Lymph node follicular dendritic cells follicular. Medical search. Frequent questions

Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. (wikipedia.org)
Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). (wikipedia.org)
The mantle zone of the follicles contains resting and memory B-cells. (medcell.org)
These follicles, having true germinal centers, are similar to the follicles of the spleen and lymph nodes. (medscape.com)
Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
This is most likely attributable to the very different microenvironment of the bone marrow relative to lymph nodes and, in particular, the absence of follicles in bone marrow. (umn.edu)
Scattered follicles showing onion skinning of the mantle zones and hyalinised atrophic germinal centres with predominance of follicular dendritic cells and "lolipop"shaped blood vessels were noted. (iriakerala.org)
FDCs remain uninfected but can bind (via complement receptors) and retain intact infectious virions for long periods of time in the form of immune complexes and can infect CD4+ TFH cells within B cell follicles. (nanostring.com)
TNF α plays an important role in the formation of primary B cell follicles and follicular dendritic cells [ 16 ]. (hindawi.com)
Follicular dendritic cells (FDCs) are well characterized for their role in supporting B cell Ag encounter in primary follicles and in the GC LZ. (ox.ac.uk)
CRCs are also present in splenic and peripheral lymph node primary follicles. (ox.ac.uk)
Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
We applied a western blot analyses to compare the relative percentage of the di-, mono- and unglycosylated PrPC (i.e. glycoform ratio) as well as the expression of truncated PrPC forms in tissues from the CNS and lymphoid structures (lymphoid follicles, lymphocytes and follicular dendritic cells) of bovine and human. (unibo.it)
PrPC was highly glycosylated in spleen and lymphoid follicles isolated from bovine tonsils, mesenteric lymph nodes, ileal and jejunal Peyer's patches. (unibo.it)
The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)
Histologic sections show multiple lymph nodes in which there are numerous follicles, most of which are small, but with some variation in size. (medium.com)
The follicles are abnormally distributed in the cortex and medulla of the lymph node, and a few follicles are present in perinodal adipose tissue. (medium.com)
Most of the follicles also show Castleman-like changes with regression of germinal centers, decreased germinal center B-cells, increased follicular dendritic cells and some follicles show expanded mantle zones with onion skin-like changes. (medium.com)
The follicles are composed of B-cells, positive for CD20 and PAX-5 and negative for CD3 and CD5. (medium.com)
In the germinal centers of follicles, CD10+ cells are greatly decreased but BCL-6+ cells are present. (medium.com)
The antibody specific for CD23 highlights many follicular dendritic cells within the follicles. (medium.com)
The antibody specific for Ki-67 highlights germinal center cells and shows that some of the follicles are polarized with dark and light zones. (medium.com)
In other follicles replaced mostly by follicular dendritic cells, Ki-67+ cells are decreased and/or pushed to the periphery of the germinal centers. (medium.com)
9 Early PrPSc deposition could be discovered in FDCs within B cell follicles in lymphoid tissue of sufferers with vCJD 10 and in rodents inoculated with scrapie by peripheral routes. (kinasechem.com)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)

Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. (wikipedia.org)
SDF-1 (CXCL12), a CXC chemokine, has a primary role in signalling the recruitment of haematopoietic stem-cell precursors to the bone marrow during embryonic development. (biomedcentral.com)
T cells develop from stem cells in the bone marrow that have travelled to an organ in the chest called the thymus. (msdmanuals.com)
Angioimmunoblastic T-cell lymphoma is known to frequently involve bone marrow. (umn.edu)
We assessed 27 bone marrow specimens involved by angioimmunoblastic T-cell lymphoma from 20 patients. (umn.edu)
BCL-6 as a single antibody was difficult to interpret because many normal bone marrow cells are dimly positive, but BCL-6/CD3 dual staining highlighted BCL-6+ T-cells in all cases assessed. (umn.edu)
We conclude that the recognition and classification of angioimmunoblastic T-cell lymphoma in bone marrow are made difficult by the uncommon expression of CD10 (25%), rarity of follicular dendritic cells, and lack of CXCL13 expression at this site. (umn.edu)
Splenic endothelial cell lines support development of dendritic cells from bone marrow. (southernbiotech.com)
Biopsies of the bone marrow, lymph node, and skin are key in diagnosing AILD (see Workup). (medscape.com)
[ 6 ] The lymphomatous infiltrate in some bone marrow specimens from these AILD patients contained numerous small or scattered large B cells, and these cells resembled either benign lymphoid aggregates or T-cell-rich large B-cell lymphoma, respectively. (medscape.com)

Immunohistochemical analysis with a newly available monospecific anti-K19 antibody showed, also for the first time, that the cells in the normal lymph node which express K19 are the B-lymphocytes of the marginal zone, and also the follicular dendritic cells. (soton.ac.uk)
Immunohistochemical methods have shown the cells of origin to be the marginal zone B-lymphocytes and the follicular dendritic cells. (soton.ac.uk)
The immune system can remember every antigen encountered because after an encounter, some lymphocytes develop into memory cells. (msdmanuals.com)
CXCL13 was not expressed by atypical lymphocytes in all cases but did stain stromal cells consistent with follicular dendritic cells in 1 case. (umn.edu)
In addition to lymphocytes, dendritic cells can also produce LT α [ 15 ]. (hindawi.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
The antibody LT20 reacts with an extracellular epitope of CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. (exbio.cz)
Normal human lymphocytes from lymph node. (exbio.cz)
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). (exbio.cz)
Hultin LE, Hausner MA, Hultin PM, Giorgi JV: CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. (exbio.cz)
8 That is perhaps because B lymphocytes stimulate maturation of follicular dendritic cells (FDCs) by giving tumor necrosis aspect- (TNF-) and lymphotoxin / (LT/) trimers to lymphoid organs. (kinasechem.com)
Furthermore, B lymphocytes exert a significant organogenic function in the GALT 21,22 and so are apt to be mixed up in B cell-dependent advancement of the follicle-associated epithelium (FAE). (kinasechem.com)
Cells are slightly larger than lymphocytes . (wikidoc.org)
A significant number of non-neoplastic T cells (resting CD4 + T cells and activated small- or medium-sized CD8 + lymphocytes) may coexist with a minor neoplastic T-cell population. (medscape.com)
Although the aberrant activation of the T cell response observed in pSS has partially been explained by the interaction of T lymphocytes both with the ductal epithelium and the infiltrating B cells via costimulatory molecules (i.e. (biomedcentral.com)

They form a stable network due to intercellular connections between FDCs processes and intimate interaction with follicular B cells. (wikipedia.org)
Interaction between FDCs precursors and lymphoid cells mediated by TNF-a and lymphotoxin (LT) is crucial for normal FDC development and maintenance. (wikipedia.org)
FDCs are among main producers of the chemokine CXCL13 which attracts and organises lymphoid cells. (wikipedia.org)
To become selected as a future memory cell, GC B cells must bind the antigen presented on FDCs, otherwise they enter apoptosis. (wikipedia.org)
By secreting the bridging factor MFGE8, which crosslinks apoptotic cells and phagocytes, FDCs promote selective debris removal from the GC. (wikipedia.org)
Factor Mfge produced in lymphoid tissues mainly by FDCs is known to enhance engulfment of apoptotic cells. (wikipedia.org)
Noncognate (not antigen specific) B cells play a significant role in the transport of antigens to FDCs. (wikipedia.org)
They capture immune complexes in CR1/2-dependent way either directly from the lymph or from macrophages, and move to the lymphoid tissue, where they transfer complement opsonized antigen to the FDCs. (wikipedia.org)
FDCs, in turn, attract B cells with chemoattractant CXCL13. (wikipedia.org)
To generate follicular structures, FDCs need to be stimulated by lymphotoxin (LT), a mediator produced by B cells. (wikipedia.org)
The stimulation of CXCR5 on B cells upregulates LT production, which leads to FDCs activation and stimulates further CXCL13 secretion, thus generating a positive feed-forward loop. (wikipedia.org)
Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)-LFA-1 (CD11a) and VCAM-VLA-4 molecules. (wikipedia.org)
Activated B-cells with low affinity to antigen captured on FDCs surface as well as autoreactive B-cells undergo apoptosis, whereas B cells bound to FDCs through the antigen complex, survive due to apoptosis blockage caused by interaction with FDCs. (wikipedia.org)
Metastatic or recurrent follicular dendritic cell sarcoma (FDCS) is a disabling condition on the Compassionate Allowance List, which qualifies an individual for an expedited approval process. (callfred.com)
FDCS is a rare, malignant cancer that affects the body's follicular dendritic cells, which are cells that help sustain the functions of the body's immune system. (callfred.com)
FDCS usually occurs in the lymph nodes, but can manifest in other areas of the body implicated in the immune system's function, including the liver, spleen, bowel, and pancreas. (callfred.com)
Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT, formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia") is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. (cochinreporter.in)
CRCs are gp38(+) with low to undetectable expression of FDC markers, but CRC-like cells in the DZ are lineage marked, along with FDCs and fibroblastic reticular cells, by CD21-Cre- and Ccl19-Cre-directed fluorescent reporters. (ox.ac.uk)
11 In mouse spleens, mature FDCs have already been been shown to be essential for both prion PrPSc and replication deposition, 12,13 although prion 6H05 replication in lymph nodes may appear in the lack of mature FDCs. (kinasechem.com)

These features may be responsible for the recruitment and activation of T cells, macrophages and dendritic cells, characterizing the stromal component of this lymphoma, and may point towards innate immunity and a tumor tolerogenic immune response in T-cell/histiocyte-rich large B-cell lymphoma. (haematologica.org)
Therein the accumulation of PrP Sc is initially confined to tingible body macrophages but in the later clinical disease phase a reaction pattern resembling follicular dendritic cells (FDC) can be seen. (biomedcentral.com)
It is present in circulating monocytes and in most but not all tissue macrophages from different sites, including lung alveolar macrophages, liver Kupffer cells, placental Hofbauer cells, and interfollicular and sinus histiocytes of lymph nodes and tonsils, but negative in germinal center tingible body macrophages and splenic white pulp macrophages. (cellnetix.com)
The loss of TNF α delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells. (hindawi.com)
The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen. (hindawi.com)
LT α is also required for the recruitment of dendritic cells, neutrophils, and macrophages to the mesentery in response to pristane [ 10 ]. (hindawi.com)
The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
Scattered non-granumloma forming epithelioid macrophages , hyalinized vessels and a few reactive T cells or mast cells are seen along with the lymphoma cells in MCL . (wikidoc.org)
It binds to an ICOS ligand expressed by B-cells, macrophages, and DCs. (hostforstudent.com)
ICOSL is expressed on B cells, macrophages, and dendritic cells and can be induced on nonhematopoietic cells. (hostforstudent.com)

The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
The T-cell/histiocyte-rich large B-cell lymphoma signature is hallmarked by up-regulation of CCL8, interferon-γ, indoleamine 2,3 dioxygenase, VSIG4 and Toll-like receptors. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
4 In the World Health Organization (WHO) classification of 2001, T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is defined by the presence of a limited number of scattered large B cells in a background rich in T cells, with or without histiocytes. (haematologica.org)
Gene expression profiling of lymphomas clearly illustrated that apart from the characteristics of the tumor cells, the microenvironment of the tumor also defines the profile of the lymphoma, and, more importantly, plays a role in predicting the prognosis. (haematologica.org)
However, the histologic and immunophenotypic features of angioimmunoblastic T-cell lymphoma at this site are poorly defined. (umn.edu)
By contrast, programed death-1 immunohistochemical staining and double labeling using antibodies specific for BCL-6 and CD3 were helpful in appreciating the follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma. (umn.edu)
Tru cut biopsy from omental deposit- IHC results confirm Non Hodgkin Lymphoma - Diffuse large B cell Lymphoma- non GCB type. (iriakerala.org)
The pathogenesis of PTLDs seems to be multifactorial-EBV is main one .Antigenic stimulation Plasmacytoid dendritic cells (PDCs) , regulatory T cells are other factors .Whilst most are high-grade B-cell non-Hodgkin's lymphoma (NHLs), a few are classical Hodgkin's lymphomas. (iriakerala.org)
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Lymphoma b cell. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
The translocation t(11;14)(q13;q32) is considered the precipitating oncogenic event that induces cell cycle deregulation in mantle cell lymphoma due to overexpression of cyclin D1 . (wikidoc.org)
However, less commonly, mutations in CCDN2 and CCDN3 have also been identified in cases of mantle cell lymphoma lacking the t(11;14) translocation. (wikidoc.org)
Pleomorphic and blastic type(together known as the blastoid variant): The pleomorphic type are similar to diffuse large B-cell lymphoma ( DLBCL ). (wikidoc.org)
Follicular dendritic cells (FDC) are a hallmark of mantle cell lymphoma and may also be involved in its pathogenesis . (wikidoc.org)
Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. (najms.com)
Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A. Histiocytic sarcoma arising in indolent small b-cell lymphoma: Report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (najms.com)
Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature. (najms.com)
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
AILD is a type of peripheral T-cell lymphoma that is clinically characterized by high fever and generalized lymphadenopathy. (medscape.com)
AILD-type dysplasia with an oligoclonal T-cell pattern has frequently been shown to progress into AILD-type lymphoma. (medscape.com)
Krenacs et al have suggested that the phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma appears consistent with the phenotype of activated follicular B-helper T cells. (medscape.com)
AILD, specifically angioimmunoblastic T-cell lymphoma, is mainly derived from CD2 + CD3 + CD4 + CD5 + CD7 - mature T-helper cells with varying expression and partial loss of detectable CD4. (medscape.com)
Dunleavy et al noted that overexpression of the chemokine CXCL13 and vascular endothelial growth factor-A in angioimmunoblastic T cell lymphoma suggests that it may be derived from follicular helper T cells. (medscape.com)
T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2016, case 26, and is a non-Hodgkin B-cell lymphoma, low-grade. (cap.org)
The histologic findings are diagnostic of non-Hodgkin B-cell lymphoma, low-grade. (cap.org)
The histology of small lymphoid cells which appear mature, with lymphoplasmacytic differentiation, the presence of Dutcher bodies (in some slides) along with the immunophenotypic findings of negative CD5 and CD10 and lambda light chain restricted B-cell population are consistent with a marginal zone lymphoma. (cap.org)
They describe being distinctly unwell a few days to weeks after the booster - one developing leukemia, two work colleagues Non-Hodgkin's lymphoma, and an old friend who has felt like he has had Long COVID since receiving his booster and who, after getting severe bone pain, has been diagnosed as having multiple metastases from a rare B cell disorder. (truthwatchnz.is)

1,2 In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid follicular dendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, and salivary gland as well as basal epithelium of the respiratory system. (roche.com)
Mature T cells are stored in secondary lymphoid organs (lymph nodes, spleen, tonsils, appendix, and Peyer patches in the small intestine). (msdmanuals.com)

Castleman disease otherwise known as angiofollicular or benign giant lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. (iriakerala.org)
Follicular hyperplasia, marked eosinophilic infiltrate and eosinophilic abscesses, and the proliferation of postcapillary venules are characteristic histological findings. (medscape.com)

1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)

Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. (exbio.cz)
Cell proliferation in the meninges is reduced, causing loss of arachnoid fibroblasts that express Raldh2, an enzyme required for retinoic acid synthesis. (silverchair.com)
Its function is clearly costimulatory for T-cell proliferation and cytokine secretion. (hostforstudent.com)

Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)

The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different. (haematologica.org)
8 , 10 - 12 Recently, genome-wide analysis of isolated tumor cells from NLPHL and THRLBCL revealed further similarities between the tumors cells of the two lymphomas. (haematologica.org)
Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system. (roche.com)
Based on the imaging features, differential diagnostic possibilities of lymph nodal mass/paraganglioma / hemangiopericytoma / solitary fibrous tumor were considered. (iriakerala.org)
Targeted delivery of tumor necrosis factor-α to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin. (southernbiotech.com)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site. (nih.gov)
On the other hand, dendritic cells (DCs) that infiltrate tumor tissues are involved in tumor suppression. (biomedcentral.com)

Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)

Recently, transformation of CLL into histiocytic/dendritic/Langerhans cell sarcoma (all are myeloid origin), dubbed as "transdifferentiation", has also been reported. (najms.com)
Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)

The colonic mucosa is normal and there is a diffuse infiltrate of lymphoid cells in the lamina propria, submucosa, and muscularis propria extending to the serosal surface. (cap.org)

Supposedly, this separation from the sites of earliest antigen processing and capture provide a protected environment in which opsonized antigens can be displayed for a long time without being proteolyzed or removed by phagocytic cells. (wikipedia.org)
These antigens are then taken up in a non-degradative cycling endosomal compartment for later presentation to B cells. (wikipedia.org)
As B-cells proliferate, they undergo somatic hypermutation (mutation of the immunoglobulin gene) in order to enhance the binding affinity between the antigens and the antibodies. (medcell.org)
The roles of the M cells include absorption, transport, processing, and presentation of antigens to subepithelial lymphoid cells. (medscape.com)
M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
Normally, only the T cells that learn to ignore the body's own antigens (self-antigens) are allowed to mature and leave the thymus. (msdmanuals.com)
T cells can potentially recognize an almost limitless number of different antigens. (msdmanuals.com)
Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)

After oral exposure, 2 squirrel monkeys had PrPres in brain, Substantial progress has been made in testing species spleen, and lymph nodes at 69 months postinfection. (cdc.gov)
CD169 mediates the capture of exosomes in spleen and lymph node. (southernbiotech.com)

In addition grafts retain some of the histological features of the pretransplantation tissue, such as follicular dendritic cell-associated B-cell aggregates, lymphatic and HEV markers. (biomedcentral.com)
These cells circulate in the bloodstream and the lymphatic system. (msdmanuals.com)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
Here we show that prion replication in the GALT and subsequent neuroinvasion was independent of B cells within the mucosa-associated lymphatic tissue and that the remaining M 6H05 cells are most likely important for this process. (kinasechem.com)
Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
B-cell heavy chain rearrangement study on blood sample (pure CLL) and liver metastatic NEC (pure NEC, no contamination from CLL) revealed that these two tumors shared similar monoclonal peaks. (najms.com)
Dendritic cell tumors associated with low-grade b-cell malignancies. (najms.com)

However, the properties of stromal cells supporting B cells in the DZ are relatively unexplored. (ox.ac.uk)
Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)

To investigate the role of SDF-1 in recirculation and homing in vivo we have developed a model in which human peripheral lymph nodes (huPLN) are transplanted into SCID mice. (biomedcentral.com)

Typically, neoplastic cells lack CD1a, desmin and CD45 staining. (biomedcentral.com)

1,2 NGFR has been shown to be a reliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants. (roche.com)
P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. (roche.com)
Clear cell sarcoma ( AKA melanoma of the soft parts). (librepathology.org)
The reports of innate immune suppression after mRNA for several weeks would fit, as all these patients to date have melanoma or B cell based cancers, which are very susceptible to immune control - and that is before the reports of suppressor gene suppression by mRNA in laboratory experiments. (truthwatchnz.is)

Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)
Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. (wikipedia.org)
In normal lymphoid tissue, recirculating resting B cells migrate through the FDC networks, whereas antigen-activated B cells are intercepted and undergo clonal expansion within the FDC networks, generating germinal centers (GC). (wikipedia.org)
Follicular DCs receptors CR1, CR2 and FcγRIIb trap antigen opsonized by complement or antibodies. (wikipedia.org)
This results in the formation of germinal centers (GCs), where antigen-activated B cells are trapped to undergo somatic mutation, positive and negative selection, isotype switching, and differentiation into high-affinity plasma cells and memory B cells. (wikipedia.org)
the latter are antigen-presenting cells (APCs) that function as memory cells interacting with type 1 THCs. (medscape.com)
When memory cells encounter an antigen for the second time, they recognize it immediately and respond quickly, vigorously, and specifically to that particular antigen. (msdmanuals.com)
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. (exbio.cz)
CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. (hostforstudent.com)
T cells are primed by antigen-presenting cells in the T cell zones of the periarteriolar lymphoid sheaths of the spleen, the paracortex of LNs, and the dome area of Peyer's patches (PPs) * lining the intestine. (rupress.org)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)

By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
Within lymph nodes are follicular T cells, B lymphocyte populations and dendritic cells, which are only in that tissue. (newslodi.com)
Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b + CD11c + dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. (southernbiotech.com)
mice, which Capn1 have normal lymphocyte counts but lack the two cytokines TNF- and LT, 26 to B cell-deficient MT mice, 27 and to RAG-1? (kinasechem.com)

In mice lacking B cells, or with blocked TNF-a and lymphotoxin (LT) production, cells with FDC phenotype are missing. (wikipedia.org)
Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. (biomedcentral.com)
This is the first description of huPLN transplantation into SCID mice, and of the functional effects of SDF-1 regarding the migration of human cells into huPLN in vivo . (biomedcentral.com)
mice have problems with severely-reduced cellularity of PPs (>90% much less B and T cells) 17 and from impaired intestinal immunity in a number of disease versions. (kinasechem.com)
These mice are well-suited to dissect the function of mucosa-associated immune system tissues as a result, including B cells, in the pathogenesis of enterically-initiated prion disease. (kinasechem.com)
mice had some FDC-M1-positive cells in their atrophic Peyers patches, but not in spleen nor in lymph nodes. (kinasechem.com)

Follicular DCs have high expression of complement receptors CR1 and CR2 (CD 35 and CD 21 respectively) and Fc-receptor FcγRIIb (CD32). (wikipedia.org)

Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
3-4 Anti-NGFR labels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignacies of the breast. (roche.com)
8. Lui O, Mak N, Leung K. Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells. (southernbiotech.com)

Chronic inflammation of MALT from infective or autoimmune disorders can lead to the development of extranodal marginal zone B-cell lymphomas, or MALTomas. (medscape.com)

13 Despite the similarities of their malignant cells, an important difference between the two lymphomas lies in their clinical presentation and prognosis. (haematologica.org)
Baer MR, Krantz SB, Cousar JB, Glick AD, Collins RD. Malignant histiocytoses developing in patients with b-cell lymphomas. (najms.com)
[ 2 ] It has become clear that AILD is a clonal T-cell disorder involving deregulation of B-cells and endothelial cells against a background involving a unique malignant microenvironment. (medscape.com)

GC B cells must cycle between these zones to achieve efficient Ab affinity maturation. (ox.ac.uk)
Tfh cells are a subset of CD4+ T cells that function in the lymph node (LN) and spleen to promote survival, affinity maturation, and class switch recombination of B cells (1, 2). (hostforstudent.com)

Follicular DCs network typically forms the center of the follicle and does not extend from the follicle to the interfollicular regions or T-cell zone. (wikipedia.org)

Antibodies specific for CD21 and CD35 did not highlight follicular dendritic cells in any biopsy specimens. (umn.edu)
I will show data using an array of spatial profiling approaches in FFPE lymph nodes, including RNAscope in situ hybridization and NanoString® GeoMx® and CosMx™ Spatial Molecular Imager (SMI) platforms, to characterize the impact of anti-CD21 treatment on FDC-SIV trapping and the impact to the transcriptional landscape of cells within the B cell follicle tissue microenvironment and cellular immune neighborhoods surrounding infected cells. (nanostring.com)
CD21 highlights scattered attenuated follicular dendritic meshworks with the B-cells completely over-running and extending beyond the confines of the dendritic meshwork. (cap.org)

Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis. (southernbiotech.com)

Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. (cdc.gov)

In the distal ileum clear time-dependent variations were visible concerning the amount of PrP Sc , the tissue structures affected, and the cells involved. (biomedcentral.com)
Up to a year of age, the ileal PP represent the major gut-associated lymphoid tissue in ruminants possessing an extensive bed of follicular dendritic cells and a specialised epithelium actively engaged in the uptake and transcytosis of macromolecules from the gut, explaining the restriction of PrP Sc to this region of the gut [ 7 ]. (biomedcentral.com)
Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. (cellnetix.com)
Given that cellular prion protein (PrPC), is sine qua non for PrP-res formation and the development of TSE, it is well possible that tissue-specific PrPC properties may represent one of the host factors influencing the cell tropism of the infectious agent. (unibo.it)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)

[ 12 , 27 ] Reports have also demonstrated the presence of plasmacytoid dendritic cells in a lesion of Kimura disease. (medscape.com)

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests. (roche.com)
Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le NGFR (Nerve Growth Factor Receptor) (MRQ-21) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter le NGFR dans les tissus fixés au formol et enrobés à la paraffine, colorés sur les instruments VENTANA BenchMark IHC/ISH. (roche.com)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment. (exbio.cz)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
Diffuse large cell lymphomas and their mimics. (llu.edu)
B-cell lymphomas. (llu.edu)

Stimulation of B cells leads to the production of immunoglobulin A (IgA) and immunoglobulin M (IgM) within the Peyer patches, preventing adherence of bacteria and viruses to the epithelium and thus blocking entry to the subepithelial layers of the intestine. (medscape.com)

Wan-Sheng Liu ABSTRACT Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. (silverchair.com)

Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. (ox.ac.uk)
Recent work identified a novel stromal population of Cxcl12-expressing reticular cells (CRCs) in murine GC DZs. (ox.ac.uk)

Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)

Nodal nevus - benign nevus in lymph node. (librepathology.org)

This is a medium power view of a secondary follicle in a lymph node. (medcell.org)

HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)

It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)

However, diagnostic CT imaging of cervical nodes might be preferred over MRI by virtue of objective enhancement signal-intensity properties alone. (medscape.com)
120 HU) when compared with other common diseases affecting cervical lymph nodes. (medscape.com)

White blood cells The immune system is designed to defend the body against foreign or dangerous invaders. (msdmanuals.com)
Complement System One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and. (msdmanuals.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
In addition to the highly studied CD4+ T cell reservoir (and other infected cellular reservoirs) that harbor integrated, replication-competent provirus within their cellular DNA, an additional less studied HIV reservoir that is resistant to clearance by host immune mechanisms is follicular dendritic cells (FDC). (nanostring.com)
MEXICO - The immune system cells found in lymph nodes could help develop a vaccine against HIV, according to a study by the Center for Research in Infectious Diseases (cieni). (newslodi.com)
Previous studies show that the immune response of lymph nodes is the most associated with the protection of a vaccine. (newslodi.com)
The vaccine would be developed by the scientific basis through the concepts of innate and adaptive immune responses, the first occurs immediately when the cells recognize specific patterns on pathogens. (newslodi.com)
The memories of these immune cells (T cells and memory B cells) are allowing the researchers to generate vaccines and study their behavior in HIV infection allowing them to advance this mode of treatment. (newslodi.com)
Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
A protein found on T cells (a type of immune cell) that helps keep the body's immune responses in check. (hostforstudent.com)

Collectively, our data demonstrate that PTPN22 controls cDC2 homeostasis, which in turn ensures appropriate cDC2-dependent T cell responses under antigenic challenge. (frontiersin.org)

Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD20 (LT20) APC. (exbio.cz)

14 On the other hand, the function of intestinal B cells in prion pathogenesis pursuing oral challenge continues to be unclear. (kinasechem.com)

Real-time two-photon microscopy of Peyer's patch GCs demonstrates B cells moving in close association with CRC processes. (ox.ac.uk)
The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. (rupress.org)

B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized and disorganized. (wikipedia.org)
After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (exbio.cz)
Petrie RJ, Deans JP: Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. (exbio.cz)
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells. (hostforstudent.com)
Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison). (cdc.gov)
Of greatest interest is the~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. (cdc.gov)

Anatomy39

Organisms8

Diseases22

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes19

Disciplines and Occupations1

Health Care1

Follicles25

Bone-marrow10

Lymphocytes19

FDCs20

Macrophages11

Lymphoma42

Tonsils2

Hyperplasia2

Interdigitating dendritic cell sarcoma2

Proliferation5

Mesenteric lymph1

Tumor10

Sarcoma is a rare1

Langerhans8

Infiltrate1

Antigens8

Spleen and lymph2

Lymphatic5

Tumors5

Stromal cells2

Peripheral lymph1

Neoplastic cells1

Melanoma4

Antigen12

Lymphocyte4

Mice6

Receptors1

Differentiation3

Marginal zone1

Malignant3

Affinity2

Interfollicular1

CD213

Induces1

Biopsy1

Tissue5

Plasmacytoid1

Antibody4

Lymphomas4

Epithelium1

Abstract1

Reticular2

Nonhematopoietic cells1

Benign1

Secondary1

Follicle1

Stimulation1

Cervical2

Immune10

Antigenic1

Human peripheral1

PATHOGENESIS1

Peyer's2

Receptor6