AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
NitrosaminesLung NeoplasmsUrethaneMice, Inbred ALungCarcinogensButylated HydroxytolueneAnticarcinogenic AgentsIsothiocyanatesCell Transformation, NeoplasticBenzo(a)pyreneAdenomaCarcinoma, Non-Small-Cell LungGenes, rasProto-Oncogene Proteins p21(ras)AdenocarcinomaGene Expression Regulation, NeoplasticCatechinTeaCell Line, TumorTobaccoCell ProliferationMice, TransgenicLung DiseasesNeoplasms, ExperimentalSignal TransductionMice, KnockoutImmunohistochemistryMutationPlants, ToxicMice, Inbred C57BLReverse Transcriptase Polymerase Chain ReactionLung InjuryTumor Suppressor Protein p53Mice, Inbred StrainsProto-Oncogene Proteins c-aktApoptosisAntineoplastic AgentsLung TransplantationDisease Models, AnimalCarcinogenesisIndolesGene Expression ProfilingPromoter Regions, GeneticBlotting, WesternProto-Oncogene ProteinsImmunoblottingAcute Lung InjurySmokingEnzyme ActivationMammary Neoplasms, ExperimentalIntestinal NeoplasmsNeoplasmsMice, NudeLung Volume Measurements9,10-Dimethyl-1,2-benzanthraceneMammary Neoplasms, AnimalLung Diseases, InterstitialTumor Suppressor ProteinsRNA, MessengerGenes, Tumor SuppressorGenes, APCMammary Glands, AnimalEpithelial CellsSkin Neoplasmsbeta CateninNeoplasm TransplantationPrecancerous ConditionsNeoplasm ProteinsPulmonary AlveoliTumor Cells, CulturedTotal Lung CapacityColonic NeoplasmsExtravascular Lung WaterCell DivisionLoss of HeterozygosityMice, Inbred BALB CBreast NeoplasmsDisease ProgressionCocarcinogenesisBronchoalveolar Lavage FluidNeoplasm InvasivenessPapillomaProto-Oncogene Proteins c-mycSmall Cell Lung CarcinomaCarcinoma, Small CellRNA, Small InterferingGene SilencingDown-RegulationOncogenesDNA MethylationNeoplasm MetastasisBase SequenceGenes, p53Adenomatous Polyposis Coli ProteinCarcinoma, Squamous CellTranscription FactorsDNA, NeoplasmFibroblastsUp-Regulation
MetastasisTumorsCancersNSCLCInactivationChemoprevention of lung cancerAdenocarcinomaExposureCellsMortalityMiceToxicityPromotesFacilitated lung tumorCarcinogenesisProgressionMalformationsMetastaticTissuesSCLCInhibitionPathwaysEpithelialRemain unclearSmall cell lMolecularGenesHuman lungTumor typesNodulesSusceptibilityTumoursEmbryonicCases of lung cancerPromoted lung cancer cellLymph-nodeKinaseSmokersAdditionallyTherapiesChronic lung diseaseLiverMutationsLesionsTobacco smokeOrgansRegenerativeAdenomasData on lungReduction in lungLaboratory animalsRecurrence
Metastasis17
  • Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
  • These findings suggest that lncRNA JPX, a mediator of Twist1 signaling, could predispose lung cancer cells to metastasis and may serve as a potential target for targeted therapy. (biomedcentral.com)
  • Although many advances have been made in the diagnosis and treatment of lung cancer in recent years, metastasis still remains the main challenge posed by advanced lung cancer leading to high mortality [ 3 ]. (biomedcentral.com)
  • As an oncogene, JPX affected the tumor size, TNM staging, and metastasis of lung cancer. (biomedcentral.com)
  • We tested the role of systemic fetuin in tumor cell growth and metastasis by injecting Lewis lung carcinoma (LLC) cells into fetuin-A null and their wild-type (WT) littermate control C57BL/6 mice via the tail vein, s.c., and intrasplenic routes. (ac.ke)
  • In the experimental metastasis assay, the lungs of the WT mice were filled with metastatic nodules, whereas the lungs of the fetuin-A null mutant mice were virtually free of colonies at the end of 2 weeks. (ac.ke)
  • Similarly, intrasplenic injection of LLC cells resulted in rapid colonization of the liver with metastasis to the lungs within 2 weeks in the WT but not fetuin-A null mice. (ac.ke)
  • The anti-cancer impact of propofol on cervical cancer cells growth in vivo was determined by means of xenograft tumor model and lung metastasis model. (aging-us.com)
  • However, the molecular changes driving lung cancer invasion and metastasis remain unclear. (aacrjournals.org)
  • In this study, we identified fibulin-5, a vascular ligand for integrin receptors, as a suppressor of lung cancer invasion and metastasis. (aacrjournals.org)
  • Furthermore, overexpression of fibulin-5 in H460 lung cancer cells inhibited metastasis in mice. (aacrjournals.org)
  • Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway. (aacrjournals.org)
  • The 5-year survival rate of lung cancer is below 20%, with most patients dying from distant metastasis ( 1 ). (aacrjournals.org)
  • However, the mechanism of lung cancer metastasis is poorly understood. (aacrjournals.org)
  • It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
  • Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
  • This study aimed to identify the compounds that target Src to suppress lung cancer tumourigenesis and metastasis and investigate their underlying molecular mechanisms. (oncotarget.com)
Tumors12
  • Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)
  • Tumors were also found to develop more quickly in mice overexpressing IGF-IR in the type II alveolar cells ofthe lung that were treated with doxycycline in utero in comparison to postnatally, however this finding was not statistically significant. (uoguelph.ca)
  • The objective of this study was to investigate the potential of iron as iron (III) oxide (Fe2O3) to initiate lung tumors in A/J mice, a lung tumor susceptible strain. (cdc.gov)
  • In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
  • The resultant tumors and their growth were evaluated based on lung weight, tumor area, and tumor burden. (news-medical.net)
  • Additionally, a lesser number of tumors were observed in the lungs of mice treated with GLSF and metformin. (news-medical.net)
  • Fibulin-5 was silenced by promoter hypermethylation in a majority of lung cancer cell lines and primary tumors. (aacrjournals.org)
  • The expression levels of fibulin-5 and MMP-7 were inversely correlated in lung tumors. (aacrjournals.org)
  • High dietary phosphate consumption causes the growth of lung and skin tumors in experimental animal models. (uwaterloo.ca)
  • These findings provide a basis for further studies that associate CYP2A13 haplotypes with incidences of smoking-related lung tumors and for studies on the mechanisms of the low-expression phenotype of the 7520G-containing allele. (aspetjournals.org)
  • Loss-of-function mutations inactivate SMARCA4 in approximately 10% of non-small-cell lung cancers (NSCLC) and nearly 100% of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) tumors, noted coauthor William Foulkes, MD, James McGill professor of medicine, oncology and human genetics at McGill University and head of the Cancer Genetics Laboratory, Lady Davis Institute for Medical Research, in Montreal, Quebec, Canada. (cancernetwork.com)
  • The model-based analysis suggests that humans would be expected to be 100- fold less sensitive to ST-inducted lung tumors than mice, based on pharmacokinetic differ- ences. (cdc.gov)
Cancers8
  • The aberrant expression of secretory mucin MUC5AC has been documented during the tumourigenesis and progression of various cancers . (bvsalud.org)
  • Small cell lung cancer (SCLC), a poorly differentiated and highly aggressive tumor, constitutes approximately 15% of all lung cancers ( 1 ). (spandidos-publications.com)
  • Lung cancers are histologically classified as Small Cell Lung Cancer (SCLC) or Non-Small Cell Lung Cancer (NSCLC). (frontiersin.org)
  • Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. (hindawi.com)
  • Cyclin-dependent kinase 4/6 (CDK4/6) inhibition, a treatment used with some breast cancers, might also prove effective against tumor suppressor SMARCA4 ( BRG1 ) mutation-harboring lung cancers and a rare, aggressive form of SMARCA4 mutation-driven ovarian cancer, suggest preclinical findings reported in a pair of papers in Nature Communications . (cancernetwork.com)
  • Many cancer in humans, including (to var- mice and rats and tumours of the lar- of these issues result from the fact ying extents) cancers of the lung, ynx in hamsters. (who.int)
  • In The Cancer Genome Atlas (TCGA), lung cancer samples included 10.5 tobacco smoking-associated SGMs per genome on average: 73% of cancers had at least one, and 39% had at least 10 of these protein-truncating mutations. (medscape.com)
  • Further analyses revealed that tobacco smoking seems to be the strongest driver of SGMs, not only in lung cancer and head and neck cancers, but also in esophageal cancers, all of which involve direct exposure to smoke. (medscape.com)
NSCLC6
  • In 2010, there were 222,520 new cases of lung cancer diagnosed in the US, 85% being non small cell lung cancer (NSCLC) and 157,300 lung cancer related deaths. (inknowvation.com)
  • These activities have led to the discovery of the 88 kDa granulin precursor (GP88), an autocrine growth factor preclinically validated as playing a role in NSCLC tumorigenesis. (inknowvation.com)
  • Screening in high-risk smokers results in a reduction in lung cancer mortality, however, screening efforts are primarily focused on non-small cell lung cancer (NSCLC). (frontiersin.org)
  • Lung cancer is the leading cause of cancer-related death, and NSCLC constitutes nearly 85%-90% of all cases. (scielo.br)
  • Lung cancer is divided into two major groups: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (scielo.br)
  • There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
Inactivation1
  • Both p53 gene inactivation and Sp1 overexpression in lung ADC may enhance MUC5AC expression, especially in KRAS-mutated cases. (bvsalud.org)
Chemoprevention of lung cancer2
  • These results provide a basis for further development of mixtures of PEITC-NAC and MI for chemoprevention of lung cancer. (csbsju.edu)
  • Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
Adenocarcinoma7
  • Molecular insight of p53/Sp1/MUC5AC axis in the tumorigenesis and progression of lung adenocarcinoma. (bvsalud.org)
  • However, little is currently known on the function of MUC5AC in lung adenocarcinoma . (bvsalud.org)
  • The present study focused on the tumour-promoting role of MUC5AC and its regulatory mechanisms in lung adenocarcinoma . (bvsalud.org)
  • Subsequently, small interfering RNA and small hairpin RNA were used to knockdown MUC5AC in lung ADC cell lines to elucidate its role in tumorigenesis and progression of lung adenocarcinoma via in vitro functional assays and xenograft mouse models. (bvsalud.org)
  • Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)
  • In addition, rhodomycin A rendered gefitinib-resistant lung adenocarcinoma cells more sensitive to gefitinib treatment, implying a synergistic effect of the combination therapy. (oncotarget.com)
  • This tions in the KRAS gene are frequent- quently at very low doses ( Hecht, indicates considerable concordance ly observed in lung adenocarcinoma 1998) . (who.int)
Exposure10
  • Here, we show that chronic (6-month) exposure of human lung epithelial cells to single-walled (SW) CNTs at the workplace-relevant concentration induced an emergence of lung CSCs, as indicated by the induction of CSC tumor spheres and side population (SP). (oncotarget.com)
  • Lung cancer is the leading cause of cancer-related death, and environmental and occupational exposure is a major cause of most cases [ 1 , 2 ]. (oncotarget.com)
  • Tumorigenic response in lung tumor susceptible A/J mice after sub-chronic exposure to calcium chromate or iron (III) oxide. (cdc.gov)
  • Mice were euthanized 70 weeks after the first exposure and lung nodules were enumerated. (cdc.gov)
  • In conclusion, evidence from this study, in combination with our previous studies, demonstrate that exposure to iron alone may be a potential risk factor for lung carcinogenesis. (cdc.gov)
  • Compared with cigarettes, G2 and G3 e-cigarettes resulted in significantly lower levels of exposure to a potent lung carcinogen and cardiovascular toxicant. (bmj.com)
  • There is evidence that, although incidence is almost always associated with environmental factors such as smoking or occupational exposure, susceptibility has a genetic component with early onset lung cancer following Mendelian inheritance. (bmj.com)
  • In the short-term exposure study in mice, B[a]P was found to disrupt the architecture of the lung and alveoli while causing an increased infiltration of inflammatory cells as compared to the control group. (news-medical.net)
  • 1997. Lung function and long term exposure to air pollutants in Switzerland. (cdc.gov)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
Cells12
  • The impact of JPX on Twist1 expression, cell growth, invasion, apoptosis, and in vivo tumor growth were investigated in lung cancer cells by western blotting, rescue experiments, colony formation assay, flow cytometry, and xenograft animal experiment. (biomedcentral.com)
  • Interestingly, JPX and Twist1 were coordinately upregulated in lung cancer tissues and cells. (biomedcentral.com)
  • Two doxycycline-inducible transgenic mouse models in which the IGF-IR was overexpressed in either the Clara cells or the type II alveolar cells of the lung were used in this study. (uoguelph.ca)
  • It was discovered that mice overexpressing IGF-IR in the type II alveolar cells of the lung developed a greater tumor burden than mice overexpressing IGF-IR in the Clara cells. (uoguelph.ca)
  • However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. (spandidos-publications.com)
  • We here demonstrated that casticin decreased sphere‑ and colony‑formation capabilities, and downregulated uPAR and CD133 in second‑generation spheres, which were considered as lung cancer stem‑like cells (LCSLCs), from SCLC H446 cells, in a concentration‑dependent manner. (spandidos-publications.com)
  • Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
  • The above biological processes have important roles in tumorigenesis, cancer development and chemoresistance in tumor cells. (spandidos-publications.com)
  • We have identified a key transcriptional regulator of this process, without which AT1 cells lose their molecular and cellular characteristics and the lung undergoes alveolar simplification as in BPD. (mdanderson.org)
  • We are studying how lung endothelial cells respond to Vegfa during intussusceptive angiogenesis and whether and how the same Vegfa signaling elicits distinct responses from those during the well-characterized retinal sprouting angiogenesis. (mdanderson.org)
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
Mortality10
  • Lung cancer is the leading cause of mortality from cancer in both men and women in developed countries. (bmj.com)
  • Lung cancer is one of the leading causes of cancer mortality worldwide, and most lung cancer deaths are caused by tobacco smoking and second-hand smoking. (news-medical.net)
  • Lung Cancer remains the leading cause of cancer and mortality for men and women worldwide. (inknowvation.com)
  • Despite advances in diagnosis and treatment, the morbidity and mortality of lung cancer remains to mount up. (intechopen.com)
  • The high mortality rate of lung cancer is largely due to the spread of disease to other organs. (aacrjournals.org)
  • Low-dose computed tomography (LDCT) screening among high-risk populations remains an effective strategy for curbing mortality, with an observed 20% reduction in lung cancer-associated mortality ( 3 ). (frontiersin.org)
  • Methods We collected, harmonised and standardised population-wide data on all-cause and lung-cancer mortality by age, gender, educational and occupational level in 14 European populations in 1990-1994 and 2000-2004. (bmj.com)
  • It is generally believed that the high mortality rate of lung cancer cases may be a result of the aggressiveness and invasive and metastatic potential of the disease and the fact that it is not easily detectable until it reaches advanced stages [ 2 ]. (hindawi.com)
  • Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
  • Lung cancer is a predominant type of cancer that causes high mortality, and the survival rate remains relatively low even after surgery, chemotherapy or radiotherapy [ 1 ]. (oncotarget.com)
Mice15
  • Lung colonization responded to the levels of serum fetuin-A in a dose-dependent manner, as observed by the formation of half as many colonies in mice heterozygous for the fetuin-A locus compared with homozygous WT mice and restoration of lung colonization by the administration of purified fetuin-A to fetuin-A-null mice. (ac.ke)
  • In the present experiment the effect of food restriction, with or without prior adrenalectomy, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tumor development in A/J mice was explored. (shengsci.com)
  • Food restriction (27%), beginning 3 weeks after a single oral dose of 0.5 mg DMBA and continued for the duration of the experiment (14 weeks), significantly inhibited lung adenoma development, whereas adrenalectomy 2 weeks before initiating food restriction abolished the tumor inhibitory effect of underfeeding and also enhanced tumor development in the ad libitum fed mice. (shengsci.com)
  • Inhibition of Lung Tumorigenesis in A/J Mice by N-Acetyl-S-(N-2-phenet" by S. S. Hecht, P. Upadhyaya et al. (csbsju.edu)
  • Isothiocyanates, their N-acetylcysteine conjugates, and myo-inositol (MI) are inhibitors of lung tumorigenesis in A/J mice. (csbsju.edu)
  • Significant reductions in lung tumor multiplicity were observed in mice treated with PEITC, PEITC-NAC, PPITC and PPITC-NAC. (csbsju.edu)
  • Reduction of lung tumor multiplicity by PEITC-NAC plus MI was greater than that in the mice treated with the agents alone in all temporal sequences. (csbsju.edu)
  • Both CaCrO4 and Fe2O3 significantly increased gross-observed lung tumor multiplicity in A/J mice (9.63 +/- 0.55 and 3.35 +/- 0.30, respectively) compared to sham (2.31 +/- 0.19). (cdc.gov)
  • 1, 2 Moreover, susceptibility is largely intrinsic to the lung itself as shown by the classical experiments involving lung explants from sensitive and resistant mice. (bmj.com)
  • In a preclinical study published in the journal Frontiers in Pharmacology , researchers from the USA investigated the potential chemopreventive effects of a mushroom - Ganoderma lucidum (GL)-derived commercial product named GLSF in vitro and in mice with lung carcinogenesis induced by two tobacco smoke carcinogens, namely benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (news-medical.net)
  • They found that mice treated with GLSF had lower B[a]P-induced lung toxicity and reduced NNK-induced lung tumor development. (news-medical.net)
  • In the present study, researchers aimed to gather preclinical evidence on the potential effects of GLSF, which contains the spore and fruiting body of GL in a 30:8 ratio, on lung carcinogenesis in mice induced by NNK and B[a]P. (news-medical.net)
  • However, pretreating the mice with GLSF was found to reduce B[a]P-induced lung toxicity (with an efficacy comparable to curcumin), as demonstrated by the improved histology of the harvested lung tissue samples, as well as lower LDH activity, malondialdehyde levels, and inflammatory cell infiltration in them. (news-medical.net)
  • In the long-term carcinogenesis study, the mice treated with NNK showed a 58.24% increase in lung weight and increased the expression of inflammatory and angiogenesis markers compared to the control. (news-medical.net)
  • As predicted, treatment of mice with GLSF showed a significant decrease in lung weight and tumor area. (news-medical.net)
Toxicity2
  • The lung toxicity was measured using lactate dehydrogenase (LDH) activity assay, lipid hydroperoxide (LPO) assay, histology, and immunohistology analysis. (news-medical.net)
  • The A/J mouse, which relatively high concentrations, pro- is highly susceptible to lung tumour duces avoidance reactions, stress, development, appears to present weight loss, and other indicators of a relatively reproducible system for toxicity that are widely different from Part 1 · Chapter 5. (who.int)
Promotes1
  • Our findings suggest that high MUC5AC expression promotes tumourigenesis and progression of lung ADC. (bvsalud.org)
Facilitated lung tumor1
Carcinogenesis1
Progression3
  • Further research is needed to determine how excessive dietary phosphate consumption influences initiation and promotion of tumorigenesis, and to elucidate prognostic benefits of reducing phosphate burden to decrease tumor cell growth and delay metastatic progression. (uwaterloo.ca)
  • Our data also reveal that the inhibitory effect of rhodomycin A on lung cancer progression may act through suppressing the Src-related multiple signalling pathways, including PI3K, JNK, Paxillin, and p130cas. (oncotarget.com)
  • Furthermore, Reimand said, the team identified APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) enzyme-driven SGMs, "which may help decipher the role of APOBECs in tumorigenesis and progression. (medscape.com)
Malformations4
  • Congenital lung malformations considered in this article are those occurring in the lung below the carina. (medscape.com)
  • The aim here is to provide a concise approach to congenital lung malformations. (medscape.com)
  • Congenital lung malformations represent 5-18.7% of all congenital anomalies. (medscape.com)
  • My lab is interested in the normal developmental processes that build the lung and how such processes go awry during lung malformations, injury and tumorigenesis. (mdanderson.org)
Metastatic3
  • We observed that lncRNA JPX was upregulated in lung cancer metastatic tissues and was closely correlated with tumor size and an advanced stage. (biomedcentral.com)
  • The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. (hindawi.com)
  • The bone is one of the most common metastatic sites for lung cancer [ 8 , 9 ]. (hindawi.com)
Tissues4
  • RT-qPCR and western blotting were conducted to detect the expression levels of lncRNA JPX and Twist1 in lung cancer cell lines and tissues. (biomedcentral.com)
  • We found that MUC5AC was upregulated in lung ADC tissues and cell lines , especially in KRAS-mutant cases and correlated with poor prognosis . (bvsalud.org)
  • Therefore, the expression of important markers of inflammation and angiogenesis (Cox-2, NF-kB, and VEGF-A) and those of apoptosis (cleaved-caspase-3 and cleaved-PARP) was also measured in the lung tissues. (news-medical.net)
  • We first determined the level of total CYP2A13 mRNA in 18 normal lung biopsy tissues to assess the extent of interindividual variation. (aspetjournals.org)
SCLC2
  • Small cell lung cancer (SCLC) is characterized by poor prognosis and challenging diagnosis. (frontiersin.org)
  • Although SCLC constitutes the minority of lung cancer cases, it represents an aggressive form of cancer characterized by a high growth fraction, early development of metastases, and extremely poor prognosis, with less than 7% 5-year survival rate ( 2 ). (frontiersin.org)
Inhibition1
  • In 2004, Dmitry published a series of articles regarding the Wip1 phosphatase inhibition of tumorigenesis through p38 MAP kinase , and after establishing his lab in 2004 at IMCB in Singapore, he continued interrogating the role of Wip1 phosphatase in cancer but also in aging . (lifeboat.com)
Pathways1
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
Epithelial3
  • The early division and growth of the lung bud is directed by the epithelial-mesenchymal interaction. (medscape.com)
  • An embryonic mouse lung showing the epithelial progenitors in green and the airways in magenta. (mdanderson.org)
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
Remain unclear1
  • However, the function and mechanism of most aberrantly expressed lncRNAs as ceRNAs in lung cancer remain unclear. (biomedcentral.com)
Small cell l4
  • 2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. (scielo.br)
  • 2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (scielo.br)
  • ONCOLOGY spoke with Eric Ko, MD, PhD, who recently published a review article with his colleagues on strategies for combining radiation therapy with immunotherapy for the treatment of non-small-cell lung cancer. (cancernetwork.com)
  • The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)
Molecular5
  • We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
  • Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
  • This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
  • Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
  • Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
Genes3
  • We have also attempted to verify a series of differentially expressed candidate susceptibility genes to lung tumours in our previous microarray analysis with semiquantitative reverse transcriptase PCR (RT-PCR). (bmj.com)
  • Changes in the activity of proto-oncogenes and cancer suppressor genes are crucial in tumorigenesis ( 4 ). (frontiersin.org)
  • Transcriptomic meta-analyses reveal significant numbers of genes with inverse patterns of expression in Alzheimer's disease and lung cancer, and with similar patterns of expression in Alzheimer's disease and glioblastoma. (nature.com)
Human lung6
  • The type I insulin-like growth factor receptor (IGF-IR) has been observed to be overexpressed in the majority lung cancer cell lines and human lung tumor biopsies. (uoguelph.ca)
  • The aim of this study was to identify any impact of CYP2A13 single-nucleotide polymorphisms (SNPs) on CYP2A13 expression in human lung. (aspetjournals.org)
  • CYP2A13 genetic polymorphisms may be associated with interindividual differences in susceptibility to tobacco-related tumorigenesis, because the resultant variations in CYP2A13 expression and metabolic activity can significantly alter the extent of NNK metabolic activation in human lung. (aspetjournals.org)
  • In the present study, we determined the potential impact of selected CYP2A13 SNPs on levels of CYP2A13 expression in human lung. (aspetjournals.org)
  • Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
Tumor types1
  • Histopathological analysis showed that bronchiolo-alveolar adenomas (BAA) and carcinomas (BAC) were the primary lung tumor types in all groups and were increased in the exposed groups compared to sham. (cdc.gov)
Nodules1
  • These nodules probably represent the origin of primary meningiomas in the lung. (medscape.com)
Susceptibility1
  • Sequence variations that affect CYP2A13 expression may contribute to interindividual differences in susceptibility to tobacco-related tumorigenesis. (aspetjournals.org)
Tumours1
  • This chapter addresses the con- Coherence: carcinogenicity the induction of lung tumours, both cordance in studies of carcinogen- of tobacco smoke in humans benign and malignant, by cigarette icity and mechanisms between versus experimental animals smoke. (who.int)
Embryonic1
  • Thus, asymmetry of lung buds (three main bronchi on the right, two on the left) is apparent in the embryonic phase. (medscape.com)
Cases of lung cancer1
  • It is estimated that, in 2014, there will be approximately 224,000 newly diagnosed cases of lung cancer and 159,000 deaths from lung cancer [ 1 ]. (hindawi.com)
Promoted lung cancer cell1
  • It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
Lymph-node2
  • In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
Kinase1
  • 2005) Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. (scielo.br)
Smokers3
  • This is important for developing practical approaches to lung cancer chemoprevention in smokers and ex-smokers. (csbsju.edu)
  • how- lung cancer in smokers. (who.int)
  • Concordance: carcinogenicity of tobacco smoke in humans pound likely to be involved in the dence from studies of haemoglobin versus carcinogenicity of etiology of lung cancer in smokers. (who.int)
Additionally2
  • Additionally, JPX upregulated Twist1 by competitively sponging miR-33a-5p and subsequently induced EMT and lung cancer cell invasion. (biomedcentral.com)
  • Additionally, downregulation of MUC5AC reduced tumourigenesis in mouse models. (bvsalud.org)
Therapies1
  • Given the paucity of efficient drug -targeted approaches of KRAS-driven lung ADCs, therapies directed at downstream effectors such as MUC5AC could have huge prospects. (bvsalud.org)
Chronic lung disease2
  • Bronchopulmonary dysplasia (BPD) is a major chronic lung disease associated with preterm birth and characterized by alveolar simplification with dysmorphic microvasculature. (mdanderson.org)
  • We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
Liver1
  • of the liver, the kidney, and the lung (8). (lu.se)
Mutations2
  • NNK and B[a]P are known procarcinogens in tobacco smoke that can lead to deoxyribonucleic acid (DNA) mutations and, eventually, lung cancer. (news-medical.net)
  • For example, tobacco-driven SGMs in lung cancer correlate with smoking history, meaning these mutations are potentially preventable. (medscape.com)
Lesions1
  • Fetal lung lesions occur in an estimated 1 in 15,000 live births. (medscape.com)
Tobacco smoke2
  • These studies demonstrated ic problems associated with animal sufficient evidence that tobacco that cigarette smoke can induce tu- studies of tobacco smoke expo- smoking causes multiple types of mours of the lung and nasal cavity in sure have been recognized. (who.int)
  • These tobacco smoke evident in laboratory ciated with risk of lung cancer, after and other aromatic amines are com- animals and epidemiological obser- correction for duration and intensity ponents of mainstream cigarette vations in humans ( Witschi, 2007 ). (who.int)
Organs1
  • Although they secrete the amniotic fluid, the lungs are unnecessary as organs of respiration in fetal life. (medscape.com)
Regenerative1
  • Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
Adenomas1
  • Previously, classical genetic studies involving cross breeding of mouse strains with differing susceptibilities have identified chromosomal areas associated with predisposition to developing spontaneous and chemically induced lung adenomas. (bmj.com)
Data on lung1
  • In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
Reduction in lung1
  • There was a significant trend for reduction in lung tumor multiplicity with increased duration of treatment by the chemopreventive agents. (csbsju.edu)
Laboratory animals1
  • PyV-induced tumorigenesis in laboratory animals, by simian virus 40 (SV40) or by multiple human PyVs, such as JC virus (JCV), is used extensively as a cell transformation model. (cdc.gov)
Recurrence1
  • By continuously analyzing breath particles, we anticipate the ability to detect any signs of lung cancer recurrence at an early phase, facilitating prompt medical attention and tailored treatment strategies," explains Sandra Linstedt. (lu.se)