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  • Mice
  • B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. (jax.org)
  • Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NODJg mu(null)) are resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). (jax.org)
  • Stable T and B lymphocyte repopulation was achieved in irradiated NODJg mu(null) mice reconstituted with syngeneic bone marrow admixed with NOD B lymphocytes. (jax.org)
  • IDDM susceptibility was restored in NODJg mu(null) mice reconstituted with syngeneic marrow plus B lymphocytes, but not with syngeneic marrow only. (jax.org)
  • T cell responses to GAD were restored only in NODJg mu(null) mice reconstituted with syngeneic marrow plus B lymphocytes. (jax.org)
  • Hence, B lymphocytes appear to contribute to IDDM in NOD mice as APC with a preferential ability to present certain beta cell Ags such as GAD to autoreactive T cells. (jax.org)
  • Study from Itga3 (α3 integrin)/Gpr56 double knockout mice showed increased neuronal overmigration compared to Gpr56 single knockout mice, indicating cooperation of GPR56 and α3β1 integrin in modulation of the development of the cerebral cortex. (wikipedia.org)
  • immunology
  • The Max Planck Society for the Advancement of Science is an independent, non-profit research organization that primarily promotes and supports research at its own institutes Immunology Molecular Biology Cellular Microbiology Parasitology Lymphocyte Development Molecular Immunology International Max Planck Research School for Infectious Diseases and Immunology(IMPRS-IDI). (wikipedia.org)
  • activity
  • Fischer A, Dupandy A, Griscelli C (1981) Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. (springer.com)
  • Role
  • In this role he facilitates business relationships and economic cooperation between Poland and the U.S. and assists in cultural exchanges. (wikipedia.org)