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  • gene
  • We identified a potentially novel connection between rs10846744, the immune checkpoint inhibitor lymphocyte activation gene 3 ( LAG3 ), and atherosclerosis. (jci.org)
  • In contrast, the amount of pol II recruited to promoters was essentially the same with or without activation, suggesting that enhanced gene expression in response to LPS+IL-4 is not regulated by pol II recruitment. (cancer.gov)
  • These results suggest that under basal conditions pol II complexes are in closed confirmations and activation promotes complex opening and gene expression. (cancer.gov)
  • The γc glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. (wikipedia.org)
  • rheumatoid
  • In addition to its reactivity to gut-associated lymphoid tissues, Act-1 antibody also stains large numbers of lymphocytes in rheumatoid synovium, and has been shown by Dr. A. A. Ansari of Emory University to prevent or delay onset of AIDS in a monkey-model of Simian Immunodeficiency Virus-induced AIDS. (wikipedia.org)
  • antibody
  • Williams J., Deloria D., Hansen J.A., Dinarello C., Loertscher J., Shapiro H., Strom T., 1985, The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 (64.1) Monoclonal antibody and purified interleukin. (springer.com)
  • Dr. Lynn Baird's group showed the antibody reacted with a single protein band of 63Kd, and Dr. Atul Bhan's group showed that it stained tissue lymphocytes but did not react with non-lymphoid tissues. (wikipedia.org)
  • Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). (wikipedia.org)
  • complexes
  • The answer to this riddle emerged from the experiment summarized in Table VI, which showed that as little as a 2-fold molar excess of monovalent ligand could thwart primary B cell activation by multiply substituted hapten carrier complexes. (jimmunol.org)
  • macrophages
  • TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)," Biochemical and Biophysical Research Communications , vol. 396, no. 3, pp. 721-725, 2010. (hindawi.com)
  • CD48 interaction with CD2 has been shown to promote lipid raft formation, T cell activation and the formation of caveolae for macrophages through cell signal transductionthe via GPI moieties. (wikipedia.org)
  • Kv1.3-channels are important for the activation of T-lymphocytes, and thus for the activation of macrophages. (wikipedia.org)
  • role
  • The levels of surface expression of IgD isotype has been associated with differences in B cell activation status but their role in serum is poorly understood. (wikipedia.org)
  • cell
  • Class-switching is mediated by the AID (activation-induced cytidine deaminase) enzyme and only occurs after the B cell binds an antigen through its B cell receptor, and is further activated through interaction with a T helper cell. (wikipedia.org)
  • Pathways
  • Signaling pathways are often inactivated by enzymes that reverse the activation state and/or induce the degradation of signaling components. (wikipedia.org)
  • primary
  • Furthermore, the manner through which activation thresholds might be established, as well as how this could accommodate affinity and kinetic differences between primary and secondary responses, was unexplored territory. (jimmunol.org)
  • Receptor
  • This result offered a profound conceptual insight: receptor cross-linking and the resultant aggregation mediated by multivalent ligand must be the ultimate determinant of activation. (jimmunol.org)
  • Class-switching is mediated by the AID (activation-induced cytidine deaminase) enzyme and only occurs after the B cell binds an antigen through its B cell receptor, and is further activated through interaction with a T helper cell. (wikipedia.org)
  • affinity
  • Furthermore, the manner through which activation thresholds might be established, as well as how this could accommodate affinity and kinetic differences between primary and secondary responses, was unexplored territory. (jimmunol.org)
  • naive
  • Secondary or peripheral lymphoid organs, which include lymph nodes and the spleen, maintain mature naive lymphocytes and initiate an adaptive immune response. (wikipedia.org)
  • cellular
  • The system also includes all the structures dedicated to the circulation and production of lymphocytes (the primary cellular component of lymph), which also includes the bone marrow, and the lymphoid tissue associated with the digestive system. (wikipedia.org)