Lung transplant clinical outcomes lung transplantation. Medical search. Frequent questions

the care of adults with advanced lung disease and lung transplant recipients. (ucsf.edu)
Via genome sequencing of both lung transplant recipients and donors, we examine genetic ancestral markers that are associated with graft rejection and dysfunction. (nih.gov)
These sites collect longitudinal bio-samples and clinical data in heart- and lung-transplant recipients for the GRAFT consortium. (nih.gov)
Today, a main focus of the transplant community is the long-term outcomes of lung and heart allograft recipients. (terasaki.org)
METHODS: Pediatric first-time LTx recipients transplanted between January 2000 and December 2020 were identified in the United Network for Organ Sharing Registry to compare post-transplant survival according to ECMO support at time of transplant. (bvsalud.org)
In the absence of any reliable treatments for established bronchiolitis obliterans, investigators from Mayo Clinic in Jacksonville, Florida, are conducting a clinical trial of mesenchymal stem cells in lung transplant recipients with chronic rejection. (mayoclinic.org)
At Henry Ford Transplant, our expert surgeons continue to find new, safer surgical techniques for transplant recipients and living donors. (henryford.com)
Background The incidence and consequences of deep venous thrombosis (DVT) and pulmonary embolism (PE) have not been described recently in lung transplant recipients. (elsevierpure.com)
We sought to characterize DVT and PE in a contemporary series of lung transplant recipients and describe their association with clinical outcomes. (elsevierpure.com)
Methods The records of all lung transplant recipients from July 1, 2008, to June 30, 2013, were reviewed and analyzed. (elsevierpure.com)
Conclusions The incidence of DVT and PE in lung transplant recipients is high. (elsevierpure.com)
Outcomes after heart and lung transplants have improved, and many recipients survive long enough to develop secondary renal failure, yet remain healthy enough to undergo kidney transplantation. (johnshopkins.edu)
Outcomes were compared with primary kidney recipients using matched controls (MC) to account for donor, recipient and graft characteristics. (johnshopkins.edu)
Furthermore, renal transplantation reduced the risk of death compared with dialysis by 43% for KAH and 54% for KAL recipients. (johnshopkins.edu)
Our findings that renal grafts function well and provide survival benefit in KAH and KAL recipients, but are limited in longevity by the general life expectancy of these recipients, might help inform clinical decision-making and allocation in this population. (johnshopkins.edu)
Purpose of review: This article will review the epidemiology, diagnosis, prevention and management of influenza in solid organ transplant recipients. (northwestern.edu)
Recent findings: A number of recent studies have documented that influenza vaccination is both well tolerated and generally effective in producing an immunologic response in most solid organ transplant (SOT) recipients. (northwestern.edu)
Summary: Influenza is associated with significant morbidity and mortality, particularly in lung transplant recipients. (northwestern.edu)
During her final year of training at New York University, she conducted research on small airway abnormalities in lung transplant recipients at the Andre Cournand Physiology Laboratory at Bellevue Hospital Center, and was a core member of the team of intensivists in the medical intensive care unit at Bellevue Hospital Center during New York City's initial surge of COVID-19 in the spring of 2020. (columbia.edu)
Her research interests include infections and outcomes in lung transplant recipients. (columbia.edu)
There remains a very limited pool of donor organs and long waiting times for potential transplant recipients. (wustl.edu)
The authors report two cases of isolated gastro-intestinal tuberculosis in renal transplant recipients that illustrates the difficulty of making this diagnosis and a brief review of the literature on its clinical presentation, diagnosis, and therapeutic approach. (hindawi.com)
In transplant recipients, MT infection can be due to primary infection, reactivation of latent TB foci favored by immunosuppression (IS), or, in a lesser extent (4%), it can be transmitted by the allograft [ 3 , 5 , 6 ]. (hindawi.com)
Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
October's transplant recipients came to Packard Children's from all over California and the western United States. (financialcontent.com)
Immunogenicity of a Third Dose of BNT162b2 Vaccine among Lung Transplant Recipients-A Prospective Cohort Study. (cdc.gov)
Torque teno virus DNA load as a predictive marker of antibody response to a three-dose regimen of COVID-19 mRNA-based vaccine in lung transplant recipients. (cdc.gov)
Lung Transplant Recipients Immunogenicity after Heterologous ChAdOx1 nCoV-19-BNT162b2 mRNA Vaccination. (cdc.gov)
Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients. (cdc.gov)
The group included 78 kidney-transplant recipients, 12 liver-transplant recipients, 8 lung-transplant or heart-transplant recipients, and 3 pancreas-transplant recipients. (cdc.gov)
COVID-19 in lung transplant recipients. (cdc.gov)

METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. (smw.ch)
RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
A total of 50% of the patients died by the ninth post-transplant year. (smw.ch)
Patients who underwent single lung transplantation in our center (Marseille, France) between January 2009 and January 2022 were retrospectively included. (frontiersin.org)
31 patients mainly transplanted for emphysema or pulmonary fibrosis were included. (frontiersin.org)
The aim of this study was to examine the causes and outcomes of hospitalisation in patients with pulmonary arterial hypertension (PAH). (ersjournals.com)
The short-term outcomes after discharge are poor and remarkably worse in patients with underlying CTD or renal impairment. (ersjournals.com)
Thus our study aimed to analyse the causes, clinical characteristics and outcomes of hospitalisation, as well as prognostic factors for mortality, in a cohort of PAH patients closely followed at a specialised pulmonary hypertension clinic. (ersjournals.com)
Invasive pulmonary aspergillosis (IPA) is associated with high morbidity and mortality rates in immuno-compromised patients including those undergoing hematological stem cell or solid organ transplantation (particularly lung transplants) and some patients in critical care, including those with COVID-19- or influenza-associated pulmonary aspergillosis. (globenewswire.com)
Aspergillus infection also plays an important role in severe asthma and cystic fibrosis and has been correlated with poorer clinical outcomes in patients with chronic obstructive pulmonary disease. (globenewswire.com)
Chronic lung infections with Aspergillus can leave patients with extensive and permanent lung damage, requiring a lifetime of antifungal treatment. (globenewswire.com)
In this program, patients with a variety of different clinical profiles who had failed previous antifungal treatment options responded well when opelconazole was added to their treatment regimen. (globenewswire.com)
Unfortunately, half of these patients will die within 5 - 6 years after transplant because of transplant rejection. (nih.gov)
APO is now exploring whether these novel genomic approaches risk stratify other pulmonary patients for long-term outcomes. (nih.gov)
APO is also planning a clinical trial to assess whether early detection and treatment of rejection improves survival in lung transplant patients and also engaged in additional studies to understand molecular mechanisms of transplant rejection. (nih.gov)
In our cohort of patients, we examine demographic and clinical characteristics, as well as differential levels of cell free DNA, to explore outcomes of allograft failure, acute cellular rejection, and chronic lung allograft dysfunction in individuals of European and non-European ancestry. (nih.gov)
The goal of this research is to better inform pre- and post-transplant clinical management and further refine donor-recipient organ matching to improve long-term outcomes and survival in lung transplant patients. (nih.gov)
I am interested in examining the potential for leveraging sensitive biomarkers, such as donor-derived cell free DNA (ddfcfDNA), to augment immunosuppression monitoring, specifically in patients with equivalent immunosuppressive blood levels, but who go on to have disparate outcomes. (nih.gov)
Joshua Mooney, MD, MS, is a board certified pulmonologist and critical care physician who specializes in the care of interstitial lung disease and lung transplant patients. (stanford.edu)
He performs health services and outcomes research focused on understanding and improving the lives and care of patients with advanced lung disease and is actively involved in clinical trials to improve outcomes in interstitial lung disease. (stanford.edu)
Trends indicate that sicker patients are increasingly being transplanted, thereby limiting improvements in early post-transplant survival. (terasaki.org)
More lung and heart transplant patients are coming to transplant on dialysis. (terasaki.org)
In heart transplant, there is an increase in the number of heart retransplant patients and an increase in patients on extracorporeal membrane oxygenation. (terasaki.org)
For lung transplant, more patients are on a ventilator prior to transplant than in the past 25 years. (terasaki.org)
Given that sicker/riskier patients are now receiving more heart and lung transplants, future studies need to take place to better understand these patients so that they can have the same survival as patients entering transplant with less severe illnesses. (terasaki.org)
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. (nature.com)
There is limited information on LTx outcomes in these patients. (bvsalud.org)
The care of patients with progressive lung disease has been transformed by orthotopic lung transplantation. (mayoclinic.org)
Patients with interstitial lung disease, who have the highest death rates among patient diagnostic groups awaiting transplant, make up one of the largest groups referred for transplantation. (mayoclinic.org)
The current allocation system favors such patients by adjusting the lung allocation score based on underlying disease, in the hopes of a more timely intervention. (mayoclinic.org)
The decision concerning single- or double-lung transplantation is often of major concern to patients and is influenced by organ availability, age and functional status - single lung is generally a shorter, less complex operation - as well as past surgical history, but in general, carefully selected patients have good quality of life and often excellent lung function after single-lung transplantation. (mayoclinic.org)
A 2010 study of 1,231 patients with cancer of the throat, published in the medical journal Cancer, found that Medicaid patients and people lacking any health insurance were both 50 percent more likely to die when compared with privately insured patients-even after adjusting for factors that influence cancer outcomes. (riograndefoundation.org)
At the Henry Ford Transplant, you'll find a team dedicated to comprehensive care that offers our patients a second chance at life. (henryford.com)
Through research and innovation, we're constantly working to improve treatment options for our transplant patients. (henryford.com)
These patients continue their transplant care at Henry Ford when they reach adulthood. (henryford.com)
The lives of three Los Angeles-area kidney transplant patients were transformed by one of the West Coast's first three-way living donor kidney transplant chains, made possible through the generosity of a non-directed, altruistic kidney donor from New York City -- announced today at a joint news conference. (news-medical.net)
Therefore, we conducted an international registry analysis to compare post-LTx outcomes for cystic fibrosis (CF) patients using the UNOS registry in the United States and the National Health Service (NHS) Transplant Registry in the United Kingdom. (northumbria.ac.uk)
Patients with CF who underwent lung or heart-lung transplantation in the United States or United Kingdom between January 1, 2000 and December 31, 2011 were included. (northumbria.ac.uk)
Results The study comprised 117 patients who underwent 123 transplants. (elsevierpure.com)
The idea is to be able to bring to patients in lung failure the technologies now available to patients in heart failure, to have technology that gives patients the quality of life where they re able to be mobile and not be tethered in the intensive care unit, said William Wagner, PhD, director of the McGowan Institute. (regenerativemedicine.net)
No prospective trial was conducted with tacrolimus in lung transplant patients. (medpagetoday.com)
RV failure occurs in 0.1% of patients post cardiotomy, 2 to 3% following cardiac transplant, and in as many as 30-40% of patients after LVAD implantation. (acc.org)
5-6 However, patients requiring RVAD have consistently had worse outcomes than those who do not need an RVAD, even when compared to other patients with RV failure. (acc.org)
After replacing the diseased liver in HPS patients, the lungs return to normal within approximately one year3. (rarediseases.org)
The vast majority of HPS patients (82%) initially present with features of their liver disease, while a minority (18%) present with lung (pulmonary) complaints first. (rarediseases.org)
Prof Nölke continues to be actively involved in clinical research with recent co-authorships in papers addressing clinical topics such as medium to long-term outcome following tracheal surgery in Children, sequential single lung transplant to maximise donor to transplant conversion or survival benefit of single lung transplantation in patients with idiopathic pulmonary fibrosis. (blackrockhealth.com)
Antiviral resistance emerges rarely in transplant patients and should be considered in all patients with an inadequate clinical and/or virologic response. (northwestern.edu)
Antiviral therapy is associated with improved outcomes in transplant patients and treatment should be continued until clinically and virologic response have been documented. (northwestern.edu)
She is thrilled to be back in her home city and apply her broad clinical expertise to help patients with advanced lung diseases for whom lung transplantation is a therapeutic option. (columbia.edu)
She strives to infuse her clinical practice with humanism and a holistic mindfulness of what is at stake for her patients and their loved ones. (columbia.edu)
Established in 1990, we have performed more than 2,200 transplants in children and young adults with over 100 unique diagnoses for patients from all over the world. (duke.edu)
Established in 1990 as one of the first dedicated pediatric transplant units, our focus has expanded with the unique needs of pediatric and young adult stem cell transplant, cellular therapy, gene therapy and high risk oncology patients in mind. (duke.edu)
Our team also works closely with the full complement of Duke pediatric specialists to provide specialized care for patients who have additional medical problems or experience complications after transplantation. (duke.edu)
In this study, we re-design an existing prehab smartphone application (BeFitMe™) using a novel standalone Apple Watch platform to increase accessibility and usability for vulnerable patients.Design Science Research Methodology was used to (1) develop an approach to clinical research using standalone Apple Watches, (2) re-design BeFitMe™ for the Apple Watch platform, and (3) incorporate user feedback into app design. (stanford.edu)
Definition of the long-term outcome of single lobe transplants in pediatric patients. (wustl.edu)
Tuberculosis is a disease relatively frequent in renal transplant patients, presenting a wide variety of clinical manifestations, often involving various organs and potentially fatal. (hindawi.com)
Gastrointestinal tuberculosis, although rare in the general population, is about 50 times more frequent in renal transplant patients. (hindawi.com)
In transplanted patients the incidence of this opportunistic agent is even more frequent, with 512 cases/100.000 inhabitants/year and it is often linked to adverse outcomes [ 1 - 3 ]. (hindawi.com)
However, unlike general population, in renal transplant (RT) patients, extrapulmonar (occurring in 15%) and disseminated diseases (33-49%) are very frequent [ 1 - 3 , 7 ]. (hindawi.com)
In these patients atypical presentation is the rule and it requires a high clinical suspicion for its diagnosis [ 8 ]. (hindawi.com)
Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. (biomedcentral.com)
Lung transplantation is a life-saving surgical procedure for patients with end-stage lung diseases. (biomedcentral.com)
For example, we are conferencing with oncologists who have patients with rare liver tumors that require a very high level of transplant knowledge and experience. (financialcontent.com)
From caring for the youngest transplant patients, to pioneering care for patients with rare diseases who are the first with their condition to be transplanted, to performing complex multi-organ transplants - this team is the best of the best. (financialcontent.com)
Jennings MT, Dezube R, Paranjape S, et al: An observational study of outcomes and tolerances in patients with cystic fibrosis initiated on lumacaftor/ivacaftor. (msdmanuals.com)
The addition of tofacitinib to conventional disease-modifying antirheumatic drugs could help alleviate sclerosis in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), suggests research. (medwirenews.com)
Zhou Junfei (People's Hospital of Zhengzhou University, China) and co-authors note that "treatment options for SSC-ILD remain limited and treatments such as gamma globulin, autologous hematopoietic stem cell transplant, and lung transplantation are reserved for patients with severe situations with limited efficacy. (medwirenews.com)
Clinical characteristics and outcome of immunocompromised patients with COVID-19 caused by the Omicron variant: a prospective observational study. (cdc.gov)
SARS-CoV-2 infection in two patients following recent lung transplantation. (cdc.gov)
Donor-Derived DNA Predicts Lung Transplant Rejection Before any clinical signs of graft failure are evident in patients who undergo lung transplant, experimental research suggests that donor-derived cell-free DNA could help predict a poor outcome. (medscape.com)
Survival Trend Seen With LVAD in Advanced Heart Failure Some patients with advanced heart failure not on the transplantation wait list might benefit from an LVAD, but robust evidence is lacking on the optimal management of patients in this 'grey zone. (medscape.com)
Bone marrow transplants are not working in 100% of patients. (medlineplus.gov)
Also, I'd like to figure out why a transplant works in some patients rather than others and also focus our approach instead of generally suppressing the whole immune system. (medlineplus.gov)

Causes of primary diastolic dysfunction include an anatomic obstruction that prevents ventricular filling (eg, pulmonary venous obstruction), a primary reduction in ventricular compliance (eg, cardiomyopathy, transplant rejection), external constraints (eg, pericardial effusion), and poor hemodynamics after the Fontan procedure (eg, elevated pulmonary vascular resistance). (medscape.com)
Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
Greer M, Werlein C, Jonigk D. Surveillance for acute cellular rejection after lung transplantation. (smw.ch)
The Laboratory of Applied Precision Omics, led by Dr. Sean Agbor-Enoh, aims to develop novel approaches to detect and treat lung transplant rejection. (nih.gov)
APO aims develop novel approaches to detect and treat lung transplant rejection. (nih.gov)
Transplant rejection is detected by analyzing a biopsy of the transplanted organ. (nih.gov)
Could early detection and treatment of rejection save the transplanted organ from rejection? (nih.gov)
The focus of APO is to investigate whether early detection and treatment of rejection improves transplant survival. (nih.gov)
APO has developed an approach that picks up transplant rejection 2 - 3 months before biopsy. (nih.gov)
Maintenance of immunosuppression after solid-organ transplant is essential in order to prevent short-and long-term complications such as acute cellular rejection and chronic lung allograft dysfunction. (nih.gov)
Nationwide, one-year survival following lung transplant continues to improve, but longer term outcomes remain a challenge, due in large part to chronic allograft rejection from bronchiolitis obliterans, characterized by inexorable small airways obstruction. (mayoclinic.org)
Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. (medigraphic.com)
Thromboxane B2 and lung transplantation: Correlation of rejection with levels detected in bronchoalveolar lavage. (medigraphic.com)
Urinary thromboxane B2 excretion during acute rejection in cyclosporine treated experimental lung allotransplantation. (medigraphic.com)
Once your child has undergone their transplant they will have to take immunosuppressive (anti-rejection) medication every day, for the rest of their life. (gosh.nhs.uk)
1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression. (ncl.ac.uk)
3. Transplant therapeutic effect: haematopoietic stem cell transplant for leukaemia, lymphoma, and primary immunodeficiency, islet transplant and beta-cell replacement for type1 diabetes, corneal/limbal stem cell transplant for damaged tissue repair and identification of biomarkers of tolerance and rejection. (ncl.ac.uk)
4. Transplant complications: The risk factors and pathogenesis, the prevention and development of novel therapies are introduced and discussed in the context of acute and chronic kidney graft rejection, non-immune injury in chronic lung allograft rejection and graft-versus-host disease in haematopoietic stem cell transplant. (ncl.ac.uk)
Tacrolimus (Prograf) won FDA approval late Friday to prevent lung transplant rejection, a newsworthy development on two counts. (medpagetoday.com)
Prospective trial data in other indications -- tacrolimus is already approved for preventing allograft rejection in liver, kidney, pancreas, bowel, and heart transplantation -- supported the new approval, the FDA added. (medpagetoday.com)
It also noted that the drug was already in routine use off-label to prevent lung transplant rejection. (medpagetoday.com)
Despite remarkable short-term recovery, long-term lung survival continues to face several major challenges, including chronic rejection and severe toxic side effects due to global immunosuppression. (biomedcentral.com)
BALB/c → C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium, and collagen deposition during rejection. (biomedcentral.com)
Unfortunately, this therapeutic strategy is vulnerable by the occurrence of chronic rejection, which occurs when the recipient's immune response impairs the transplanted organ through microvascular disruption. (biomedcentral.com)
Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)

Replacement with a healthy lung can promote the recovery of the diaphragm to its anatomical morphology, reinforcing the close relationship between these two organs. (frontiersin.org)
Sykes, M. & Sachs, D. H. Transplanting organs from pigs to humans. (nature.com)
As the nationwide need for organs continues to grow, the shortage of donor lungs is a major limitation. (mayoclinic.org)
This technology, which is currently confined to use within clinical trials, delivers low-pressure oxygenated perfusate that comprises hyperosmolar solutions to isolated organs, combined with protective (low-pressure, low-inspired oxygen) ventilation, and close monitoring for indicators of improving function. (mayoclinic.org)
Ex vivo lung perfusion (EVLP) offers the potential of providing many more organs for transplant. (mayoclinic.org)
Henry Ford Transplant offers transplantation of the liver , kidney , pancreas , intestine and multivisceral organs , heart , lung and bone marrow stem cell . (henryford.com)
Donor chains have enormous potential to expand the donor pool and to provide better matched organs for the many individuals who are in desperate need of lifesaving transplants," Kapur said. (news-medical.net)
5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor organs for transplantation. (ncl.ac.uk)
The potential for increasing the limited pool of donor organs through expanded use of living donor lobes poses ethical and clinical concerns. (wustl.edu)
Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)

American Journal of Transplantation. (wustl.edu)
American Journal of Transplantation , 9 (3), 578-585. (johnshopkins.edu)
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 0 0. (cdc.gov)

Transplant Proc 1992;24:2022-2023. (medigraphic.com)

INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)
Small airway lymphocytic inflammation in chronic lung allograft dysfunction? (ucsf.edu)
However, even early post-transplant survival (within the first post-transplant year) needs improvement, as early graft failure still accounts for many allograft losses. (terasaki.org)

Erasmus ME, van der Bij W. Death after lung transplantation: improving long term survival despite perilous early postoperative years. (smw.ch)
Survival in adult lung transplantation: where are we in 2020? (smw.ch)
CT12 Chapter 5: Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
BACKGROUND: Survival outcomes of children on extracorporeal membrane oxygenation (ECMO) at time of lung transplant (LTx) remain unclear. (bvsalud.org)
When you need a transplant, you want the best possible care at a medical center that has experienced staff, the latest treatment options and excellent survival rates. (henryford.com)
Our one-year and three-year patient survival rates following transplantation meet or exceed expected outcomes. (henryford.com)
There are of course associated risks with transplantation, and while the early survival rates after the transplant are good, there can be no guarantees that any particular transplant will be a success. (gosh.nhs.uk)
Since 2003, survival in children after lung or heart-lung transplant has significantly improved at GOSH, giving a survival of over 70 per cent at five years, and an estimated survival of more than 50 per cent by seven years. (gosh.nhs.uk)
Both the United States and United Kingdom have similar early survival outcomes, suggesting important dissemination of best practices internationally. (northumbria.ac.uk)

Join us the first week of each month to address the unique experiences stem cell transplant caregivers face. (henryford.com)
The division is supported by the Duke Stem Cell Transplant Laboratory (FACT and CAP accredited and CLIA certified), the Carolinas Cord Blood Bank (an FDA licensed, FACT and CAP accredited public cord blood bank), and the Robertson GMP Cell Manufacturing Laboratory (FDA registered and FACT accredited). (duke.edu)

The patient with interstitial lung disease presents a few unique challenges, particularly if the lung condition is a manifestation of a systemic disease such as a rheumatologic disorder. (mayoclinic.org)

Fraser has completed three fellowships: pediatric cardiac surgery at the Royal Children's Hospital, cardiac transplant research at the Johns Hopkins Hospital and cardiovascular surgery at the Texas Heart Institute. (wikipedia.org)
Dr. Fraser's clinical career has been dedicated to the surgical treatment of congenital heart disease and has included the development of leading pediatric heart and lung transplant and mechanical circulatory support programs. (wikipedia.org)
In 2002, Fraser's team developed the first pediatric lung transplant program in the Southwest United States, which grew to become the largest in the nation. (wikipedia.org)
In 2005, he performed the first successful pediatric heart/lung transplant in the Southwest. (wikipedia.org)
Oleh Akchurin, MD, PhD, is an Assistant Professor of Pediatrics and Rohr Family Clinical Scholar in Pediatrics at Weill Cornell College of Medicine, New York, NY and an attending pediatric nephrologist in New York-Presbyterian Hospital/Weill Cornell Medical Center. (the-asci.org)
Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: a comparative study from the Pediatric Cardiomyopathy Registry. (medscape.com)
Her survey will assess interest in receiving evidence based pediatric obesity prevention and treatment in primary care settings, as well as perceived barriers and facilitators to participating in pediatric obesity focused clinical trials research. (umc.edu)
Pediatric primary care providers (n = 36) will participate in focus groups to examine knowledge of pediatric overweight and obesity expert prevention and treatment recommendations, as well as needs and interest for an obesity specific practice network and pediatric obesity clinical trials research. (umc.edu)
Results will inform the development and implementation of pediatric obesity clinical trials in primary care settings, as well as the creation of a research practice network. (umc.edu)
Our doctors work with pediatric specialists at Children's Hospital of Michigan to provide seamless care for children who need heart, liver and kidney transplants. (henryford.com)
The Pittsburgh Pediatric Ambulatory Lung (PPAL) aims to serve as a bridge to transplantation or recovery in children with acute and chronic lung failure. (regenerativemedicine.net)
The Pittsburgh Pediatric Ambulatory Lung was among the first cohort of initiative-funded projects. (regenerativemedicine.net)
6 Department of Pediatrics, Division of Pediatric Transplant Hepatology, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA. (nih.gov)
and translational and basic science researchers from the Pediatric Acute Lung Injury and Sepsis Investigators Network, the EBMT, the Pediatric Blood and Marrow Transplant Consortia, and several other institutions with extensive experience in sinusoidal obstructive syndrome. (nih.gov)
The Division of Pediatric Transplant and Cellular Therapy offers cutting-edge transplantation and cell therapies delivered by internationally recognized specialists. (duke.edu)
The Division of Pediatric Transplant and Cellular Therapy (PTCT) in the Duke Department of Pediatrics is an internationally-renowned transplant program. (duke.edu)
The Division of Pediatric Transplant and Cellular Therapy has been accredited by the Foundation for Accreditation of Cellular Therapy (FACT) since 2005 and has been a member of the National Marrow Donor Program since 1991. (duke.edu)
The division offers a rich and creative research environment involving collaborations with experts in multiple disciplines at the national and international levels, including the Pediatric Transplantation and Cellular Therapy Network (PTCTN), Children's Oncology Group (COG), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), Blood and Marrow Transplant Clinical Trials Network (BMT CTN), among other organizations. (duke.edu)
Zumbach said their pediatric transplant surgeon, Amy Gallo, MD , reassured them that everything would be fine when the time came for Charli's transplantation. (financialcontent.com)
The Packard Children's Pediatric Transplant Center is a national leader in the field of pediatric organ transplantation and a destination center for the most acute and complex cases, which require highly specialized care. (financialcontent.com)
It's our highest-volume month ever for solid organ transplants," said Debra Strichartz, administrative director of the Pediatric Transplant Center . (financialcontent.com)

Currently, the only known cure for HPS is a liver transplant. (rarediseases.org)
The Zumbachs, who are from Angels Camp, California, came to Palo Alto in September when Stanford Children's Health transplant specialists who run a liver transplant clinic at the Madera Children's Hospital told Charli's mother, Toni, "We need to get her to Packard Children's now. (financialcontent.com)
5. Have a portosystemic shunt or scheduled for transjugular intrahepatic portosystemic shunt placement or highly likely to receive a liver transplant during the study. (who.int)

Single Lung Transplant - In this operation a patient receives one lung (left or right), although this is rarely carried out in children. (gosh.nhs.uk)

The study will compare the time to a composite endpoint of relative decline in lung function [10% relative decline in forced vital capacity (FVC), first respiratory hospitalization, lung transplantation, or all-cause mortality] The secondary objectives will be to examine the effect of NAC on the components of the primary composite endpoint, the rates of clinical events, change in physiology, change in health status, and change in respiratory symptoms. (stanford.edu)
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined in lung transplantation. (nih.gov)
The primary outcome was all-cause mortality. (northumbria.ac.uk)
Instead, the primary evidence for the drug's effectiveness in this setting came from the federal government's transplant registry , along with Social Security mortality records. (medpagetoday.com)

In contrast with left heart failure (LHF), the course and outcomes of acute or decompensated RHF have been seldom described [ 1 , 2 ]. (ersjournals.com)
Clinical practice guidelines suggest their measurement is helpful for diagnosis or ruling out heart failure especially in the acute settings. (wikidoc.org)
Acute right ventricular (RV) failure occurs in multiple settings, including acute myocardial infarction (MI), fulminant myocarditis, acute decompensated heart failure, acute pulmonary embolism, decompensated pulmonary hypertension, following cardiac transplant, and in post-cardiotomy shock. (acc.org)

Whether you're considering a lung transplant or maintaining your health if you've had a transplant, this list can help you learn about transplant centers, including the one your cystic fibrosis care team may have referred you to. (cff.org)
While these devices are helpful in supplying oxygen to children suffering from cystic fibrosis, pulmonary hypertension, and pulmonary fibrosis, among other diseases, during the wait for lung transplants, they restrict mobility. (regenerativemedicine.net)

The Genomic Alliance for Transplantation (GRAfT), established by Dr. Hannah Valantine in 2015 , is a consortium of NHLBI and 8 heart and lung transplant programs located in 5 hospitals within geographic proximity of the National Institutes of Health (NIH), directed by Dr. Hannah Valantine. (nih.gov)
The resources for the GRAfT-GTD study provide support at all clinical sites for patient recruitment, enrollment and bio-sample collection, while also supporting the laboratory of transplant genomics at NHLBI to perform measurements of ddcfDNA (donor derived - cell free DNA), computational analysis, host and manage the biorepository of clinical data and all bio-samples, and the data coordinating center for GRAfT at NHLBI. (nih.gov)
We demonstrated that iPSC-derived MSC treatment leads to significant increases in hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, and IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post transplantation. (biomedcentral.com)

He is the Associate Medical Director for Lung and Heart/Lung Transplantation at Stanford and director of the Pulmonary Fibrosis Foundation Care Center at Stanford. (stanford.edu)
Results of single-lung transplantation for bilateral pulmonary fibrosis. (medigraphic.com)

Although ex vivo lung perfusion (EVLP) is able to recover marginal quality donor lungs, extension of normothermic support beyond 6 h has been challenging. (nature.com)
Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering. (nature.com)
Extended criteria donor lungs and clinical outcome: results of an alternative allocation algorithm. (nature.com)
A partnership explores ex vivo lung perfusion and ventilation to resuscitate and support donor lungs that would otherwise be unavailable for transplant. (mayoclinic.org)
It is estimated that less than 20 percent of all donor lungs are suitable for transplant. (mayoclinic.org)
In a unique academic-industry partnership with United Therapeutics Corp., Mayo Clinic is furthering the study of ex vivo lung perfusion and ventilation to resuscitate and support donor lungs that would otherwise be unavailable for transplant. (mayoclinic.org)
Additional strategies include the use of donor lungs following cardiac death and the traditional donors following brain death, although the former involves a more resource-intense commitment from the transplant procurement team. (mayoclinic.org)
Development of optimal methods of preserving cadaveric donor lungs. (wustl.edu)

The division collaborates with the Marcus Center for Cellular Cures which conducts discovery, IND enabling, laboratory-based, and translational research in the fields of transplantation and cellular therapies and provides multiple opportunities for fellows to be exposed to and gain skills in all aspects of transplant and cellular therapies research. (duke.edu)

For children and adult with advanced lung diseases, transplantation is often the only treatment. (nih.gov)
Confounders can and often do drive the transmission of mycobacterial diseases, as well as impact surveillance and treatment outcomes. (bvsalud.org)
Dr. Magda then completed an additional year of specialization in Advanced Lung Diseases and Transplant Pulmonology at University of California, Los Angeles, the largest lung transplant program by volume in the western United States, where she also worked as an attending intensivist during Los Angeles' second surge of COVID-19 in the winter of 2021. (columbia.edu)
There has been an expansion in the number of diseases for which lung transplantation is a therapeutic option. (wustl.edu)
Better definition of the optimal window for transplantation for various diseases. (wustl.edu)
Determination of the full range of diseases for which lung transplantation can be considered an appropriate therapeutic option. (wustl.edu)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 0 0. (cdc.gov)
European Journal of Clinical Microbiology and Infectious Diseases. (lu.se)

As a leading medical research center for organ and bone marrow stem cell transplants, Henry Ford Transplant offers access to advanced clinical trials in every type of transplant program. (henryford.com)
Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)
Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)
I wanted to develop a way to have half-match donors contribute bone marrow and for the outcomes to be successful. (medlineplus.gov)
Not everyone can get a bone marrow transplant. (medlineplus.gov)

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 0 0. (cdc.gov)

The influence of lung disease on the diaphragm has been poorly studied. (frontiersin.org)
Lung transplantation (LTx), by replacing a diseased lung with a healthy one, is an interesting model to evaluate the evolution of the diaphragmatic morphology before and after transplantation in the context of lung disease. (frontiersin.org)
He specializes in advanced lung disease and lung transplantation. (ucsf.edu)
He is the Associate Medical Director of the Advanced Lung Disease and Lung Transplant clinical program and also founded and now co-Directs the UCSF Advanced Lung Disease and Lung Transplant Research Program. (ucsf.edu)
3) Developing and validating novel instruments to measure HRQL, functioning/disability, and frailty for use in advanced lung disease and lung transplantation. (ucsf.edu)
Transplant Infectious Disease. (elsevierpure.com)
Background: Pulmonary vascular disease (PVD) represents an important clinical indication for lung transplant (LTx) in infants, children, and adolescents. (bvsalud.org)
2. HLA system and tissue typing: the genetic organization and polymorphisms of the HLA system, the protein structure of HLA antigens, non-HLA genetics, HLA in health and disease, and the impact of HLA matching on donor selection and transplant outcomes. (ncl.ac.uk)
This trend has evolved because many centers have demonstrated improved outcomes with primary corrective surgery as an initial intervention in the neonate with congenital heart disease. (medscape.com)
The hepatopulmonary syndrome (HPS) is a rare lung complication of liver disease. (rarediseases.org)
Sinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially life-threatening complication that occurs in children undergoing haemopoietic stem-cell transplantation (HSCT). (nih.gov)
In most cases, the disease involves the lungs. (hindawi.com)
Transplant infectious disease : an official journal of the Transplantation Society 2020 12 0. (cdc.gov)

European journal of clinical investigation 2020 0 0. (cdc.gov)
Journal of clinical medicine 2020 11 0. (cdc.gov)

Techniques of successful clinical double-lung transplantation. (medigraphic.com)
Double lung transplant (sometimes called bilateral lung transplant) - In this operation a patient receives two lungs. (gosh.nhs.uk)
Long-term outcome in single versus double lung transplantation. (wustl.edu)

Researchers also use the Patient Registry to study CF treatments and outcomes and to design CF clinical trials. (cff.org)
The program contributes data to the Center for International Blood and Marrow Transplant Research (CIMBTR) and has been a core center of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) since it was established in 2001. (duke.edu)
Since Nocardia species infections are very often sporadic, information from randomized clinical trials comparing the clinical efficacy of specific antimicrobial agents is lacking. (antimicrobe.org)

Eberlein M, Arnaoutakis GJ, Yarmus L, Feller-Kopman D, Dezube R, et al: The effect of lung size mismatch on complications and resource utilization after bilateral lung transplantation. (msdmanuals.com)

Normothermic ex vivo lung perfusion in clinical lung transplantation. (nature.com)

Dr. Fraser's research interests have included congenital heart surgery outcomes, cardiopulmonary transplantation, mechanical circulatory support, neurologic protection, and bioengineering. (wikipedia.org)
The structure of the program at UCSF allowed him the opportunity to get involved in the circulatory support program and heart and lung transplantation. (blackrockhealth.com)

J Heart Lung Transplant. (smw.ch)
International Society for Heart and Lung Transplantation. (smw.ch)
He remained at UCSF, where he completed a residency in Internal Medicine, and fellowships in Pulmonary, Critical Care Medicine, and Lung/Heart-Lung Transplantation. (ucsf.edu)
He is a member of the International Society for Heart and Lung transplantation and American Thoracic Society. (ucsf.edu)
He is a core investigator with the UCSF Respiratory Epidemiology Group and served as Chair of the International Society of Heart and Lung Transplantation Pulmonary Council Quality of Life Workforce from 2012-2021. (ucsf.edu)
In this chapter, we review the experience of heart and lung transplantation as reported to the Organ Procurement Transplant Network/United Network of Organ Sharing registry and investigate the factors responsible for causing failure in the first post-transplant year. (terasaki.org)
Wheezing may be an important clinical sign, suggesting congestive heart failure in infants. (medscape.com)
ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). (medscape.com)
The combined venture is a multiyear development with plans to begin construction of a three-story lung restoration center within the heart of Mayo Clinic's campus in Florida in 2017. (mayoclinic.org)
The first lung transplant in man (1963) and the first Heart transplant in man (1964). (medigraphic.com)
J Heart Lung Transplant 1998;17:703-709. (medigraphic.com)
Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart-lung transplant report-2005. (medigraphic.com)
J Heart Lung Transplant 2005;24:956-967. (medigraphic.com)
Laurence Faucette lived for 6 weeks after the transplant of a genetically modified pig heart and did well until a few days before his death. (medscape.com)
We were the first in Detroit to perform individual transplants of the heart, intestine, kidney, liver and lung. (henryford.com)
This information from Great Ormond Street Hospital (GOSH) is for parents of children and young people undergoing assessment for possible lung or heart-lung transplantation. (gosh.nhs.uk)
The Cardiothoracic Transplant Unit at GOSH has been established since 1988 when the first heart transplant at GOSH was performed. (gosh.nhs.uk)
Combined heart-lung transplant - In this operation a patient receives a heart and both lungs. (gosh.nhs.uk)
During the early years of the lung and heart-lung transplant programme at GOSH (1998) approximately half of the children who received a transplant survived less than four years following transplantation. (gosh.nhs.uk)
No child can be accepted onto the waiting list for a lung or heart-lung transplant without having been reviewed in person by members of the transplant team, which includes a paediatric transplant consultant. (gosh.nhs.uk)
We used national data reported to United Network for Organ Sharing (UNOS) to evaluate outcomes of 568 kidney after heart (KAH) and 210 kidney after lung (KAL) transplants performed between 1995 and 2008. (johnshopkins.edu)
Median time to kidney transplant was 100.3 months after heart, and 90.2 months after lung transplant. (johnshopkins.edu)
Prof Nölke has actively engaged in developing safer delivery of cardiothoracic surgery in Ireland with his previous roles as National Lead for Cardiothoracic training, Head of Cardiothoracic Surgery and heart and lung transplantation at the Mater Misericordiae University Hospital and current roles as Clinical Director at MMUH and Responsible Person for the Irish Heart Valve Bank. (blackrockhealth.com)
J Heart Lung Transplant 31(5):492-500, 2012. (msdmanuals.com)
NIH MedlinePlus magazine spoke with Courtney Fitzhugh, M.D., a Lasker Clinical Research Scholar at the National Heart, Lung, and Blood Institute, about the current and future outlook for this important treatment. (medlineplus.gov)

abstract = "This workshop has identified several factors associated with enhanced success, some major gaps in knowledge, and some unresolved issues in the field of lung transplantation. (wustl.edu)
ABSTRACT We aimed to study the clinical pattern of nocardiosis in a tertiary care hospital in Saudi Arabia using a retrospective review of cases from 1987 to 2003. (who.int)

DASI) are among the few patient-reported outcome and frailty measures developed specifically for the field. (ucsf.edu)
To examine the construct and predictive validity of frailty phenotypes in lung transplant candidates. (nih.gov)
We estimated the association between frailty and disability using the Lung Transplant Valued Life Activities disability scale. (nih.gov)
We estimated the association between frailty and risk of delisting or death before transplant using multivariate logistic and Cox models, respectively. (nih.gov)
By either measure, frailty correlated more strongly with exercise capacity and grip strength than with lung function. (nih.gov)
Frailty is prevalent among lung transplant candidates and is independently associated with greater disability and an increased risk of delisting or death. (nih.gov)

Construction of a three-story lung restoration center at Mayo Clinic's campus in Florida will begin in 2017. (mayoclinic.org)
In 2017, the European Society for Blood and Marrow Transplantation (EBMT) proposed the first paediatric diagnostic and severity grading guidelines for sinusoidal obstructive syndrome, intended for implementation across European centres. (nih.gov)

After completing his medical degree at University of Texas Medical Branch, Fraser studied as a resident at Johns Hopkins Hospital, where he specialized in general, cardiothoracic and thoracic transplant surgery. (wikipedia.org)

RATIONALE: Organ size matching is an important determinant of successful allocation and outcomes in lung transplantation. (bvsalud.org)

The results are collated and your child's case will be discussed at the regular transplant assessment meeting also known as the Joint Cardiac Conference (JCC). (gosh.nhs.uk)

The hope is that this marks the first of many such collaborations among the nation's transplant centers," said Dr. Sandip Kapur, chief of transplant surgery and associate professor of surgery at NewYork-Presbyterian/Weill Cornell. (news-medical.net)

Wildevuur CR, Benfield JR. A review of 23 human lung transplantations by 20 surgeons. (medigraphic.com)
Our ability to take on cases that would be rejected for transplant elsewhere is a credit to the level of expertise, not only of our surgeons, but the entire transplant care team," said Esquivel, who led Charli Zumbach's transplantation with Dr. Gallo. (financialcontent.com)

Fungus may be inhaled and cause lung infection. (columbiasurgery.org)

2. To provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplantation. (ncl.ac.uk)
Despite initial therapeutic outcomes, conventional stem cells face key limitations. (biomedcentral.com)

Dezube R, Arnaoutakis GJ, Reed RM, et al: The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation. (msdmanuals.com)

The study aimed to evaluate the diaphragm morphology (height and thickness) in single-lung transplantation (SLTx), using computed tomography (CT), by assessing the evolution of the hemidiaphragm of the transplanted and the native side. (frontiersin.org)
While computed tomography (CT) is the gold standard, it is rarely used in an organ-donor context, and chest X-ray (CXR) may offer a practical and accurate solution in estimating lung volumes for donor and recipient size matching. (bvsalud.org)

Scheffert JL, Raza K. Immunosuppression in lung transplantation. (smw.ch)

Nuclear lung ventilation/perfusion scanning: This is performed to exclude chronic thromboembolic pulmonary hypertension (Group IV PH). (medscape.com)
This facility will house the lung perfusion program as well as space for research carried out by the Center for Individualized Medicine and Center for Regenerative Biotherapeutics, to further investigation for years to come. (mayoclinic.org)

Thanks to a living-donor kidney transplant a friend and colleague, a music teacher and vocalist continues to share her gift. (henryford.com)

Anatomy8

Organisms6

Diseases49

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment88

Phenomena and Processes14

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science4

Named Groups2

Health Care38

Geographicals1

Recipients31

Patients73

Rejection25

Organs10

Journal of Transplantation3

20231

Allograft9

Survival10

Stem cell trans2

Interstitial Lung Di1

Pediatric21

Liver Transplant3

Single-lung transplant1

Mortality4

Acute3

Cystic fibrosis2

GRAFT3

Pulmonary fibrosis2

Donor lungs8

Translational Research1

Diseases8

Bone marrow5

20221

Disease13

20202

Double-lung3

Trials3

Complications1

Vivo lung perfusion1

Circulatory support2

Heart25

Abstract2

Frailty6

20172

Thoracic1

Allocation1

Cardiac1

Centers1

Surgeons2

Infection1

Therapeutic2

Bilateral1

Computed tomography2

Immunosuppression1

Perfusion2

Living-donor kidney transplant1