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  • tumor
  • We now propose a clinical trial to test whether donor lymphocytes infusion (DLI) using TK-transduced cells permits to induce a graft-versus-tumor (GVT) effect for treatment of relapse after HSCT, while GVHD can be controlled by GCV treatment. (bioportfolio.com)
  • However, other studies have not shown these differences and the degree of impact transfusion has on infection and tumor recurrence is not well understood. (wikipedia.org)
  • These T cells, referred to as tumor-infiltrating lymphocytes (TIL), are multiplied using high concentrations of Interleukin-2, anti-CD3 and allo-reactive feeder cells. (wikipedia.org)
  • Receptors
  • In this way MHC molecules chaperone which type of lymphocytes may bind to the given antigen with high affinity, since different lymphocytes express different T-Cell Receptor (TCR) co-receptors. (wikipedia.org)
  • Antigen presentation: MHC molecules bind to both T cell receptor and CD4/CD8 co-receptors on T lymphocytes, and the antigen epitope held in the peptide-binding groove of the MHC molecule interacts with the variable Ig-Like domain of the TCR to trigger T-cell activation Autoimmune reaction: Having some MHC molecules increases the risk of autoimmune diseases more than having others. (wikipedia.org)
  • cytokines
  • The extraction of G-CSF lymphocytes from the blood and expanding in vitro against a tumour antigen before reinjecting the cells with appropriate stimulatory cytokines. (wikipedia.org)
  • Before reinfusion, lymphodepletion of the recipient is required to eliminate regulatory T cells as well as unmodified, endogenous lymphocytes that compete with the transferred cells for homeostatic cytokines. (wikipedia.org)
  • B-lymphocytes, NK cells and cytokines also play a role in it. (wikipedia.org)
  • cells
  • Anti-CD40L antibody may prevent host T cells from inducing costimulatory signals in donor lymphocytes or islet grafts. (umassmed.edu)
  • This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. (wikipedia.org)
  • If undiagnosed or left untreated, HIV usually progresses to AIDS, defined as possessing a CD4+ lymphocyte count under 200 cells/μl or HIV infection plus co-infection with an AIDS-defining opportunistic infection. (wikipedia.org)
  • If there is IL-4, CD4+ T-lymphocytes become Th2 cells secreting IL-4 and IL-5. (wikipedia.org)
  • Immediately after a cancer cell is recognized, the Lymphocytes and/or the NK cells attack the cancer cell to kill it. (wikipedia.org)
  • These two modalities affect not only the cancer affected cells, but also the normal cells Now in AIET, specific types of cells mainly the NK cells and T lymphocytes are isolated from the peripheral blood of the cancer patients (during remission in patients who undergo chemotherapy) by proven methods, expanded to 25-30 fold and activated and then reinfused back into the patient's body. (wikipedia.org)
  • with an aim of inducing the lymphocytes which will carry their activity of destroying the tumour cells. (wikipedia.org)
  • peripheral blood
  • In fact, such harmless autoimmunity can be considered as physiologic since it is observed in all healthy individuals, both at the B cell level (natural autoantibodies) 1 and at the T cell level (one can derive MHC class II or organ specific T cell lines from normal peripheral blood lymphocytes) 2 Progression to pathogenic autoimmunity requires autoreactive B and/or T cell activation. (springer.com)
  • infection
  • and (3) whether there are differences in the response of children who acquired HIV infection perinatally (just before, during, or just after the time of birth) versus those who acquired HIV infection by transfusion. (clinicaltrials.gov)
  • treatment
  • The available treatment for hemophilia at the time included transfusion of large volumes of fresh frozen plasma to replenish the missing clotting factors. (wikipedia.org)
  • tissue
  • However, in the presence of IL-6 or IL-21 along with TGF-β, CD4+ T-lymphocytes acquire tissue-destructive Th17 phenotype and secrete IL-17. (wikipedia.org)
  • patients
  • Klein developed a topical treatment for skin cancer with 5-fluorouracil, developed one of the first effective treatments for Kaposi's sarcoma, and was amongst the first to clinically explore the use of lymphocytes to help cancer patients, earning him the nickname "the Father of Immunotherapy. (wikipedia.org)
  • Leukopheresis is the removal of PMNs, basophils, eosinophils for transfusion into patients whose PMNs are ineffective or where traditional therapy has failed. (wikipedia.org)