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  • donor lung
  • It is estimated that it takes an average of one to two years to receive a suitable donor lung, and the wait is made less predictable by the necessity for tissue match. (encyclopedia.com)
  • tissue
  • The lungs, which were tissue-matched to each individual pig, were grown in the laboratory. (webmd.com)
  • The researchers assessed the development of lung tissue and integration of the bioengineered lungs at 10 hours, two weeks, one month and two months after the transplants. (webmd.com)
  • About 85% of lungs made available for donation are not used due to tissue damage that potentially could be repaired with perfusion or other techniques. (latimes.com)
  • The bioengineered lung facilitates the development of a blood supply and provides for the establishment of natural lung microbial flora," John Hunt, who studies tissue engineering at Nottingham Trent University in the UK and was not involved in this research, tells BBC News . (the-scientist.com)
  • Death occurred on the 29th post-operative day and an autopsy revealed abundance of foamy macrophages in lung tissue consistent with ASMD cells. (medworm.com)
  • Effect of lung tissue directed antibodies was measurable in the alveolar macrophages much before the antibodies became detectable in the circulation or diagnosis of CLAD. (eurekalert.org)
  • Considered to be in remission, Spencer remained unbothered by any cancer-related health complaints until his doctors connected the dots from chemotherapy as a baby to the scar tissue in his lungs as a teen. (fox43.com)
  • Caughey and his fellow researchers studied lung biopsy samples from 22 lung transplant patients, with the goal of detecting genes and gene products associated with inflammation and formation of scar tissue in breathing passages. (bio-medicine.org)
  • Using a customized version of a conventional laboratory technique, they found that they were able to look at hundreds of gene products simultaneously in lung tissue samples only a few millimeters across. (bio-medicine.org)
  • allograft
  • The findings have been published in The Journal of Clinical Investigation , in a research paper titled "Central memory CD8 T lymphocytes mediate lung allograft acceptance. (digitaljournal.com)
  • mortality
  • It carries a one per cent chance of mortality and leaves the donor with a minimal reduction in lung capacity. (hospitalnews.com)
  • Accelerated coronary atherosclerosis is a major cause of morbidity and mortality in cardiac transplant recipients. (ahajournals.org)
  • In response to a study examining psychosocial risk factors of mortality in lung transplant recipients, Vanessa L. Gutiérrez, from the Universidade Federal de São Paulo in Brazil, and colleagues discuss sleep as an additional confounding factor. (empr.com)
  • Mood factors and poor sleep could be involved in post-transplant decreased quality of life and premature mortality. (empr.com)
  • Thus, we believe that the assessment of sleep and their features would better clarify the predictors of mortality in the post-transplant patients of the study from Smith et al, due to evidence of the relationship between poor sleep, mood disorders, and mortality," the authors write. (empr.com)
  • pulmonary fibrosis
  • The sisters both became ill about 10 years ago with idiopathic pulmonary fibrosis, a little-understood scarring of the lungs that often requires a transplant and kills more people than breast cancer every year, said Scheinin. (seacoastonline.com)
  • Pulmonary fibrosis is when the deep tissues of the lung becoming thick, stiff and scarred, which interferes with a person's ability to breathe. (fox43.com)
  • complication
  • He underwent a bone-marrow transplant for leukaemia about two years ago but later developed graft-versus-host disease, a complication in which the newly transplanted material attacks the recipient's body, Kyodo News said. (medindia.net)
  • The study, published June 14 in Science Translational Medicine , also demonstrates targeting these cells could lead to novel treatments for PGD, a complication that currently impacts more than half of transplant patients. (eurekalert.org)
  • vivo lung perfusion
  • Since 2014, Frost has dedicated himself full-time to developing a mobile, dishwasher-sized prototype ex vivo lung perfusion machine - the device keeping lungs alive outside the body - that performs to industry standard. (utoronto.ca)
  • The thesis Ex Vivo Lung Perfusion - clinical and experiment studies was defended at a disputation held on 26 September. (healthcanal.com)
  • biopsy
  • The biopsy tissues obtained from the lungs are examined by a pathologist. (medindia.net)
  • Routinely, 4-8 transbronchial biopsy samples are obtained from the transplanted lung. (bioportfolio.com)
  • At the 1 year post transplant bronchoscopy, the presence of the cough reflex will be assessed by placing 3 to 5 ml of 5% dextrose and placement of the bronchial biopsy forceps on teh airway mucosa. (clinicaltrials.gov)
  • The presence of the cough reflex will be assessed with administartion of mecahnical (Biopsy foreceps) and chemical (dextrose solution) at the level of the main carina, native lung airway and proximal and distal to the airway anastomosis. (clinicaltrials.gov)
  • perfusion
  • Keshavjee and his team used the Toronto XVIVO Lung Perfusion System, which was designed for this purpose. (latimes.com)
  • Researchers treated 23 sets of lungs that were impaired in some manner - and would have been rejected for transplant - with perfusion for four hours and transplanted 20 of them that looked viable after the treatment. (latimes.com)
  • The perfusion technique essentially repairs damage caused by swelling or inflammation in the lung, Dark said. (latimes.com)
  • time of transplant
  • This is a clinically-relevant finding because it would likely be easy to develop a drug that kills these cells at the time of transplant," said Bharat, also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. (eurekalert.org)
  • survive
  • Unhealthy or damaged lungs can make it difficult for your body to get the oxygen it needs to survive. (mayoclinic.org)
  • To allow the transplanted organ to survive in a new body, medicines are used to trick the immune system into not attacking the transplant. (lifebridgehealth.org)
  • But first, coauthor Joan Nichols of the University of Texas Medical Branch at Galveston tells Popular Science , the team will "need to prove that the animals can survive on the oxygen provided by the engineered lung alone. (the-scientist.com)
  • But now, Baby Jack is the youngest child in more than a decade to survive a heart and lung transplant, and his parents know he`s a true miracle. (fox61.com)
  • Tiffany says it's still in early phases, and since Baby Jack is the first in a decade to survive the double transplant, longterm prognosis is dicey. (fox61.com)