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  • tumor
  • Tumor-infiltrating lymphocytes (TILs) have been shown to directly attack tumor cells in a variety of types of cancer, and multiple independent studies have demonstrated that the presence of TILs is strongly correlated with increased survival. (fhcrc.org)
  • They also found that low counts were associated with a lower overall survival rate, even when they accounted for patient age, tumor stage and metastasis. (bio-medicine.org)
  • adaptive
  • These peptides are presented on the surface of cells by human leukocyte antigen molecules for binding by T cell receptors (TCRs) on the surface of T-lymphocytes, the primary mediators of the cellular adaptive immune response. (fhcrc.org)
  • Lymphocytes include natural killer cells (Phagocytes) (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). (wikipedia.org)
  • The lymphocytes involved in adaptive immunity (i.e. (wikipedia.org)
  • Leukocytosis
  • Leukocytosis is white cells (the leukocyte count) above the normal range in the blood. (wikipedia.org)
  • and leukocytosis in which eosinophil count is elevated is eosinophilia. (wikipedia.org)
  • An extreme form of leukocytosis, in which the WBC count exceeds 100,000/µL, is leukostasis. (wikipedia.org)
  • For lung diseases such as pneumonia and tuberculosis, WBC count is very important for the diagnosis of the disease, as leukocytosis is usually present. (wikipedia.org)
  • cells
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (fpnotebook.com)
  • Lymphocytes are white blood cells that play an important role in the immune system. (reference.com)
  • Lymphocytes are made up of NK cells (natural killer cells), T cells and B cells. (reference.com)
  • T-PLL has the immunophenotype of a mature (post-thymic) T-lymphocyte, and the neoplastic cells are typically positive for pan-T antigens CD2, CD3, and CD7 and negative for TdT and CD1a. (wikipedia.org)
  • Lymphocytes normally represent 20 to 40% of circulating white blood cells. (wikipedia.org)
  • The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. (wikipedia.org)
  • Effector lymphocytes function to eliminate the antigen, either by releasing antibodies (in the case of B cells), cytotoxic granules (cytotoxic T cells) or by signaling to other cells of the immune system (helper T cells). (wikipedia.org)
  • Lymphocytes can be further classified as T cells, B cells, and natural killer cells. (wikipedia.org)
  • receptors
  • In this study, we report a robust approach based on unique molecular identifiers that allows profiling Ag receptors for several hundred to thousand lymphocytes while preserving qualitative and quantitative information on clonal composition of the sample. (sigmaaldrich.com)
  • important
  • Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins. (fpnotebook.com)
  • The number of leukocytes in the blood is often an indicator of disease, and thus the WBC count is an important subset of the complete blood count. (wikipedia.org)
  • Lung
  • Types of blood test include a full or complete blood count, erythrocyte sedimentation rate and blood metabolic panel, according to the National Heart, Lung. (reference.com)
  • Human Immun
  • The purpose of this study is to test the safety of an investigational medication, TXA127, and its ability to increase T-lymphocyte counts, specifically CD4+ T-lymphocytes, in persons infected with human immunodeficiency virus who are taking highly active anti-retroviral therapy. (clinicaltrials.gov)
  • cell
  • Specifically, it remains challenging to obtain comprehensive information on the clonal composition of small lymphocyte populations, such as Ag-specific, functional, or tissue-resident cell subsets isolated by sorting, microdissection, or fine needle aspirates. (sigmaaldrich.com)
  • therapy
  • This is a Phase I, single institution, open-label, within-dosing-cohort-schedule randomized, dose escalation study of TXA127 in HIV-infected subjects with CD4+ T-lymphocyte counts less than 250 per mm3 who have responded to highly active retroviral therapy (HAART). (clinicaltrials.gov)
  • range
  • Both doses of ozanimod reached anticipated range of 60-70% decreased lymphocyte count, and were well tolerated, with a safety profile consistent with a previous phase 1 study in healthy volunteers. (wikipedia.org)