD20. (jbstjournal.com)
  • For a better clinical application of the detailed phenotypic results examined by 3-FCM, it could be considered that the unusual expression or alternation of B cell-lineage antigens and defectiveness of common antigen may be useful to detect small number of lymphoma cells in peripheral blood or bone marrow. (kagoshima-u.ac.jp)
  • CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. (biolegend.com)
  • CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. (thermofisher.com)
  • CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (thermofisher.com)
  • Combinations of CD45 isoforms are crucial for immune function and disease. (exbio.cz)
  • The CD45 molecules are single chain integral membrane proteins comprising at least five isoforms ranging from 180 to 220 kDa. (beckman.com)
  • All the monoclonal antibodies that belong to the CD45 cluster react with this part of the antigen and are able to recognize all CD45 isoforms. (beckman.com)
  • Recognizes all CD45 isoforms as well as the known mouse CD45 alloantigens (CD45-1/Ly 5a and CD45-2/Ly 5b) (15). (rndsystems.com)
  • CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure (1‑5). (rndsystems.com)
  • Expression of different patterns of alternatively spliced CD45 isoforms is associated with distinct functions. (ox.ac.uk)
  • In this study we show that the A138G polymorphism is the cause of altered CD45 isoform expression, promoting splicing towards low molecular weight CD45 isoforms. (ox.ac.uk)
  • In particular, we examined expression of these phenotypic markers in relation to the expression of CD45 isoforms. (ox.ac.uk)
  • In some individuals, expansions of antigen-specific CD8+ T lymphocytes bearing specific TCR Vbeta chains were restricted to cells of particular CD45 isoforms. (ox.ac.uk)
  • BD Tritest™ CD3 fluorescein isothiocyanate (FITC)/CD4 phycoerythrin (PE)/CD45 peridinin chlorophyll protein (PerCP) is a three-color direct immunofluorescence reagent for use with a suitably equipped flow cytometer to identify and determine the percentages and absolute counts of mature human T lymphocytes (CD3 + ) and helper/inducer (CD3 + CD4 + ) T-lymphocytes subsets in erythrocyte-lysed whole blood. (bdbiosciences.com)
  • CD45R is found on B lymphocyte and T lymphocyte subsets. (ximbio.com)
  • Cyto-Chex BCT has been FDA 510(k) cleared for consistent recovery of HIV-associated lymphocyte subsets (CD3, CD4, CD8, CD19, CD16/CD56 and CD45) for up to 14 days. (streck.com)
  • HIV-1 may infect thymic precursor cells destined to become CD4 and CD8 lymphocytes and contribute to the numerical decline in both subsets on disease progression. (ox.ac.uk)
  • To investigate the relationship between CD8 activation and infection by HIV-1 in vivo, activated subsets of CD8 lymphocytes in peripheral blood mononuclear cells (PBMCs) of HIV-seropositive individuals were investigated for CD4 expression and HIV infection. (ox.ac.uk)
  • CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
  • With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
  • The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. (bdbiosciences.com)
  • Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA. Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. (bdbiosciences.com)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • Endometrium from pregnant heifers had greater mRNA abundance for the inhibitory molecules, CD274 and lymphocyte activating gene 3 (LAG3), and greater cytotoxic T lymphocyte-associated protein 4 (CTLA4), molecules that can interact with receptors on antigen-presenting cells and induce lymphocyte tolerance. (psu.edu)
  • The specific targeting of responding CD8 lymphocytes may provide a functional explanation for the previously observed impairment of cytotoxic T-lymphocyte (CTL) function disproportionate to their numerical decline in AIDS and for the deletion of specific clones of CTLs responding to HIV antigens. (ox.ac.uk)
  • We analyzed cytotoxic T-lymphocytes (CTLs) in peripheral blood of 39 patients on day +30 after allo-HSCT. (cttjournal.com)
  • CD45 isoform expression can change in response to cytokines. (biolegend.com)
  • Cosenza-Nashat MA, Kim MO, Zhao ML, Suh HS, Lee SC: CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. (exbio.cz)
  • Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. (ox.ac.uk)
  • Although the detailed composition of these pools is not completely understood, there is known to be heterogeneity, in particular of CD45 isoform expression. (ox.ac.uk)
  • We found that a spectrum of phenotypes exists stably, from CD45R0(high)/RA(low) through CD45RA(high)/R0(low), and that expression of other surface markers such as CD28 and CD62L, and also TCR usage, may vary in parallel with CD45 isoform expression. (ox.ac.uk)
  • Immunity against CMV comprises a large population of CD8+ T lymphocytes with heterogeneous potential, a spectrum in which CD45 isoform expression may play a central role. (ox.ac.uk)
  • If the KIR receptors of NK cell find their cognate antigen on the surface of target cell, formation of the lytic synapse is inhibited. (wikipedia.org)
  • The first step of the adaptive immune response involves the interaction of T cells that express T-cell receptors (TCRs) with peptide-loaded major histocompatibility complexes expressed by antigen-presenting cells (APCs). (ox.ac.uk)
  • d-SMAC (distal-SMAC) enriched in CD43 and CD45 molecules. (wikipedia.org)
  • 5-7 These molecules are important components of the immunological synapse (IS), which enables antigen-dependent communication between T cells and antigen-presenting cells (APCs). (ashpublications.org)
  • Adhesion molecule pairs, such as CD2-CD58 and CD11a-CD54, induce a transient adhesion of T cells to APCs, after which the T-cell receptor (TCR) scans the cell surface for antigens presented in the context of human leukocyte antigen (HLA) molecules. (ashpublications.org)
  • Upon antigen recognition, F-actin polymerization enables stabilization of the mature IS with a central region that contains the TCR-HLA molecules and interacting adhesion molecules in the periphery. (ashpublications.org)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • Immunoprecipitation of 125I-labelled iIEL analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis under reducing and non-reducing conditions revealed polypeptides of 60,000 and 200,000 molecular weights, respectively indicating that the antigen, which appears distinct from molecules described in other species, is expressed on the cell surface as a complex. (ox.ac.uk)
  • CMV-specific CTLs were identified by flow cytometry using fluorochrome-labeled monoclonal antibodies against CD3, CD8, CD45 molecules, viability reagent and tetramers consisting of in-house produced MHC class I monomers loaded with one of two immunodominant epitopes of viral pp65 protein (NLVPMVATV (NLV) and TPRVTGGGAM (TPR) peptides that are present in HLA-A*02 and -B*07 antigens, respectively, bound to phycoerythrin-conjugated streptavidin. (cttjournal.com)
  • The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN) are typically positive for CD45, HLA-DR, CD43, CD4, CD56, and cutaneous lymphocyte-associated antigen (CLA). (medscape.com)
  • If this is true, a full understanding of how close contact formation leads to signaling would require insights into the structures of, and interactions between, large membrane proteins like CD45 and other proteins forming the glycocalyx, such as CD43. (ox.ac.uk)
  • Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
  • The CD45 antibody, clone 2D1, is derived from hybridization of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood mononuclear cells (PBMCs). (bdbiosciences.com)
  • Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. (bdbiosciences.com)
  • Preliminary data suggests that mab 4-39 is binding to a lektin, that can be found mainly on B-Lymphocytes and endothelial cells. (uni-muenchen.de)
  • CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. (thermofisher.com)
  • Bijian K, Zhang L, Shen SH: Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells. (exbio.cz)
  • Complementation of Antigen-Presenting Cells to Generate T Lymphocytes with Broad Target Specificity. (texaschildrens.org)
  • CD45 antigen is expressed at high levels on all hematopoietic cells including T and B lymphocytes, monocytes, granulocytes, NK cells and dendritic cells, but is not expressed on non-hematopoietic cells. (woofahs.com)
  • Upon i.m. injection of DNA vectors expressing Nef mut -derivatives, nanovesicles containing antigens fused with Nef mut are released by muscle cells, can freely circulate into the body, and can be internalized by antigen-presenting cells (APCs). (nature.com)
  • CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds (3, 6‑8). (rndsystems.com)
  • Confocal immunofluorescent analysis of Raw 264.7 (left, positive) and C2C12 (right, negative) cells using CD45 (D3F8Q) Rabbit mAb (green). (cellsignal.com)
  • Compared to cyclic heifers, CD45 + uterine cells from pregnant heifers exhibited greater degranulation. (psu.edu)
  • Results: No difference in antigen expression between normal and malignant endothelial cells (ECs) was found for CD54, CD109, CD137, CD141, CD144 and CXCR7. (researchgate.net)
  • CD4(+) and CD4(-) CD8 lymphocytes, CD4 lymphocytes, other T cells, and non-T cells were purified using paramagnetic beads, and proviral sequences were quantified by PCR using primers from the long terminal repeat region. (ox.ac.uk)
  • Frequencies of activated CD8 lymphocytes were higher in HIV-infected study subjects than in seronegative controls, and they frequently coexpressed CD4 (mean frequencies on CD69(+), CD71(+), and HLA class II(+) cells of 23, 37, and 8%, respectively, compared with 1 to 2% for nonactivated CD8 lymphocytes). (ox.ac.uk)
  • Oddly enough, FA was steady in vivo however, not in vitro, with regards to the antigen dosage and the proper period period since T\cell activation, as seen in murine monoclonal T cells. (baxkyardgardener.com)
  • The difference of antigen expression as defined by the fluorescent intensity of FCM was significantly clear in CD20 and CD22 between lymphoma cells and normal B lymphocyte. (kagoshima-u.ac.jp)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
  • An antigen has been identified, recognized by a novel monoclonal antibody CC45, which is expressed by a subpopulation of bovine gamma/delta T-cell receptor-positive (gamma/delta TCR+) T cells restricted in their distribution to the intestinal epithelium. (ox.ac.uk)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • infiltrate included lymphocytes and plasma cells around the perivascular zones. (cdc.gov)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)
  • the remainder arise from T lymphocytes or natural killer cells. (msdmanuals.com)
  • Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. (bdbiosciences.com)
  • In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148 (11‑14). (rndsystems.com)
  • Bernard A, Boumsell L, Hill C. Joint report of the first international workshop on human leucocyte differentiation antigens by the investigators of the participating laboratories: T2 protocol. (bdbiosciences.com)
  • Cyto-Chex BCT is a direct draw blood collection tube that maintains cellular morphology and surface antigen expression, including cluster of differentiation (CD) markers prior to analysis by flow cytometry. (streck.com)
  • The stage of lymphocyte differentiation at which the oncogenic event occurs determines the disease presentation and outcome. (msdmanuals.com)
  • We recently identified a polymorphism in exon 6 (A138G) of the gene encoding CD45 (PTPRC) that results in altered CD45 splicing. (ox.ac.uk)
  • PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. (ximbio.com)
  • We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a loss of glutamic acid 339 and tyrosine 340 in the first fibronectin type III module of the extracellular domain of CD45, is associated with failure of surface expression of CD45 and SCID. (aston.ac.uk)
  • CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. (thermofisher.com)
  • Neither the B-lymphocyte antigen CD19 nor the T-cell surface glycoprotein CD3 gamma chain (hybridization with a dual probe showed an absence of the fusion (Physique S3A). (eprf.ca)
  • This is the second description of a clinically relevant CD45 mutation, provides direct evidence for the importance of CD45 in immune function in humans, and suggests that abnormalities in CD45 expression are a possible cause of SCID in humans. (aston.ac.uk)
  • In contrast, most markers (CD3, CD5, CD13, CD14, CD19, CD45, HLA-DR, and TdT) showed strong correlation between PB and BM samples in AML group.Conclusions:The findings of this study suggests that targeted gating strategy for blast population as well as selection of a suitable panel of monoclonal antibodies may be essential for diagnosis of leukemia resulting in similar immunotyping pattern in PB and BM. (medscimonit.com)
  • CD45 has also been reported to bind galectin-1 and CD22. (biolegend.com)
  • B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. (dimabio.cn)
  • Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. (dimabio.cn)
  • The non-restricted CD45 epitope is present on the surface of all human leucocytes, lymphocytes, eosinophils monocytes, basophils and neutrophils by order of decreasing level of expression. (beckman.com)
  • The pDC markers, CD123 (strong), TCL-1 (90% of cases), CD45RA, blood dendritic cell antigen (BCDA)-2 (expressed in more mature cases), and myxovirus A (MxA) may be detected by flow cytometric immunophenotyping (FCI) and/or immunohistochemical (IHC) staining. (medscape.com)
  • Human peripheral blood lymphocytes were stained with CD45RA FITC and CD45RO (clone UCHL1) Brilliant Violet 605™ (top) or mouse IgG2a, κ Brilliant Violet 605™ isotype control (bottom). (biolegend.com)
  • All four have the C77G polymorphism of CD45 exon 4, which alters the splicing and CD45RA/CD45R0 phenotype of lymphocytes. (ox.ac.uk)
  • The use of prophylactic infusion of selected lymphocytes (CD45RA- fraction, CMV-specific T-lymphocytes) probably can improve the reconstitution of antiviral immunity, reduce the frequency of reactivation and increase overall survival in these categories of patients. (cttjournal.com)
  • April 13 - 15, 1994", "subitem_description_type": "Other"}, {"subitem_description": "A case of CD45-negative, CDlO-positive lymphoblastic lymphoma (LBL) with precursor B lymphocyte (pre-B) phenotype, was analyzed by using 3 color flow cytometry (3-FCM) in addition to morphological observation and immunohistochemistry. (kagoshima-u.ac.jp)
  • Non-Hodgkin lymphoma is not one disease but rather a category of lymphocyte cancers with a number of subgroups largely divided into aggressive and indolent types. (msdmanuals.com)
  • CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders (6, 7). (rndsystems.com)
  • Cohen SB, Weetman AP Activated interstitial and intraepithelial thyroid lymphocytes in autoimmune thyroid disease. (bdbiosciences.com)
  • Human polymorphic CD45 variants are associated with autoimmune and infectious diseases and alter the phenotype and function of lymphocytes, establishing CD45 as an important regulator of immune function. (ox.ac.uk)
  • We have therefore investigated the CD8+ T-lymphocyte response against CMV directly ex vivo using Class I tetramers combined with stains for a range of phenotypic markers followed by four-colour flow cytometric analysis. (ox.ac.uk)
  • Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
  • Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
  • Ramos CA, Dotti G " Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy. . (bcm.edu)
  • Progressive depletion of CD4+ T-lymphocytes is associated with an increased likelihood of clinical complications. (cdc.gov)
  • CD45 has also been reported to react weakly with mature blood erythrocytes and platelets. (woofahs.com)
  • There is also evidence for the induction of CD4 expression and susceptibility to infection by HIV-1 of CD8 lymphocytes activated in vitro. (ox.ac.uk)
  • Activated CD8 lymphocytes were identified by expression of CD69, CD71, and the human leukocyte antigen (HLA) class II, the beta-chain of CD8, and the RO isoform of CD45. (ox.ac.uk)
  • The level of CD4 expression of the double-positive population approached that of mature CD4 lymphocytes. (ox.ac.uk)
  • Combined, these findings provide evidence that antigenic stimulation of CD8 lymphocytes in vivo induces CD4 expression that renders them susceptible to HIV infection and destruction. (ox.ac.uk)
  • We investigated the first SCID patient to be described with minimal cell surface expression of the leukocyte common (CD45) Ag. (aston.ac.uk)
  • In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as a T/B cell or Natural Killer cell. (wikipedia.org)
  • The process of formation begins when the T-cell receptor (TCR) binds to the peptide:MHC complex on the antigen-presenting cell and initiates signaling activation through formation of microclusters/lipid rafts. (wikipedia.org)
  • CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. (biolegend.com)
  • This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. (thermofisher.com)
  • CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. (thermofisher.com)
  • CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. (thermofisher.com)
  • Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. (exbio.cz)
  • As control we used a human leukocyte antigen DR (HLA DR) antibody with equal inhibitory capacities on cell proliferation. (biomedcentral.com)
  • We developed a CD8 + T-cell-based vaccine platform based on intramuscular (i.m.) injection of a DNA vector coding for antigens of interest fused at the C-terminus of a biologically inactive Human Immunodeficiency Virus (HIV)-Type 1 Nef protein (Nef mut ) having an unusually high efficiency of incorporation into EVs. (nature.com)
  • Immunoprecipitation of CD45 protein from BaF3 cell extracts. (cellsignal.com)
  • However, it is unknown whether this synapse is fully assembled and leads to T-cell activation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class II (HLA-II). (ashpublications.org)
  • Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. (bdbiosciences.com)
  • Both CD4+CD25-T parasites and CD4+CD25+T friends in cell-mediated read verbundwerkstoffe 14 symposium verbundwerkstoffe icons had Antigen-induced employees of CD44, CD45, GITR and CD152 as those in material points( Address(es also activated), determining the metabolism findings were increased after problem unstain. (heidsoftware.com)
  • Therefore, we utilized subunit vaccines to research whether homologous vaccination with different P/B intervals (2 vs. four weeks) or changed antigen thickness would influence the FA of the peptide\particular Compact disc8 T\cell response. (baxkyardgardener.com)
  • Beyond this basic grouping, SCID may be categorized according to phenotypic lymphocyte profiles that include both B-cell status (B + or B - ) and NK-cell status (NK + or NK - ) in addition to T-cell status (T - , because there is always a T-cell deficiency in SCID). (medscape.com)
  • The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
  • The position of bands on the nitrocellulose strips allows this antibody reactivity to be associated with specific viral antigens. (cdc.gov)
  • Lymphocytes in lungs are maintained separately from the pool of circulating lymphocytes, and their continuous loss through intraepithelial migration toward the airways is constantly replenished by homeostatic proliferation 9 . (nature.com)
  • Identification of a molecule uniquely expressed on a gamma/delta TCR+ subset within bovine intestinal intraepithelial lymphocytes. (ox.ac.uk)
  • CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton (9, 10). (rndsystems.com)
  • Immunophenotyping relies on detecting specific antigenic determinants on the surface of WBCs by antigen-specific monoclonal antibodies that have been labeled with a fluorescent dye or fluorochrome, such as phycoerythrin (PE) or fluorescein isothiocyanate (FITC). (cdc.gov)
  • Rapid flow cytometric method for measuring lymphocyte subset activation. (bdbiosciences.com)
  • Disease associations and altered immune function in CD45 138G variant carriers. (ox.ac.uk)
  • There is increasing evidence that CD8 lymphocytes may represent targets for infection by human immunodeficiency virus type 1 (HIV-1) in vivo whose destruction may contribute to the loss of immune function underlying AIDS. (ox.ac.uk)
  • CD8+ T lymphocytes contain lytic granules - specialized secretory lysosomes filled with perforin, granzymes, lysosomal hydrolases (for example cathepsins B and D, β-hexosaminidase) and other cytolytic effector proteins. (wikipedia.org)
  • Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. (ox.ac.uk)
  • Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
  • This document has been developed by CDC to give guidance to laboratories performing lymphocyte immunophenotyping assays in human immunodeficiency virus-infected persons. (cdc.gov)
  • CD4+ T-lymphocyte levels are also used as prognostic indicators in patients with human immunodeficiency virus (HIV) disease (8). (cdc.gov)
  • The CD69 antigen is a surface homodimer formed by the association of 28-kDa and 32-kDa chains that are held together by disulfide bridges. (bdbiosciences.com)