MoleculeAntibodiesMannose-6-phosphCytotoxicProteinsTransgenic miceDifferentiationInducesAntibodyCellularTumorHigh-affinity receptorPeripheral bloodMacrophagesActivationImmunoglobulinCD45ROCharacterizationExpressionEncodesSurfaceIsoformsImmune systemPhosphorylationCellsSusceptibilityViralToleranceDeficiencyComplexesUbiquitousGeneMoleculesMembrane-boundResponsesSpecificFoundBindVirusMajorHumanProfilesCell lines
Molecule5
- To identify this receptor we selected a monoclonal antibody (MAb) directed to the surface of B95a cells which inhibits MV binding and contamination and identified the acknowledged molecule as SLAM (CD150). (careersfromscience.org)
- It is rapidly induced on naive lymphocytes after activation and cross-linking antibodies to SLAM stimulate B-and T-cell proliferation (2 7 32 Since SLAM is usually a signal-transducing molecule the antiproliferative effect exerted by MV contact to the cell surface of lymphocytes could possibly be mediated by IDH-C227 SLAM. (careersfromscience.org)
- The virus CD46 molecule is the cellular receptor. (bestessaywriters.com)
- This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells . (wikidoc.org)
- The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
Antibodies1
- Although anti-SLAM and/or anti-CD46 antibodies stop virus binding they don't hinder the contact-mediated proliferation inhibition. (careersfromscience.org)
Mannose-6-phosph1
- Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
Cytotoxic2
- Granzyme B is abundantly stored in the granules of cytotoxic T lymphocytes and NK cells. (biolegend.com)
- The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
Proteins4
- Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
Transgenic mice1
- To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
Differentiation1
- Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)
Induces3
- Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
- Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
- Recently we found that direct contact of the MV glycoproteins hemagglutinin (H) and fusion protein (F) with the cell surface of lymphocytes or lymphoid cell lines induces a dominant negative signal in the contacted cells leading to this proliferative inhibition (33 44 It is likely that this unfavorable signal is usually transduced by a receptor present on the surface of lymphoid cells. (careersfromscience.org)
Antibody3
- The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
- For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
- Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
Cellular4
- Measles trojan (MV) interacts with cellular receptors on the top of peripheral bloodstream lymphocytes (PBL) which mediate trojan binding and uptake. (careersfromscience.org)
- The H protein targets the cellular receptors of the CD46 and CD150. (bestessaywriters.com)
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
- This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. (antibodies-online.com)
Tumor3
- Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
- Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
High-affinity receptor1
- A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Peripheral blood1
- One aspect of the viral immunosuppression is the proliferation inhibition in response to mitogens T-cell receptor cross-linking or recall antigens of IDH-C227 peripheral blood mononuclear cells (PBMC) isolated from patients (ex vivo) and in vitro. (careersfromscience.org)
Macrophages1
- The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
Activation4
- These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
- [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
- The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
- A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
Immunoglobulin2
- Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)
- Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
CD45RO1
- Figure 3: Characteristics of CD3/CD46-activated, sorted CD3 + CD4 + CD45RA + CD45RO + T cells. (nature.com)
Characterization1
- The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
Expression1
- Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Encodes1
- IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
Surface4
- Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
- Due to the previous development of vaccine candidates against the related highly pathogenic coronaviruses SARS-CoV and MERS-CoV, the antigen that elicits immune protection is known: the surface spike protein of SARS-CoV-2 or specific domains encoded in that protein, e.g., the receptor binding domain. (bvsalud.org)
- B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
- T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
Isoforms1
- Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
Immune system2
- The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
- Van Parijs, A. & Abbas, A. K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. (nature.com)
Phosphorylation1
- When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation. (rush.edu)
Cells8
- Figure 4: Suppressive and proliferative properties of CD3/CD46-activated CD4 + T cells. (nature.com)
- Wild-type MV strains WTFb and Wü5679 (same as TC5679 in reference 35) were isolated from patients with acute measles (Erlangen Germany 1990 and Würzburg Germany 1996 respectively [35]) and propagated on BJAB cells since these cells in contrast to B95a cells do not IDH-C227 contain EBV and express CD46 and SLAM and therefore do not exert a selective pressure for one of the receptors. (careersfromscience.org)
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
- Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
- Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
- Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
- The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
- CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)
Susceptibility1
- During and weeks after acute measles delayed-type hypersensitivity skin test responses to recall antigens are suppressed and there is an increased susceptibility to opportunistic infections which aggravates the course of the disease. (careersfromscience.org)
Viral2
- Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
- We investigated the virus-mediated SLAM modulation and the effect of SLAM engagement around the viral contact-mediated proliferation inhibition of lymphocytes. (careersfromscience.org)
Tolerance1
- These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
Deficiency1
- Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
Complexes2
- Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
- The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
Ubiquitous1
- 00:01:59.26 However, pigs, and most mammalian species, and also non-mammalian species, in fact, 00:02:07.05 express an antigen that is quite ubiquitous and that causes. (ibiology.org)
Gene1
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
Molecules1
- The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
Membrane-bound1
- Complex immunobiology of lymphotoxin (LTα) is due to multiple modalities of signal transduction, involving a soluble homotrimer and membrane-bound heterotrimers that engage at least three different receptors. (rusimmun.ru)
Responses1
- A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
Specific1
- The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
Found1
- Thus it is identical to the MV receptor recently found by Tatsuo et al. (careersfromscience.org)
Bind1
- [12] The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. (wikidoc.org)
Virus1
- The info suggest that proliferation inhibition induced by MV get in touch with is in addition to the existence or absence of the virus-binding receptors SLAM and CD46. (careersfromscience.org)
Major2
- CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)
- This graph shows the total number of publications written about "Antigens, CD98" by people in this website by year, and whether "Antigens, CD98" was a major or minor topic of these publications. (wakehealth.edu)
Human1
- The human interferon-gamma receptor. (wikidoc.org)
Profiles3
- Below are the most recent publications written about "Antigens, CD98" by people in Profiles. (wakehealth.edu)
- Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
- Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles. (rush.edu)
Cell lines1
- CD46 (3 16 23 It has been exhibited that MV can efficiently be isolated from patients using B-cell lines such as B95a (19) which lack a complete CD46 (15 28 indicating the presence of another receptor. (careersfromscience.org)