Lungs administration inhalation. Medical search. Frequent questions

Together, these data suggest that overexpression of VEGF in the lung may be one mechanism of increased pulmonary vascular permeability in the early stages of acute lung injury. (nih.gov)
No information has been located regarding the lethal effects of acute exposure to radium via inhalation. (cdc.gov)
Acute effects from inhalation of EtO vapors include respiratory irritation and lung injury, headache, nausea, vomiting, diarrhea, shortness of breath, and cyaonosis (blue or purple coloring of skin). (osha.gov)
Inhalers are a cornerstone therapy for acute and chronic lung illnesses and diseases. (pharmacytimes.com)
We are excited to share these new data from our Phase 1b trial, which clearly demonstrates the ability of RLS-0071 to dramatically inhibit neutrophil infiltration and pro-inflammatory cytokines such as IL-1ß and IL-8 in a human model of LPS-initiated acute lung disease," said Ulrich Thienel, Ph.D., M.D., chief executive officer of ReAlta. (vabio.org)

Occupational exposure to PCBTF can occur through inhalation and dermal contact during its production and use. (nih.gov)
No studies were located regarding lethality in animals after inhalation exposure to radium. (cdc.gov)
The histopathology of rat lung following exposure to zinc oxide/hexachloroethane smoke or installation with zinc chloride followed by treatment with 70% oxygen. (nih.gov)
Ideally, the inhalation route could deliver high doses of antibodies directly to the lungs while limiting system exposure and reducing potential side effects. (genengnews.com)
At current U.S. levels of exposure, chronic inhalation generally takes a decade or longer to cause disease. (cdc.gov)
Occupations with hazardous exposures to crystalline silica continue to emerge and occupational exposures that exceed Occupational Safety and Health Administration (OSHA) and Mine Safety and Health Administration (MSHA) permissible exposure limits (PELs) continue to be regularly documented. (cdc.gov)
as part of a class study of nickel compounds for which there was little information on the toxic and carcinogenic effects of inhalation exposure. (nih.gov)
The few studies that assessed exposure-response for lung cancer, including the two that observed excess risks compared with the general population, provided weak or inconclusive evidence of a dose-response. (ecetoc.org)
Numerous epidemiology studies have failed to adequately demonstrate an increased risk of lung cancer due to occupational exposure to carbon black. (ecetoc.org)
The current Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) for hydrogen cyanide is 10 ppm (11 milligrams per cubic meter (mg/m(3))) as an 8-hour time-weighted average (TWA) concentration. (axishistory.com)

Inhaling sufficient amounts of RCS causes a fibrosing interstitial lung disease called silicosis. (cdc.gov)

Metered-dose inhalers are the preferred method of administration because they have a lower incidence of adverse effects than other routes. (medscape.com)
Like nebulizers, inhalers are also used to send medicine into your lungs. (medlineplus.gov)
A systematic literature review reports that within a lung-diseased US population sample, 4 of 5 patients used their inhalers incorrectly. (pharmacytimes.com)

Worker inhalation of silica particles can lead to the development of disabling lung diseases, such as silicosis and cancer . (osha.gov)
In the USA, recently-promulgated regulations by the Occupational Safety and Health Administration (OSHA) provide a comprehensive set of interventions to control RCS exposures and provide RCS-exposed workers with health surveillance for early detection of silicosis. (cdc.gov)
Inhalation of crystalline silica can cause silicosis, a preventable but incurable type of lung fibrosis. (cdc.gov)
People only get silicosis from inhaling respirable crystalline silica dust into their lungs. (cdc.gov)
But breathed in as dust, in quantity and over time, crystalline silica can cause a host of occupational lung diseases, including silicosis, pulmonary tuberculosis, and lung cancer. (nwlaborpress.org)

Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro studies with human cells and in silico modeling in lieu of additional animal studies. (nih.gov)
Next, a comprehensive set of safety studies was performed, demonstrating that the nanoparticle formulation does not induce any toxicity when delivered to the lungs. (nature.com)
Before we initiate the proposed clinical Phase I study of inhaled 5-azacytidine we will determine the minimal effective dose as well as the lung toxicity of inhaled 5-azacytitine in a relevant murine model of lung premalignancy. (elsevierpure.com)
Endpoints will be: lung toxicity, efficacy in delaying lung tumor development, and tumor suppressor gene reexpression in the bronchial epithelium. (elsevierpure.com)
Endpoints will be: tolerability and toxicity with special emphasis on lung toxicity, tumor suppressor gene reexpression in the bronchial epithelium, and changes in methylation patterns in the bronchial epithelium. (elsevierpure.com)

Inhalation of those tiny particles can lead to heart attacks and even death, especially among older people, public health experts report. (thefiscaltimes.com)

Administer short-acting beta-adrenergic agents and ipratropium bromide bronchodilators to maximize lung function. (medscape.com)
Combivent Respimat (ipratropium bromide and albuterol) Inhalation Spray is a combination of an anticholinergic bronchodilator and a selective beta2-adrenergic bronchodilator that open airways in the lungs to help patients with COPD breathe better indicated for the treatment of chronic obstructive pulmonary disease (COPD). (rxlist.com)

Administration of AdVEGF165 by the intratracheal route (10(9) plaque-forming units [pfu]) to C57Bl/6 mice showed increased expression of VEGF messenger RNA in lung tissue by Northern analysis. (nih.gov)
To confirm the specificity of these observations, mice were pretreated with intranasal administration of an adenovirus vector expressing a truncated soluble form of the VEGF receptor flt-1 (Adsflt). (nih.gov)
The resulting nanocomplexes were then evaluated for their ability to transfect the lungs of mice. (nature.com)
Using the P76 polymer, mRNA of increasing sizes encoding for a variety of proteins was successfully formulated and delivered to the lungs of mice for protein expression. (nature.com)
Male and female F344/N rats and B6C3F1 mice were exposed to nickel sulfate hexahydrate (greater than 98% pure) by inhalation for 16 days, 13 weeks, or 2 years. (nih.gov)
Absolute and relative lung weights of male and female mice exposed to 7 mg/m3 or greater were significantly greater than those of the controls. (nih.gov)
Nickel concentrations in the lungs of mice exposed to 3.5 mg/m3 were greater than those in the controls. (nih.gov)
Carbon black is not carcinogenic to mice (oral, skin or inhalation), hamsters (inhalation or intratracheal), guinea pigs (inhalation), rabbits (skin or inhalation), primates (skin or inhalation) or rats (oral). (ecetoc.org)
in rats and mice, the 5-minute inhalation LC(50) values are 484 ppm and 323 ppm, respectively [Sax and Lewis 1989]. (axishistory.com)
Preliminary studies in our laboratory have demonstrated a 75-fold increase in the therapeutic index of 5-azacytidine when the intratracheal route of administration is used against orthotopic human lung cancer models in nude mice. (elsevierpure.com)

It also causes or is a risk factor for a spectrum of diseases, including lung cancer, chronic obstructive pulmonary disease, chronic renal disease, increased susceptibility to tuberculosis, and various autoimmune diseases. (cdc.gov)
Liver and lung diseases are investigated with imaging and biopsies. (orpha.net)
Aim: In the treatment of obstructive lung diseases, large number of drugs (both bronchodilator and antiinflammatory drugs) have been used by inhalation. (turkailehekderg.org)

Intratracheal administration of AdVEGF165 resulted in a dose-dependent increase in lung wet/dry weight ratios over time, lung histology showed widespread intra- alveolar edema, and pulmonary capillary permeability was significantly increased as quantified by the Evans blue dye assay and [(131)I]albumin permeability. (nih.gov)
Adsflt (10(9) pfu) pretreatment completely abrogated the increased lung wet/dry weight ratio caused by AdVEGF165 administration, whereas an identical adenovirus vector with an irrelevant transgene had no effect upon subsequent AdVEGF165-induced pulmonary edema. (nih.gov)
SPIRIVA HANDIHALER (tiotropium bromide inhalation powder) is indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. (nih.gov)
Both the inhalation of the smoke and instillation of zinc chloride produced similar effects that included pulmonary edema, alveolitis and, at a later stage, some fibrosis. (nih.gov)
The pulmonary route hasn't worked so well for omalizumab, a mAb that is approved for subcutaneous administration in the treatment of asthma. (genengnews.com)
Breathing silica dust is also associated with tuberculosis, lung cancer, and chronic obstructive pulmonary disease (COPD). (cdc.gov)
Pulmonary embolism (PE) is blockage of the main artery (or a distal branch of the main artery) that supplies blood to the lungs by material (typically a thrombus, or blood clot, but may also be a tumour, air, or fat) that originates elsewhere in the body, most commonly in the leg. (cadth.ca)
A gamma camera acquires images of the lungs and pulmonary vessels. (cadth.ca)

Respirable crystalline silica (RCS) refers to particles small enough to remain suspended in air and be inhaled into the deep lung. (cdc.gov)
The Occupational Safety and Health Administration (OSHA) estimated in 2003 that over 2 million workers were potentially exposed to crystalline silica dust in general industry, construction and maritime industries. (cdc.gov)

In 2009, the Obama Administration also named silica as a priority. (nwlaborpress.org)

New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons. (nih.gov)
In support of this goal, computational fluid-particle dynamics models were developed to estimate site-specific deposition of inhaled aerosols containing the fungicide, chlorothalonil, in the rat and human for comparisons to prior rat inhalation studies and new human in vitro studies. (nih.gov)

Using proprietary technology, the Company believes the dry powder particles will be able to "supersaturate" when they come into contact with lung tissue. (empr.com)
There's been a recent report about the vascular effects of the Spike protein alone (not coronavirus infection per se), and another presentation on similar effects in lung tissue. (seekingalpha.com)
These are almost certainly looking at the same phenomena - the lungs are of course full of vascular tissue, and what's being seen in both cases is very likely mediated by effects on the vascular endothelium. (seekingalpha.com)
The particles are so small that when you breathe them in, they cut your lung tissue, and cause tiny scars in your lungs. (nwlaborpress.org)
Our basic therapeutic strategy consists of exploiting the demethylaring properties of 5-azacytidine while avoiding its cytotoxic effects by using demethylating, non-cytotoxic doses, directly delivered to the target tissue, the bronchial epithelium, by inhalation over long periods of time. (elsevierpure.com)

Preventing or slowing the progression of lung disease is the major goal of AAT deficiency (AATD) management. (medscape.com)
Most patients are identified only after they develop lung disease, and the goals of treating AATD emphysema are similar to those for treating all forms of emphysema. (medscape.com)
This makes them a good choice for young children and for people with severe lung disease. (medlineplus.gov)
Some individuals remain healthy, while others develop a severe lung or liver disease, rarely both. (orpha.net)
Onset of lung disease is generally between 20 and 50 years of age. (orpha.net)
The USnational registry for childhood interstitial and diffuse lung disease: Report of study design and initial enrollment cohort. (stanfordchildrens.org)
INTRODUCTION: Childhood interstitial and diffuse lung disease (chILD) encompasses a broad spectrum of rare disorders. (stanfordchildrens.org)
End-stage lung disease is the principal cause of death. (medscape.com)
Lung transplantation is indicated for the treatment of end-stage lung disease. (medscape.com)

Aggressively treatment of infections may help decrease the potential for additional lung injury from an influx of neutrophils into the alveolus. (medscape.com)
We know now that the huge majority of such infections are spread by inhalation of virus-laden droplets from other infected people, so the route of administration is via the nose and/or lungs, and the cells lining your airway are thus the first ones to get infected. (seekingalpha.com)

Long-term inhalation of NiO is damaging to the lungs, causing lesions and in some cases cancer. (wikipedia.org)
Two of the three studies of carbon black production workers observed excess risk for lung cancer and other studies provided mixed evidence for an increased risk for lung and other cancers. (ecetoc.org)
Three studies of female rats that inhaled carbon black and three additional studies of female rats exposed intratracheally found significant increases in the incidence of malignant lung tumours, providing sufficient evidence that carbon black can cause cancer in animals. (ecetoc.org)
For lung cancer in rats, it was concluded that a sequence of events that starts with impaired clearance and accumulation of particles in the lung, causing inflammation, cell injury and production of reactive oxygen species that eventually lead to mutations, was well supported by experimental evidence, although some data also supported alternative pathways. (ecetoc.org)
High retained mass lung burdens and decreased lung clearance have been observed in coal miners, which led the Working Group to conclude that animal cancer data obtained under conditions of impaired lung clearance are relevant to humans. (ecetoc.org)
This proposal represents the first step of a long term program aimed at developing targeted epigenetic strategies for the treatment of advanced bronchial premalignancy and eventually the prevention of lung cancer. (elsevierpure.com)

Ultrasound waves can only penetrate so deep, but are helpful to check for lung thickening, or abscess formation along the edge of the lungs, while radiographs can help evaluate consolidation or scarring. (petmd.com)
The tiniest airborne particles in soot - known as PM 2.5 - are especially dangerous because they penetrate lungs and blood streams and worsen bronchitis. (thefiscaltimes.com)

9 Aerochamber spacers-long, hollow tubes with optional masks enabling direct lung deposition regardless of breath and hand coordination-often prevent thrush. (pharmacytimes.com)
Lung deposition of two bronchodilators in subjects with (COPD) when administered via standard jet nebulizer or Handihaler® using functional respiratory imaging (FRI). (ers-education.org)

Now, writing in Nature Materials , Rotolo and co-authors 4 report on mRNA polymeric nanoparticles that can be safely delivered to the lungs of animals of various species using a nebulizer to elevate the local production of therapeutic proteins (Fig. 1 ). (nature.com)
You will need to clean your nebulizer to prevent bacteria from growing in it, since bacteria can cause a lung infection. (medlineplus.gov)

Cystic fibrosis (CF) lung transplant recipients (LTRs) exhibit a disproportionately high rate of life-threatening invasive aspergillosis (IA). (stanfordchildrens.org)
Only studies conducted by inhalation and intratracheal administration in rats have shown significant increases in benign and malignant lung tumours and lesions described as benign cystic keratinising squamous-cell (KSC) tumours. (ecetoc.org)

If such changes occur, reduce budesonide inhalation suspension slowly. (nih.gov)
Lung tumours in humans are primarily located in the bronchial airways, whereas in the rat they occur in the parenchyma and are alveolar in origin. (ecetoc.org)
Death can occur within seconds or minutes of the inhalation of high concentrations of hydrogen cyanide gas. (axishistory.com)
While cannabis users in North America often retain the smoke in their lungs for up to a minute or longer, preliminary laboratory data suggest that the retention of almost all of the cannabinoids in the inhaled smoke may occur after a considerably shorter interval (less than half a minute may be sufficient).399,487 By contrast. (druglibrary.org)
The onset of psychological effects is almost immediate when smoking the more potent forms of cannabis, and the peak effects usually occur within minutes of administration. (druglibrary.org)

Maintenance treatment of COPD: 1 actuation of TRELEGY ELLIPTA 100/62.5/25 mcg once daily administered by oral inhalation. (nih.gov)
We also investigated the effect of salbutamol inhalation on S cond and S acin in patients with asthma and compared it with that obtained in patients with COPD. (atsjournals.org)
This study primarily demonstrated significant, but partially reversible, acinar airway impairment in patients with asthma, as compared with the more severe baseline acinar airway impairment in patients with COPD, which was not reversible after salbutamol inhalation. (atsjournals.org)

To test this hypothesis, we developed an in vivo model of VEGF overexpression in the lung on the basis of delivery to the respiratory epithelium of the VEGF165 complementary DNA by an E1(-) adenovirus vector (AdVEGF165). (nih.gov)
Using skills were evaluated according to the chart prepared by the Turkish Respiratory Society 'Inhalation Therapies' Working Study Group. (turkailehekderg.org)

In the following section the drug-induced damage will be presented according to their site of observation as airways and lung parenchyma. (medscape.com)
20 healthy volunteers were exposed to a subway and a control environment for 2 h, followed by measurements of lung function and the inflammatory response in the lower airways (bronchoscopy) and in the peripheral blood. (ersjournals.com)
In the conductive airways convective gas transport predominates and results in an increased S cond if there is an increased concentration difference between lung units subtended from these conductive airways and/or if there is a increased degree of unequal emptying of these units. (atsjournals.org)
Briefly, we can state that a marked change in acinar lung structure-bringing about a change in asymmetry of cross-sectional area of two daughter airways or changing the respective volumes of lung units subtended by any given branch point-is likely to result in increased S acin . (atsjournals.org)

This Notice is to inform potential applicants of the Food and Drug Administration (FDA) intent to publish a Funding Opportunity Announcement (FOA) for physiologically based absorption and pharmacokinetic modeling and simulation for non-gastrointestinally absorbed drug products in humans, allow potential applicants sufficient time to develop meaningful collaborations and responsive projects and encourages teams with complementary expertise in the physiologically based modeling and simulation experience to apply for this new FOA. (nih.gov)
It is well known that mercury compounds are readily absorbed through the unbroken skin as well as through the lungs by inhalation and by intestinal absorption after ingestion. (fda.gov)
Cannabis smoke is usually inhaled deep into the lungs and held there for an extended time, in order to maximize absorption of the active compounds. (druglibrary.org)

This species-specific response (tumour formation and KSC lesions) by the rat to carbon black, not seen in any other laboratory species and which has not been reported in humans, strongly suggests that the results of the rat inhalation bioassay should not be considered directly relevant when assessing human risk. (ecetoc.org)

Aerosols in the 1-5 µm range readily penetrated the deep region of the human lung following both oral and nasal breathing. (nih.gov)

The FDA has granted Orphan Drug Designation to Tacrolimus Inhalation Powder (TFF Pharmaceuticals) for prophylaxis of lung allograft rejection. (empr.com)

Provide similar efforts to improve lung function in patients with AATD emphysema as those provided to patients with emphysema from the usual causes. (medscape.com)
Pseudomonas aeruginosa is the most important Gram‐negative pathogen that persists in CF patients' lungs. (intechopen.com)
Its potency, pleasant smell and lack of bronchoirritant effects make it useful in operations on patients, particularly small children who need inhalation induction. (ispub.com)
Advise patients to rinse the mouth following inhalation. (nih.gov)
In addition, cost pressures in the healthcare system and patients' busy schedules are requiring increasing levels of self-administration. (pharmamanufacturing.com)
Due to the errors made during inhaler drug administration patients either don't take targeted doses, or even any medication. (turkailehekderg.org)
Patients should exhale fully before placing the canister to the mouth, 6 and they must coordinate inhalation with firing the canister. (pharmacytimes.com)
6 After administering the dose, patients should hold their breath for 10 seconds while the drug fully disperses and deposits in the lungs. (pharmacytimes.com)
8 Patients should rinse their mouths with water after administration and spit out any drug remaining in the mouth. (pharmacytimes.com)

For oral inhalation only. (nih.gov)
As with chemically synthesized small-molecule drugs, the oral delivery of biopharmaceuticals is generally viewed as the most desired route of administration. (pharmamanufacturing.com)
Advanced particle engineering is facilitating the oral delivery of biologics to the lungs. (pharmamanufacturing.com)
Aerosol Dosage Form C25158 C78418 Concomitant Medication Dose Form CAPSULE cap A solid pharmaceutical dosage form that contains medicinal agent within either a hard or soft soluble container or shell, usually used for the oral administration of medicine. (nih.gov)

The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined. (nih.gov)

Carbon black -induced lung tumour formation, including KSC lesions, occurs only in rats. (ecetoc.org)
Repeated administration of cyanide caused central nervous system lesions involving degeneration of the myelin sheath in rats and monkeys [Grant 1986]. (axishistory.com)

Further validation studies in hamsters, ferrets, cows and monkeys confirmed the efficiency of this polymer formulation in delivering mRNA to the lungs of different animals. (nature.com)

In an in vivo study in rats, urban PM 10 particles and UF carbon black particles were instilled in the lungs, and bronchoalveolar lavage (BAL) was performed after 6 h. (ersjournals.com)
There was a minority opinion in the Working Group that would support the classification of carbon black in Group 2A, and invoked the analogy with quartz particles, which are carcinogenic in the lung of rats and humans. (ecetoc.org)

A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species. (nature.com)

Long-term administration of corticosteroids does not protect the lung from progressive emphysema, but it is associated with many detrimental adverse effects. (medscape.com)

it is intended for topical application to the skin as well as local application into the nose (nasal aerosols), mouth (lingual aerosols), or lungs (inhalation aerosols). (nih.gov)

The recommended dose of Combivent Respimat is one inhalation four times a day. (rxlist.com)
Thirty subjects were randomized into three cohorts (10 subjects per cohort) that first inhaled lipopolysaccharide (LPS) and then received three administrations of RLS-0071 at 10 mg/kg (low dose), a 120 mg/kg loading dose followed by two administrations of 40 mg/kg (high dose) or placebo at 1 hour, 8 hours and 16 hours timepoints after the initial LPS inhalation. (vabio.org)

The activity of each nanocomplex is then screened in vivo by delivering it to the lungs via nebulization. (nature.com)

The pathophysiology of lung alveolar damage is based on the protease-antiprotease balance hypothesis. (orpha.net)

We hypothesized that the angiogenic mediator, vascular endothelial growth factor (VEGF), known to be expressed in the lung and to be capable of inducing local edema in skin, might evoke the development of lung edema if expressed in excess amounts. (nih.gov)

After zinc chloride instillation, the pathological changes largely spared the periphery of the lung, while following smoke inhalation they were more diffuse. (nih.gov)

Large amounts of feed material or saliva work their way back up the esophagus, and either travel out the nose or down the trachea to the lungs. (petmd.com)

Advise the patient to rinse his/her mouth with water without swallowing after inhalation to help reduce the risk. (nih.gov)

Subsequent oxygen administration had little effect on the development or progression of the pathological changes. (nih.gov)

the dust which is stirred and beaten up by digging penetrates into the windpipe and lungs and produces difficulty in breathing. (cdc.gov)

[ 76-78 ] Identifying drug adverse effects is of high importance for two major reasons, to stop administration and prevent further damage and to prevent further evaluation of newly introduced treatment modalities. (medscape.com)
Do not swallow SPIRIVA capsules, as the intended effects on the lungs will not be obtained. (nih.gov)
The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. (nih.gov)
This workshop aimed to summarize existing knowledge and identify research gaps surrounding the use of cannabis and cannabinoids and the resulting effects on heart, lung, blood, and sleep (HLBS) health. (nih.gov)

It is combined with oxygen and incrementally increasing doses of a more potent inhalational anesthetic (eg, sevoflurane) and delivered via mask inhalation. (medscape.com)
Intravenous administration of sulbactam/ampicillin and cefotaxime, and oxygen inhalation was started. (cdc.gov)

Inflammation (including degeneration and necrosis of the bronchiolar epithelium) occurred in the lungs of all exposed groups of males and females. (nih.gov)

Fig. 1: Screening of mRNA nanocomplexes for protein expression in the lungs. (nature.com)
From the initial screen, five promising formulations were identified based on their efficiency in delivering mRNA to the lungs, and finally a single lead polymer candidate containing a dithiol group, identified as P76, was selected. (nature.com)

Several drug formulations have been inculpated for lung injury after administration either by iv. (medscape.com)

Nitrous oxide is administered by inhalation, absorbed by diffusion through the lungs, and eliminated via respiration. (medscape.com)

You might think those things would be required by the Occupational Safety and Health Administration (OSHA) - which has a mandate under federal law to protect worker health and safety. (nwlaborpress.org)

Aspiration pneumonia occurs when foreign material gets into the trachea and enters the lungs, carrying bacteria which then causes an infection. (petmd.com)
If left untreated, bacteria settle into the favorable warm, moist environment of the lungs, and begin to proliferate (increase) unchecked. (petmd.com)

These changes can arise from uneven conductive airway narrowing and/or changes in P-V characteristics of lung units subtended by branch points proximal to the diffusion front. (atsjournals.org)

2 A V/Q scan is a combination of two nuclear tests that involve administration of inhaled and intravenous radioisotopes to measure ventilation and perfusion in all areas of the lungs. (cadth.ca)
A ventilation study is performed after inhalation of tracers such as xenon-133 ( 133m Xe) gas, krypton ( 81m Kr), or technetium-99m( 99m Tc)-labelled aerosols of diethylenetriamine pentaacetic acid ( 99m Tc-DTPA) or 99m Tc-labelled carbon microparticles ( 99m Tc-technegas). (cadth.ca)

The Food and Drug Administration has not been provided with well controlled studies to document the effectiveness of these preparations. (fda.gov)
In this application we propose to perform preclinical studies and the first human study of 5-azacytidine by inhalation. (elsevierpure.com)

prolonged retention of inhaled smoke is not common among cannabis users in either India or Jamaica, although deep inhalation techniques are typically used.412,534 On the basis of the present data, then, it would appear that under optimal conditions, a smoker may absorb up to one-half of the THC available in the cannabis material. (druglibrary.org)

Discontinue budesonide inhalation suspension and institute alternative therapy if paradoxical bronchospasm occurs. (nih.gov)
An inflammatory reaction occurs in the lungs due to the foreign material. (petmd.com)

Drug administration is the giving of a drug by one of several means (routes). (msdmanuals.com)

Anatomy18

Organisms15

Diseases45

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Psychiatry and Psychology2

Phenomena and Processes41

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care13

Geographicals1

Acute5

Exposure10

Interstitial lung di1

Inhalers3

Silicosis5

Toxicity5

Particles can lead1

Ipratropium bromide2

Mice10

Diseases3

Pulmonary8

Crystalline2

Silica1

Vitro2

Tissue5

Disease9

Infections2

Cancer6

Penetrate2

Deposition2

Nebulizer2

Cystic2

Occur5

COPD3

Respiratory2

Airways4

Absorption3

Bioassay1

Human lung1

Powder1

Patients9

Oral4

Asthma1

Lesions2

Hamsters1

Rats2

Therapeutic1

Corticosteroids1

Nasal1

Dose2

Nebulization1

Alveolar1

Development of lung1

Diffuse1

Nose1

Rinse1

Progression1

Dust1

Effects4

Oxygen2

Inflammation1

MRNA2

Formulations1

Respiration1

Occupational1

Bacteria2

Diffusion1

Ventilation2

Studies2

Typically1

Occurs2

Routes1