Lung healthy cells. Medical search. Frequent questions

Radiotherapy is one of the most effective approaches to achieve tumor control in cancer patients, although healthy tissue injury due to off-target radiation exposure can occur. (nature.com)
In this study, we used a model of acute radiation injury to the lung, in the context of cancer metastasis, to understand the biological link between tissue damage and cancer progression. (nature.com)
We exposed healthy mouse lung tissue to radiation before the induction of metastasis and observed a strong enhancement of cancer cell growth. (nature.com)
Importantly, these tissue perturbations endowed arriving cancer cells with an augmented stemness phenotype. (nature.com)
Fig. 1: Radiation exposure in healthy lung tissue enhances metastasis. (nature.com)
Fig. 4: Radiation-primed neutrophils perturb the lung tissue environment. (nature.com)
During a biopsy, a doctor or nurse takes samples of cells or tissue from the abnormal area. (macmillan.org.uk)
This is most often the case when a pathologist examines a small number of malignant cells or tissue in a cytology or biopsy specimen. (wikipedia.org)
Some previous studies also demonstrated that MSCs act as gene therapy delivery vehicles and attenuate lung injury through enhancing the target gene expression in specific damaged tissue sites in the lungs [ 14 , 15 ]. (hindawi.com)
Researchers have engineered a tissue-mimicking hydrogel model to show that more elastic tissues induce T cells to become effector-like T cells with strong tumor-killing potential, while more viscous tissues induce them to become memory-like T cells. (sciencedaily.com)
Researchers at Harvard's Wyss Institute and Harvard SEAS led by David Mooney engineered a tissue-mimicking hydrogel model to show that more elastic tissues induce T cells to become effector-like T cells with strong tumor-killing potential, while more viscous tissues induce them to become memory-like T cells. (sciencedaily.com)
Now, a research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), led by Wyss Core Faculty member David Mooney, Ph.D., took a novel biomaterials approach to investigate the effect of tissue mechanics on the state of T cells. (sciencedaily.com)
This enabled them to demonstrate a distinct impact of tissue viscoelasticity on T cell development and function in vitro and in vivo , and to identify a molecular pathway driving the phenomenon. (sciencedaily.com)
Mice implanted with human lung tissue model pathogen infection and immune responses. (nature.com)
Lung tissue harbors various cell types that are involved in the infection and immunity of many human pathogens, and it could be an ideal source for humanizing mouse models. (nature.com)
Pursuing this line, Wahl, J. Victor Garcia and colleagues created lung-only mice (LoM) by implanting human lung tissue subcutaneously into the backs of immunodeficient mice. (nature.com)
To further model human immunity against pathogens in vivo, the team created a second model, BLT-L mice, by implanting autologous bone marrow-liver-thymus tissue and lung tissue into the immunodeficient mice. (nature.com)
The researchers, who report their findings today in Nature , analyzed human lung tissue to identify the new cells, which they call respiratory airway secretory cells (RASCs). (worldhealth.net)
In lung tissue from people with COPD, as well as from people without COPD who have a history of smoking, they observed many AT2 cells that were altered in a way that hinted at a faulty RASC-to-AT2 transformation. (worldhealth.net)
With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors. (snopes.com)
Epithelial stem/progenitor cells are critical for tissue repair, to maintain a healthy lung. (lung.org)
The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
When lung tissue becomes inflamed from an infection or other cause, cells called histiocytes cluster to form nodules called granulomas. (healthline.com)
Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
Lung cancer is an uncontrolled and abnormal growth of cells in lungs, this growth of abnormal cells do not carry out the functions of the normal lung cell and also do not help in developing healthy lung tissue. (maxhealthcare.in)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
Asthma affects your airways (which bring air to the lung tissue), while COVID-19 affects your lung tissue itself. (nebraskamed.com)
An inhaler won't help your lung tissue work better. (nebraskamed.com)
In IPF, the lung loses that ability as it becomes filled with other kinds of tissue that make it very stiff. (lu.se)

Small cell lung cancer (SCLC) makes up about 15% of lung cancers in the United States. (healthline.com)
Smoking tobacco is the cause of most lung cancers and the biggest risk factor. (macmillan.org.uk)
NSCLC accounts for about 85% of all lung cancers. (wikipedia.org)
Adenocarcinomas account for about 40% of lung cancers. (wikipedia.org)
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)
The successful campaign of adoptive T cell therapies, a type of immunotherapy in which immune T cells are collected from a patient, enhanced outside of the body, and reinfused back into the same patient, especially against blood cancers is well under way. (sciencedaily.com)
Other cancers, such as lung cancer, typically occur in later life and are therefore rarely present simultaneously with pregnancy. (biomedcentral.com)
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in pregnant women, accounting for approximately 85% of all gestational cancers [ 6 ]. (biomedcentral.com)
According to the World Health Organization, lung cancer has the highest mortality rate of all cancers. (frontiersin.org)
Lung cancer is one of the leading causes of cancer deaths among both male and female, it claims more lives each year than do prostate, ovarian and breast cancers combined. (maxhealthcare.in)
Non-small cell lung cancer - Non- small lung cancer is also known as (NLCLC), this is a common term for several types of lung cancers that act in a similar way. (maxhealthcare.in)

And instead of functioning normally, these cells accumulate, bind together and form cancerous tumors in the lungs. (moffitt.org)
The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)

If you have non-small-cell lung cancer (NSCLC), your disease began with changes to your genes. (webmd.com)
Cancer immunotherapy (CIT), as a monotherapy or in combination with chemotherapy, has been shown to extend overall survival in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). (jmir.org)
Non-small cell lung cancer (NSCLC) is the most common lung cancer. (macmillan.org.uk)
Non-small cell lung cancer not otherwise specified (NOS) is when the expert doctor in cell types (pathologist) cannot say for certain which type of NSCLC it is. (macmillan.org.uk)
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). (wikipedia.org)
The most common types of NSCLC are squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma, but several other types occur less frequently. (wikipedia.org)
Non-squamous-cell carcinoma almost occupies the half of NSCLC. (wikipedia.org)
Lung cancer in people who have never smoked is almost universally NSCLC, with a sizeable majority being adenocarcinoma. (wikipedia.org)
On relatively rare occasions, malignant lung tumors are found to contain components of both SCLC and NSCLC. (wikipedia.org)
The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with unresected stage I or II (Stage IIB N0, M0) non-small cell lung cancer (NSCLC). (policylab.us)
Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
She was diagnosed with non-small cell lung cancer (NSCLC) with bone metastasis and pneumocystis pneumonia (PCP). (biomedcentral.com)
Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
Although valuable progress has been made in the treatment of NSCLC in previous years, the high metastasis rate, post-operative recurrence rate and resistance to chemotherapeutic drugs in lung cancer have led to unsatisfactory outcomes ( 4 , 5 ). (spandidos-publications.com)
In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)

This healthy atlas will be used to enhance our understanding of childhood lung disease, develop new diagnosis and treatment options, and ultimately improve outcomes for children with lung diseases. (edu.au)
Altered immune responses in the lungs, including inflammation, are common features of many childhood respiratory diseases. (edu.au)
Establishing a reference atlas of cells from the healthy paediatric airway will allow us to understand what is normal, what is changing with disease, and develop better diagnostic and treatment options for children with respiratory diseases. (edu.au)
MSCs are able to ameliorate various kinds of lung injury and are intensively investigated to develop a therapeutic approach for treating lung diseases such as RILI, idiopathic pulmonary fibrosis (IPF), and emphysema which are lacking a specific and effective therapy [ 8 , 9 ]. (hindawi.com)
A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania. (worldhealth.net)
AT2 cells are known to become abnormal in COPD and other lung diseases, and the researchers found evidence that defects in RASCs might be an upstream cause of those abnormalities. (worldhealth.net)
This technique can be readily used by people with lung diseases such as chronic bronchitis, emphysema, asthma, etc. this exercise can also be practiced by healthy individuals for improved lung health. (pulseuniform.com)
Infections, inflammatory diseases, and other factors such as the following are associated with lung granulomas. (healthline.com)
Lung granulomas are associated with some common variable immunodeficiency disorders (CVID) that prevent your body from fighting infections and diseases. (healthline.com)
Dr. Bernard Thébaud and his team are hoping to harness stem cells from umbilical cords to treat chronic lung diseases in extremely premature babies like Olivia Eberts. (ottawahospital.on.ca)
Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
Zanamivir is recommended for early treatment of flu in people 7 years and older, though it is not recommended for use in children with underlying respiratory disease, including asthma and other chronic lung diseases. (cdc.gov)
Her academic journey has been driven by a burning interest to understand what she considers to be the biggest mystery in this world, the human lung, particularly concerning diseases such as idiopathic pulmonary fibrosis (IPF). (lu.se)
It is of interest to us all to understand how they work and how we can develop new treatments for diseases that target the lungs. (lu.se)
I have studied reasons why the lung develops diseases that are currently not curable and why there is damage occurring in the lung that does not seem to stop but progresses into the development of a disease that we die from. (lu.se)

Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung. (wikipedia.org)
We will study epithelial progenitor cells, how their function is affected by their location relative to a tumor, and by the presence of immune cells. (lung.org)
Our pilot data showed that epithelial stem/progenitor cells are impaired in people with lung cancer, coinciding with an increased presence of immune cells. (lung.org)
The goal of this proposal is to design a portable bronchoscope that can determine the health status of the tracheal epithelial lining cells by analyzing changes in their metabolic profile. (dtic.mil)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
[ii] Dye JAAdler KB Effects of cigarette smoke on epithelial cells of the respiratory tract. (who.int)
They are called epithelial cells. (lu.se)
In this report, we show that infection with influenza A virus and treatment with the resulting host signals (febrile-range temperatures, norepinephrine, extracytoplasmic ATP, and increased nutrient availability) induce the release of bacteria from biofilms in a newly developed biofilm model on live epithelial cells both in vitro and during in vivo colonization. (lu.se)

Large cell carcinoma. (webmd.com)
Squamous cell carcinoma develops in the cells that line the airways. (macmillan.org.uk)
As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small-cell carcinoma. (wikipedia.org)
In these cases, the tumors are classified as combined small-cell lung carcinoma (c-SCLC), and are (usually) treated as "pure" SCLC. (wikipedia.org)
Recent studies, though, suggest that the "ratio of centrally to peripherally occurring" lesions may be converging toward unity for both adenocarcinoma and squamous-cell carcinoma. (wikipedia.org)
citation needed] Squamous-cell carcinoma (SCC) of the lung is more common in men than in women. (wikipedia.org)
LCLC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer. (wikipedia.org)
A cavitating right lower lobe squamous cell carcinoma. (medscape.com)
Squamous cell carcinoma: Cancer that begins in squamous cells, which are thin, flat cells that look like fish scales. (doereport.com)
Large cell carcinoma: Cancer in which the cells are large and look abnormal when viewed under a microscope. (doereport.com)
Adenosquamous carcinoma: Cancer that begins in cells that look flattened when viewed under a microscope. (doereport.com)
Undifferentiated carcinoma: Cancer cells that do not look like normal cells and multiply uncontrollably. (doereport.com)
Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
This type of a cancer includes squamous cell carcinoma, adenocarcinoma and large cell carcinoma. (maxhealthcare.in)
It's insensitive to chemotherapy as compared to small cell carcinoma (SCLC). (maxhealthcare.in)

According to a 2019 study , up to 36 percent of people with IBD had granulomas in their lungs or organs other than their gastrointestinal tracts. (healthline.com)

My focus has been on a specific lung disease called idiopathic pulmonary fibrosis (IPF). (lu.se)

These biological specimens will then be analysed using novel laboratory techniques to develop the first reference dataset of immune cells in the respiratory system of children. (edu.au)
Human innate and adaptive immune cells are systematically reconstituted in BLT-L mice, thus facilitating examining various immune responses upon infection. (nature.com)
We were surprised at just how many different human pathogens replicated in the models and at how well the human immune cells in BLT-L mice could control infection, just like they would in people," says Wahl. (nature.com)
Our pilot data showed that these cells are impaired in people with lung cancer, coinciding with an increased presence of immune cells. (lung.org)
Immunologic Mechanisms: Smoking weakens the function of body defense immune cells and the production of antibodies in humans and animals. (who.int)

The mechanical features of tissues, for example, bone, muscle, different internal organs, and blood, can vary widely, and pathological tissues such as tumor masses or fibrotic tissues are mechanically significantly different from healthy tissues. (sciencedaily.com)
The lungs are a pair of cone-shaped breathing organs that are found within the chest. (doereport.com)
For diaphragmatic breathing, make use of your diaphragm muscles that separate the organs in the abdomen from the lungs. (pulseuniform.com)
During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
An inflammatory issue in which inflammatory cells can form clumps in various organs like the lungs. (healthline.com)
Smoking cigarettes damages all organs of the body, and it is particularly damaging to the lungs as it reduces its capacity and causes cancer. (medicaldaily.com)
As one of our vital organs, the lungs are crucial for our survival. (lu.se)

If someone stops smoking, their risk of developing lung cancer gets lower over time. (macmillan.org.uk)
The American Cancer Society states that a man's lifetime risk of developing lung cancer is about 1 in 16, while a woman's is 1 in 17. (moffitt.org)
There is still much to understand about the link between diet and lung malignancies, but taking beta carotene supplements has been linked to increased likelihood of developing lung cancer, particularly among smokers. (moffitt.org)

It is also one of the two main divisions of lung cancer along with non-small cell lung cancer. (healthline.com)
But then there are certain looks I see by nurses, staffs etc that say "pity" when the words small cell lung cancer are used. (cancer.org)
If you are worried about non-small cell lung cancer, we have more information about the signs and symptoms of lung cancer. (macmillan.org.uk)
If tests show you have non-small cell lung cancer, your specialist will arrange further tests. (macmillan.org.uk)
A listing of 3 Non-Small Cell Lung Cancer clinical trials in North Dakota actively recruiting volunteers for paid trials and research studies in various therapeutic areas. (policylab.us)
Go to Small Cell Lung Cancer for complete information on this topic. (medscape.com)
The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
The approval of KEYTRUDA as a first treatment instead of chemotherapy for patients who express high levels of PD-L1 has the potential to transform the way metastatic non-small cell lung cancer is treated," said Dr. Roy Baynes, senior vice president, head of clinical development, and chief medical officer, Merck Research Laboratories. (merck.com)
CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer. (nih.gov)
Non-small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. (doereport.com)
Refer to the PDQ summary on Small Cell Lung Cancer Treatment for more information. (doereport.com)
The five types of non-small cell lung cancer have different kinds of cancer cells. (doereport.com)
For most patients with non-small cell lung cancer, current treatments do not cure the cancer. (doereport.com)
Clinical trials are taking place in most parts of the country for patients with all stages of non-small cell lung cancer. (doereport.com)

All types can occur in unusual histologic variants and as mixed cell-type combinations. (wikipedia.org)
However, due to a lack of age-appropriate normative reference ranges, we have limited understanding of the immunological changes that occur in the lungs of children with respiratory disease and how this compares with normal immunity and healthy respiratory system development. (edu.au)
Lung cancer forms when changes (mutations) occur in the DNA of previously healthy lung cells. (moffitt.org)
These instructions can go haywire when cellular mutations occur, resulting in cells that rapidly divide and survive longer than they should. (moffitt.org)
The goal of this project is to identify changes in the lung that occur during lung cancer development, to improve early detection. (lung.org)
Lung granulomas, also referred to as rheumatoid or lung nodules, occur in 20 percent of people with RA, a condition that causes joint pain and inflammation. (healthline.com)
Lung granulomas may occur with this condition that mostly affects the salivary and lacrimal glands, preventing your body from producing enough saliva and tears. (healthline.com)
These tumors may occur in both lungs or just one and they disrupt the functioning of the lungs. (diethealthclub.com)
Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)

Identifying new cell types, in particular new progenitor cells, that are injured in COPD could really accelerate the development of new treatments," said study first author Maria Basil, MD, Ph.D., an instructor of Pulmonary Medicine. (worldhealth.net)
Victoria Ptasinski defended her Ph.D. thesis 'Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis' on Monday, November 27, 2023. (lu.se)

On April 14th, 2022, the chest CT of the local hospital showed multiple exudative lesions in both lungs, multiple bone destruction in the thoracic vertebrae, and pathological fracture of the 7th rib on the right and the 2nd and 6th ribs on the left (Fig. 1 A and B). (biomedcentral.com)

Fine crackles were heard in both lungs. (cdc.gov)
The respiratory sounds of both lower lungs were reduced, and scattered wet rales were heard in both lungs. (biomedcentral.com)

This study will develop a reference atlas of healthy cells in the paediatric airway in order to understand the changes caused by childhood lung disease. (edu.au)
earlyAIR's mission is to develop a cell atlas of the healthy paediatric airway. (edu.au)
This project will collect samples at multiple locations of the respiratory tract, including the upper (nose and throat) and lower airway (lungs). (edu.au)
The cells line tiny airway branches, deep in the lungs, near the alveoli structures where oxygen is exchanged for carbon dioxide. (worldhealth.net)
They soon recognized that RASCs, which don't exist in mouse lungs, are "secretory" cells that reside near alveoli and produce proteins needed for the fluid lining of the airway. (worldhealth.net)
Ozone exposure induces airway neutrophilia and modifies innate immune monocytic cell-surface phenotypes in healthy individuals. (nih.gov)
We used a human O(3) inhalation challenge model to examine the effectiveness of clinically relevant doses of inhaled corticosteroids on airway inflammation and markers of innate immune activation in healthy volunteers. (nih.gov)
A similar effect was observed on the airway-specific serum biomarker Clara cell protein 16 (CCP16). (nih.gov)
This study confirmed and extended data demonstrating the protective effect of FP against O(3)-induced airway inflammation and immune cell activation. (nih.gov)

ARDS is driven by an acute severe innate immune dysregulation, often characterised by inflammation , coagulation and cell injury . (bvsalud.org)
The device is intended to be used to quickly single out which individuals is showing injury and inflammation in the trachea and lung and therefore to provide them with the most adequate and early care. (dtic.mil)
This is a rare but serious type of vasculitis , inflammation of the blood vessels in your nose, throat, lungs, and kidneys. (healthline.com)

When these cells become cancerous, they can overproduce hormones or other biologically active substances that lead to the development of endocrine paraneoplastic syndromes. (healthline.com)
The result of all these changes to your genes: Some cells become cancerous and grow out of control. (webmd.com)
On a chest X-ray, some lung granulomas can potentially look like cancerous growths. (healthline.com)
This can cause mutation, which leads to the development and growth of cancerous cells. (diethealthclub.com)

This occurs when tumor cells cause an overproduction of the hormone cortisol. (healthline.com)
Zolbetuximab is a monoclonal antibody that targets the cell surface molecule CLDN18.2, which is expressed in normal gastric mucosa cells and is retained in mG/GEJ tumor cells. (medscape.com)
PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. (doereport.com)
Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells. (doereport.com)
Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)

Lung cancer is caused as a result of the rapid growth of abnormal cells that form a tumor. (diethealthclub.com)

Now researchers report that microbiota regulate the ability of lung dendritic cells to generate immune responses. (sciencedaily.com)
Microbiota--the trillions of bacteria that co-exist in the body--regulate the ability of lung dendritic cells to generate immune responses, according to a study led by researchers from the Icahn School of Medicine at Mount Sinai, published online in the Journal of Experimental Medicine . (sciencedaily.com)
To study the production of IgA within the lungs, the researchers used mouse models to isolate specialized cells called dendritic cells and cultured them with antibody-producing B cells. (sciencedaily.com)
To the researchers' surprise, they found that when they isolated lung dendritic cells from "germ free" or antibiotic-treated mice, the production of IgA was highly impaired. (sciencedaily.com)
Further, when the germ-free mice were fed with a component of bacterial cell wall called LPS, the lung dendritic cells started instructing B cells to produce IgA again. (sciencedaily.com)

It is closely correlated with a history of tobacco smoking, more so than most other types of lung cancer. (wikipedia.org)

Metastatic-niche labelling reveals parenchymal cells with stem features. (nature.com)
Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. (hindawi.com)
It has been observed that mesenchymal stem cells (MSCs) could home and engraft within the injured tissues and differentiate into vascular cells and alveolar cells to regenerate the damage in the irradiated mouse lung [ 10 ]. (hindawi.com)
CXCR4 is a G protein-linked seven transmembrane spanning receptor that has been identified as a receptor of stromal cell-derived factor-1 (SDF-1) for stem cells [ 22 - 24 ]. (hindawi.com)
Human-mouse chimeric models (humanized mice), generated by engrafting human tissues and/or stem cells into immunodeficient mice, are powerful tools for in vivo studies of human pathogens. (nature.com)
The scientists showed that RASCs have stem-cell-like properties enabling them to regenerate other cells that are essential for the normal functioning of alveoli. (worldhealth.net)
Could stem cells fight lung disease in our tiniest patients? (ottawahospital.on.ca)
Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
Through a close collaboration with AstraZeneca, Victoria's research has aimed to uncover the underlying causes of IPF, developing innovative stem cell-based technologies along the way. (lu.se)

Imagine our horror and shock when we got a call saying the biopsy came back indicating the cancer was small cell. (cancer.org)
They look at the biopsy samples under a microscope to check for cancer cells. (macmillan.org.uk)
You usually have a biopsy to find out for certain if you have lung cancer. (macmillan.org.uk)
Your doctors may arrange more detailed tests on cancer cells taken during a biopsy or surgery. (macmillan.org.uk)
the histologic pattern was not previously recognized and similar to open lung biopsy specimens from the three other cases. (cdc.gov)

Adenocarcinoma of the lung is currently the most common type of lung cancer in "never smokers" (lifelong nonsmokers). (wikipedia.org)
Historically, adenocarcinoma was more often seen peripherally in the lungs than SCLC and squamous-cell lung cancer, both of which tended to be more often centrally located. (wikipedia.org)
Adenocarcinoma: Cancer that begins in cells that have glandular (secretory) properties. (doereport.com)
Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)

Transfection with CXCR4 enhanced the quantity of transplanted HUMSCs in the radiation-induced injured lung tissues. (hindawi.com)
Contrarily, some studies suggested that the quantity of exogenous MSCs transplanted in the injured lung tissues is so less to influence the biological effects of MSCs [ 2 , 16 , 17 ]. (hindawi.com)

Fig. 3: Primed neutrophils support metastatic colonization in irradiated lungs. (nature.com)
Fig. 6: Radiation exposure boosts Notch signaling and stemness in metastatic cells. (nature.com)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)

Radiotherapy, the commonly used treatment for thoracic malignant tumor, can lead to severe complications in some patients, like radiation-induced lung injury (RILI). (hindawi.com)
The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. (cdc.gov)

Fig. 2: Radiation exposure induces the infiltration and local activation of lung neutrophils. (nature.com)
Following exposure, hMSCs and their conditioned media were evaluated for a broad panel of relevant properties, including viability, levels of expression of inflammatory cytokines , gene expression , cell surface human leukocyte antigen expression, and activation of coagulation and complement pathways. (bvsalud.org)
Staying away from people while they smoke can help reduce secondhand smoke exposure and lower your risk of lung cancer. (moffitt.org)
Prolonged radon exposure is currently recognized as the second leading cause of lung cancer. (moffitt.org)
Many studies suggest that heavy, long-term exposure to diesel exhaust can lead to the development of lung cancer. (moffitt.org)
B-cell lymphocytic bronchiolitis and alveolar ductitis in a man with exposure to metalworking fluid s - a novel occupational lung disease. (cdc.gov)

A thoracoscopy lets the doctor look at the lining of the lungs (pleura). (macmillan.org.uk)
A thin membrane called the pleura surrounds the lungs. (doereport.com)

Dr. Baker and his colleagues found that senescent macrophages appear to block the immune system from being able to respond to and eliminate the abnormal growth of cells. (webindia123.com)

The lungs bring oxygen into the body and take out carbon dioxide, which is a waste product of the body's cells. (doereport.com)
By breathing, we feed oxygen to all cells within our body. (pulseuniform.com)
The helpful coating helps your lung cells give you oxygen. (nebraskamed.com)
Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)

The cancer begins in squamous cells, the flat cells that line the inside of the lung airways. (webmd.com)

We found that locally activated neutrophils were key drivers of the tumor-supportive preconditioning of the lung microenvironment, governed by enhanced regenerative Notch signaling. (nature.com)

Fig. 5: Notch is activated in the lung epithelium and enhances spontaneous metastasis. (nature.com)
Fig. 7: Radiation-primed neutrophils boost lung metastasis via their degranulation activity. (nature.com)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)

or family history of lung cancer. (maxhealthcare.in)
The PRS was evaluated for association with lung cancer risk adjusting for age, sex, total pack-years, family history of lung cancer, history of COPD, and the top five principal components for genetic ancestry. (cdc.gov)

Sickle cell disease is a blood disorder linked to ischemic stroke that affects mainly Black children. (cdc.gov)

When this inflammatory disease affects the lungs, symptoms may include a dry cough, shortness of breath, and wheezing. (healthline.com)
The coronavirus attacks your lungs, which causes shortness of breath. (nebraskamed.com)
Shortness of breath, whether caused by COVID-19 or something else, affects your lung tissues. (nebraskamed.com)

The bronchi are sometimes also involved in lung cancer. (doereport.com)

The disease starts in cells that release substances, like mucus. (webmd.com)
Studies have shown that persons who have underlying HIV infection or other causes of immunosuppression and those who are not immunosuppressed but have chronic lung disease may often be colonized by P. jirovecii ( 11 - 13 ). (cdc.gov)
The disease causes some red blood cells to form an abnormal sickle shape. (cdc.gov)
earlyAIR is a paediatric component of the global Human Cell Atlas consortium that aims to create comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing, monitoring, and treating disease. (edu.au)
See also Lung Cancer Staging -- Radiologic Options , a Critical Images slideshow, to help identify stages of the disease process. (medscape.com)
With studies like this we're starting to get a sense, at the cell-biology level, of what is really happening in this very prevalent disease," said senior author Edward Morrisey, Ph.D., the Robinette Foundation Professor of Medicine, a professor of Cell and Developmental Biology, and director of the Penn-CHOP Lung Biology Institute at Penn Medicine. (worldhealth.net)
According to the Centers for Disease Control and Prevention (CDC), cigarette smokers are 15 to 30 times more likely to develop lung cancer or die from the disease than people who do not smoke. (moffitt.org)
Whether you are a patient living with lung disease or a caregiver, join the Patient & Caregiver Network for timely education, support and connection. (lung.org)
Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (lung.org)
Introduction: Identification of a novel lung disease in workers can lead to further understanding of occupational hazards. (cdc.gov)
If this bacterial disease is in the lungs, symptoms may include a chronic cough, coughing up blood or phlegm, and chest pain. (healthline.com)
Lung cancer diets offer new hope to patients suffering from the disease, but the fact remains that this is the most fatal of all types of cancer and is also the most easily preventable. (diethealthclub.com)
We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
It has been documented that smokers incur a 2- to 4-fold increased risk of invasive pneumococcal lung disease, a disease associated with high mortality. (who.int)

Please share your experiences and ANY information you can on your small cell treatments. (cancer.org)
More research is needed, Morrisey said, but the findings point to the possibility of future COPD treatments that work by restoring the normal RASC-to-AT2 differentiation process -- or even by replenishing the normal RASC population in damaged lungs. (worldhealth.net)

Despite increased interest in mesenchymal stromal cell (MSC)-based cell therapies for acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and our understanding of the potential in vivo mechanisms of MSC actions in ARDS remains limited. (bvsalud.org)
Clinical-grade human bone marrow -derived MSCs (hMSCs) were exposed to bronchoalveolar lavage fluid (BALF) samples obtained from ARDS patients or from healthy volunteers . (bvsalud.org)
If lung cancer is found, participation in one of the many clinical trials being done to improve treatment should be considered. (doereport.com)
See Clinical Presentations of Lung Cancer: Slideshow , a Critical Images slideshow, to help efficiently distinguish lung carcinomas from other lung lesions, as well as how to stage and treat them. (medscape.com)

He had a tumor, less than 4cm in his right lung and a small spot in his brain that the tumor board is actually still discussing. (cancer.org)
The results came back that the cancer, that was thought to beisolated to her right lung, had in fact spread to ten other spots on the right side of the body. (gofundme.com)
There is a right lung and a left lung. (doereport.com)
The right lung, which is slightly larger, has 3 lobes. (doereport.com)

But his initial diagnosis was NON small cell. (cancer.org)
If your GP thinks your symptoms could be caused by lung cancer, they will arrange tests to help make a diagnosis. (macmillan.org.uk)

People may be diagnosed with lung cancer after seeing their GP about their symptoms. (macmillan.org.uk)

Other paraneoplastic syndromes are caused by cancer cells releasing hormones or other substances. (healthline.com)
Others are caused by the production of hormones and other biologically active substances by cancer cells. (healthline.com)
Humoral hypercalcemia happens when cancer cells cause parathyroid hormone-related molecules to overproduce. (healthline.com)
Acromegaly is characterized by the abnormal secretion of growth hormone and insulin-like growth factor 1 by cancer cells. (healthline.com)
Sometime doctors take a blood sample and look for pieces of cancer cells and of the tumour DNA. (macmillan.org.uk)
Unlike chemotherapy , which involves using specific drugs to attack and destroy cancer cells, immunotherapy works by boosting a person's immune response against cancer tumors. (medicalnewstoday.com)
it killed lung, breast and brain cancer cells and left the healthy cells alone. (snopes.com)
it triggers the mitochondria which in turn fights the cancer cells. (snopes.com)
You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. (snopes.com)
The cancer cells of each type grow and spread in different ways. (doereport.com)
After lung cancer has been diagnosed, tests are done to find out if cancer cells have spread within the lungs or to other parts of the body. (doereport.com)
A botanical review of the food item found that compounds in saffron display high toxicity against cancer cells. (naturalnews.com)
The most striking and characteristic metabolic alteration in cancer cells is anomalous glucose metabolism and cancer cells tend to utilize glycolysis to obtain energy even under aerobic conditions via a process called 'aerobic glycolysis' ( 9 ). (spandidos-publications.com)
The smoke may contain ultra-fine particles, toxic compounds (e.g., benzene, toluene, hydrogen cyanide), viruses (e.g., human papilloma virus [HPV]), and cancer cells (Guideline for Surgical Smoke Safety). (cdc.gov)

inflamed lung environments differentially affect mesenchymal stromal cells. (bvsalud.org)

The treatment options and prognosis (chance of recovery) depend on the stage of the cancer (whether it is in the lung only or has spread to other places in the body), tumor size, the type of lung cancer, whether there are symptoms, and the patient's general health. (doereport.com)

Importantly, the phenotypes, functions, and gene expression programs of T cells trained in variations of the system correlated well with those we found in T cells in mechanically distinct tissues from patients with cancer or fibrosis," said Mooney who also is the Robert P. Pinkas Family Professor of Bioengineering at SEAS, and leads the Wyss Institute's Immunomaterials Initiative. (sciencedaily.com)
We will use lung tissues from patients with early-stage lung cancer. (lung.org)

Four cases of a novel B-cell lymphocytic bronchiolitis and alveolar ductitis occurred among non-smoking workers at a machine fabrication facility. (cdc.gov)
Discussion: A case of progressive B-cell lymphocytic bronchiolitis and alveolar ductitis with novel histologic characteristics (distinct from hypersensitivity pneumonitis and follicular bronchiolitis) shared by three other cases was identified at a single workplace shown to have MWF populated with multiple microorganisms. (cdc.gov)

By engineering a 3-dimensional model of the extracellular matrix (ECM), produced by cells that are responsible for tissues' different stiffnesses and viscoelasticities, they were able to tune both parameters independently. (sciencedaily.com)
The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)

When airborne silica (for example, quartz dust) is inhaled, it can penetrate deep into the lungs and lead to the development of lung cancer. (moffitt.org)

If you have any lung cancer symptoms or notice anything that is unusual for you, see your GP straight away. (macmillan.org.uk)
While lung granulomas usually have no symptoms, their underlying cause may present symptoms. (healthline.com)
There are seldom symptoms associated with lung granulomas themselves. (healthline.com)
Lung granulomas with no abnormal symptoms may not need to be treated. (healthline.com)
Symptoms of this lung infection include fever, dry cough, chest pain, and red bumps on your lower legs. (healthline.com)

According to the latest statistical report from the American Cancer Center from 2021, lung cancer has the second-highest incidence and the highest mortality rate among all malignancies ( 2 ). (spandidos-publications.com)

Pro-inflammatory, pro- coagulant and major histocompatibility complex ( self -recognition) related gene expression was markedly upregulated in hMSCs exposed ex vivo to BALF obtained from healthy volunteers . (bvsalud.org)
In in vivo and in vitro studies, MSCs were found to alleviate irradiation-induced lung injuries not only by the secretion of cytokines, growth factors, and paracrine molecules but also by immunomodulatory effect. (hindawi.com)

People who do not smoke can still develop lung cancer, but their risk is much lower. (macmillan.org.uk)
Lung cancer is also more common in older people. (macmillan.org.uk)
As it is difficult for doctors to detect it early on, people with lung cancer need to receive the best, most targeted therapy in order to make a positive outlook more likely. (medicalnewstoday.com)
To ensure the most favorable outcomes for people with lung cancer , healthcare professionals must choose the best type of treatment for each individual. (medicalnewstoday.com)
The model allows healthcare practitioners to find which people with lung cancer would benefit the most from immunotherapy. (medicalnewstoday.com)
To develop the new AI model, the team first used data from computed tomography (CT) scans from 50 people with lung cancer. (medicalnewstoday.com)
You know that you should be eating healthy foods and exercising, but even though those two principles are simple enough to follow, millions of people still do not eat right or exercise regularly. (progressivehealth.com)
People who do not smoke but are frequently around those who do also have a higher risk of lung cancer. (moffitt.org)
Join over 700,000 people who receive the latest news about lung health, including COVID-19, research, air quality, inspiring stories and resources. (lung.org)
People with leukemia may develop lung granulomas due to lymphomatoid granulmatosis, a rare condition caused by the overproduction of lymphocytes, or white blood cells. (healthline.com)
But in the mucus-clogged lungs of people with cystic fibrosis, the bacterium finds an ideal habitat. (newscientist.com)
The recommended dietary allowance (RDA)-the amount most healthy people need each day to remain healthy-has been determined for most vitamins. (msdmanuals.com)

Thus, their study demonstrates how commensal bacteria may affect important aspects of lung immunity, in turn increasing our susceptibility to allergies and infections. (sciencedaily.com)

Anyone can get a gene mutation that causes lung cancer. (webmd.com)
What causes lung cancer? (moffitt.org)

The PulseNet specimens have no connection other than symbiotic flora, colonization, contamination, or infection by bacteria that at some point years ago were progeny of the same cell. (cdc.gov)

Anatomy26

Organisms13

Diseases70

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment59

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science5

Health Care17

Tissue30

Cancers12

Tumors in the lungs2

NSCLC16

Diseases15

Epithelial8

Carcinoma16

20191

Idiopathic pulmonar1

Immune cells5

Organs7

Developing lung cancer3

Small Cell L14

Occur9

Progenitor cells2

20221

Heard in both lungs2

Airway9

Inflammation3

Cancerous4

Tumor cells7

Growth of abnormal cells1

Dendritic cells5

Types of lung cancer1

Stem15

Biopsy5

Adenocarcinoma4

Injured lung tissues2

Metastatic3

Malignant2

Exposure6

Pleura2

Abnormal growth of cells1

Oxygen4

Squamous1

Microenvironment1

Metastasis4

Family history of lung cancer2

Sickle Cell Di1

Shortness3

Involved in lung cancer1

Disease14

Treatments2

Clinical4

Right lung4

Diagnosis2

Diagnosed with lung cancer1

Cancer cells14

Stromal cells1

Type of lung cancer1

Tissues from patients2

Alveolar2

Extracellular matrix2

Development of lung1

Symptoms5

20211

Vivo2

People12

Immunity1

Causes lung cancer2

Colonization1