• Our laboratory uses transgenic and knockout mice to study the molecular mechanisms responsible for the normal control of T-lymphocyte reactivity and the changes that occur when T-lymphocytes become either aggressive against self antigens or inappropriately reactive against substances (allergens) normally present in the environment. (nyu.edu)
  • These cells have also been shown to inhibit the development of organ-specific autoimmune diseases suggesting that they inhibit immune responses to tissue-specific self-antigens. (ox.ac.uk)
  • Activation of CD4+ T cells is usually crucial for the removal of many invading pathogens, but inadvertently they can also become responsive to self antigens, thus leading to autoimmune diseases. (globaltechbiz.com)
  • In addition, Maca polysaccharides have good immune-regulatory activity on macrophages by regulating the polarization and increasing the phagocytosis [ 16 ]. (hindawi.com)
  • The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)
  • The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. (edu.au)
  • MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. (edu.au)
  • It is usually well known that innate immune cells are important causes of hepatic inflammation, because the liver is usually selectively enriched in macrophages (Kupffer cells), natural monster (NK), and natural monster T (NKT) cells [1]. (globaltechbiz.com)
  • Tumor-associated macrophages (TAM) and lymphocytes (TAL) were shown to produce IL 1 and IL 2, respectively. (jax.org)
  • Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes. (cdc.gov)
  • The number of HO-1 positive alveolar macrophages was significantly elevated in lungs of mice treated with OVA + PM/OVA compared to OVA/OVA. (cdc.gov)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • The possible role of circulating soluble tumor antigen in modifying the immune response to tumors is discussed. (rupress.org)
  • They provide help for antigen-presenting cells and CD8+ cytotoxic T lymphocytes to initiate and promote adaptive immune responses. (globaltechbiz.com)
  • The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses. (marksteinlab.org)
  • Here, using a mouse model, we describe a dual role for the let-7 microRNAs in the regulation of CD8 T cell responses, where maintenance of the naive phenotype in CD8 T cells requires high levels of let-7 expression, while generation of cytotoxic T lymphocytes depends upon T cell receptor-mediated let-7 downregulation. (marksteinlab.org)
  • Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
  • Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
  • Our results found that PBC stimulated a greater change in numbers of CD16 + NK cells and CD8 + T cells in comparison to CWI, suggesting a larger catecholamine response after PBC could result in a morepronounced mobilisation of lymphocytes than CWI. (researchgate.net)
  • This provides the first evidence for the effect of PBC exposure on redistribution of immune cells. (researchgate.net)
  • An increase in circulating leukocyte subsets such as CD8⁺ T cells and CD56loCD16⁺ natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. (researchgate.net)
  • The "pro-tolerogenic" antigen-loaded DC will migrate to draining mesenteric lymph nodes, where they will present the food protein-derived peptides to naive T cells and favour the induction of a subpopulation of T cells, namely regulatory T cells (Treg). (frontiersin.org)
  • Two-color analysis of the expression of CD40 on mouse and rat spleen cells. (bdbiosciences.com)
  • The HM40-3 antibody reacts with CD40, a 40-50-kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. (bdbiosciences.com)
  • Methods: We replaced DCs by peripheral mononuclear cells and myelin autoantigens by glatiramer acetate (Copaxone (R)), a drug approved for the treatment of MS. Spleen cells were loaded with Copaxone (R), incubated with mitomycin C (MICCop) and injected into mice after the first bout of relapsing-remitting EAE. (uni-koeln.de)
  • Immunosuppression mediated by MICCop was investigated in vivo by daily assessment of clinical signs of paralysis and in in vitro restimulation assays of peripheral immune cells. (uni-koeln.de)
  • The number and inhibitory activity of CD4(+)CD25(+)FoxP3(+) regulatory T cells were analysed by histology, flow cytometry and in vitro mixed lymphocyte cultures. (uni-koeln.de)
  • Results: MICCop cells were able to inhibit the harmful autoreactive T-cell response and prevented mice from further relapses without affecting general immune responses. (uni-koeln.de)
  • Administered MICCop migrated to various organs leading to an increased infiltration of the spleen and the central nervous system with CD4(+)CD25(+)FoxP3(+) cells displaying a suppressive cytokine profile and inhibiting T-cell responses. (uni-koeln.de)
  • The aim of this work was to analyze the number and distribution of T (CD3, CD4 and CD8) and B (IgA) cells in lungs of Toxocara canis experimentally infected BALB/c mice. (vin.com)
  • Increases in cytotoxic CD8 cells in the acute phase and helper CD4 cells in late phase infection suggest a mixed immune response elicited by T. canis . (vin.com)
  • In both cases the cells localized at the tissue parenchyma, possibly due to the release of secretory/excretory antigens in the tissue by the migratory route followed by the parasite. (vin.com)
  • This type of changes in lymphocyte cells in the lung may predispose to allergic reactions as suggested in asthmatic human beings. (vin.com)
  • OX40 is transiently expressed after T-cell receptor engagement and is upregulated on the most recently antigen-activated T cells within inflammatory lesions (e.g. sites of autoimmune destruction and on tumor-infiltrating lymphocytes). (nih.gov)
  • Expression of cytokines and chemokines in bronchoalveolar lavage (BAL) was quite different in mice exposed to four particle types, as well as expression of antigen presentation-related surface proteins on BAL cells. (cdc.gov)
  • With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
  • Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (bioskinrevive.com)
  • In contrast with CD10, CD19 and CD20 antigen, CD22 antigen is still present on lymphoplasmacytoid cells but is dininished on the fully mature plasma cells. (bioskinrevive.com)
  • Currently many stem or progenitor cell therapies including T cell receptor (TCR) or chimeric antigen receptor (CAR) focusing on epitopes indicated on malignant cells are under development for medical translation (17C20). (bioskinrevive.com)
  • Ongoing projects focus on glial cells (astrocytes and microglia) and how they coordinate with immune cells from the blood to affect bystander brain injury in the days after stroke. (stanford.edu)
  • We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. (cdc.gov)
  • Single-cell transcriptomics and functional assays defined a high ratio of CD8(+) T cells versus T-reg cells as a predictor of response to immune checkpoint blockade (ICB). (unav.edu)
  • Consequently, growth of MB49 in IL-10 knockout (KO) mice, whose infiltrating cells are unable to produce IL-10, allows for the removal of the IL-10 normally associated with this tumor. (jefferson.edu)
  • little attention has been devoted to the mechanisms and other immune cells. (hindawi.com)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
  • Mice primed with either ovalbumin or methylated BSA also showed enhanced antigen-specific immune response of both T and B cells, an immunological abnormality that exacerbated antigen-induced arthritis. (jci.org)
  • Clearance of persistent RSV infections in immunodeficient mice following transfer of primed T cells. (microbiologyresearch.org)
  • Interferon-mediated self limiting growth of respiratory syncytial virus in mouse embryo cells. (microbiologyresearch.org)
  • The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
  • The sharp contrast in susceptibility to EAE between the two types of anti-MBP transgenic mice, one carrying regulatory lymphocytes and the other not, enables us to pursue identifying and characterizating those cells. (nyu.edu)
  • Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
  • Although cross-reactivity of murine CD8+ T cells does not directly translate to humans, the molecular interactions involved in triggering T cell responses are the same in mouse and man. (ox.ac.uk)
  • and the properties of immune cells regulating autoimmunity. (columbiagypsy.net)
  • this activation occurs following a uptake of ICs into innate immune cells and the interaction of the cargo DNA or RNA with internal nucleic acid detectors. (columbiagypsy.net)
  • The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. (nature.com)
  • X. Sedimentation velocity characterization of antigen-binding cells and antibody forming-cell progenitors in the in vitro microculture immune response of unprimed cba mice to nip-pol antigen. (jax.org)
  • Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. (ox.ac.uk)
  • Recent findings suggest that the lack of tumor immunogenicity is partly due to a population of cells called CD4+ CD25+ regulatory T cells since depletion of these cells in mice can result in tumor rejection. (ox.ac.uk)
  • Alternatively, immune responses in mice depleted of regulatory cells may target tumor antigens that are not tissue-specific, but which are shared by tumors of diverse origins. (ox.ac.uk)
  • Immune cells that reside in or travel through the liver have the potential to initiate either (a) innate and adaptive immune responses in case of infections, for example, in response to lipopolysaccharide (LPS) or bacterial superantigens or (b) immunological tolerance to the vast majority of TC-A-2317 HCl supplier harmless antigens during homeostasis [1]. (globaltechbiz.com)
  • Inflammatory responses upon liver injury comprise resident as well as infiltrating immune cells. (globaltechbiz.com)
  • In addition, the infiltration of monocytes upon liver injury is usually an important cellular mechanism to perpetuate chronic inflammation and to activate profibrogenic hepatic stellate cells (HSC) in mice and men [3, 4]. (globaltechbiz.com)
  • However, during conditions of chronic liver damage, adaptive immune cells are also crucially involved in the pathogenesis of hepatic inflammation. (globaltechbiz.com)
  • This paper will present the concept of different CD4+ T-helper cell subsets and summarize their proposed functions during liver diseases, with a focus on the current knowledge about the role of Th17 cells and their associated cytokines in liver inflammation in mice and men. (globaltechbiz.com)
  • Previous data had indicated that sarcoma-bearing mice receiving combination therapy consisting of a single i.p. injection of cytoxan (CY) and an i.v. injection of tumor-sensitized T cells (immune cells) rejected the neoplasm. (jax.org)
  • This report is concerned with the hypothesis that the transfer of immune cells results in the amplification of T cell responses at the tumor site. (jax.org)
  • Professor Milling is an immunologist, focussing on the biology of antigen presenting cells in the intestine, and on how these cells respond to infectious or inflammatory stimuli. (wixsite.com)
  • The aim of this work is to understand the vital roles that antigen presenting cells play, both in the induction and polarisation of adaptive immune responses against pathogens, and in the pathology of inflammatory diseases, especially ankylosing spondylitis, psoriatic arthritis, alopecia, and inflammatory bowel disease. (wixsite.com)
  • Importantly, mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection. (fairdomhub.org)
  • Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic and splenic immune cells and reduction in global antiviral gene pathways. (fairdomhub.org)
  • Max Planck Institute (MPI) cells, a non-transformed mouse line that has an AM phenotype and genotype, were treated with mass-, surface area- (s.a.), and particle number- (p.n.) equivalent concentrations of respirable asbestiform and non-asbestiform riebeckite/tremolite EMP for 24h. (cdc.gov)
  • There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)
  • Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)
  • Postexposure prophylaxis (PEP) with hepatitis B immune globulin (HBIG) and/or hepatitis B vaccine series should be considered for occupational exposures after evaluation of the hepatitis B surface antigen status of the source and the vaccination and vaccine-response status of the exposed person. (cdc.gov)
  • As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
  • In mice, this three-step therapy induced CD4- and CD8-dependent systemic immune responses that enhanced T-cell infiltration into distant tumors, leading to their eradication and significantly improving survival. (aacrjournals.org)
  • Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)
  • Given the potent suppressive properties of this cytokine, we hypothesized that its presence at the site of progressively growing tumors represents an immune escape mechanism utilized by tumors to avoid detection by the immune system. (jefferson.edu)
  • Those studying tumors engineered to produce IL-10 by way of gene-transfection uniformly reported that IL-10 enhances the anti-tumor immune response. (jefferson.edu)
  • Upon mRNA intratumoral injections in the transplantable mouse cancer models CT26, MC38, and B16OVA, potent therapeutic effects were observed following repeated injections into the tumors. (unav.edu)
  • Although it is known that the immune system can mount responses to a variety of tumors it is clear that most tumors exhibit weak or even undetectable immunogenicity. (ox.ac.uk)
  • In addition, it was demonstrated by in situ labeling with 3H-TdR that lymphocytes associated with the regressing tumors were proliferating. (jax.org)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • Vaccination of BALB/c mice with DREP-GP, DREP-VP40, or DREP-GP+DREP-VP40 vectors, followed by immediate electroporation resulted in a mixed IgG subclass production, which recognized EBOV GP and/or VP40 proteins. (frontiersin.org)
  • FA is an adverse reaction that results from an inappropriate and excessive immune response against dietary proteins. (frontiersin.org)
  • This reproducible immune reaction results from an impaired induction of oral tolerance, i.e., a suppressive immune process at local and systemic levels that physiologically allows harmless dietary proteins to be tolerated by the immune system, thus avoiding chronic intestinal inflammation due to their regular consumption. (frontiersin.org)
  • Specific Treg then provide active tolerance to the harmless food proteins at all mucosal surfaces, either via cell contact or via their secretion of immunosuppressive factors that both prevent the induction of adaptive T helper (Th) lymphocytes in response to antigenic re-exposure ( 7 ). (frontiersin.org)
  • The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. (cdc.gov)
  • We used our platform based on retrovirus-derived enveloped virus-like particles (eVLPs) harnessed with variable surface proteins (VSPs) from the intestinal parasite Giardia lamblia, affording them resistance to degradation and the triggering of robust mucosal cellular and antibody immune responses after oral administration. (bvsalud.org)
  • These antigens include organic dusts containing bacteria, fungi,4 animal or plant proteins, or low-molecular-weight chemicals. (cdc.gov)
  • The QuantiFERON ® -TB Gold IT test is a test for Cell Mediated Immune (CMI) responses to petide antigens that simulate mycobacterial proteins. (cdc.gov)
  • Our study indicates that co-expression of GP and VP40 antigens based on the SFV replicon vector generates EBOV VLPs in vitro , and vaccination with recombinant DREP vectors containing GP and VP40 antigens induces Ebola antigen-specific humoral and cellular immune responses in mice. (frontiersin.org)
  • Humoral and cellular immune responses were then determined by ELISA and in vitro antigen restimulation assay. (uni-koeln.de)
  • In vitro assays for lymphocyte cytotoxicity and humoral antibody were found to be less reliable indicators of tumor progress. (rupress.org)
  • Antigen-initiated B-lymphocyte differentiation. (silverchair.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune responses. (nature.com)
  • The results emphasize the importance of directing antibody responses towards protective epitopes, as the majority of anti-PfRAMA mAbs were unable to inhibit merozoite invasion of erythrocytes. (bvsalud.org)
  • Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with matrix protein (VP40). (frontiersin.org)
  • Polyclonal antibodies against PfRAMA are able to inhibit P. falciparum growth and interact synergistically when combined with antibodies against P. falciparum reticulocyte-binding protein 5 (PfRh5) or cysteine-rich protective antigen (PfCyRPA). (bvsalud.org)
  • This review describes the journey from in vitro experiments through preclinical mouse models to the successful translation of the first OX40 agonist to the clinic for the treatment of patients with cancer. (nih.gov)
  • These findings advance our understanding of immune-mediated control of CoV in vitro and in vivo, knowledge that could help inform strategies to combat infection by emerging CoV. (fairdomhub.org)
  • Furthermore, interactions of CD40 with its ligand, CD154, are involved in the initiation and effector stages of cell-mediated immune responses. (bdbiosciences.com)
  • Our results demonstrate that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis. (fairdomhub.org)
  • 4 ]. A relationship between activated or lymphocytes and enzyme-linked immuno- memory-effector lymphocyte populations sorbent assay (ELISA) for CD117. (who.int)
  • IFN-I have potent direct antiviral activities, also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. (mdpi.com)
  • The pathogenesis of malaria is associated with blood-stage infection and there is strong evidence that antibodies specific to parasite blood-stage antigens can control parasitemia. (bvsalud.org)
  • This provides a strong rational for applying blood-stage antigen components in a multivalent vaccine, as the induced antibodies in combination can enhance protection. (bvsalud.org)
  • Our results confirmed previous finding of synergy between PfRAMA-, PfRh5- and PfCyRPA-specific antibodies, thereby paving the way of testing these antigens (or fragments of these antigens) in combination to improve the efficacy of blood-stage malaria vaccines. (bvsalud.org)
  • ANA production can precede symptoms and indications of disease by 5 or more years, with more complete serological evaluation demonstrating increasing creation of antibodies to nuclear antigens such as for example DNA, Sm, RNP, Ro, and La.4 This stage of disease could be known as preautoimmunity because symptomatology isn't manifest. (columbiagypsy.net)
  • The effect of heterophile antibodies in the QuantiFERON ® -TB Gold IT ELISA is minimized by the addition of normal mouse serum to the green diluent and the use of F(ab')2 monoclonal antibody fragments as the IFN-γ capture antibody coated the microplate wells. (cdc.gov)
  • The presentation in cryptococcosis varies with the site of infection and the patient's immune status. (medscape.com)
  • It is commonly believed that exposure to cold environmental temperatures depresses immune function and increases the risk for infection. (researchgate.net)
  • For example, coxsackievirus B3 (CB3) infection of susceptible mice results in inflammation of the heart (myocarditis) that resembles myocarditis in humans. (cdc.gov)
  • Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women. (cdc.gov)
  • Pulmonary A2 strain respiratory syncytial virus infection of BALB/c laboratory mice persisted for up to 7 days after initial infection with peak virus titres being recovered on day 4. (microbiologyresearch.org)
  • Infection was found to elicit a pulmonary major histocompatibility complex-restricted cytotoxic T lymphocyte (CTL) response which was first detectable 6 days after infection and optimal 7 to 9 days after infection. (microbiologyresearch.org)
  • This local CTL response was preceded by a rapid transient virus-specific lymphocyte transformation response which was detectable only 3 days after intranasal infection. (microbiologyresearch.org)
  • Immunoglobulin class specific antibody response in serum, spleen, lungs and bronchioal- veolar washings after primary and secondary Sendai virus infection of germ free mice. (microbiologyresearch.org)
  • Primary respiratory syncytial virus infection in mice. (microbiologyresearch.org)
  • In addition, these findings could have key implications for animal model development as well as further research into how SARS-CoV-2 modulates the type I IFN response early during infection. (fairdomhub.org)
  • Here, we show that interferon-inducible lymphocyte antigen 6 complex, locus E (LY6E) potently restricts cellular infection by multiple CoVs, including SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). (fairdomhub.org)
  • To determine the prevalence of TB infection, NHANES participants 6 years of age and older who consented to this component were skin tested with a tuberculin-purified protein derivative (PPD) product, tubersol, a commercially available antigen. (cdc.gov)
  • After incubation of the blood with antigens for 16 to 24 hours and in conjunction with a regularly scheduled shipment, specimens were sent to a contracted laboratory on frozen refrigerant packs or dry ice where the QFT-GIT test for tuberculosis infection was conducted. (cdc.gov)
  • Immune globulin and antiviral agents (e.g., interferon with or without ribavirin) are not recommended for PEP of hepatitis C. For HCV postexposure management, the HCV status of the source and the exposed person should be determined, and for HCP exposed to an HCV positive source, follow-up HCV testing should be performed to determine if infection develops. (cdc.gov)
  • To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-kappa B, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. (unav.edu)
  • In situ immunization aims at generating antitumor immune responses through manipulating the tumor microenvironment. (aacrjournals.org)
  • Antigen stimulation of lymphocytes induces CD229 clustering to sites of T cell‑B cell contact (7). (rndsystems.com)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotube s (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets. (cdc.gov)
  • The results revealed that pulmonary exposure to fibrous materials led to discrete local immune cell polarization patterns with a TH2-like response caused by ASB and TH1-like immune reaction to NCF, while CNT and CNC caused non-classical or non-uniform responses. (cdc.gov)
  • These alterations in immune response following pulmonary exposure should be taken into account when testing the applicability of new nanosized materials with fibrous morphology. (cdc.gov)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • Our findings suggest that fine PM enhances allergic inflammatory response in pulmonary tissue through mechanisms involving increased oxidative stress. (cdc.gov)
  • This review paper will 1) present an overview of human physiological responses to cold exposure, 2) present the human studies examining the effects of cold exposure on immune responses, and 3) summarize recent experiments from our laboratories examining the effects of exercise and fatigue on immune responses during subsequent cold exposure. (researchgate.net)
  • Based on the review of the literature, there is no support for the concept that cold exposure depresses immune function. (researchgate.net)
  • Hypothermic stress as a result of exposure to cold environments and cold water has been shown to increase circulating catecholamine concentration and subsequently influence lymphocyte mobilisation (Jansky et al. (researchgate.net)
  • 12] However, the findings concerning the effects of cold exposure on human immune function are inconsistent. (researchgate.net)
  • Due to their immunotoxical and biocidal properties, such exposure may disrupt the host-intestinal microbiota's beneficial exchanges and may interfere with intestinal barrier and gut-associated immune system development in fetuses then the neonates. (frontiersin.org)
  • By focusing on immune-related hazards, numerous reports emphasized a large potential for immune-related consequences due to NP exposure through the diet ( 4 ). (frontiersin.org)
  • Here we used a mouse (C57BL/6) model of environmental pollutant exposure by administration of a particulate matter (SRM1649b at 300 μg/day/mouse) suspension intra-nasally beginning 2 months before conception and during gestation, in comparison to saline-exposed controls. (nature.com)
  • Our treatment regimen entailed chronic exposure whereby pregnant mice were infused with 0.5 mg/kg/day of IMD via a subcutaneous osmotic mini-pump from gestational day 3 to postnatal day 21. (boerenlandvogels.nl)
  • The aim of this study was to assess how exposure to fine PM collected from Sacramento, CA, shapes the allergic airway immune response in BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA). (cdc.gov)
  • BALB/c mouse splenocytes were simultaneously stained with PE-conjugated anti-mouse CD5 mAb 53-7.3 (Cat. (bdbiosciences.com)
  • BALB/c mice were given NCF, CNC, CNT, and ASB on Day 1 by oropharyngeal aspiration. (cdc.gov)
  • in vivo in the spleen and lymph nodes of crazy type mice, with specificity confirmed through in vivo obstructing and depletion studies. (bioskinrevive.com)
  • We also focus on a transgenic mouse model for asthma to determine in vivo the factors controlling the synthesis of important interleukins involved in the asthmatic process such as IL-4 and IL-5 and the increased production of immunoglobulin E. (nyu.edu)
  • Combined single-clade candidate HIV-1 vaccines induce T cell responses limited by multiple forms of in vivo immune interference. (ox.ac.uk)
  • However, combining single-clade HIV-1 vaccines into multi-clade formulations resulted in multiple forms of in vivo immune interference such as original antigenic sin and antagonism, which dampened or even abrogated induction of responses to epitope variants and reduced the breadth of induced T cell responses. (ox.ac.uk)
  • His team studies the functions of carefully-defined antigen presenting cell subsets in vivo , and the responses they induce from T lymphocytes, using samples from mice and from people. (wixsite.com)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • It was reported recently that PPARγ activation by its agonistic ligands modifies lymphocyte function. (jci.org)
  • Because of the vesicant activity of doxorubicin, microparticles made of biodegradable polymer poly(lactide-co-glycolide) or PLGA can safely deliver doxorubicin intratumorally and are effective vaccine adjuvants, (ii) enhancing T-cell activation using anti-OX40 and (iii) sustaining T-cell responses by checkpoint blockade using anti-CTLA-4. (aacrjournals.org)
  • It is a mouse monoclonal antibody directed against the alpha chain of the protein lymphocyte function-associated antigen 1 which is involved in immune reactions. (wikipedia.org)
  • Mouse monoclonal antibody to NPM1. (globaltechbiz.com)
  • Hence, it is an attractive target to modulate immune responses: OX40 blocking agents to inhibit undesirable inflammation or OX40 agonists to enhance immune responses. (nih.gov)
  • Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
  • Mice in the OVA + PM/OVA group displayed significantly increased airway inflammation compared to OVA/OVA animals. (cdc.gov)
  • Sedimentation velocity and buoyant density characterization of virgin antibody-forming cell progenitors in the adoptive immune response of unprimed CBA mice to 4-hydroxy-3-iodo-5-nitrophenylacetic acid-polymerized bacterial flagellin antigen. (silverchair.com)
  • Host immune responses … to CoV are complex and regulated in part through antiviral interferons. (fairdomhub.org)
  • To fulfill these criteria, we developed a thermostable, orally administered vaccine that can induce a robust mucosal neutralizing immune response. (bvsalud.org)
  • Conclusion: We describe a clinically applicable cell therapeutic approach for controlling relapses in autoimmune encephalomyelitis by specifically silencing the deleterious autoimmune response. (uni-koeln.de)
  • In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) ( 3 ). (cdc.gov)
  • Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger. (cdc.gov)
  • Currently, we are examining the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, in transgenic mice bearing antimyelin basic protein (MBP) T-lymphocytes. (nyu.edu)
  • In order to assess the specificity of MICCop-induced suppression, treated EAE mice were challenged with the control protein ovalbumin. (uni-koeln.de)
  • Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
  • In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. (edu.au)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • T cell transfer, Kaempferol hematopoietic stem cell or progenitor cell transfer, little molecule and antibody-based immunotherapies, and combos thereof, entire body immuno-positron emission tomography (immunoPET) concentrating on of immune system cell subtypes could offer spatial and temporal details that is difficult utilizing current strategies. (bioskinrevive.com)
  • In this study, we evaluated a small molecule compound called QL-007, which could potentially influence capsid assembly, using HBV replicated and susceptible cell models as well as mice infected with rAAV-HBV. (bvsalud.org)
  • The proliferation and trafficking of T lymphocytes in immune responses are necessary events in determining inflammatory responses. (bioskinrevive.com)
  • Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
  • The resulting dysregulated intestinal homeostasis in the infant may significantly impede the induction of oral tolerance, a crucial process of immune unresponsiveness to food antigens. (frontiersin.org)
  • Total cell number, mononuclear phagocytes, polymorphonuclear leukocytes, lymphocytes, and LDH levels were significantly increased in ASB and CNT-exposed mice. (cdc.gov)
  • We found that these factors were significantly negatively correlated with tumor purity and positively correlated with the immune score in the immunophenotyping analysis. (hindawi.com)
  • A test is considered positive for an IFN-γ response to the TB Antigen tube that is significantly above the Nil IFN-γ IU/mL value. (cdc.gov)
  • CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)
  • 1984. Depression in B- and T-lymphocyte mitogen- induced blastogenesis in mice exposed to low concentrations of benzene. (cdc.gov)
  • The QuantiFERON ® -TB Gold IT system uses specialized blood collection tubes, which are used to collect whole blood via venipuncture, which include a Nil control tube, TB Antigen tube and a Mitogen tube (positive control). (cdc.gov)
  • For each subject, 1 mL of blood was collected by venipuncture directly into each of three QFT GIT blood collection tubes in the order Nil (grey cap), TB Antigen (red cap), Mitogen (purple cap). (cdc.gov)
  • Each tube (Nil, TB Antigen, Mitogen) was identifiable by its label once the cap was removed. (cdc.gov)
  • Using MB49, we demonstrate that tumor-induced IL-10 inhibits the generation of a type I immune response against a tumor antigen as measured by Interferon (IFN)-γ production, cytotoxic T lymphocyte (CTL) generation, and delayed type hypersensitivity (DTH) reaction. (jefferson.edu)
  • CD229 knockout mice show minimally impaired immune responses, suggesting functional redundancy with other molecules (11). (rndsystems.com)
  • This vaccination regimen also led to the generation of both Th1 and Th2 cellular immune responses in mice. (frontiersin.org)
  • Because they may measure a wide range of immune responses and cellular immune-related activities, these tests are increasingly recommended and well-liked. (delvens.com)
  • This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with similar populations of Lewis, Sprague-Dawley, and LOU16 rat leukocytes. (bdbiosciences.com)
  • Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
  • Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
  • First, MB49 expresses the male antigen, H-Y. Thus, when grown in syngeneic female mice, H-Y provides a surrogate tumor-specific antigen for study. (jefferson.edu)
  • Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. (edu.au)
  • James Allison is a blues-loving scientist from a small town in South Texas who shook off the immunotherapy naysayers and proved the human immune system could fight cancer. (mdanderson.org)
  • Upcoming potential applications of T cell targeted immunoPET consist of monitoring immune system cell subsets in response to immunotherapy, autoimmunity, and lymphoproliferative disorders, adding general to preclinical immune system cell monitoring. (bioskinrevive.com)
  • Lymphocyte monitoring during immunotherapy protocols, such as for example recognition of circulating lymphocytes from entire tumor or bloodstream infiltrating lymphocytes from tissues biopsy, will not supply the whole selection of spatial and dynamic Kaempferol information required. (bioskinrevive.com)
  • Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
  • To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
  • We develop a multifocal HCC model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes. (unav.edu)
  • The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. (edu.au)
  • The TAM expressed Ir gene products (Ia) and were able to present the synthetic polymer GAT to specifically sensitized lymphocytes. (jax.org)
  • There was no way of knowing then, but Allison's initial research on the immune system at MD Anderson laid the groundwork for his return in 2012 as the father of immune checkpoint blockade - an entirely new way of treating cancer that's yielding unprecedented results. (mdanderson.org)
  • I have devoted the large majority of our work on the role of the innate and adaptive immune response to this fungus. (uc.edu)
  • Although most normal immune responses against pathogens require the action of T-lymphocytes, their improper control lies at the heart of two types of disease: autoimmunity and allergy. (nyu.edu)
  • portal vein is usually rich of potential antigens produced from the gut-resident commensal microflora, ingested food, or also pathogens under infectious conditions. (globaltechbiz.com)
  • Following the incubation period, plasma is harvested and the amount of IFN-γ produced in response to the peptide antigens is measured by ELISA. (cdc.gov)
  • In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse CD229 is observed. (rndsystems.com)
  • Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how they affect short-term brain injury and long term outcomes like dementia and depression. (stanford.edu)
  • PPARγ is also known to regulate inflammatory responses. (jci.org)
  • Recent advances in single-cell sequencing enable recovery of the complete adaptive immune receptor sequences in addition to transcriptional information. (nature.com)
  • Together, this dataset provides a resource for immunologists that can be integrated with future single-cell immune repertoire and transcriptome sequencing datasets. (nature.com)
  • The immune cell proportion was also evacuated via the CIBERSORT method. (hindawi.com)
  • CD22 antigen is present in the most B-cell leukemias and lymphomas but not T-cell leukemias. (bioskinrevive.com)
  • Direct cell labeling is suffering from restrictions of radionuclide half-life, probe dilution Kaempferol because of cell department, and potential dangerous effects because of the radiosensitivity of lymphocytes. (bioskinrevive.com)
  • However, recent successful preclinical and clinical trials have advocated for the significance of B cell-dependent immunopathogenic responses and has led to the development of novel biologicals that target specific B cell phenotypes. (medsci.org)
  • The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
  • These findings indicate that PPARγ plays a critical role in the control of B cell response and imply a role in diseases in which B cell hyperreactivity is involved, such as arthritis and autoimmunity. (jci.org)
  • Systemic cell-mediated and antibody responses in infants with respiratory syncytial virus infections. (microbiologyresearch.org)
  • The FluoroSpot assay revealed that COVID-19 patients had the lowest antibody response, whereas three individuals (C4, C5, and C7) had the strongest T-cell responses. (delvens.com)
  • We assessed in mice whether broad CD8+ T cell responses capable of efficient recognition of multiple HIV-1 clades could be induced using current single-clade vaccine constructs that were or will be used in clinical trials in Europe and Africa. (ox.ac.uk)
  • Placental transcriptomes, at day 19 of gestation, were determined using bulk RNA-seq from whole placentas of exposed (n = 4) and control (n = 4) animals and scRNAseq of three distinct placental layers, followed by flow cytometry analysis of the placental immune cell landscape. (nature.com)
  • Ultimately, we have identified a novel let-7-mediated mechanism, which acts as a molecular brake controlling the magnitude of CD8 T cell responses. (marksteinlab.org)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)
  • Although some ANAs can have immune activity, the manifestation of ANAs appears to be widespread in humans. (columbiagypsy.net)
  • In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)
  • Fibrous nanocellulose, crystalline nanocellulose, carbon nanotube s, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice. (cdc.gov)
  • Immunogens which elicit such synergistic antibody mixtures could increase the potency of vaccine-elicited responses to provide robust and long-lived immunity against challenging disease targets. (bvsalud.org)
  • This pattern may occur with insufficient lymphocytes, reduced lymphocyte activity due to prolonged specimen transport or improper specimen handling, including filling/mixing of the blood tubes, or inability of the patient's lymphocytes to generate IFN-γ. (cdc.gov)
  • In regards to this review, OX40 agonists enhance anti-tumor immunity, which leads to therapeutic effects in mouse tumor models. (nih.gov)
  • Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. (uc.edu)
  • Although the study entails only a limited quantity of individuals, the considerable immunophenotyping provides intriguing evidence for a unique immune profile that may determine the transition from normal to aberrant immunity. (columbiagypsy.net)