• Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and Foxp3-counteracting interleukin-6 (IL-6), lower numbers of phospho-STAT3-containing lymphocytes, and higher Foxp3 + T-cell counts in the colon. (nature.com)
  • Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. (thermofisher.com)
  • Intracellular staining of human peripheral blood mononuclear cells (PBMCs) with PCH101 antibody using the anti-human Foxp3 Staining Set and protocol reveals approximately 0.5-4% of lymphocytes staining, with the majority of staining occurring in the CD25^bright population. (thermofisher.com)
  • The immune cell markers CD4, FOXP3 and CD68 were also stained and quantified. (jcancer.org)
  • Furthermore, we found a positive correlation between stromal PD-L2 expression and the infiltration of CD68 + macrophages and CD4 + Foxp3 + Treg cells in NPC stromal tissues (Pearson correlation=0.181 and 0.098, respectively). (jcancer.org)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • These cells expand in the periphery, causing tissue infiltration and damage due to breakdown of both central (e.g., autoimmune regulator, AIRE protein dysfunction) and peripheral (FOXP3 + deficiency) tolerance mechanisms [ 3 ]. (hindawi.com)
  • RNA expression of genes involved in immune oncology and oncogenic signaling pathways was analyzed in 40 VSCC, matched for prognostic clinicopathological variables, analyzed for HPV and p53 status, and selected based on T cell infiltration. (bmj.com)
  • Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. (biomedcentral.com)
  • Intrathyroidal lymphocytic infiltration is the initial histologic abnormality in persons with autoimmune thyroid disease and can be correlated with the titer of thyroid antibodies. (medscape.com)
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. (cusabio.com)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • Differentiation into Th1 depends on the presence of IFN-γ and IL-12, which bind to receptors on the surface of CD4 T cells 5 . (bvsalud.org)
  • The distribution of CD3, CD4, CK20 and CD68, cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) antigen were determined by immunohistochemistry. (biomedcentral.com)
  • ISH of SARS-CoV-2 RNA showed positive signal which mostly overlapped with CD68 positivity. (biomedcentral.com)
  • After appropriate heat induced antigen retrieval with BOND Epitope Retrival Solution1 or 2, sections were incubated with the primary monoclonal antibody against the CD68 (clone PGM, ZSBio, China), CD3 and CD4, CMV antigen and HSV antigen (Abcam) respectively. (biomedcentral.com)
  • Results: Patients with MMR-D showed a higher T-bet/CD4 ratio ( p = 0.02), a higher rate of CD80 expression and CD8 lymphocyte infiltration compared to those with no MMR-D. Moreover, in the MMR-D group, the Treg marker FoxP-3 was not expressed ( p = 0.05). (oncotarget.com)
  • Obesity elicits immune cell infiltration of adipose tissue provoking chronic low-grade inflammation. (diabetesjournals.org)
  • The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)
  • Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
  • Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. (tilsinbreastcancer.org)
  • In these patients, the proportion of CD4 lymphocytes is lower in the thyroid than in the peripheral blood. (medscape.com)
  • The principal immunological abnormalities described for this syndrome include hypogammaglobulinaemia, B-cell lymphopaenia, CD4/CD8 ratio inversion, low T CD4 lymphocyte counts, and alteration of the mitogenic T cell response [ 4 ]. (ecancer.org)
  • Geng et al suggested that APOE modulated immune response by inhibiting antigen-activated lymphocytes [ 9 ]. (jcancer.org)
  • In order to differentiate into Th1 or Th2 cells, CD4 T cells must become antigen-activated. (bvsalud.org)
  • Results High intraepithelial infiltration with CD4 or CD8 T cells was associated with longer overall and recurrence-free survival and formed an independent prognostic factor, outperforming molecular subtype and stage of the disease. (bmj.com)
  • Lymphocyte infiltration in breast cancer: a key prognostic factor that should not be ignored. (tilsinbreastcancer.org)
  • Lymphocytes prognostic in breast cancer. (tilsinbreastcancer.org)
  • Here we demonstrate that Cd44v7 -deficient T cells - like Cd44 wild-type ( Cd44 WT ) T cells - provoked disease in two different colitis models: the model induced by CD4 + CD45RB high T-cell transfer into Rag2 -deficient mice and a new model based on ovalbumin (OVA)-specific T-cell transfer into Rag -sufficient, OVA-challenged mice. (nature.com)
  • Methods The type, location, and infiltration pattern of T cells were studied in 109 patients with primary VSCC FIGO stage I-III. (bmj.com)
  • Strong T cell infiltrated VSCC displayed a coordinated immune response reflected by a positive association between T cells and different lymphocyte and myeloid cell subsets. (bmj.com)
  • Although the aberrant activation of the T cell response observed in pSS has partially been explained by the interaction of T lymphocytes both with the ductal epithelium and the infiltrating B cells via costimulatory molecules (i.e. (biomedcentral.com)
  • In addition, tumor infiltrating mononuclear cells (TIMC) and T cell subpopulations (CD4, CD8, T-bet and FoxP-3) were quantified. (oncotarget.com)
  • We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
  • Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
  • While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
  • In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
  • MHC-II molecules drive the development, activation, and homeostasis of CD4 + T-helper cells. (hindawi.com)
  • The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
  • A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • The focus of Dr. Baker's research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. (cuanschutz.edu)
  • Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)
  • IFN-γ R1 was detected at an early stage during the active phase of disease, but the expression of positive cells remained unaltered during the remaining period of the study. (bvsalud.org)
  • CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)
  • CD4 T cells may assume different phenotypes under different stimulations, changing to Th1 and Th2 cells. (bvsalud.org)
  • Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expression was performed in early-stage and late-stage VSCC. (bmj.com)
  • T lymphocytes were analyzed for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral blood and labial gland biopsies. (biomedcentral.com)
  • Compared with the CB promoter, the dual promoter effectively decreased pullulanase-induced cytotoxic T lymphocyte responses and enabled persistent therapeutic gene expression in adult GSD IIIa mice. (jci.org)
  • We also found a positive correlation between autophagy enhancement and the increased salivary gland expression of IL-21 and IL-23, providing a further link between innate and adaptive immune responses in pSS. (biomedcentral.com)
  • Tumor-infiltrating lymphocytes in breast cancer: A new predictor for responses to therapy. (tilsinbreastcancer.org)
  • Although the cell lines did not differ in their intrinsic radiosensitivity, one of the HPV-positive tumor models, MOC1-HPV K1, showed a significantly longer growth delay after irradiation with a single dose of 15 Gy compared to parental MOC1 tumors. (biomedcentral.com)
  • Characteristics of the newly developed HPV-positive OSCC tumor models correlate with the transcriptomic profile of MOC1-HPV cell lines. (biomedcentral.com)
  • Diagnostic and therapeutic implications of tumor-infiltrating lymphocytes in breast cancer. (tilsinbreastcancer.org)
  • Tumor Infiltrating Lymphocytes - The Next Step in Assessing Outcome and Response to Treatment in Patients with Breast Cancer. (tilsinbreastcancer.org)
  • Relevance of tumor-infiltrating lymphocytes in breast cancer. (tilsinbreastcancer.org)
  • Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer. (tilsinbreastcancer.org)
  • Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)
  • Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo. (biomedcentral.com)
  • These findings suggest that CD4 + T lymphocyte autophagy could play a key role in pSS pathogenesis. (biomedcentral.com)
  • In the current study, we aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS. (biomedcentral.com)
  • Our study provides evidence for the first time that autophagy is upregulated in CD4 + T lymphocyte salivary glands from pSS patients. (biomedcentral.com)
  • Some patients with HPV-positive OSCC have a better prognosis and respond better to various treatment modalities, including radiotherapy or immunotherapy. (biomedcentral.com)
  • Retinitis is the most common manifestation of CMV disease in patients who are HIV positive. (medscape.com)
  • The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of lymphocyte B depletion and hypogammaglobulinaemia is known as Good's syndrome and may affect up to 5% of patients with thymoma. (ecancer.org)
  • Conclusions: CRC with MMR-D showed a higher CD80 expression, and CD8+ and Th1 T-cell infiltration. (oncotarget.com)
  • APOE is a potential independent biomarker for PTC and APOE expression is positively correlated with immune cell infiltration in PTC. (jcancer.org)
  • Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral transduction. (biomedcentral.com)
  • Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. (nature.com)
  • Understanding the clinical significance of PD-L2 expression, together with immune cell infiltration, might provide clues for biomarker screening in NPC immunotherapy. (jcancer.org)
  • PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes. (tilsinbreastcancer.org)
  • The increased Fas expression in intrathyroidal CD4 T lymphocytes may be the cause of CD4 lymphocyte reduction in these individuals. (medscape.com)
  • Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. (tilsinbreastcancer.org)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • We observed mucosal epithelium shedding, intestinal mucosal erosion, focal inflammatory necrosis with hemorrhage, massive neutrophil infiltration, macrophage proliferation accompanied by minor lymphocyte infiltration. (biomedcentral.com)
  • The transfer of lymphocytes or ethylene di-isocyanate (HDI), which are used in a serum from sensitized mice can cause clinical disease in naive variety of industries including polyurethane foam mice. (cdc.gov)
  • In Graves disease, B and T lymphocyte-mediated autoimmunity are known to be directed at 4 well-known thyroid antigens: thyroglobulin, thyroid peroxidase, sodium-iodide symporter and the thyrotropin receptor. (medscape.com)
  • A chest radiograph finding consistent with pneumonia and a bronchoalveolar lavage (BAL) result that is CMV positive is a common method for diagnosis. (medscape.com)
  • She is currently engaged in efforts to identify allosteric inhibitors of ITK that could be used in combination with active site kinase inhibitors to target ITK and thereby interfere with autoimmune T cell infiltration. (cuanschutz.edu)
  • In conclusion, we developed and characterized a novel immunocompetent mouse model of HPV-positive OSCC that exhibits increased radiosensitivity and enables studies of immune-based treatment approaches in HPV-positive OSCC. (biomedcentral.com)