Lymph nodes dendritic cells follicular. Medical search. Frequent questions

The mantle zone of the follicles contains resting and memory B-cells. (medcell.org)
These follicles, having true germinal centers, are similar to the follicles of the spleen and lymph nodes. (medscape.com)
Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
This is most likely attributable to the very different microenvironment of the bone marrow relative to lymph nodes and, in particular, the absence of follicles in bone marrow. (umn.edu)
Scattered follicles showing onion skinning of the mantle zones and hyalinised atrophic germinal centres with predominance of follicular dendritic cells and "lolipop"shaped blood vessels were noted. (iriakerala.org)
FDCs remain uninfected but can bind (via complement receptors) and retain intact infectious virions for long periods of time in the form of immune complexes and can infect CD4+ TFH cells within B cell follicles. (nanostring.com)
The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)
TNF α plays an important role in the formation of primary B cell follicles and follicular dendritic cells [ 16 ]. (hindawi.com)
Follicular dendritic cells (FDCs) are well characterized for their role in supporting B cell Ag encounter in primary follicles and in the GC LZ. (ox.ac.uk)
CRCs are also present in splenic and peripheral lymph node primary follicles. (ox.ac.uk)
Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
We applied a western blot analyses to compare the relative percentage of the di-, mono- and unglycosylated PrPC (i.e. glycoform ratio) as well as the expression of truncated PrPC forms in tissues from the CNS and lymphoid structures (lymphoid follicles, lymphocytes and follicular dendritic cells) of bovine and human. (unibo.it)
PrPC was highly glycosylated in spleen and lymphoid follicles isolated from bovine tonsils, mesenteric lymph nodes, ileal and jejunal Peyer's patches. (unibo.it)
Histologic sections show multiple lymph nodes in which there are numerous follicles, most of which are small, but with some variation in size. (medium.com)
The follicles are abnormally distributed in the cortex and medulla of the lymph node, and a few follicles are present in perinodal adipose tissue. (medium.com)
Most of the follicles also show Castleman-like changes with regression of germinal centers, decreased germinal center B-cells, increased follicular dendritic cells and some follicles show expanded mantle zones with onion skin-like changes. (medium.com)
The follicles are composed of B-cells, positive for CD20 and PAX-5 and negative for CD3 and CD5. (medium.com)
In the germinal centers of follicles, CD10+ cells are greatly decreased but BCL-6+ cells are present. (medium.com)
The antibody specific for CD23 highlights many follicular dendritic cells within the follicles. (medium.com)
The antibody specific for Ki-67 highlights germinal center cells and shows that some of the follicles are polarized with dark and light zones. (medium.com)
In other follicles replaced mostly by follicular dendritic cells, Ki-67+ cells are decreased and/or pushed to the periphery of the germinal centers. (medium.com)
9 Early PrPSc deposition could be discovered in FDCs within B cell follicles in lymphoid tissue of sufferers with vCJD 10 and in rodents inoculated with scrapie by peripheral routes. (kinasechem.com)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)

It is also expressed in follicular dendritic cells in spleen and lymph nodes. (wikipedia.org)
After oral exposure, 2 squirrel monkeys had PrPres in brain, Substantial progress has been made in testing species spleen, and lymph nodes at 69 months postinfection. (cdc.gov)
Direct activation of B cells by CD8α+ DCs was critical for optimal Clec9A-mediated antibody responses as it enabled B cells to effectively acquire help from cognate CD4+ T cells at the T/B borders within the spleen and lymph nodes. (edu.au)

Immunohistochemical analysis with a newly available monospecific anti-K19 antibody showed, also for the first time, that the cells in the normal lymph node which express K19 are the B-lymphocytes of the marginal zone, and also the follicular dendritic cells. (soton.ac.uk)
Immunohistochemical methods have shown the cells of origin to be the marginal zone B-lymphocytes and the follicular dendritic cells. (soton.ac.uk)
The immune system can remember every antigen encountered because after an encounter, some lymphocytes develop into memory cells. (msdmanuals.com)
CXCL13 was not expressed by atypical lymphocytes in all cases but did stain stromal cells consistent with follicular dendritic cells in 1 case. (umn.edu)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
In addition to lymphocytes, dendritic cells can also produce LT α [ 15 ]. (hindawi.com)
The antibody LT20 reacts with an extracellular epitope of CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. (exbio.cz)
Normal human lymphocytes from lymph node. (exbio.cz)
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). (exbio.cz)
Hultin LE, Hausner MA, Hultin PM, Giorgi JV: CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. (exbio.cz)
8 That is perhaps because B lymphocytes stimulate maturation of follicular dendritic cells (FDCs) by giving tumor necrosis aspect- (TNF-) and lymphotoxin / (LT/) trimers to lymphoid organs. (kinasechem.com)
Furthermore, B lymphocytes exert a significant organogenic function in the GALT 21,22 and so are apt to be mixed up in B cell-dependent advancement of the follicle-associated epithelium (FAE). (kinasechem.com)
Cells are slightly larger than lymphocytes . (wikidoc.org)
Unlike TFH and B cells that were potently activated in the steady-state, cross-priming of cytotoxic lymphocytes (CTLs) by Clec9A-targeted antigen required co-administration of adjuvant. (edu.au)

Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
The CD11c(high) subset is detected in mesenteric lymph nodes and spleen of BALB/c mice, but is virtually absent from C57BL/6 mice. (cnrs.fr)

Metastatic or recurrent follicular dendritic cell sarcoma (FDCS) is a disabling condition on the Compassionate Allowance List, which qualifies an individual for an expedited approval process. (callfred.com)
FDCS is a rare, malignant cancer that affects the body's follicular dendritic cells, which are cells that help sustain the functions of the body's immune system. (callfred.com)
FDCS usually occurs in the lymph nodes, but can manifest in other areas of the body implicated in the immune system's function, including the liver, spleen, bowel, and pancreas. (callfred.com)
Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT, formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia") is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. (cochinreporter.in)
CRCs are gp38(+) with low to undetectable expression of FDC markers, but CRC-like cells in the DZ are lineage marked, along with FDCs and fibroblastic reticular cells, by CD21-Cre- and Ccl19-Cre-directed fluorescent reporters. (ox.ac.uk)
11 In mouse spleens, mature FDCs have already been been shown to be essential for both prion PrPSc and replication deposition, 12,13 although prion 6H05 replication in lymph nodes may appear in the lack of mature FDCs. (kinasechem.com)

The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
The T-cell/histiocyte-rich large B-cell lymphoma signature is hallmarked by up-regulation of CCL8, interferon-γ, indoleamine 2,3 dioxygenase, VSIG4 and Toll-like receptors. (haematologica.org)
These features may be responsible for the recruitment and activation of T cells, macrophages and dendritic cells, characterizing the stromal component of this lymphoma, and may point towards innate immunity and a tumor tolerogenic immune response in T-cell/histiocyte-rich large B-cell lymphoma. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
4 In the World Health Organization (WHO) classification of 2001, T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is defined by the presence of a limited number of scattered large B cells in a background rich in T cells, with or without histiocytes. (haematologica.org)
Gene expression profiling of lymphomas clearly illustrated that apart from the characteristics of the tumor cells, the microenvironment of the tumor also defines the profile of the lymphoma, and, more importantly, plays a role in predicting the prognosis. (haematologica.org)
Angioimmunoblastic T-cell lymphoma is known to frequently involve bone marrow. (umn.edu)
However, the histologic and immunophenotypic features of angioimmunoblastic T-cell lymphoma at this site are poorly defined. (umn.edu)
We assessed 27 bone marrow specimens involved by angioimmunoblastic T-cell lymphoma from 20 patients. (umn.edu)
We conclude that the recognition and classification of angioimmunoblastic T-cell lymphoma in bone marrow are made difficult by the uncommon expression of CD10 (25%), rarity of follicular dendritic cells, and lack of CXCL13 expression at this site. (umn.edu)
By contrast, programed death-1 immunohistochemical staining and double labeling using antibodies specific for BCL-6 and CD3 were helpful in appreciating the follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma. (umn.edu)
Tru cut biopsy from omental deposit- IHC results confirm Non Hodgkin Lymphoma - Diffuse large B cell Lymphoma- non GCB type. (iriakerala.org)
The pathogenesis of PTLDs seems to be multifactorial-EBV is main one .Antigenic stimulation Plasmacytoid dendritic cells (PDCs) , regulatory T cells are other factors .Whilst most are high-grade B-cell non-Hodgkin's lymphoma (NHLs), a few are classical Hodgkin's lymphomas. (iriakerala.org)
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Lymphoma b cell. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
The diagnosis of CBCL is established by analysis of skin biopsy specimen, using histomorphology and cytomorphology, immunohistochemistry and phenotypic features, and genotyping and cytogenetic studies (see Workup of Cutaneous B-Cell Lymphoma). (medscape.com)
Marginal zone B-cell lymphoma (MZL) (MALT-type) is an indolent cutaneous lymphoma, accounting for approximately 10% of all cutaneous lymphomas. (medscape.com)
The translocation t(11;14)(q13;q32) is considered the precipitating oncogenic event that induces cell cycle deregulation in mantle cell lymphoma due to overexpression of cyclin D1 . (wikidoc.org)
However, less commonly, mutations in CCDN2 and CCDN3 have also been identified in cases of mantle cell lymphoma lacking the t(11;14) translocation. (wikidoc.org)
Pleomorphic and blastic type(together known as the blastoid variant): The pleomorphic type are similar to diffuse large B-cell lymphoma ( DLBCL ). (wikidoc.org)
Scattered non-granumloma forming epithelioid macrophages , hyalinized vessels and a few reactive T cells or mast cells are seen along with the lymphoma cells in MCL . (wikidoc.org)
Follicular dendritic cells (FDC) are a hallmark of mantle cell lymphoma and may also be involved in its pathogenesis . (wikidoc.org)
Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. (najms.com)
Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A. Histiocytic sarcoma arising in indolent small b-cell lymphoma: Report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (najms.com)
Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature. (najms.com)
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2016, case 26, and is a non-Hodgkin B-cell lymphoma, low-grade. (cap.org)
The histologic findings are diagnostic of non-Hodgkin B-cell lymphoma, low-grade. (cap.org)
The histology of small lymphoid cells which appear mature, with lymphoplasmacytic differentiation, the presence of Dutcher bodies (in some slides) along with the immunophenotypic findings of negative CD5 and CD10 and lambda light chain restricted B-cell population are consistent with a marginal zone lymphoma. (cap.org)

Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)
We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations. (biomedcentral.com)
1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
Sarcoma - as may have spindle cells. (librepathology.org)
Clear cell sarcoma ( AKA melanoma of the soft parts). (librepathology.org)
Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)
Recently, transformation of CLL into histiocytic/dendritic/Langerhans cell sarcoma (all are myeloid origin), dubbed as "transdifferentiation", has also been reported. (najms.com)
Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)

1,2 In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid follicular dendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, and salivary gland as well as basal epithelium of the respiratory system. (roche.com)
Mature T cells are stored in secondary lymphoid organs (lymph nodes, spleen, tonsils, appendix, and Peyer patches in the small intestine). (msdmanuals.com)
It is present in circulating monocytes and in most but not all tissue macrophages from different sites, including lung alveolar macrophages, liver Kupffer cells, placental Hofbauer cells, and interfollicular and sinus histiocytes of lymph nodes and tonsils, but negative in germinal center tingible body macrophages and splenic white pulp macrophages. (cellnetix.com)

Its function is clearly costimulatory for T-cell proliferation and cytokine secretion. (hostforstudent.com)
Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)
Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. (exbio.cz)
Cell proliferation in the meninges is reduced, causing loss of arachnoid fibroblasts that express Raldh2, an enzyme required for retinoic acid synthesis. (silverchair.com)
Follicular hyperplasia, marked eosinophilic infiltrate and eosinophilic abscesses, and the proliferation of postcapillary venules are characteristic histological findings. (medscape.com)

Castleman disease otherwise known as angiofollicular or benign giant lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. (iriakerala.org)

CD11c(low) langerin+ cells represent skin-derived Langerhans cells, as demonstrated by their high expression of DEC-205/CD205, maturation markers, and recruitment to skin-draining lymph nodes upon imiquimod-induced inflammation. (cnrs.fr)
Langerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. (cnrs.fr)
Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)

The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different. (haematologica.org)
8 , 10 - 12 Recently, genome-wide analysis of isolated tumor cells from NLPHL and THRLBCL revealed further similarities between the tumors cells of the two lymphomas. (haematologica.org)
Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system. (roche.com)
Based on the imaging features, differential diagnostic possibilities of lymph nodal mass/paraganglioma / hemangiopericytoma / solitary fibrous tumor were considered. (iriakerala.org)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
In 2007, the EORTC published a revised tumor-node-metastasis (TNM) staging system for non-mycosis fungoides/Sézary syndrome. (medscape.com)
Targeted delivery of tumor necrosis factor-α to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin. (southernbiotech.com)
There is increasing evidence that T cells are able to control tumor growth and survival in cancer patients, both in early and late stages of the disease. (aacrjournals.org)
However, tumor-specific T-cell responses are difficult to mount and sustain in cancer patients, and are limited by numerous immune escape mechanisms of tumor cells selected during immunoediting. (aacrjournals.org)
Likewise, bispecific antibodies for engagement of other cytotoxic immune cells were constructed, for instance, targeting Fcγ RI/CD64 on macrophages and Her2/neu or EGFR on tumor cells. (aacrjournals.org)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

ICOSL is expressed on B cells, macrophages, and dendritic cells and can be induced on nonhematopoietic cells. (hostforstudent.com)
The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen. (hindawi.com)
volume = {37}, number = {0046-8177 (Print)}, pages = {68--77}, abstract = {The mononuclear phagocyte system of human lymphoid tissue comprises macrophages and dendritic cells (DCs). (cnrs.fr)

As B-cells proliferate, they undergo somatic hypermutation (mutation of the immunoglobulin gene) in order to enhance the binding affinity between the antigens and the antibodies. (medcell.org)
The roles of the M cells include absorption, transport, processing, and presentation of antigens to subepithelial lymphoid cells. (medscape.com)
M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
Normally, only the T cells that learn to ignore the body's own antigens (self-antigens) are allowed to mature and leave the thymus. (msdmanuals.com)
T cells can potentially recognize an almost limitless number of different antigens. (msdmanuals.com)
Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
Characterization of CD4+ T cells responding to Clec9A-targeted antigens revealed that they had the phenotype, localization pattern and effector functions consistent with T follicular helper cells (TFH) that provide B cell help. (edu.au)

Splenic endothelial cell lines support development of dendritic cells from bone marrow. (southernbiotech.com)

Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)
the latter are antigen-presenting cells (APCs) that function as memory cells interacting with type 1 THCs. (medscape.com)
When memory cells encounter an antigen for the second time, they recognize it immediately and respond quickly, vigorously, and specifically to that particular antigen. (msdmanuals.com)
CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. (hostforstudent.com)
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. (exbio.cz)
An alternative approach to engage T cells for cancer therapy are antibodies, which are bispecific for a surface target antigen on cancer cells, and for CD3 on T cells. (aacrjournals.org)
These are capable of connecting any kind of cytotoxic T cell to a cancer cell, independently of T-cell receptor specificity, costimulation, or peptide antigen presentation. (aacrjournals.org)
Pioneering work by Kufer and colleagues ( 6 ) showed that CD3/target antigen-bispecific antibodies of this particular design had an exceptionally high potency, and could likewise engage CD8 + and CD4 + T cells for redirected lysis of cancer cells at very low effector to target (E:T) ratios. (aacrjournals.org)
T cells are primed by antigen-presenting cells in the T cell zones of the periarteriolar lymphoid sheaths of the spleen, the paracortex of LNs, and the dome area of Peyer's patches (PPs) * lining the intestine. (rupress.org)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)
B cells were rapidly activated through recognition of native antigen presented on the surface of CD8α+ DCs upon Clec9A-targeted immunization. (edu.au)

Crucial cells in CLE pathogenesis comprise plasmacytoid dendritic cells (pDCs) as major producers of type I IFN, T cells exerting cytotoxic effects, and B cells, previously believed to contribute via secretion of autoantibodies. (frontiersin.org)
[ 12 , 27 ] Reports have also demonstrated the presence of plasmacytoid dendritic cells in a lesion of Kimura disease. (medscape.com)

Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. (biomedcentral.com)
To investigate the role of SDF-1 in recirculation and homing in vivo we have developed a model in which human peripheral lymph nodes (huPLN) are transplanted into SCID mice. (biomedcentral.com)
This is the first description of huPLN transplantation into SCID mice, and of the functional effects of SDF-1 regarding the migration of human cells into huPLN in vivo . (biomedcentral.com)
CONCLUSION: Environmental co-exposure to peanut and PM induces peanut-specific Tfh cells and peanut allergy in mice. (bvsalud.org)
The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
Chi3l1 deficient mice respond with fewer TFH cells in the lung draining lymph nodes during the Aspergillus asthma model, and they also have less inflammatory cells in their airways. (lung.org)
mice have problems with severely-reduced cellularity of PPs (>90% much less B and T cells) 17 and from impaired intestinal immunity in a number of disease versions. (kinasechem.com)
These mice are well-suited to dissect the function of mucosa-associated immune system tissues as a result, including B cells, in the pathogenesis of enterically-initiated prion disease. (kinasechem.com)
mice, which Capn1 have normal lymphocyte counts but lack the two cytokines TNF- and LT, 26 to B cell-deficient MT mice, 27 and to RAG-1? (kinasechem.com)
mice had some FDC-M1-positive cells in their atrophic Peyers patches, but not in spleen nor in lymph nodes. (kinasechem.com)
While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. (cnrs.fr)

By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
13 Despite the similarities of their malignant cells, an important difference between the two lymphomas lies in their clinical presentation and prognosis. (haematologica.org)
Chronic inflammation of MALT from infective or autoimmune disorders can lead to the development of extranodal marginal zone B-cell lymphomas, or MALTomas. (medscape.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
B-cell lymphomas account for the majority of nodal lymphomas, whereas primary cutaneous B-cell lymphomas (CBCLs) represent 20-25% of all cutaneous lymphomas. (medscape.com)
The frequency of cutaneous lymphomas is 0.3 case per 100,000 population per year, with 10% (in the United States) to 20% (in Europe) being cutaneous B-cell lymphomas (CBCLs), marginal zone lymphomas, or follicle center lymphomas (FCLs). (medscape.com)
We analyzed 6 HCLs, 7 marginal zone lymphomas, 12 lymphoplasmacytic lymphomas, 7 follicular lymphomas, 5 chronic lymphocytic leukemias, 5 mantle cell lymphomas, 1 multiple myeloma (lymphocytic variant), and 3 bone marrows not involved by any B-cell neoplasm. (allenpress.com)
Baer MR, Krantz SB, Cousar JB, Glick AD, Collins RD. Malignant histiocytoses developing in patients with b-cell lymphomas. (najms.com)
Here, we studied the expression of 2 monocyte-derived markers, CD14 and CD169 (sialoadhesin), in reactive human lymphoid tissue as well as in a series of 51 B-cell lymphomas by immunohistochemistry on paraffin-embedded tissue. (cnrs.fr)
The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
Diffuse large cell lymphomas and their mimics. (llu.edu)
B-cell lymphomas. (llu.edu)

In addition grafts retain some of the histological features of the pretransplantation tissue, such as follicular dendritic cell-associated B-cell aggregates, lymphatic and HEV markers. (biomedcentral.com)
These cells circulate in the bloodstream and the lymphatic system. (msdmanuals.com)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
Here we show that prion replication in the GALT and subsequent neuroinvasion was independent of B cells within the mucosa-associated lymphatic tissue and that the remaining M 6H05 cells are most likely important for this process. (kinasechem.com)

However, the properties of stromal cells supporting B cells in the DZ are relatively unexplored. (ox.ac.uk)
Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests. (roche.com)
Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le NGFR (Nerve Growth Factor Receptor) (MRQ-21) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter le NGFR dans les tissus fixés au formol et enrobés à la paraffine, colorés sur les instruments VENTANA BenchMark IHC/ISH. (roche.com)
BCL-6 as a single antibody was difficult to interpret because many normal bone marrow cells are dimly positive, but BCL-6/CD3 dual staining highlighted BCL-6+ T-cells in all cases assessed. (umn.edu)
IL-4 producing TFH cells are critical in generating IgE antibody, which is a defining feature of allergic disease (another monoclonal antibody treatment used for asthma patients recognizes IgE). (lung.org)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment. (exbio.cz)
By using just one CD3-specific binding arm, such bispecific antibodies can monovalently bind to all T cells, but do so only with rather low affinity ( 7 ), which will not trigger T-cell signaling by CD3, unless the BiTE antibody is presented to the T cell in a multivalent fashion by a target cell ( 8 ). (aacrjournals.org)

Typically, neoplastic cells lack CD1a, desmin and CD45 staining. (biomedcentral.com)
Our dual staining approach confirmed that only the neoplastic cells of HCL were positive for both CD103 and Pax5. (allenpress.com)

In the distal ileum clear time-dependent variations were visible concerning the amount of PrP Sc , the tissue structures affected, and the cells involved. (biomedcentral.com)
Up to a year of age, the ileal PP represent the major gut-associated lymphoid tissue in ruminants possessing an extensive bed of follicular dendritic cells and a specialised epithelium actively engaged in the uptake and transcytosis of macromolecules from the gut, explaining the restriction of PrP Sc to this region of the gut [ 7 ]. (biomedcentral.com)
Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. (cellnetix.com)
Within lymph nodes are follicular T cells, B lymphocyte populations and dendritic cells, which are only in that tissue. (newslodi.com)
I will show data using an array of spatial profiling approaches in FFPE lymph nodes, including RNAscope in situ hybridization and NanoString® GeoMx® and CosMx™ Spatial Molecular Imager (SMI) platforms, to characterize the impact of anti-CD21 treatment on FDC-SIV trapping and the impact to the transcriptional landscape of cells within the B cell follicle tissue microenvironment and cellular immune neighborhoods surrounding infected cells. (nanostring.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Given that cellular prion protein (PrPC), is sine qua non for PrP-res formation and the development of TSE, it is well possible that tissue-specific PrPC properties may represent one of the host factors influencing the cell tropism of the infectious agent. (unibo.it)

Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b + CD11c + dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. (southernbiotech.com)

Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis. (southernbiotech.com)
8. Lui O, Mak N, Leung K. Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells. (southernbiotech.com)

The colonic mucosa is normal and there is a diffuse infiltrate of lymphoid cells in the lamina propria, submucosa, and muscularis propria extending to the serosal surface. (cap.org)

14 On the other hand, the function of intestinal B cells in prion pathogenesis pursuing oral challenge continues to be unclear. (kinasechem.com)

3-4 Anti-NGFR labels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignacies of the breast. (roche.com)
DEP-induced peanut allergy and Tfh-cell differentiation depended on IL-1 but not IL-33 signaling, whereas neither cytokine alone was necessary for UPM-mediated sensitization. (bvsalud.org)

Tfh cells are a subset of CD4+ T cells that function in the lymph node (LN) and spleen to promote survival, affinity maturation, and class switch recombination of B cells (1, 2). (hostforstudent.com)
GC B cells must cycle between these zones to achieve efficient Ab affinity maturation. (ox.ac.uk)

An important step in this process is the recognition of endogenous nucleic acids released from dying cells by various pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and other cytosolic receptors. (frontiersin.org)
Dendritic cells (DC) are endowed with an array of receptors that can be exploited for immunotherapy. (edu.au)

P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. (roche.com)

Wan-Sheng Liu ABSTRACT Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. (silverchair.com)

Antibodies specific for CD21 and CD35 did not highlight follicular dendritic cells in any biopsy specimens. (umn.edu)
CD21 highlights scattered attenuated follicular dendritic meshworks with the B-cells completely over-running and extending beyond the confines of the dendritic meshwork. (cap.org)

SDF-1 (CXCL12), a CXC chemokine, has a primary role in signalling the recruitment of haematopoietic stem-cell precursors to the bone marrow during embryonic development. (biomedcentral.com)
T cells develop from stem cells in the bone marrow that have travelled to an organ in the chest called the thymus. (msdmanuals.com)
However, normal bone marrow contains CD103-positive cells, which are not B cells, making it difficult to be certain about low-level involvement by HCL. (allenpress.com)
Paraffin blocks including representative bone marrow biopsies, clots, or lymph node biopsies were obtained from the AmeriPath Northeast files (Shelton, Connecticut). (allenpress.com)

1,2 NGFR has been shown to be a reliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants. (roche.com)

[ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)

Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. (cdc.gov)

Exposure to UPM or DEP triggered activation and migration of lung dendritic cells to draining lymph nodes and induction of peanut-specific CD4+ Th cells. (bvsalud.org)
Under polarizing inflammatory conditions, cDC2 induce Th2 responses in the lung ( 9 , 10 ), drive Th17 responses through IL-23 secretion ( 11 - 17 ), and initiate SIRPα dependent induction of T follicular helper cells (T FH ) and germinal center (GC) formation ( 18 ). (frontiersin.org)
We characterized CD4 T cells recruited to lung draining lymph nodes and found that the majority of IL-4 producing CD4 T cells express surface markers of T follicular helper cells (TFH). (lung.org)
Of greatest interest is the~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. (cdc.gov)

The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
B-cell heavy chain rearrangement study on blood sample (pure CLL) and liver metastatic NEC (pure NEC, no contamination from CLL) revealed that these two tumors shared similar monoclonal peaks. (najms.com)
Dendritic cell tumors associated with low-grade b-cell malignancies. (najms.com)

Nodal nevus - benign nevus in lymph node. (librepathology.org)

Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
1 CD103 is expressed on intraepithelial T cells, some subsets of memory T cells (CD8 positive), and dendritic cells. (allenpress.com)

The gene is expressed in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. (wikipedia.org)
Stimulation of B cells leads to the production of immunoglobulin A (IgA) and immunoglobulin M (IgM) within the Peyer patches, preventing adherence of bacteria and viruses to the epithelium and thus blocking entry to the subepithelial layers of the intestine. (medscape.com)

Mantle zone B-cells are negative for CD5. (medium.com)

Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. (ox.ac.uk)
Recent work identified a novel stromal population of Cxcl12-expressing reticular cells (CRCs) in murine GC DZs. (ox.ac.uk)

Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)

This is a medium power view of a secondary follicle in a lymph node. (medcell.org)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)

However, diagnostic CT imaging of cervical nodes might be preferred over MRI by virtue of objective enhancement signal-intensity properties alone. (medscape.com)
120 HU) when compared with other common diseases affecting cervical lymph nodes. (medscape.com)

It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
Collectively, our data demonstrate that PTPN22 controls cDC2 homeostasis, which in turn ensures appropriate cDC2-dependent T cell responses under antigenic challenge. (frontiersin.org)

Using genetic approaches from parasitic infections that cause similar immune system activation to allergic disease, we have identified genes that are important in the interactions between the cells that initiate and maintain allergic inflammation (dendritic cells) and the effector cells that cause inflammatory damage during allergic reactions (T cells). (lung.org)

White blood cells The immune system is designed to defend the body against foreign or dangerous invaders. (msdmanuals.com)
Complement System One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and. (msdmanuals.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
MEXICO - The immune system cells found in lymph nodes could help develop a vaccine against HIV, according to a study by the Center for Research in Infectious Diseases (cieni). (newslodi.com)

Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD20 (LT20) APC. (exbio.cz)

Furthermore, targeting Clec9A primed long-lived memory CD4+ T cells capable of robust secondary TFH responses, even in the absence of adjuvant. (edu.au)

Real-time two-photon microscopy of Peyer's patch GCs demonstrates B cells moving in close association with CRC processes. (ox.ac.uk)
The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. (rupress.org)

It is these contacts that allow adaptive immunity between T cells and B cells are generated, which are responsible for producing antibodies. (newslodi.com)
Lymphoid cells concerned with humoral immunity. (lookformedical.com)
This thesis describes the complex interactions between CD8α+ DCs and T and B cells mediated by Clec9A to promote and/or regulate immunity. (edu.au)
Collectively, the data presented in this thesis reveal the versatile capacity of CD8α+ DCs to interact with various cell types to promote immunity/tolerance and reinforces the notion that targeting Clec9A in vivo is a promising strategy to exploit for immunotherapy. (edu.au)

What cytokines do TFH cells secrete? (hostforstudent.com)
Interleukin (IL)-4, IL-5, and IL-13, which are canonical type 2 cytokines produced by TH2 cells, prominently mediate the development of asthma and airway inflammation, manifesting as enhanced IgE-mediated sensitization, airway hyperreactivity (AHR), as well as eosinophil infiltration (1, 10). (hostforstudent.com)
As the two major cell types in the spleen, B cells and T cells produce cytokines and chemokines [ 18 ]. (hindawi.com)
Using a mouse model of asthma triggered by the mold Aspergillus fumigatus, we focused our attention to CD4 T cells, which are known to produce cytokines critical in asthma (these include IL-4, IL-5 and IL-13 targets for monoclonal antibodies used to treat asthma patients). (lung.org)
Not only the molecular differences leading to the different clinical presentations need to be better understood, but also the pathogenic mechanisms of CLE in general: the precise role of involved cell types, the impact of different cytokines described in the disease, and their interaction and regulation in a complex network need further exploration. (frontiersin.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells. (hostforstudent.com)
After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (exbio.cz)
Petrie RJ, Deans JP: Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. (exbio.cz)
Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison). (cdc.gov)

Anatomy25

Organisms4

Diseases5

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes6

Disciplines and Occupations1

Follicles23

Spleen and lymph nodes3

Lymphocytes18

Mesenteric lymph2

FDCS7

Lymphoma43

Sarcoma8

Tonsils3

Proliferation7

Hyperplasia1

Langerhans9

Tumor13

Macrophages and dendritic cells4

Antigens7

Splenic1

Antigen12

Plasmacytoid2

Mice11

Lymphomas12

Lymphatic4

Stromal cells2

Antibody8

Neoplastic cells2

Tissue8

Lymphocyte1

Induces2

Infiltrate1

PATHOGENESIS1

Differentiation2

Maturation2

Receptors2

S1001

Abstract1

CD212

Bone4

Melanoma1

Lineage1

Biopsy1

Lung4

Tumors4

Nodal1

Subsets2

Epithelium2

Mantle1

Reticular2

Nonhematopoietic cells1

Follicle2

Cervical2

Antigenic2

Effector cells1

Immune system4

Human peripheral1

Secondary1

Peyer's2

Immunity4

Cytokines9

Receptor4