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  • Protein
  • O-acetylserine (thiol) lyase is a pyridoxal phosphate-dependent enzyme, and a lysine residue at the N-terminal region of this protein is involved in binding this cofactor (Saito et al. (thefreedictionary.com)
  • Delta-crystallin shares around 90% sequence identity with arginosuccinate lyase, showing that it is an example of a 'hijacked' enzyme - accumulated mutations have, however, rendered the protein enzymatically inactive. (ebi.ac.uk)
  • The protein encoded by this gene belongs to the HMG-CoA lyase family. (nih.gov)
  • 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (also known as HMG-CoA lyase deficiency ) is an uncommon inherited disorder in which the body cannot process a particular protein building block ( amino acid ) called leucine. (nih.gov)
  • PMID
  • When the backbone of pectin is methylated it is known as pectin, and can be cleaved by pectin lyase, a microbial virulence factor [ PMID: 9195887 ]. (ebi.ac.uk)
  • When the backbone of pectin is demethylated it is known as pectate, and can be cleaved by pectate lyase virulence factors, or hydrolysed by polygalacturonases [ PMID: 12324535 , PMID: 11518536 ]. (ebi.ac.uk)
  • A number of enzymes, belonging to the lyase class, for which fumarate is a substrate have been shown [ PMID: 3282546 ] to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes. (ebi.ac.uk)
  • Adenylosuccinase, EC:4.3.2.2 (adenylosuccinate lyase) [ PMID: 1574589 ], which catalyses the eighth step in the de novo biosynthesis of purines, the formation of 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and fumarate from 1-(5-phosphoribosyl)-4-(N-succino-carboxamide). (ebi.ac.uk)
  • fumarate
  • Arginosuccinase, EC:4.3.2.1 (argininosuccinate lyase), which catalyses the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine. (ebi.ac.uk)
  • subunit
  • Influence of multiple cysteines on human 3-hydroxy-3-methylglutaryl-CoA lyase activity and formation of inter-subunit adducts. (nih.gov)
  • hydrolases
  • He covers chiral discrimination in the active site of oxidoreductases, transferases and chiral discrimination, the influence of chirality on the hydrolysis reactions within the active site of hydrolases, the influence of chirality on the reactions in the active site of lyases , and chiral discrimination in the active site of ligases. (thefreedictionary.com)
  • deficiency
  • Application of multiplex ligation-dependent probe amplification, and identification of a heterozygous Alu-associated deletion and a uniparental disomy of chromosome 1 in two patients with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. (nih.gov)
  • 3-HMG Coenzyme A Lyase Deficiency: Macrocephaly and Left Ventricular Noncompaction with a Novel Mutation. (nih.gov)
  • T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency. (nih.gov)
  • The signs and symptoms of HMG-CoA lyase deficiency usually appear within the first year of life. (nih.gov)
  • HMG-CoA lyase deficiency is sometimes mistaken for Reye syndrome, a severe disorder that develops in children while they appear to be recovering from viral infections such as chicken pox or flu. (nih.gov)
  • Bischof F, Nägele T, Wanders RJ, Trefz FK, Melms A. 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in an adult with leukoencephalopathy. (nih.gov)
  • 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: review of 18 reported patients. (nih.gov)
  • cDNA
  • Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4932442H07 product:2-hydroxyphytanoyl-CoA lyase (EC 4.1. (nih.gov)
  • crystal
  • Crystal structure of Proteus vulgaris chondroitin sulfate ABC lyase I at 1.9A resolution. (ebi.ac.uk)
  • main
  • Pectin lyases, pectate lyases and galacturonases all act on forms of pectin, one of the main components of the cell wall. (ebi.ac.uk)