Lymphocyte hematopoietic leukemia lymphocytic chronic b cell. Medical search. Frequent questions

MYLOTARG (gemtuzumabozogamicin) together with daunorubicin and cytarabine has been granted a positive opinion for the treatment of patient's age 15 years and above with previously untreated, de novo, CD33-positive acute chronic myelocytic leukemia (AML), except acute promyelocytic leukemia (APL). (medgadget.com)

The most commonly diagnosed blood cancers are non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma. (medgadget.com)
Hematologic Malignancie market report is segmented on the basis of type, therapy and by regional & country level.Based upontype, Hematologic Malignancie market is classified intoLeukemia, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Lymphoma,Multiple Myeloma and Others. (medgadget.com)
Additionally,Leukemia is diagnosed 10 times more often in adults than children.New cases of leukemia, lymphoma and myeloma are expected to account for 10 percent of the estimated 1,762,450 new cancer cases diagnosed in the US in 2019. (medgadget.com)
Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic myelogenous leukemia in blast crisis (90%), diffuse large B-cell lymphoma (variable), follicular center cells (70%), hairy cell leukemia (10%), and myeloma (some). (wikipedia.org)
It tends to be negative in acute myeloid leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and marginal zone lymphoma. (wikipedia.org)
CD10 is found on non-T ALL cells, which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells or lymphomas, which originate in more mature B cells. (wikipedia.org)
Indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. (nih.gov)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
These data provide the basis for advanced approaches of resistance-preventive and biomarker-guided cellular targeting of functionally relevant lymphoma driver mutations sparing normal B cells. (bvsalud.org)
In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Investigating the impact of demographic disparities on clinical outcomes in cutaneous T-cell lymphoma (CTCL): A multicenter retrospective cohort analysis. (yale.edu)
Treatment patterns and real-world effectiveness of rituximab maintenance in older patients with mantle cell lymphoma: a population-based analysis Di M, Long J, Kothari S, Sethi T , Zeidan A, Podoltsev N, Shallis R, Wang R, Ma X, Huntington S. Treatment patterns and real-world effectiveness of rituximab maintenance in older patients with mantle cell lymphoma: a population-based analysis. (yale.edu)
Bristol Myers Squibb (NYSE: BMY) today announced the first disclosure of results from the primary analysis of the pivotal TRANSCEND CLL 004 study, a Phase 1/2, open-label, single-arm multicenter study evaluating Breyanzi (lisocabtagene maraleucel, liso-cel) in adults with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). (dalycity.com)
The HDAC9 gene is located in chromosome 7p21, which is frequently amplified in B-cell tumours such as mantle cell lymphoma (MCL) and in B-cell non-Hodgkin's lymphoma cell lines. (sunderland.ac.uk)
Consistently, initial analysis of patient samples and/or publicly available microarray data highlighted high levels of HDAC9 expression in chronic lymphocytic leukemia, folicullar lymphoma and MCL. (sunderland.ac.uk)
The purpose of the study is to find out if an investigational drug called PRGN-3007 UltraCAR-T cells (PRGN-3007 T cells) can help people with ROR1-positive hematologic chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and solid tumor triple negative breast cancer (TNBC) malignancies. (moffitt.org)
About 2 to 10% of CLL cases develop into diffuse large B-cell lymphoma (called Richter's transformation). (msdmanuals.com)
Vivimusta (bendamustine hydrochloride injection) is an alkylating drug indicated for treatment of patients with chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. (rxlist.com)
The dose of Vivimusta for indolent B-cell non-Hodgkin lymphoma (NHL) is 120 mg/m2 infused intravenously over 20 minutes on Days 1 and 2 of a 21-day cycle, up to 8 cycles. (rxlist.com)
1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
Mantle cell lymphoma can have a clinical presentation very similar to that of CLL, but it is more aggressive. (medscape.com)
Several features aid in the distinction of mantle cell lymphoma from CLL. (medscape.com)
Mantle cell lymphoma expresses CD5 and CD19 but not CD23 antigen, which is expressed in CLL. (medscape.com)
Mantle cell lymphoma typically expresses FMC-7. (medscape.com)
Importantly, expression of CD20 is bright in mantle cell lymphoma, whereas it is dim in CLL. (medscape.com)
Another problem to be considered is splenic lymphoma with villous lymphocytes. (medscape.com)
The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia. (who.int)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
In our practice, hematologic neoplasms are mainly lymphoproliferative syndromes and the most common varieties are non-Burkitt non Hodgkin lymphoma, high grade lymphomas, chronic lymphocytic lymphoma and multiple myeloma. (bvsalud.org)
NK-cell lineages all of which are further incidence of leukaemia and lymphoma, and radiodiagnosis physician (for imag- classified as distinct entities including it is important to investigate whether ing). (who.int)
To avoid immunosuppression in chronic lymphocytic leukaemia (CLL), there is an association between pesti- these patients all cases were selected non-Hodgkin lymphoma (NHL), cide exposure and lymphoproliferative before initiation of chemotherapy. (who.int)

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin. (harvard.edu)
The majority of patients with chronic lymphocytic leukaemia (CLL) present incidentally due to a lymphocytosis found on routine blood tests. (rcpjournals.org)
Lymphocytosis is commonly caused by transient viral infections but can remain persistent in chronic infections (hepatitis B, hepatitis C, HIV or tuberculosis) and chronic lymphocytic leukaemia (CLL). (rcpjournals.org)
Chronic lymphocytic leukaemia is diagnosed where there are ≥5.0 10 9 /L monoclonal B lymphocytes (as confirmed by flow cytometry immunophenotyping) and a blood film confirming lymphocytosis, smudge cells and small, matureappearing leukaemia cells. (rcpjournals.org)
1 Lymphocytosis can also be seen in chronic conditions (hepatitis B, hepatitis C, HIV and tuberculosis) and in chronic lymphocytic leukaemia (CLL). (rcpjournals.org)
Chronic lymphocytic leukaemia peripheral blood film showing lymphocytosis with a population of small mature lymphocytes and numerous smear/smudge cells. (rcpjournals.org)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Stereotactic biopsy revealed infiltration by lymphocytes compatible with the diagnosis of chronic lymphocytic leukaemia (CLL). (karger.com)
Cramer SC, Glaspy JA, Efrid JT, Louis DN: Chronic lymphocytic leukaemia and the central nervous system: A clinical and pathological study. (karger.com)
Elter T, Hallek M, Engert A. Fludarabine in chronic lymphocytic leukaemia. (medscape.com)
Nicoloso MS, Kipps TJ, Croce CM, Calin GA. MicroRNAs in the pathogeny of chronic lymphocytic leukaemia. (medscape.com)

For examples, acute myelogenous leukemia and chronic myelogenous leukemia. (medgadget.com)
BOSULIF (bosutinib) has been granted a positive opinion for the treatment of adults with newly diagnosed chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML). (medgadget.com)
The image below depicts an impending retinal vein obstruction and intraretinal hemorrhage in a patient with chronic myelogenous leukemia. (medscape.com)
Chronic myelogenous leukemia (CML) is characterized by an uncontrolled proliferation of granulocytes. (medscape.com)
Acute myelogenous leukemia (AML) is a group of neoplastic disorders of the hematopoietic precursor cells of the bone marrow. (medscape.com)
The same five-year survival rate for patients diagnosed with acute myelogenous leukemia is around 14 percent, while an estimated 32 percent of patients with chronic myelogenous leukemia exceed this five-year survival period. (717698.com)
In laboratory experiments at Pennsylvania State University, researchers found that a component of Omega 3 known as Delta-12-J3 Prostaglandin or D12PGJ3 can selectively target the stem cells of chronic myelogenous leukemia or CML. (717698.com)
in particular, patients with rare diseases like spinal muscular atrophy and certain cancers such as chronic myelogenous leukemia may now be prescribed personalized medicine treatments that simply didn't exist a couple of decades ago. (cdc.gov)

For examples include acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphomas and multiple myeloma. (medgadget.com)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
Amongst them we can distinguish chronic lymphocytic leukemia, in which there is an increase in leukocytes and lymphocytes in peripheral blood and lymphomas, which are diseases of the lymph nodes with different histologies, clinical behavior and course and requiring very different treatment modalities. (bloodcellbarcelona.com)
O'Neill BP, Habermann TM, Banks P, O'Fallon JR, Earle JD: Primary central nervous system lymphomas as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia. (karger.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
Hematopoietic progenitors expressing CD10 are considered "common lymphoid progenitors", which means they can differentiate into T, B or natural killer cells. (wikipedia.org)
In leukemias, a clone of malignant cells may arise at any stage of maturation, that is, in the lymphoid, myeloid, or pluripotential stage. (medscape.com)
B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they harbor tumor-specific-stereotyped sequences in the form of point mutations that drive self-engagement of the BCR and autologous signaling. (bvsalud.org)
Human Leu T-cell differentiation antigens: quantitative expression on normal lymphoid cells and cell lines. (bdbiosciences.com)
Abstract 376: Ectopic Expression of HDAC9 in Murine Lymphoid System Leads to Altered Lymphocyte Numbers and Proliferation as Well as Predisposition to Tumorigenesis. (sunderland.ac.uk)
Within the normal lymphoid system, HDAC9 is co-expressed with BCL-6 in germinal center B-cells (∼60% of cells). (sunderland.ac.uk)
In order to examine the role of HDAC9 in the lymphoid development and pathogenesis of lymphoid malignancies we used Ig heavy chain enhancer (Eμ), which drives gene expression from early stages of B-cell development, to ectopically express HDAC9 in transgenic mice. (sunderland.ac.uk)
Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
Lymphocytes initially accumulate in the bone marrow and then spread to lymph nodes and other lymphoid tissues, eventually inducing splenomegaly, hepatomegaly, and systemic symptoms such as fatigue, fever, night sweats, early satiety, and unintentional weight loss. (msdmanuals.com)
Chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes (see the image below). (medscape.com)
Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. (hcdm.org)

Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
This is a group of diseases with varied clinical evolution and prognosis that are produced to abnormalitiers in the functioning of the hematopoietic stem cells that produce less mature elements in peripheral blood, with a defective function. (bloodcellbarcelona.com)
Peripheral blood is collected from the blood vessels, mainly from the capillaries, arteries and veins, and analyzed for the formed blood elements such as red and white blood cells, platelets and plasma. (nytimes-se.com)
Peripheral blood mononuclear cells (PBMC) were collected from healthy donors after approval by the LUMC institutional review board and informed consent according to the Declaration of Helsinki. (haematologica.org)
Furthermore, a subgroup of homozygous Eμ-fHDAC9 mice (n=16) developed tumours (81%) at middle age, and present with enlarged lymph nodes (6%) and abnormal hematopoietic elements in peripheral blood and BM. (sunderland.ac.uk)

The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients. (harvard.edu)
Multiple myeloma is a form of blood cancer that occurs in infection-fighting plasma cells (a type of white blood cell) found in the bone marrow. (canceredinstitute.org)

Correspondingly, the deletion of either murine miR-15a/16-1 or miR-15b/16-2 locus in mice is linked to B cell lymphoproliferative malignancies. (bvsalud.org)
T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
4 In addition, TCRs for minor histocompatibility antigens, including HA-1 and HA-2, have been transferred to donor-derived virus-specific T cells to treat patients with hematologic malignancies after allogeneic stem cell transplantation. (haematologica.org)
Results from TRANSCEND CLL 004 reinforce our relentless commitment to bringing the potential of CAR T cell therapy to more patients and transforming the treatment and outcomes for a broad range of hematologic malignancies," said Anne Kerber, senior vice president, head of Cell Therapy Development, Bristol Myers Squibb. (dalycity.com)
Breyanzi has shown clinically meaningful benefit across the broadest array of B-cell malignancies of any CD19-directed CAR T cell therapy and we remain dedicated to advancing innovative treatments for some of the most difficult-to-treat diseases with high unmet need. (dalycity.com)
Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. (bdbiosciences.com)

Neprilysin (/ˌnɛprɪˈlaɪsɪn/), also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. (wikipedia.org)
It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). (wikipedia.org)
Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
CD5 is intended for in vitro diagnostic use in the identification of cells expressing CD5 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. (bdbiosciences.com)
Human T-cell antigens deﬁned by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. (bdbiosciences.com)
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
Binding of a tumor antigen via the scFv activates the T cell in a major histocompatibility-independent manner which leads to a cytotoxic response [ 3 ]. (nature.com)
Furthermore, the so-called adapter CARs have been developed by splitting antigen recognition and CAR-immune cell activation. (nature.com)

The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
An accompanying proliferation of erythroid cells and megakaryocytes usually is present. (medscape.com)
Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. (thermofisher.com)
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)
Potential effects of forced CD20 expression on T-cell function were investigated by comparing CD20- and mock-transduced cytomegalovirus (CMV) specific T cells for cytolysis, cytokine release and proliferation. (haematologica.org)
Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive proliferation and accumulation of mature yet functionally incompetent lymphocytes. (medscape.com)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)

It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
Here, we demonstrate that the myeloproliferative phenotype in DKO mice correlates with an increase of hematopoietic stem and progenitor cells (HSPC) early in life. (bvsalud.org)

Prior allogeneic hematopoietic stem cell transplant (HSCT) or donor lymphocyte infusion within 6 months prior to enrollment, current acute graft versus host disease grade 2-4 by Glucksberg criteria or severity B-D by by International Bone Marrow Transplant Registry (IBMTR) index or history of severe (grade 3-4) acute graft versus host disease. (moffitt.org)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)

3 Autologous lymphocytes genetically modified with the TCR for MART-1/Melan-A have been adoptively transferred to patients with advanced melanoma. (haematologica.org)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
An autologous CAR-T or NK cell therapy comprises several steps as shown in Fig. 1 . (nature.com)

In 95% of cases, CLL is a predominantly malignant clonal disorder of B lymphocytes. (medscape.com)
Acute lymphocytic leukemia (ALL) is a malignant clonal disorder of the bone marrow lymphopoietic precursor cells. (medscape.com)
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy. (harvard.edu)
Consid- (for biopsy taking), pathologist (for bi- clonal proliferations of lymphocytes. (who.int)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)

And, malignancy in the myeloid lineage that includes precursor cells to red blood cells, platelets and white blood cells such as granulocytes. (medgadget.com)
However, unexpectedly, when both miR-15/16 clusters are eliminated, most double knockout (DKO) mice develop acute myeloid leukemia (AML). (bvsalud.org)
Moreover, in patients with CLL, significantly reduced expression of miR-15a, miR-15b, and miR-16 associates with progression of myelodysplastic syndrome to AML, as well as blast crisis in chronic myeloid leukemia. (bvsalud.org)
Using single-cell transcriptomic analyses, we presented the molecular underpinning of increased myeloid output in the HSPC of DKO mice with gene signatures suggestive of dysregulated hematopoiesis, metabolic activities, and cell cycle stages. (bvsalud.org)
CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. (thermofisher.com)
These are diseases in which bone marrow hematopoietic stem cells produce more mature elements than normal: leukocytes (chronic myeloid leukemia), red blood cells or erythrocytes (polycythemia vera) and platelets (essential thrombocythemia). (bloodcellbarcelona.com)
Hence, rpS3 may play a major role in B-cell growth and differentiation and be associated with acute myeloid leukemia along with PML. (bmbreports.org)
In CML, the abnormal cells are a type of blood cell called myeloid cells. (717698.com)
CML is often suspected on the basis of a complete blood count, which shows increased granulocytes of all types, typically including mature myeloid cells. (717698.com)
As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
From the article: 'In a real-world setting of new and emerging targeted therapies, a study found that patients with acute myeloid leukemia (AML) had unmet needs that hindered their ability to receive genomic testing and treatment options, especially for older patients with AML. (cdc.gov)

CD10 is of use in hematological diagnosis since it is expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. (wikipedia.org)
The recirculating lymphocytes selectively infiltrate the lymph nodes, the spleen, and the liver. (medscape.com)
Intro Chronic lymphocytic leukemia (CLL) probably the most common type of adult leukemia in Traditional western countries is seen as a the progressive build up of phenotypically adult monoclonal LY2784544 (Gandotinib) B lymphocytes in the peripheral bloodstream lymph nodes and bone tissue marrow. (cell-signaling-pathways.com)
Lymphocytosis should always be monitored and investigated, including carrying out a full blood count with white cell differential, blood film and examination of lymph nodes and abdomen. (rcpjournals.org)
1 CLL involves a malignant monoclonal expansion of B lymphocytes, with progressive infiltration into lymph nodes and sites of haematopoiesis including liver, spleen and bone marrow. (rcpjournals.org)

Many patients with chronic leukemias are asymptomatic. (medscape.com)
Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
BENDEKA ® is indicated for the treatment of patients with chronic lymphocytic leukemia. (guidelinecentral.com)
TRANSCEND CLL 004 is the first pivotal multicenter study of a CD19-directed CAR T cell therapy for patients with relapsed or refractory CLL after progression on a BTKi and BCL2i. (dalycity.com)
Patients with CLL typically have a higher-than-normal white blood cell count, which is determined by a complete blood count (CBC). (medscape.com)
During the chronic phase, patients have less than 10 percent blast in their blood or bone marrow samples and usually respond to standard treatments. (717698.com)
The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
Fertile male and female patients must be willing to use a contraceptive method before, during, and for at least 12 months after the last T cell infusion. (moffitt.org)
1 Patients with active T-PLL present with an exponential rise of post-thymic T cells with prolymphocytic morphology, hepatosplenomegaly, skin rash, lymphadenopathy, and effusions. (haematologica.org)
however, nearly all cases eventually relapse, and allogeneic stem cell transplantation remains the only curative treatment option for a small subset of patients. (haematologica.org)
Opdivo (nivolumab), a cancer immunotherapy drug, was approved for the treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) with disease progression on or after a platinum-based therapy.6 Opdivo nivolumab) inhibits the programmed death receptor-1 (PD-1), a protein expressed on the cell surface, which blocks the body's immune system from attacking tumors. (canceredinstitute.org)
The cancer immunotherapy drug, Keytruda (pembrolizumab), was approved for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1, the ligand for the PD-1 receptor8, as determined by an FDA-approved test called the PD-L1 IHC 22C3 pharmDx test, which is the the first test designed to detect PD-L1 expression in NSCLC 9. (canceredinstitute.org)
Pembrolizumab is a highly selective programmed cell death protein 1 (PD-1)-blocking antibody that has shown efficacy, leading to survival benefit and durable responses, in some patients with non-small cell lung cancer (NSCLC)10. (canceredinstitute.org)
Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). (medscape.com)
Improved survival in chronic lymphocytic leukemia in the past decade: a population-based study including 11,179 patients diagnosed between 1973-2003 in Sweden. (medscape.com)
In my first paper, we describe the entire antibody discovery process where we developed antibodies capable of depleting chronic lymphocytic leukemia (CLL) cells using primary cells obtained from patients. (lu.se)
Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
Among the 16 patients with chronic lymphocytic leukemia, 6 (37.5%) received Rituximab. (bvsalud.org)
The distribution of the patients with chronic lymphocytic leukemia was as follows: COP 31.25%, CHOP 31.25%, RCVP 12.5% and R-CHOP 25% and 68.75% had full response. (bvsalud.org)

Chronic lymphocytic leukemia (CLL) is a disease of the blood and bone marrow that results in the overproduction of abnormal lymphocytes. (medillsb.com)
The time for 1 cell division is prolonged with respect to that of normal bone marrow blast cells. (medscape.com)
The bone marrow is gradually replaced by blast cells. (medscape.com)
Polymerase chain reaction -based qualitative and quantitative tests detect and measure the BCR-ABL1RNA transcripts in leukemia cells taken from blood or bone marrow samples. (717698.com)
Bone marrow is the soft tissue in the center of bones that helps form all blood cells. (717698.com)
Immunophenotypic analysis of B-cells isolated from bone marrow (BM) revealed an absence of cells expressing the pre-B/immature-B cell markers normally associated with C-E Hardy's fractions. (sunderland.ac.uk)
The mouse is the most sensitive species where the target organs are bone marrow, ovary and testis a NOAEL for repeat dose toxicity in the chronic studies has not been established due to neoplasia-related toxicity. (europa.eu)
Anemia secondary to bone marrow involvement with CLL, splenic sequestration of red blood cells, and autoimmune hemolytic anemia associated with a positive Coombs test are included in the differential diagnosis of a patient with anemia who has CLL. (medscape.com)
Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)

Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
CD20-transduced T cells with and without co-transferred T-cell receptor were efficiently eliminated by complement dependent cytotoxicity induced by therapeutic anti-CD20 antibody rituximab. (haematologica.org)
Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6. (hcdm.org)

Elliott MA, Letendre L, Li C-Y, Hoyer J, Hammack JE: Chronic lymphocytic leukemia with symptomatic diffuse central nervous system infiltrating responding to therapy with systemic fludarabine. (karger.com)

Hematologic neoplasms are abnormal and anarchic proliferations of hematopoietic cells with a medullary or peripheral starting point. (bvsalud.org)

According to Leukemia Research Foundation, in2019, every three minutes, someone is diagnosed with blood cancer more than 175,000 new cases are expected in the United States. (medgadget.com)
O-GlcNAcylation of STAT5 could be required for nutrient sensing and metabolism of cancer cells. (nature.com)
16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)
in other types, most notably lung cancers, neprilysin is downregulated, and thus unable to modulate the pro-growth autocrine signaling of cancer cells via secreted peptides such as mammalian homologs related to bombesin. (wikipedia.org)
The presence of these cancer cells impairs the production of the normal blood cells needed to fight disease and infection. (medillsb.com)
The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. (bvsalud.org)
Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. (haematologica.org)
Cancer Cell. (harvard.edu)
The lymphocytes attack the patient's cancer cells because they don't see them as belonging to the body. (717698.com)
Cancer cells are dangerous as they divide very quickly and an efficient primer treatment with chemotherapy must stop their multiplication. (717698.com)
And basically, yeah, we're taking this immune cell that has failed to kill the cancer cell. (717698.com)
Decreased histone acetylation is a hallmark of cancer cells and increased HDAC expression or their mistargetting to specific gene promoters has been associated with a variety of tumors. (sunderland.ac.uk)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)
CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. (medscape.com)
Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
They work by recognizing and finding specific proteins or targets on cancer cells. (lu.se)
For example, you have a cancer cell, and you want antibodies that can kill the cancer cell or activate a certain immune cell or so on, and then you develop the antibodies based on this. (lu.se)
CLL is considered the most common form of leukemia in adults and is a type of cancer that starts in white blood cells, known as lymphocytes. (lu.se)

These are diseases produced by the abnormal function of plasma cells. (bloodcellbarcelona.com)

Global Acute Lymphocytic Leukemia Market: Trend Analysis and Forecast to 2022 - The report on Acute Lymphocytic Leukemia Market by Infinium Global Research analyzes over the period of 2015 to 2022. (powershow.com)

Flow cytometry is an important methodology for the diagnosis of chronic B-cell lymphoproliferative diseases (B-CLPD), however, sometimes the cytometrist does not find sufficient elements for the exact definition of the pathological entity involved. (bvsalud.org)

See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)

Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. (lookformedical.com)
Majumdar G: Chronic lymphocytic leukemia with cerebral infiltration. (karger.com)

T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)

And all cancers start with acquiring a mutation in a cell. (717698.com)

Herpes simplex virus thymidine kinase (HSV-tk) is a well-established suicide gene that has been successfully used to control GvHD following donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation. (haematologica.org)
Allogeneic stem cell transplantation is the only known curative therapy for CLL. (medscape.com)

Acute Lymphocytic Leukemia Drug Pipeline Analysis and Therapeutic Assessment, H2 2016 - Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)
Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)

Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
1 , 2 The anti-tumor effect of DLI is mediated by donor T cells recognizing allo-antigens on the malignant cells of the recipient. (haematologica.org)
Transfer of HSV-tk to DLI preserves the beneficial anti-tumor effect and allows in vivo elimination of donor T cells if severe GvHD occurs. (haematologica.org)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

Flow cytometry analysis of CD19 was performed by staining Raji CD19 Knock out cells with 0.25 µg Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ (Product # 12-4714-82, yellow histogram) or 0.25 µg CD19 Monoclonal Antibody (HIB19), PE, eBioscience™ (Product # 12-0199-42, blue histogram). (thermofisher.com)
Alemtuzumab is a recombinant humanized anti-CD52 monoclonal antibody against a glycosylated, glycosylphosphatidylinositol-anchored, cell-surface protein (CD52) which is expressed at high levels on T and B lymphocytes. (ashpublications.org)
Darzalex (daratumumab) is a monoclonal antibody that targets a cell surface protein called CD38, which is highly and uniformly expressed on myeloma cells. (canceredinstitute.org)

This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. (wikipedia.org)
Surprisingly, the cells closest to the last stimulatory event bore high levels of smIG, and stimulating via TLR9 and smIG yielded a phenotype more consistent with the in vivo setting. (bvsalud.org)

In vitro functional clonogenic assays for IL-7 responsive BM-derived B-cell progenitors demonstrated an increase (∼50%) in colony numbers in the transgenic BM. (sunderland.ac.uk)
CD6 is expressed in T cells 1 , medullary thymocytes 1 , a subset of NK cells 2 , some hematopoietic progenitors 3 and a small group of B lymphocytes. (hcdm.org)

Either you make too many of a certain subset of blood cells or their maturation is interrupted, their ability to mature is interrupted and you stopped making enough of these blood cells. (717698.com)

Clinical Applications of Flow Cytometry: Quality Assurance and Immunophenotyping of Lymphocytes: Approved Guideline. (bdbiosciences.com)

OUTLINE: This is a dose-escalation study of LMB-2 immunotoxin-treated, selectively-depleted donor T cells. (knowcancer.com)
LMB-2 immunotoxin is added to the PBMCs in order to selectively deplete T cells from the donor PBMCs. (knowcancer.com)

Lymphocytosis is defined as a lymphocyte count of ≥5.0 × 10 9 /L and is commonly caused by transient viral infections. (rcpjournals.org)
The B cells become continuously activated by acquisition of mutations that lead to monoclonal B-cell lymphocytosis (MBL). (msdmanuals.com)

Some chronic leukemias enter a blast phase where the clinical manifestations are similar to the acute leukemias. (medscape.com)
Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. (hindawi.com)
The durable complete responses observed with liso-cel in the TRANSCEND CLL 004 trial are remarkable and represent a major step in bringing a personalized, T-cell-based treatment approach delivered as a one-time infusion into clinical practice for a complex and historically incurable disease. (dalycity.com)
In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
Klepfish A, Gilles L, Ioannis K, Eliezer R, Ami S. Enhancing the action of rituximab in chronic lymphocytic leukemia by adding fresh frozen plasma: complement/rituximab interactions & clinical results in refractory CLL. (medscape.com)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features. (cdc.gov)

A study by Wang et al found that when they studied the landscape of somatic mutations in chronic lymphocytic leukemia, pre-mRNA splicing was an important cellular process. (medscape.com)

CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)

Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)

In vivo experiments confirm epitope-selective cytolysis in xenograft models in female mice using engrafted IGLV3-21R110 expressing cell lines or primary CLL cells. (bvsalud.org)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
6 In addition, independent annexin V/Hoechst assays of primary T-PLL cells on NK-Tert stromal support demonstrated modest single-agent activity of ibrutinib ( Figure 1D , Online Supplementary Figure S2A ). (haematologica.org)

The most recent guidelines from the International Workshop for CLL (iwCLL) state that the diagnosis requires the presence of at least 5000 B-lymphocytes/μL for at least 3 months. (medscape.com)

Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Subsequently, cells are transduced with CAR-encoding genes using (mostly) viral vectors. (nature.com)

Autoimmune side effects, however, remain a risk, emphasizing the relevance of a suicide mechanism allowing in vivo elimination of infused T cells. (haematologica.org)
Renegade T cell clones and autoimmune disease. (harvard.edu)
Autoimmune hemolytic anemia Hemolytic Anemia Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). (lecturio.com)
Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)

Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. (wikipedia.org)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
SLP-76 7 , T cell-specific adaptor protein 8 , TCR/CD3 complex 9 and Syntenin-1. (hcdm.org)
Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)

Global Acute Lymphocytic/Lymphoblastic Leukemia Therapeutics Market - The Global Acute Lymphocytic/Lymphoblastic Leukemia Therapeutics Market witnessed a rapid growth in the historic period from 2016 to 2019 and is anticipated to witness significant growth during the forecast period. (powershow.com)

The neoplastic cell is a hypoproliferative, immunologically incompetent small lymphocyte. (medscape.com)

A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. (harvard.edu)

2 , 3 Alemtuzumab is also FDA-approved for B-chronic lymphocytic leukemia (B-CLL) under the brand name Campath and used off-label for immune disorders such as graft-versus-host disease and aplastic anemia, and occasionally as a part of the conditioning regimen for solid organ and hematopoietic stem cell transplantations. (ashpublications.org)
According to the SUN criteria, disease is further classified according to onset (sudden or insidious), duration (limited or persistent), and course (acute, recurrent, or chronic). (dovepress.com)
Adverse side effects, however, may occur and lead to severe autoimmunity or graft-versus-host disease (GvHD), emphasizing the relevance of a suicide mechanism that allows efficient in vivo elimination of infused T cells. (haematologica.org)
A polymorphism and disease progression in chronic lymphocytic leukemia. (medscape.com)

Donor T cells may also induce GvHD due to recognition of allo-antigens on non-malignant tissues of the patient. (haematologica.org)

Follicular dendritic cells also express CD19. (thermofisher.com)

The data support the broad value of CD20 as safety switch in adoptive T-cell therapy. (haematologica.org)
In this study, we investigated the use of CD20 as safety switch after retroviral transfer to T cells with different cytomegalovirus (CMV) specificities, and conclude that CD20 may be broadly applicable as safeguard in adoptive T-cell therapy. (haematologica.org)

Moreover, we will review the disadvantages of CAR-T cell therapy and propose several comprehensive recommendations which might guide its development. (hindawi.com)
Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)

Anatomy39

Organisms20

Diseases41

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes49

Information Science3

Health Care2

Acute promyelo1

Lymphoma36

Leukaemia11

Myelogenous leukemia8

Lymphomas5

Lymphoid13

Peripheral blood8

Multiple Myeloma2

Malignancies12

Antigen18

Proliferation7

Stem and progenitor cells2

HSCT2

Autologous4

Clonal5

Myeloid11

Lymph5

Patients23

Bone9

Receptor5

Diffuse1

Neoplasms1

Cancer23

Abnormal1

20221

Diagnosis of chronic1

Differentiate2

Infiltration2

Prolymphocytic Leukemia1

Cancers1

Allogeneic stem cell trans2

Oncology2

Tumor7

Monoclonal antibody3

Phenotype2

Progenitors2

Subset1

Immunophenotyping1

Selectively2

Lymphocytosis2

Clinical8

Mutations1

Malignant cells1

Tumors1

Primary3

50001

Differentiation4

Genes1

Autoimmune4

Protein5

20161

Incompetent1

Genetically1

Disease4

Antigens1

Follicular1

Adoptive2

Therapy2