Lymphoblasts lymphoid precursor cells. Medical search. Frequent questions

Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
The tumor cells are clonal and characterized by an increased expression of several cellular oncogenes. (biomedcentral.com)
Any lymphoma may have a leukemic phase where the abnormal clonal cells appear in the circulation. (kuality.ca)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). (biomedcentral.com)
ALL cells can be recognized by their clonal rearrangement of immunoglobulin and T-cell receptor genes, expression of gene fusions, and leukemia-associated immunophenotypes. (ashpublications.org)
Because ALL cells arise from the oncogenic transformation of a single lymphoid precursor, they have clonal antigen-receptor (immunoglobulin and/or T-cell receptor) gene rearrangements in most cases, which can be used to distinguish ALL cells from normal lymphoid cells (expressing gene rearrangements with different sequences) and nonlymphoid cells (lacking the rearrangements). (ashpublications.org)
1. Launch Acute lymphoblastic leukemia (ALL), the most frequent childhood cancer, is certainly a heterogeneous disease occurring because of the malignant clonal proliferation of lymphoid progenitors [1]. (cancer-pictures.org)

Acute lymphoblastic leukemia, also known as acute lymphocytic leukemia or acute lymphoid leukemia (ALL), is an acute form of leukemia, or cancer of the white blood cells, characterized by the overproduction and accumulation of cancerous, immature white blood cells, known as lymphoblasts. (kuality.ca)

The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
[ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice. (biomedcentral.com)
Expression of B cell-stimulatory cytokines IL-1β, IL-6, IL-10, IL-12 p40 , IL-13 and TNFα and HIV proteins p17, gp120 and nef were elevated in the Tg mice with lymphoma. (biomedcentral.com)
Increased expression of HIV proteins and the B-cell stimulatory factors is consistent with the interpretation that one or more of these factors play a role in lymphoma development. (biomedcentral.com)
Human Immunodeficiency Virus Type I (HIV-1) infection is associated with an elevated incidence of B-cell non-Hodgkin's lymphoma (NHL) and in recent years also with Hodgkin's lymphoma [ 1 ]. (biomedcentral.com)
the most common are diffuse large B-cell lymphoma and Burkitt's lymphoma [ 1 ]. (biomedcentral.com)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
Aggressive NK-cell leukemia (also called aggressive NK-cell lymphoma, or ANKL), is a very rare type of NHL. (kuality.ca)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
I am an MRC Clinician Scientist and Honorary Consultant Paediatric Oncologist, providing a clinical service for young people with lymphoma or Langerhans cell histiocytosis at the Great North Children's Hospital, Newcastle. (ncl.ac.uk)
Our aim is to deeply characterise paediatric B-cell non-Hodgkin lymphoma to provide a comprehensive understanding of disease initiation and evolution in response to therapy. (ncl.ac.uk)
EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
B-lymphoblastic leukemia / lymphoma with t(v;11q23.3) is a neoplasm of lymph oblasts committed to the B-cell lineage in which the blasts harbor a translocation between KMT2A (also called MLL) at band 11q23/3 and any of a large number of fusion partners. (cancer.gov)
Earlier research showed that the number of Treg cells may be either elevated or reduced in Hodgkin disease and adult B cell lymphoma. (cancer-pictures.org)

Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)

Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
Chronic B cell activation may drive proliferation of antigen-selected B cell clones that accumulate genetic lesions and ultimately undergo neoplastic transformation. (biomedcentral.com)
Increasing evidence indicates that EBV miRNAs target the host mRNAs involved in cell proliferation, apoptosis and transformation. (ijbs.com)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)

Cells within the hematopoietic islets in the bone marrow contain red blood cells, granulocytes ( neutrophils , eosinophils , basophils ), monocytes and macrophages , lymphocytes , platelets , and their precursors. (wikilectures.eu)
The lymphoid precursor cell differentiates into pre-T-lymphocytes (→ T-lymphocytes) and pre-B-lymphocytes (→ B-lymphocytes → plasmocytes). (wikilectures.eu)
As a precursor and main energy source for nucleic acid biosynthesis, glutamine induces mitosis and differentiation of lymphocytes and macrophages to proliferate, and increases the production of cytokines such as TNF and IL-1 and mRNA synthesis of phospholipids. (voltrx-global.com)
It was previously thought that lymphocytes and macrophages derived their energy primarily from the oxidation of sugar, but it is now clear that these cells also use glutamine for energy, and that glutamine is utilized similarly to, if not more than, glucose. (voltrx-global.com)
Lymphocytes are a class of cell lines with immune recognition functions and can be divided into T lymphocytes (aka T cells), B lymphocytes (aka B cells) and natural killer (NK) cells according to their migration occurrence, surface molecules and functions. (voltrx-global.com)
When stimulated by antigen, T lymphocytes are transformed into lymphoblasts, which then differentiate into sensitized T lymphocytes and participate in cellular immunity, and their immune functions are mainly to fight against intracellular infections, tumor cells and allogeneic cells, etc. (voltrx-global.com)
while B lymphocytes are transformed into plasma cells, which then differentiate into plasma cells, produce and secrete immunoglobulins (antibodies) and participate in humoral immunity, and their functions are to produce antibodies, present antigens, and secrete NK cells do not depend on antigen stimulation but spontaneously exert cytotoxic effects and have the role of killing target cells. (voltrx-global.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
A slow clearance of leukemic cells by the initial course of chemotherapy, as measured by the morphologic analysis of peripheral blood or bone marrow smears 1 to 3 weeks from diagnosis, predicts a higher risk of relapse, but can be inaccurate because ALL blast cells are remarkably similar in appearance to bone marrow lymphoid precursors (alias hematogones) and, in some instances, to mature lymphocytes. (ashpublications.org)
The first demonstration that bone marrow samples apparently devoid of ALL cells may, in fact, contain measurable levels of leukemia (ie, "minimal residual disease" or MRD) was provided soon after the advent of polyclonal antisera against leukocyte antigens: combinations of cell markers were used to distinguish T-lineage ALL cells from normal immature and mature lymphocytes by immunofluorescence microscopy. (ashpublications.org)
Regulatory lymphocytes constitute a very interesting subpopulation of cells of the human disease fighting capability. (cancer-pictures.org)

They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)

Leukemia is a malignancy producing of white blood cells in bone marrow. (wikipedia.org)
Diagnostic workup of a patient with pre-B-cell acute lymphoblastic leukemia. (medscape.com)
Загальні відомості про лейкоз Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
Acute lymphoblastic leukemia (ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal hematopoietic cells without developing into normal B and T cells. (ejournals.ca)
Bone marrow appearance corresponds to Acute Lymphoblastic Leukemia (ALL-L2) with 60% lymphoblast infiltration and heterogeneous size into the bone marrow. (ejournals.ca)
The symptoms of ALL are indicative of a reduced production of functional blood cells, because leukemia wastes the resources of the bone marrow that are normally used to produce new, functioning blood cells. (kuality.ca)
There is a very rare slow-growing (indolent) type of NK-cell leukemia that has a more favorable prognosis. (kuality.ca)
It is called chronic NK-cell leukemia and is treated like T-cell large granular lymphocytic leukemia. (kuality.ca)
The most common type of lymphoid leukemia is B-cell chronic lymphocytic leukemia. (kuality.ca)
Immunologic cell marker studies, not previously reported in congenital leukemia, showed the lymphoblasts from each infant to be of the pre-B cell phenotype. (arizona.edu)
The subtype of pre-B cell acute lymphoblastic leukemia (ALL) which in childhood appears to confer an unfavorable prognosis, may have the same significance in neonatal ALL. (arizona.edu)
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. (oncotarget.com)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? (biomedcentral.com)
Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows good efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to improve long-term leukemia-free survival (LFS). (biomedcentral.com)
Patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) often have clinicopathological characteristics associated with poor prognosis, such as high tumor burden and high-risk gene mutations. (biomedcentral.com)
Early loss or exhaustion of CAR T cells, selection of CD19-negative clones, downregulation of CD19 expression, lineage switch of leukemia, and tumor microenvironment are important factors contributing to relapse after CAR T-cell therapy [ 9 , 10 ]. (biomedcentral.com)
The combination of CAR T-cell therapy and allo-HSCT has been suggested to reduce the relapse rate of leukemia. (biomedcentral.com)
Our study revealed statistically higher percentage of Treg cells in the bone marrow than in peripheral blood in the group of 42 children with acute lymphoblastic VX-680 distributor leukemia. (cancer-pictures.org)
Inside our research, we looked into a people of Compact disc4+Compact disc25highCD127low/CFoxP3+ regulatory T cells in the bone tissue marrow and peripheral bloodstream of kids with severe lymphoblastic leukemia treated in HAS1 the Section of Pediatrics, Oncology and Hematology, Medical School of Gdansk in 2011C2016. (cancer-pictures.org)

These particular types of cancers can arise as defected mature cell types that have differentiated from hematopoietic precursor cells (often in the bone marrow) and begin to quickly proliferate through the bloodstream where it can then often infiltrate other organs and tissues. (wikipedia.org)
The lymphoblasts infiltrate nodal structures or extranodal structures and is commonly associated with large mediastinal masses with a high predilection for disseminating to bone marrow and the central nervous system (CNS). (medscape.com)
In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
Macrophages are white blood cells located in tissues and are derived from monocytes, which in turn are derived from precursor cells in the bone marrow. (voltrx-global.com)
In persons with ALL, lymphoblasts are overproduced in the bone marrow and continuously multiply, causing damage and death by inhibiting the production of normal cells (such as red and white blood cells and platelets) in the bone marrow and by spreading (infiltrating) to other organs. (kuality.ca)
A immortal human bone marrow-derived cell line cell that has the characteristics: GM-CSF- or IL-3-dependent cell line. (maayanlab.cloud)
Recent clinical data indicate that patients with complex karyotypes, adverse genes, and high pre-infusion minimal residual disease (MRD) by flow cytometry in the bone marrow, were at high risk of relapse after CAR T-cell therapy. (biomedcentral.com)
High pre-lymphodepletion lactate dehydrogenase, low pre-lymphodepletion platelet count, absence of fludarabine in lymphodepletion, persistent leukemic sequence by high throughput sequencing in bone marrow after CAR T-cell infusion, and early loss of CAR T cells have also been linked to relapse after CAR T-cell therapy. (biomedcentral.com)
Bone marrow aspirate studies show a preponderance of lymphoblasts with high nuclear to cytoplasmic (N:C) ratio, finely dispersed nuclear chromatin, and prominent nucleoli. (biomedcentral.com)
Bone marrow core biopsies demonstrate diffuse replacement of normal marrow elements by uniform sheets of round to oval lymphoblasts with indented to convoluted nuclei [ 9 ] (Figure 1 ). (biomedcentral.com)
We noticed a low negative correlation between Treg cells in the bone marrow and the percentage of blasts (= ?0.36) as well as a moderate correlation between Treg cells in the bone marrow and Hb level (= +0.41) in peripheral blood before therapy. (cancer-pictures.org)
Because of the few publications regarding the impact of Tregs over the prognosis in severe youth leukemias and investigating the percentage of these cells in the bone marrow and peripheral blood of ALL children, a following study was undertaken to understand these human relationships better. (cancer-pictures.org)

It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. (biogenex.com)

At the beginning of hematopoietic cell differentiation is the pluripotent stem cell , which differentiates into lymphoid, erythroid and myeloid precursor cells . (wikilectures.eu)
The myeloid precursor cell differentiates into megakaryoblast (→ megakaryocyte → thrombocyte), myeloblast (→ promyelocyte → myelocyte → metamyelocyte → rod → segment), monoblast (→ monocyte → macrophage), eosinophiloblast (→ eosinophil), mast cells (mast cells), and basophilic granulocytes. (wikilectures.eu)
No myeloid or erythroid precursors are seen. (medscape.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

ALL may be distinguished from other malignant lymphoid disorders by the immunophenotype of the cells, which is similar to B- or T-precursor cells. (medscape.com)
All cases had a precursor B-cell immunophenotype and there was a male predominance. (johnshopkins.edu)
At diagnosis, 80% were T-cell immunophenotype, 70% were stages III to IV, 70% had mediastinal involvement, and 9% had central nervous system (CNS) disease. (ashpublications.org)

Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. (biomedcentral.com)
Murine models for human AIDS-related B cell lymphomas have been lacking. (biomedcentral.com)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
This applies to essentially ALL so-called B-cell leukemias, which are actually lymphomas. (kuality.ca)
It is grouped with T-cell lymphomas. (kuality.ca)
Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Anti-CD30 distinguishes large cell lymphomas derived from activated lymphoid cells from histocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. (biogenex.com)

The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)

Sometimes it can be cured by chemotherapy or stem cell treatment. (wikipedia.org)
There are also growth factors for stem cells themselves, SCF (stem cell factor = c-kit-ligand) and FL (flt 3-ligand). (wikilectures.eu)
Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
INTRODUCTION: The most used preemptive therapy for Epstein Barr virus reactivation post allogeneic hematopoietic stem cell (HSCT) transplant is Rituximab, 375 mg/m2, once weekly until EBV viremia negativity. (bvsalud.org)
As part of the more general topic of stem cell biology, a number of studies have suggested that the blood contains marrow derived cells that can differentiate into fibroblasts. (ipfs.io)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR T-cell therapy has emerged as a promising strategy to prolong LFS. (biomedcentral.com)
For decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been regarded as the only well-established curative cellular therapy for patients with B-ALL. (biomedcentral.com)
No consolidation with autologous or allogeneic stem cell transplantation was performed. (ashpublications.org)

This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Others can involve the formation of tumors from lymphoblasts from within the lymphoid tissue. (wikipedia.org)
Here we report a phenotypic and molecular characterization of B cell tumors that develop in Tg26 mice. (biomedcentral.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
cells were described to induce tumors in athymic mice and to synthesize lecithin. (maayanlab.cloud)

These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. (medscape.com)

I also work closely with UK and European colleagues (iBFM, EICNHL, ESID) to develop our understanding of development of lymphoid malignancy in children with inherited immune deficiency or DNA repair disorders and provide the paediatric clinical service for Langerhans cell histiocytosis and collaborate with Newcastle Human Dendritic Cell Laboratory ( http://www.hudendritic.org/ ) run by Professor Matt Collin. (ncl.ac.uk)
Regular cells in the surroundings of malignancy cells are currently under rigorous investigation. (cancer-pictures.org)

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. (lookformedical.com)

Hematopoietic cells differentiate from progenitor cells under the influence of hematopoietic growth factors (HGFs). (wikilectures.eu)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

Erythroid precursor cells differentiate into erythroblasts (→ reticulocyte → erythrocyte). (wikilectures.eu)
Erythroid precursor cell (proerythroblast) → erythroblast → reticulocyte → erythrocyte. (wikilectures.eu)

The transformed B cell population consists of CD19 + pre-BCR + CD127 + CD43 + CD93 + precursor B cells. (biomedcentral.com)
Herein, we summarize the clinical data on consolidative allo-HSCT after anti-CD19 CAR T-cell therapy, as well as the potential factors associated with allo-HSCT benefit. (biomedcentral.com)
Finally, and most importantly, we provide recommendations for the assessment and management of r/r B-ALL patients undergoing anti-CD19 CAR T-cell therapy. (biomedcentral.com)

Cytogenetics advances of B-ALL have led to the discovery of numerous additional genetic changes, including mutations involving key cellular pathways in lymphoid development, tumor suppression, and cell cycle regulation. (biomedcentral.com)

In cancer diagnosis via histology tissue image examination, muscle regions are known to have no immune cell infiltration, and thus are ignored by pathologists. (edu.pk)
A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Fibroblasts are activated connective tissue cells characterized by synthesis of proteins of the fibrous matrix, particularly the collagens . (ipfs.io)
When tissue is injured, the predominant mesenchymal cells, the fibroblast, have been believed to be derived from the fibrocyte or possibly from smooth muscle cells lining vessels and glands. (ipfs.io)
Recently, the term "fibrocyte" has also been applied to a bloodborne cell able to leave the blood, enter tissue and become a fibroblast. (ipfs.io)

By 8-12 months of age approximately 15% of the mice with cutaneous papillomas (15/100) developed splenomegaly, lymphadenopathy and extra-nodal involvement of liver, gastrointestinal tract and central nervous system (Figure 1 C, D). H&E staining of lymphoid organs liver (Figure 1 E), lymph node (Figure 1 F) and spleen (Figure 1 H) showed all with atypical lymphomatous infiltration. (biomedcentral.com)
Lymphocyte (lymphocyte) is a type of white blood cell, the smallest white blood cell, produced by lymphoid organs, is an important cellular component of the body's immune response function. (voltrx-global.com)

This condition arises from immature T cells in more than 80% of cases and immature B cells in the remainder of cases. (medscape.com)

Complete morphologic, immunologic, and genetic examination of the leukemic cells is necessary to establish the diagnosis of ALL. (medscape.com)

3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
chronic leukemias are composed of more mature cells. (curehunter.com)

In Hodgkin's disease, the CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. (biogenex.com)

EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)

CD30 functions as a receptor for TNFSF8/CD30L and may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. (biogenex.com)

Splenic functions are reduced considerably in SCD patients due to frequent splenic infarctions reducing its capability to remove defective cells and certain organisms from circulation, this reduces immunity of person significantly thus increasing the risk of frequent infections. (atomictherapy.org)
Parvovirus B19, which causes reduced production of RBC by infecting and destroying RBC's precursor cells, is a major concern in SCD patients as the RBC lifespan is 10-20days in SCD patient as compared to 90-120days in normal individuals. (atomictherapy.org)
Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. (ipfs.io)
In patients having these risk factors, consolidative allo-HSCT after CAR T-cell therapy may prolong LFS. (biomedcentral.com)
Allo-HSCT provides optimal clinical benefit in patients with MRD-negative complete remission, typically within three months after CAR T-cell therapy. (biomedcentral.com)
Another interesting issue is a link between Treg ALL and cells among patients in the developmental age. (cancer-pictures.org)

The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). (wikipedia.org)

Intriguingly, EBV miRNAs directly suppress host antiviral immunity by interfering with antigen presentation and immune cell activation. (ijbs.com)

It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. (nih.gov)
216 sets of gene knockdowns changing fitness of each cell line relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. (maayanlab.cloud)
During B-cell development, the V, D, and J segments of the immunoglobulin genes are rearranged, with deletion and random insertion of nucleotides at the junctional sites, generating a unique gene sequence for each cell and its progeny. (ashpublications.org)

Symptoms of CNS involvement are rarely noted at initial diagnosis but are more common in T-lineage and mature B cell ALL. (medscape.com)

Symptoms may vary from chronic symptoms like retinopathy, CKD, hematopoietic ulcers to severe acute complaints like "Sickle Cell Crisis" triggered by dehydration, infections, acidosis and other obscure reasons. (atomictherapy.org)

3 days) peripheral blood mononuclear cells were stained with either PerCP-Cy™5.5 Mouse Anti-Human CD134 antibody (Cat. (bdbiosciences.com)

Differentiate to erythoid cells with erythropoietin. (maayanlab.cloud)

Immunochemistry, cytochemistry, and cytogenetic markers may also aid in categorizing the malignant lymphoid clone. (medscape.com)

In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)
In this work, we identified oroxylin A (OA), a dual GLUT1/mitochondrial fusion inhibitor, which restricted glucose catabolism of hepatocellular carcinoma cells and simultaneously inhibited mitochondrial fusion by disturbing SIRT1/PDK2/PARL axis. (biomed.news)
Human colon colorectal carcinoma cell line from a male organism. (maayanlab.cloud)

Anatomy59

Organisms16

Diseases17

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Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes49

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