Lymphocytes alpha receptor interleukin 2 receptor alpha subunit. Medical search. Frequent questions

High expression of CD25 is also found on TCR activated conventional T cells (both CD8+ and CD4+ T lymphocytes), where it is considered to be a marker of T cell activation. (wikipedia.org)
Soluble IL2RA has been isolated and determined to result from extracellular proteolysis during activation of T lymphocytes. (wikipedia.org)
After activation of the receptor by its ligand, heterodimerisation of beta and gamma intracellular domains takes place. (wikipedia.org)
MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
CD25 plays a role during activation: CD25(+) naive T cells stimulated in an APC-dependent manner were shown to produce increased levels of IL-2 as compared with their CD25(-) counterparts. (ox.ac.uk)
This effect was paralleled by increased nuclear factor-kappaB (NF-kappaB), nuclear factor of activated T cells (NFATs), and activator protein-1 (AP-1) activation and preceded by a rapid T-cell receptor (TCR)-induced externalization of the annexin-1 receptor. (ox.ac.uk)
Coinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation. (cnrs.fr)
PBMC stimulated with 1 μg/mL of aCD3 and 3 ug/ml of aCD28 for 2 days were treated with Tocris cell activation cocktail 500x (Catalog # 5476 ) and Brefeldin A (Catalog # 1231/5 ) for 3 hours or naïve PBMC lymphocytes. (rndsystems.com)
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. (edu.au)
A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. (edu.au)
Interleukin-2 and interleukin-15 (IL-2, IL-15) are key participants in T and NK cell activation and function. (unideb.hu)
On the other hand, due to their distinct alpha receptor subunits, they also play opposing roles in immune processes such as activation induced cell death and immunological memory. (unideb.hu)
CD25 plays a role in lymphocyte differentiating and activation/proliferation. (thermofisher.com)
2] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
CR2/CD21 interacts with C3b degradation products C3dg and C3d and can act synergistically with the B-cell antigen receptor (BCR) in B-cell activation. (medscape.com)
it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)

Peripheral blood (PB) mononuclear cells from 22 WG-patients (17 active, 5 remission) and 22 sex- and age-matched healthy controls (HC) were examined for Treg cells by flow cytometry measuring CD4, CD25, transcription factor forkhead box P3 (FoxP3), chemokine receptor CCR4 and interferon receptor I (IFNRI). (jenner.ac.uk)
Detection of IL‑2 in PBMC cells by Flow Cytometry. (rndsystems.com)

Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
The receptors are widely expressed in humans. (medscape.com)

In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor α-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells. (ox.ac.uk)

Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. (transcriptionfactor.org)
9 days following stimulation with interferon (IFN)alpha + proteinase 3 (PR3), a reduced suppression of proliferation of responder T cells was observed for WG and proliferated CD4+CD25high Treg cells still showed downregulated co-expressions of FoxP3 and CCR4. (jenner.ac.uk)
Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. (ox.ac.uk)
Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). (bio-techne.com)
Recombinant Human IL-7 GMP Protein Bioactivity GMP-grade Recombinant Human IL-7 (Catalog # 207-GMP) stimulates proliferation of PHA-activated human peripheral blood lymphocytes. (bio-techne.com)
IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). (bio-techne.com)
IL7R takes a vital part in lymphocyte differentiation, proliferation, multiple sclerosis, as well as survival. (prospecbio.com)
Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. (bio-techne.com)
Recombinant Human IL-2 GMP Protein Bioactivity GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. (bio-techne.com)
Equivalent Bioactivity of GMP and Animal-Free grades of Recombinant Human IL-2 Equivalent bioactivity of GMP (Catalog # 202-GMP) and Animal-Free ( AFL202 ) grades of Recombinant Human IL-2 as measured in a cell proliferation assay using CTLL 2 mouse cytotoxic T cells (orange and green, respectively). (bio-techne.com)
Sharing the beta and gamma receptor subunits results in several common functions: e.g. the promotion of T cell proliferation. (unideb.hu)
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. (thermofisher.com)
PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)

The key targets in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1, Tyrosine Protein Kinase JAK2, Tyrosine Protein Kinase BTK, Interleukin 2 Receptor, Programmed Cell Death Protein 1, Alpha 1 Antitrypsin, Cells Expressing B Lymphocyte Antigen CD20, Interleukin 2 Receptor Subunit Beta, Macrophage Colony Stimulating Factor 1 Receptor, and Tyrosine Protein Kinase ITK/TSK among others. (globaldata.com)
The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
Additionally, expression of the IL-2 receptor alpha subunit can be found in non-lymphoid tissues such as lungs (alveolar macrophages), liver (Kupffer cells) and skin (Langerhans cells). (wikipedia.org)
IL2RA protein can be expressed in many types of neoplastic cells, such as in most B-cell neoplasms, T-cell lymphomas, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis, Waldenstrom macroglobuliaemia and tumor infiltrating lymphocytes. (wikipedia.org)
Interleukin (IL)-15, a major cytokine involved in cross-talk between accessory cells (dendritic cells and macrophages) and NK cells, is produced by epithelial renal cells. (nih.gov)
These cells also express IL-15 receptor alpha (IL-15Ralpha). (nih.gov)
Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. (cusabio.com)
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). (transcriptionfactor.org)
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors. (ox.ac.uk)
Although CD25(+) naive T cells respond to lower concentrations of IL-2 as compared with their CD25(-) counterparts, IL-2 responsiveness is further increased in CD31(-) naive T cells by their expression of the signaling IL-2 receptor β-chain CD122, forming with common γ-chain functional high-affinity IL-2 receptors. (ox.ac.uk)
The results indicate upregulated numbers of Treg cells in PB and nasal mucosa as well as phenotypical and functional alterations of PB Treg cells in WG, some presumably mediated through PR3 and IFN-alpha. (jenner.ac.uk)
In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. (ox.ac.uk)
Our results imply a potential application of combining T(reg) cell depletion with alpha-GalCer to stimulate NK T cells for cancer therapy. (ox.ac.uk)
Recombinant IL-2 is widely used in cell culture for the expansion of T cells. (rndsystems.com)
IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). (rndsystems.com)
IL-2 is best known for its autocrine and paracrine activity on T cells. (rndsystems.com)
It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis (1, 2). (rndsystems.com)
It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes (8). (rndsystems.com)
IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (9-11). (rndsystems.com)
The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. (edu.au)
The neuroendocrine system regulates early T cell differentiation by the transcription of neuroendocrine genes in the stromal network and expression of cognitive receptors by immature T cells. (nel.edu)
IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). (bio-techne.com)
Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (edu.au)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
Our results show that CNCM I-3690 can (i) physically maintain modulated goblet cells and the mucus layer and (ii) counteract changes in local and systemic lymphocytes. (nature.com)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)
Subsequently, binding of the CD28 co-stimulatory receptor to the DCs' CD80/86 receptor fully activates the cytotoxic T cells which then migrate to infiltrate the tumour and kill the cells by locally releasing perforin and granzymes [ 2 ] [ 3 ] . (encyclopedia.pub)
These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)
In addition, activated T cells can express an inducible co-stimulator (iCOS), a surface receptor that is structurally and functionally similar to CD28 and enhances expression of Th2-related interleukin (IL)-10 rather than immune activating IL-2 [ 8 ] . (encyclopedia.pub)
A high correlation between ex vivo tracer uptake (standardized uptake value) in the xenograft and the number of inoculated CD25-positive cells was observed ( R 2 = 0.90). (springer.com)
Because IL-2R expression is low in resting immune cells, the receptor might be a suitable biomarker to study active inflammation in chronic inflammatory diseases. (springer.com)

Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21), and the CD122 subunit binds also IL-15. (wikipedia.org)
The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. (rndsystems.com)
The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. (rndsystems.com)
By itself, CD25 binds IL-2 only with low affinity. (thermofisher.com)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
N -(4-[ 18 F]Fluorobenzoyl)interleukin-2 ([ 18 F]FB-IL2) specifically binds to interleukin-2 receptors (IL-2R) and thus may be used to detect inflammation processes using positron emission tomography (PET). (springer.com)

The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. (transcriptionfactor.org)
Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. (rndsystems.com)
The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)

Interleukin-2 receptor alpha chain (also called TAC antigen, P55 and mainly CD25) is a protein involved in assembly of high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). (wikipedia.org)
CD25 consists of three domains: extracellular (N-terminus), transmembrane (alpha-helix) and cytoplasmic (C-terminus). (wikipedia.org)
Interleukin-2 can interact with intermediate-affinity dimeric IL-2 receptor, which consists of beta (CD122) and gamma (CD132) chains or with high-affinity trimeric complex, where also alpha subunit (CD25) constructs the IL-2 receptor and provides enhanced specific binding force. (wikipedia.org)
IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen. (transcriptionfactor.org)
Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2Ralpha). (thermofisher.com)
CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. (thermofisher.com)
However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. (thermofisher.com)
The IL-2R consists of three subunits (α, β and γ chains, called CD25, CD122 and CD132, respectively). (springer.com)
CD25 contains the main binding site for IL-2 and can be present as a transmembrane or soluble receptor. (springer.com)

In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. (cancer-genetics.org)

Divergence of signaling pathways must ensue already at the plasma membrane where the cytokines interact with their receptors. (unideb.hu)
While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)
The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. (rndsystems.com)

The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. (rndsystems.com)

The interleukin-2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL-2 receptor complex (Kd ~10−11M). (wikipedia.org)
The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. (rndsystems.com)

The human protein Interleukin-2 receptor subunit alpha is encoded by a gene called IL2RA with a length around 51,6 kb. (wikipedia.org)
Homodimeric alpha chains (IL2RA) result in low-affinity receptor (Kd ~10−8M) with no signalling ability, while dimeric beta (IL2RB) and gamma chains (IL2RG) produce a medium-affinity receptor (Kd ~10−9M). (wikipedia.org)
The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (thermofisher.com)
IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (thermofisher.com)
Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. (thermofisher.com)

B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, similar to cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD1), that negatively regulates the immune response. (cnrs.fr)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. (cancer-genetics.org)

Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. (ox.ac.uk)
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)

Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
Therefore understanding molecular details of receptor organization and mapping interactions with other membrane proteins that might influence receptor conformation and function, are of key importance. (unideb.hu)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1β-stimulated chondrocytes. (biomedcentral.com)

Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. (cusabio.com)

As the name indicates, this receptor interacts with pleiotropic cytokine called Interleukin-2, which effect is mainly important for immune homeostasis. (wikipedia.org)
Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)

Immunobiology of natural killer cell receptors / E. Vivier and M. Colonna (eds. (edu.au)
T cell differentiation occurs via T cell receptors. (nel.edu)

Interleukin-2 receptor alpha chain is an integral-membrane protein, more precisely Type I transmembrane protein. (wikipedia.org)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)

The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
Tacrolimus suppresses humoral immunity (T lymphocyte) activity. (medscape.com)

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. (rndsystems.com)

ETS proto-oncogene 2, transcri. (gsea-msigdb.org)

However, while extracellular part is able to function as a binding site for Interleukin-2, short cytoplasmic domain lacks an ability to induce intracellular signalling and therefore needs to oligomerise with other IL-2 receptor subunits. (wikipedia.org)
This coupling of subunits brings together Janus kinases JAK1 and JAK3, considering their association with respective cytoplasmic parts of beta and gamma subunits. (wikipedia.org)

It stabilizes lysosomal membranes and suppresses lymphocytes and antibody production. (medscape.com)
Prednisone stabilizes lysosomal membranes and suppresses lymphocytes and antibody production. (medscape.com)

Belongs to the type I cytokine family of receptors. (lu.se)

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. (transcriptionfactor.org)

Interleukin-7 receptor (IL7R) ,is a hematopoietin receptor superfamily member. (prospecbio.com)

G protein-coupled receptor. (gsea-msigdb.org)

Fc epsilon receptor Ig [So. (gsea-msigdb.org)
Fc epsilon receptor Ig [Source. (gsea-msigdb.org)

Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)
Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)

lymphocyte cytosolic protein 2 (SH2 domain. (wikigenes.org)
lymphocyte cytosolic prote. (gsea-msigdb.org)

The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). (rndsystems.com)
The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits. (transcriptionfactor.org)

Anti-Sema3a and anti-NRP1 neutralizing antibodies were applied to block the ligand-receptor interactions. (bvsalud.org)

Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)

Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. (cusabio.com)

Intracellular receptors that can be found in the cytoplasm or in the nucleus. (edu.au)

It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)

In the presence of 1 ng/ml of recombinant IL-2, ED50 for this effect is (transcriptionfactor.org)
SARS-CoV-2 Mutant (L452R, T478K)Alternates names: N/ATaglines: Recombinant Spike RBD mutant of the SARS-CoV-2. (transcriptionfactor.org)
Recombinant Interleukin-2 (IL-2) is expressed in E. coli and has been engineered to contain the serine for cysteine substitution found in Proleukin ® (aldesleukin). (rndsystems.com)
Intact mass analysis of recombinant human IL-2 confirms the predicted molecular mass of 15549 Da. (bio-techne.com)
Recombinant Human IL-2 GMP Protein SDS-PAGE 1 μg/lane of GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa. (bio-techne.com)
Recombinant Human IL-2 GMP Protein Mass Spectrometry MALDI-TOF analysis of GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP). (bio-techne.com)
1910. The Neutralization Dose (ND 50 ) is typically 0.2-0.8 µg/mL in the presence of 0.75 ng/mL Recombinant Human IL‑23 and 10 ng/mL Recombinant Mouse IL‑2. (rndsystems.com)
In the presence of Recombinant Mouse IL-2 (10 ng/mL, Catalog # 402-ML ), Recombinant Human IL-23 (Catalog # 1290-IL ) stim-ulates IL-17 secretion in mouse splenocytes in a dose-dependent manner (orange line), as measured by the Mouse IL-17 Quantikine ELISA Kit (Catalog # M1700 ). (rndsystems.com)

The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). (transcriptionfactor.org)
The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. (ox.ac.uk)
adrenoceptor beta 2 [Sourc. (gsea-msigdb.org)
beta-secretase 2 [Source:H. (gsea-msigdb.org)
G protein subunit beta 3 [Sour. (gsea-msigdb.org)
interleukin 1 beta [Source:HGN. (gsea-msigdb.org)
2) Estimation of T cell population structure by sequencing of the recombined T cell receptor (TCR) beta locus. (europeanhealthjournal.com)

High levels of interleukin-2 receptors (IL-2R) can be found mainly on the surface of activated T lymphocytes (both CD4+ and CD8+, mainly Th1 lymphocytes) [ 1 - 3 ] after endogenous stimulation. (springer.com)

C-X-C motif chemokine ligand 2. (gsea-msigdb.org)

Anatomy31

Organisms12

Diseases5

Chemicals and Drugs139

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Activation17

Flow Cytometry2

Humans2

Subsets1

Proliferation14

Cells41

Binds6

Signal transduction3

CD259

Tumor infiltratin2

Cytokines3

Cytokine receptors1

Common gamma2

IL2RA5

Inhibitory3

Heterodimer3

Proteins5

Soluble1

Immune6

Cell receptors2

Membrane3

Immunity2

Disulfide-linked1

Proto-oncogene1

Cytoplasmic2

Suppresses2

Family of receptors1

Gene encodes1

Superfamily member1

Protein-coupled receptor1

Epsilon receptor2

Deficiency2

Cytosolic2

Consists2

Ligand-receptor1

Affinity2

IL1RL11

Intracellular1

Depletion1

Recombinant8

Beta7

Endogenous1

Chemokine1