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  • rats
  • Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats. (sigmaaldrich.com)
  • In the present study, the effects of luteolin on chronic cerebral hypoperfusion-associated neurocognitive pathologies were investigated by using rats with permanent bilateral common carotid artery occlusion, a rat model of chronic cerebral hypoperfusion. (sigmaaldrich.com)
  • Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p. (sigmaaldrich.com)
  • Luteolin (0.1, 0.2, or 0.3 mg/kg body weight/everyday (p.o.) was administered in a dose dependent manner at the initiation and also at the post-initiation stages of carcinogenesis to DMH treated rats. (ovid.com)
  • Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. (semanticscholar.org)
  • Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). (nii.ac.jp)
  • We compared the absorption and metabolism characteristics of NOB with those of luteolin (LT) in male SD rats. (iospress.com)
  • The aim of the current investigation was to scrutinize the protective effect of luteolin against the STZ induced Diabetic Cardiomyopathy (DCM) in rats. (alliedacademies.org)
  • Results of the investigation showed a reduction in fasting blood glucose level, Total Cholesterol (TC) and Triglyceride (TG) in luteolin-treated DCM rats. (alliedacademies.org)
  • Additionally, the luteolin-treated group rats confirmed the decrease the Interventricular Septal Diastolic Wall Thickness (IVSD), Left Ventricular Posterior Wall Thickness (LWPWT), Left Ventricular End-Diastolic Diameter (LVEDD) and increase in Heart Rate (HR). Luteolin also induced the significant improvement in the expression of GSK-3β and phosphorylation of Akt in the myocardium. (alliedacademies.org)
  • Long term treatment did not show any apparent toxicity in rats at a dose of 30mg/kg, implying that luteolin is relatively safe as an anticancer agent. (selfhacked.com)
  • In an experiment on rats with toxin-induced uveitis, luteolin had great success in anti-inflammatory treatment, comparable to that of prednisolone. (selfhacked.com)
  • In an experiment on rats, luteolin was found to inhibit cell death in the cells of the heart. (selfhacked.com)
  • Luteolin treatment in rats reduced brain damage caused by kainic acid by reducing glutamate levels, mitigating inflammation, and enhancing the hippocampus. (selfhacked.com)
  • In an experiment on rats with streptozotocin induced Alzheimer's disease , luteolin significantly improved spatial learning and memory impairment. (selfhacked.com)
  • extract
  • The effects of different concentrations of Luteolin extract on prednisone/prednisolone metabolism indicated the enzyme activity of 11 β -HSD, so the production rate (pmol/min per mg protein) of metabolites was used to indicate enzyme activity. (hindawi.com)
  • A liposomal luteolin formulation in olive fruit extract improved attention in children with ASDs and brain "fog" in mastocytosis patients. (frontiersin.org)
  • Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion ( Taraxacum officinale ) flower extract were studied for antioxidant activity in different in vitro model systems. (springer.com)
  • Similar suppression for both inducible enzymes was also found with the presence of dandelion flower extract, specifically, the ethyl acetate fraction of dandelion flower extract which contained 10% luteolin and luteolin-7-O-glucoside. (springer.com)
  • flavone
  • The plant-derived luteolin analogue cynaroside has a glucoside group in position 7 of the flavone A-ring and as opposed to luteolin is unable to stabilize TTR tetramers and thus prevents a cytotoxic effect. (sigmaaldrich.com)
  • Apigenin
  • Hongzheng Wang, Lei Yang, Yuangang Zu, and Xiuhua Zhao, "Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity," The Scientific World Journal , vol. 2014, Article ID 506971, 12 pages, 2014. (hindawi.com)
  • toxicity
  • This has been proven time and again in several animal studies - prompting scientists to believe that luteolin can have massive anti-amnesic effects against amyloid toxicity. (naturalpedia.com)
  • In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy metals (including zinc, manganese, lead, copper, cadmium, mercury, chromium and nickel) were investigated in HL7702 hepatocyte cells. (spandidos-publications.com)
  • Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice," American Journal of Respiratory and Critical Care Medicine , vol. 165, no. 6, pp. 818-823, 2002. (hindawi.com)
  • The toxicity of luteolin was evaluated through modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in human retinal microvascular endothelial cells (HRMECs) as well as TUNEL staining in the retina of C57BL/6J mice. (arvojournals.org)
  • Luteolin can go through the blood-brain-barrier (BBB), which shows anti-amnesic effects against the toxicity of amyloid in mice. (selfhacked.com)
  • vivo
  • Through in vitro and vivo experiments, luteolin was found to have therapeutic and preventative activities against cancer associated with estrogen . (selfhacked.com)
  • Luteolin potently inhibited UVB-induced MMP-1 expression and wrinkle formation in vitro and in vivo and therefore may be used for prevention of UVB-induced skin aging. (selfhacked.com)
  • vitro
  • Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. (go.jp)
  • Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics. (semanticscholar.org)
  • reduces
  • Luteolin is also found to suppress two major pathways involved in response to inflammation, which greatly reduces both acute and chronic inflammation . (selfhacked.com)
  • peanut shell
  • According to the report of the literature, method for extracting the active ingredient luteolin from the peanut shell includes solvent method, ultrasonic method, microwave method and supercritical CO2 method, wherein the solvent extraction method is the most widely used with the major extraction solvents used being methanol, acetone and ethyl acetate. (chemicalbook.com)
  • therapeutic
  • Our results suggest a potential therapeutic use of luteolin for cerebral hypoperfusion associated cognitive dysfunction in AD. (sigmaaldrich.com)
  • Luteolin has also been found to have antitumor properties and poses special interest for the development of preventive and/or therapeutic agent for cancers. (longevityunlocked.com)
  • exerts
  • Thus our results demonstrate for the first time that luteolin, a dietary flavonoid, exerts chemopreventive and anticarcinogenic effects against DMH induced colon cancer. (ovid.com)
  • The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway. (spandidos-publications.com)
  • apoptosis
  • With the deepening of the study on luteolin, researchers have found that it have anti-cancer activities including inhibiting the proliferation of tumor cell, inducing the apoptosis of tumor cells as well as sensitizing anti-cancer drugs. (chemicalbook.com)
  • Mice
  • Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). (springermedizin.de)
  • Luteolin also protects against high-fat diet-induced cognitive defects in obesity mice. (selfhacked.com)
  • incidence
  • On luteolin administration, colon cancer incidence, number of tumors per rat and the activities of β-glucuronidase and mucinase, were significantly decreased both in the initiation and post-initiation stages of colon carcinogenesis dependent on the three different doses given. (ovid.com)
  • Luteolin inhibited the incidence rate of tumors and decreased the size of tumors significantly. (selfhacked.com)
  • bioavailability
  • Methylated luteolin analogs with increased activity and better bioavailability could be developed into effective treatments for neuropsychiatric disorders and brain "fog. (frontiersin.org)
  • Although Luteolin is absorbed in humans ( R ), the body metabolizes luteolin and the bioavailability is not great ( R ). (selfhacked.com)
  • chemopreventive
  • The aim of the present study was to unravel the chemopreventive effect of luteolin on bacterial enzymes such as β-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, 2-dimethyl hydrazine (DMH). (ovid.com)
  • plant
  • Luteolin (3′,4′,5,7-tetrahydroxylflavone) is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species. (mdpi.com)
  • respectively
  • This experiment was divided into nine groups, which were normal group, model group, VC control group, and treated groups with different doses of orientin and luteolin (10, 20, and 40 μ g/mL), respectively. (hindawi.com)
  • The effect of luteolin on t-BH-induced and hypoxia-induced VEGF transcription and expression were evaluated by RT-PCR and Western blot, respectively. (arvojournals.org)
  • activity
  • The results show that the A-ring of luteolin, in contrast to what was previously suggested, is buried within the TBS, consequently explaining the lack of activity from cynaroside. (sigmaaldrich.com)
  • Luteolin inhibited PMA plus A23187-induced nuclear factor (NF)-κB activation, IκB degradation, and luciferase activity. (mdpi.com)
  • protein
  • Our results showed that oral administration of Luteolin significantly increased the gene and protein expressions of hepatic 11 β -HSD I and renal 11 β -HSD II, which may improve the efficacy and reduce the adverse drug effect of glucocorticoid in clinical application. (hindawi.com)
  • In activated HMC-1 cells, the phosphorylation of extra-signal response kinase (ERK 1/2) and c-jun N -terminal Kinase (JNK 1/2), but not p38 mitogen-activated protein kinase (p38 MAPK) were decreased by treatment of the cells with luteolin. (mdpi.com)
  • In addition, 20 µM luteolin had a significant inhibitory effect on multi-heavy metal mixture-induced cleavage of caspase-9, caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein. (spandidos-publications.com)
  • metabolism
  • In this paper, we chose Luteolin which is one of the main ingredients of EP and evaluated its effect and metabolism in combination with prednisone. (hindawi.com)
  • results showed
  • The results showed that luteolin and phospholipid in the complex were joined by non-covalent-bonds and did not form a new compound. (mdpi.com)
  • study
  • One Japanese study showed that luteolin can reduce the number and severity of the Japanese encephalitis virus. (naturalpedia.com)
  • The current study is to investigate whether orientin and luteolin can protect erythrocytes from oxidative injury and whether there are some differences between these two compounds with different chemical structure (Figure 1 ). (hindawi.com)
  • The findings of the current study suggest that the luteolin might have a beneficial effect against DCM via improvement the Akt/GSK-3β signalling pathway. (alliedacademies.org)
  • effect
  • These results indicated that luteolin from the flowers of Lonicera japonica exerted a regulatory effect on mast cell-mediated inflammatory diseases, such as RA, allergy disease and IBD. (mdpi.com)
  • The effect of luteolin on tertiary-butylhydroperoxide (t-BH)-induced ROS production was measured with 2′7′-dichlorofluorescein diacetate. (arvojournals.org)