AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Colorectal NeoplasmsAdenocarcinomaColonic NeoplasmsRectal NeoplasmsAdenomaLungLung NeoplasmsColonoscopyTumor Markers, BiologicalEarly Detection of CancerNeoplasm StagingPrognosisColorectal Neoplasms, Hereditary NonpolyposisGene Expression Regulation, NeoplasticNeoplasm MetastasisFluorouracilAdenocarcinoma, MucinousCell Line, TumorImmunohistochemistryStomach NeoplasmsSigmoidoscopyPancreatic NeoplasmsOrganoplatinum CompoundsColonic PolypsLeucovorinSurvival RateRisk FactorsSurvival AnalysisNeoplasm InvasivenessMutationCarcinoma, Non-Small-Cell LungNeoplasm ProteinsCarcinomaAntineoplastic AgentsOccult BloodEsophageal NeoplasmsLiver NeoplasmsCamptothecinNeoplasmsCarcinoembryonic AntigenLung DiseasesAntineoplastic Combined Chemotherapy ProtocolsDNA, NeoplasmBreast NeoplasmsProstatic NeoplasmsMass ScreeningCase-Control StudiesColonRetrospective StudiesHT29 CellsDisease ProgressionGenetic Predisposition to DiseaseDNA MethylationMicrosatellite RepeatsTreatment OutcomeProspective StudiesMice, NudeMicrosatellite InstabilityAdenomatous PolypsGenes, rasRectumFollow-Up StudiesReverse Transcriptase Polymerase Chain ReactionHCT116 CellsOvarian NeoplasmsRNA, Messengerras ProteinsIncidenceCarcinoma, Pancreatic DuctalDisease-Free SurvivalColorectal SurgeryAdenomatous Polyposis ColiMutS Homolog 2 ProteinTumor Cells, CulturedAntimetabolites, AntineoplasticPrecancerous ConditionsAdenocarcinoma, PapillaryNeoplasm Recurrence, LocalCell ProliferationRiskCarcinoma, Squamous CellGene Expression ProfilingAdenocarcinoma, Bronchiolo-AlveolarKaplan-Meier EstimatePolymerase Chain ReactionEndometrial NeoplasmsIntestinal PolypsCell Transformation, NeoplasticProto-Oncogene Proteins B-rafGerm-Line MutationSensitivity and SpecificityNeoplasms, Multiple PrimaryBarrett EsophagusUnited StatesAntibodies, MonoclonalDNA Mutational AnalysisTumor Suppressor Protein p53GenotypeProto-Oncogene ProteinsApoptosis
TumorsPrognosisTumorSquamous Cell CarcMutationsMelanomaOvarian CancerEpidermal growth fMetastasisCarcinomaMalignantRectumEndometrialDuctalMetastasesProgressionDiagnosisLiverCarcinomasGenomicNSCLCGastricCervical cancerSurvivalOncologyPolypsHistologicallyEGFRCohortsTherapeuticBiomarkerHereditaryDiagnosticGastrointestinalDetectionChemotherapyEpithelialClinicalNeoplasmsTissuesMethodsPrimaryMalignancyBreastProstateSystemic therapySymptomsMutationAnalysesBladder Cancer
Tumors13
  • At present, the biological processes related to the purity of lung cancer tumors remains unclear. (hindawi.com)
  • These cells create tumors that destroy the lung, kill health cells and over time metastasize to other parts of the body. (nutralegacy.com)
  • NEW YORK - By profiling genomic and clinical features in tumors from tens of thousands of cancer patients, a team led by investigators at Memorial Sloan Kettering Cancer Center has uncovered features that may help predict a tumor's metastatic potential and organ sites it may affect. (genomeweb.com)
  • As they reported in Cell on Thursday, the researchers analyzed targeted panel sequence data for 15,632 primary and 10,143 metastatic tumors from a total of 25,755 metastatic cancer patients in the MSK-MET cohort, including patients who had matched primary and metastatic tumor samples sequenced. (genomeweb.com)
  • In contrast to prior studies that centered on either primary or metastatic tumors as a group, the team set out to characterize integrated genomic and clinical features of metastatic disease in the context of cancer type and anatomic site of metastasis. (genomeweb.com)
  • Together with molecular data across 341 to 468 cancer genes profiled with the MSK-IMPACT clinical sequencing assay , these insights made it possible to compare molecular features found in tumors from primary or metastatic sites in individuals with or without metastases. (genomeweb.com)
  • The team's results revealed alterations that were relatively common in certain cancer types or in metastatic tumors springing up at specific target sites. (genomeweb.com)
  • We treat the full range of colon and rectum cancers, including adenocarcinomas, carcinoid tumors and gastrointestinal stromal tumors (GISTs). (bjc.org)
  • We are equipped to treat non-small cell lung cancers (NSCLCs), small cell lung cancers, lung carcinoid tumors and very rare types. (bjc.org)
  • Type I tumors are associated with unopposed estrogen stimulation and are known as endometrioid adenocarcinoma. (labtube.tv)
  • The company will present encore data indicating adagrasib , a potent and selective KRAS G12C inhibitor, is well tolerated and demonstrates meaningful clinical activity in patients with previously treated pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC), and other solid tumors harboring a KRAS G12C mutation. (biospace.com)
  • Phase 2 data from the KRYSTAL-1 study demonstrates the potential value of adagrasib monotherapy for patients with unresectable or metastatic KRAS G12C -mutated solid tumors beyond non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). (biospace.com)
  • My work on liquid biopsies has involved blood based protein signatures for pancreatic cancer, and single-cell morphometric, proteomic and genomic characterization of circulating tumor cells, in comparison to solid tumors. (lu.se)
Prognosis9
  • Several risk factors and pathologies, including ageing, smoking, obesity and diabetes have been associated with poor prognosis in colorectal cancer patients. (frontiersin.org)
  • PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. (nih.gov)
  • This study explored the expression of Ln5 and the role of its relationships with PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in the prognosis of patients with non-small cell lung cancer (NSCLC). (spandidos-publications.com)
  • Colorectal cancer ranks fourth worldwide in cancer occurrence and deaths (Shibuya K et al 2002), though it has a better prognosis than do most cancers. (bioresonancetherapy.com.sg)
  • The first step involves achievement of cure, because the risk of pelvic recurrence is high in patients with rectal cancer, and locally recurrent rectal cancer has a poor prognosis. (medscape.com)
  • Development of somatic mutation signatures for risk stratification and prognosis in lung and colorectal adenocarcinomas. (cdc.gov)
  • However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
  • 9% of cancers of uterine corpus, however is associated with more aggressive behavior and a poorer prognosis. (medscape.com)
  • First, colon cancer is the second most frequent cause of cancer death in America and its prognosis can be excellent with early diagnosis and treatment [ 15 ]. (cdc.gov)
Tumor26
  • Mutations that activate oncogenes and deactivate tumor suppressor genes are widely recognized as significant contributors to cancer development. (bvsalud.org)
  • Plasma concentrations of arsenic (As), cadmium (Cd), chromium (Cr), mercury (Hg), and lead (Pb) were measured using inductively coupled plasma mass spectrometry (ICPMS), and next-generation sequencing (NGS) of 1123 cancer -related genes was performed using the tumor tissues . (bvsalud.org)
  • These nontumor cells dilute the tumor purity in lung cancer tissues. (hindawi.com)
  • Tumor purity plays an essential role in the immune response to lung cancer. (hindawi.com)
  • We measured tumor purity in 486 lung carcinoma tissues from TCGA-LUAD FPKM by using the "estimate" R package. (hindawi.com)
  • Lung carcinoma tumor mutation burden was calculated by analyzing TCGA single nucleotide polymorphism data. (hindawi.com)
  • Based on the tumor purity and lung carcinoma gene matrix, we performed weighted gene coexpression network analysis (WGCNA), and the tumor purity-related module was identified. (hindawi.com)
  • A lung cancer tumor purity correlated coexpression network was determined. (hindawi.com)
  • Tumor purity-related coexpression factors in the tumor microenvironment have essential clinical, genomic, and biological significance in lung cancer. (hindawi.com)
  • We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)
  • With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
  • We explored the coexpression factors most related to tumor purity and related biological functions and demonstrated the most relevant biological functions and mechanism of action affecting tumor purity in the lung cancer tumor microenvironment. (hindawi.com)
  • A total of 98 tissue samples were obtained from the tumor bank of Guangdong Lung Cancer Institute (Guangzhou, China) between 2004 and 2006. (spandidos-publications.com)
  • Our work shows that genomic alterations identified in tumor samples can inform our understanding of a tumor's potential to metastasize, at least in some cancer types ," senior author Nikolaus Schultz, a researcher at MSKCC, said in an email. (genomeweb.com)
  • With insights from more than 99,400 metastatic events identified in 21,546 metastatic cancer patients, they flagged genomic patterns corresponding to metastases from dozens of cancer types that affected 21 different organs, along with suspicious primary tumor changes in individuals with metastatic disease. (genomeweb.com)
  • Even though most cancer deaths are due to metastatic disease, predicting whether or not an early-stage tumor will metastasize - as well as what organs will be eventually affected by metastases - remains a formidable challenge," Schultz explained. (genomeweb.com)
  • On the other hand, they found that high-grade serous ovarian or colorectal cancers were more often marked by copy number changes linked to relatively early stages in the tumor development process. (genomeweb.com)
  • MSK investigators are now gearing up to do related research focused on treatments that target metastatic tumor drivers through the newly-funded Marie- Jos é e and Henry R. Kravis Cancer Ecosystems Project. (genomeweb.com)
  • We hope that [MSK-MET] will be a valuable resource for the community and will stimulate further research and applications in cancer care," the authors wrote, adding that "more integrated studies are needed to fully investigate the impact of tumor cell-extrinsic effects, such as cancer therapy, target-organ microenvironment, and systemic factors. (genomeweb.com)
  • Cancer precision medicine draws on the presence of somatically acquired changes in the tumor, which serve as predictive markers of response to drugs and other therapies. (nature.com)
  • The survival outcomes of patients with metastatic colorectal adenocarcinoma based on tumor laterality has already been established based on large-scale retrospective studies. (waocp.com)
  • The patients were stratified according to the primary tumor laterality: Right-Sided Colon cancer (RCC) and Left-sided Colon cancer (LCC). (waocp.com)
  • More diverse clinical characteristics other than tumor location may be prognostic of disease-free and survival outcomes in the non-metastatic setting of colorectal cancer. (waocp.com)
  • The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
  • Stage 0 colon cancer may be treated by removing the tumor using endoscopic surgery (colonoscopy). (medlineplus.gov)
  • Even though the tumor was removed, chemotherapy is given to treat any cancer cells that may remain. (medlineplus.gov)
Squamous Cell Carc4
Mutations11
  • We investigated relationships between heavy metal exposure and the frequencies and types of gene mutations in patients with lung adenocarcinoma (LUAD) and colorectal cancer (CRC). (bvsalud.org)
  • Testing for epidermal growth factor receptor ( EGFR ) mutations is part of the current standard of care in advanced non-small cell lung cancer. (bmj.com)
  • Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • Point mutations of BRAF, are present in over 60 percent of melanomas and have been found at lower rates in lung, colon, and ovarian carcinomas. (news-medical.net)
  • These mutations can also cause cancer, making BRAF an oncogene. (news-medical.net)
  • There are over 30 mutations of BRAF that have been connected to cancer. (news-medical.net)
  • BRAF mutations are found in more than 80 percent of melanomas, but only 1-3 percent of lung cancers. (news-medical.net)
  • BRCA1/BRCA2 germline mutations and chemotherapy-related hematological toxicity in breast cancer patients. (cdc.gov)
  • These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)
Melanoma2
  • That mutation has been found in papillary thyroid carcinoma, colorectal cancer, melanoma, and non-small cell lung cancer. (news-medical.net)
  • Our medical oncologists work with dermatologists and plastic surgeons to provide expert treatment for melanoma and other skin cancers. (bjc.org)
Ovarian Cancer4
  • Our oncology team cares for people with cervical, endometrial and ovarian cancer. (bjc.org)
  • Targeted surgical prevention of epithelial ovarian cancer is cost effective and saves money in BRCA mutation carrying family members of women with epithelial ovarian cancer. (cdc.gov)
  • Germline variation in BRCA1/2 is highly ethnic-specific: evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients. (cdc.gov)
  • A patient-centered mobile health application to motivate use of genetic counseling among women with ovarian cancer: A pilot randomized controlled trial. (cdc.gov)
Epidermal growth f2
  • This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. (techscience.com)
  • Molecular Alterations and Poziotinib Efficacy, a pan-HER inhibitor, in Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancers: Combined Exploratory Biomarker Analysis from a Phase II Clinical Trial of Poziotinib for Refractory HER2-positive Breast Cancer Patients. (cdc.gov)
Metastasis4
  • The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. (lu.se)
  • Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer. (nih.gov)
  • Exclusively hepatic metastasis (es) : absence of bone, lung and brain metastases. (knowcancer.com)
  • This inhibitory effects seemed to contribute to the prevention of possible complications in the process of cancer recovery, such as recurrence and metastasis. (fortunejournals.com)
Carcinoma5
  • A colorectal carcinoma is a malignant (cancerous) new growth that arises from cells in the bowel lining. (bioresonancetherapy.com.sg)
  • We provide comprehensive care for all types of breast cancer, including ductal carcinoma, lobular carcinoma and triple negative breast cancer. (bjc.org)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
Malignant1
  • Although studies have revealed the mechanisms involved in cancer malignant characteristics and identified reasonable therapeutic targets [ 4 ], current clinical prediction and treatment outcome of lung cancer are not satisfactory [ 5 ]. (hindawi.com)
Rectum8
Endometrial11
  • He said adults who don't exercise are at increased risk of developing certain cancers like breast, endometrial, or colon, but until recently the impact of less structured forms of vigorous physical activity was unable to be measured. (scitechdaily.com)
  • Endometrial cancer is the most common gynecologic malignancy. (labtube.tv)
  • Endometrial cancer is generally classified into two types. (labtube.tv)
  • Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
  • No evidence suggests that routine endometrial sampling or transvaginal sonography to evaluate the endometrial stripe in asymptomatic women has a role in early detection of uterine cancer, even in women who take tamoxifen after breast cancer or has a cancer syndrome. (medscape.com)
  • Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)
  • This article discusses endometrial cancer and uterine sarcomas. (medscape.com)
  • While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
  • Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
  • This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
  • Besides colon cancer, women affected have a 40-60% risk of endometrial cancer by age 70 years, compared to a baseline population risk of 1.5% at the same age. (medscape.com)
Ductal2
  • The Company's lead asset is onvansertib, a PLK1 inhibitor being evaluated in combination with standard-of-care (SoC) therapeutics in clinical programs targeting indications such as RAS-mutated metastatic colorectal cancer (mCRC) and metastatic pancreatic ductal adenocarcinoma (mPDAC), as well as in investigator-initiated trials in small cell lung cancer (SCLC) and triple negative breast cancer (TNBC). (fox59.com)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
Metastases8
  • Tissue microarrays from 629 resected primary lung cancers and 422 resected pulmonary epithelial metastases from various sites (whereof 275 colorectal cancer) were investigated for the immunohistochemical expression of CDH17, GPA33, MUC2, MUC6, SATB2, and SMAD4, for comparison with CDX2, CK20, CK7, and TTF-1. (lu.se)
  • MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)
  • Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. (lu.se)
  • These cancers were also less likely to show metastases-associated chromosomal stability. (genomeweb.com)
  • The researchers also found associations between primary cancer subtypes and the body sites that were later impacted by metastatic disease, including an overrepresentation in liver metastases among patients with metastatic forms of lung neuroendocrine cancer and an uptick in ovarian or peritoneum metastases in individuals with advanced lobular breast cancer. (genomeweb.com)
  • Multi-Centre Phase III Open Label Randomized Trial Comparing CPT-11 In Combination With A 5-FU/FA Infusional Regimen To The Same 5-FU/FA Infusional Regimen Alone, As Adjuvant Treatment After Resection Of Liver Metastases For Colorectal Cancer. (knowcancer.com)
  • This encore presentation follows the recent inclusion of adagrasib in the National Comprehensive Center Network (NCCN) Guidelines for both PDAC and Central Nervous System (CNS) Cancers for patients living with previously treated KRAS G12C -mutant PDAC and non-small cell lung cancer (NSCLC) with CNS metastases, respectively. (biospace.com)
  • Positron-emission and computed tomography revealed liver, lung, and bone metastases. (cdc.gov)
Progression7
  • Recently, Cdc42 has been shown to actively assist in cancer progression. (wikipedia.org)
  • In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
  • The study is designed to investigate the effect and molecular mechanism of KIF18A on the progression of colorectal cancer. (aging-us.com)
  • The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on progression-free survival (PFS) and overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration. (policylab.us)
  • Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression," the authors wrote. (genomeweb.com)
  • For example, cancer-related aberrantly spliced variants have been shown to be actively involved in the initiation and/or progression of some types of cancer [ 4 ]. (biomedcentral.com)
  • In this context, we assess the reliability of the neurotensinergic system to cancer progression as well as the regulation and mechanism of the system in order to determine its potential in colorectal cancer diagnosis, surveillance and screening. (springer.com)
Diagnosis10
  • About 35% of all cancer patients are defined as having metastatic disease [ 2 ], of which less than 20% patients can survive more than 5 years from the date of diagnosis [ 3 ]. (aging-us.com)
  • Liquid biopsy has shown potential for early cancer detection and diagnosis. (ajmc.com)
  • Additionally, it may be possible to create more accurate and specific liquid biopsy methods for cancer diagnosis by analyzing the methylation patterns of cancer and benign disease samples. (ajmc.com)
  • The study highlights the potential of liquid biopsy methods for improving cancer diagnosis and detection, suggesting that further development and validation of these methods could have important implications for improving cancer survival and quality of life," concluded the study authors. (ajmc.com)
  • Plasma NTS had an optimal sensitivity of 60.4% and specificity of 71.6% for the diagnosis of colorectal polyps and cancers. (springer.com)
  • Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients. (cdc.gov)
  • Serum miR-16 as a potential biomarker for human cancer diagnosis: results from a large-scale population. (cdc.gov)
  • Symptoms, initial diagnosis, and treatment are similar to other forms of colorectal. (msdmanuals.com)
  • Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. (who.int)
  • We analyzed registry data for 3,291 women and 3,009 men diagnosed with colon cancer between 1996 and 2000 and followed until 2011 on lymph node investigation, stage at diagnosis, surgery, chemotherapy, wait times and survival. (cdc.gov)
Liver3
  • P=.501) and the most common were in the lungs, and liver. (waocp.com)
  • Carcinomas tend to invade nearby tissue and spread (metastasize) to distant organs such as the liver, lungs, bone, and brain. (bioresonancetherapy.com.sg)
  • The liver, lungs, and peritoneum are the most common metastatic sites of CRC. (medscape.com)
Carcinomas1
  • In particular, an increase in chromosomal instability turned up in metastatic forms of lung or prostate adenocarcinomas and in hormone receptor- and HER2-positive breast carcinomas originating in the duct, the researchers reported. (genomeweb.com)
Genomic4
  • Unveiling the metal mutation nexus: Exploring the genomic impacts of heavy metal exposure in lung adenocarcinoma and colorectal cancer. (bvsalud.org)
  • These findings suggest that heavy metal exposure can impact genomic stability in cancer -related genes , underscoring the importance of heavy metal exposure in cancer development. (bvsalud.org)
  • Methylation patterns in cell-free DNA (cfDNA) have come about as a hopeful genomic feature for identifying the presence of cancer and detecting its origin. (ajmc.com)
  • Clinical and genomic data generated for participants from the MSK-MET cohort so far is available online via the cBioPortal for Cancer Genomics database. (genomeweb.com)
NSCLC2
  • Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
  • Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)
Gastric1
  • Meat consumption and risk of esophageal and gastric cancer in the Golestan Cohort Study, Iran. (who.int)
Cervical cancer3
  • In one study studying the role of Cdc42 in cervical cancer, immunohistochemistry was used to detect Cdc42 expression in three types of tissues: normal cervical tissues, cervical intraepithelial neoplasia (CIN) I or below, CIN II or above, and cervical cancer tissues. (wikipedia.org)
  • Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved pseudopodia formation. (wikipedia.org)
  • SCT-1000 is under development for the prevention of human Papillomavirus (HPV) associated cancers such as genital wart, cervical cancer, anal cancer, head and neck cancer, vaginal cancer, adenocarcinoma and vulvar cancer. (pharmaceutical-technology.com)
Survival11
  • There was evidence that Cdc42 inhibition by AZA197 treatment suppresses proliferative and pro-survival signaling pathways via PAK1-ERK signaling and reduces colon cancer cell migration and invasion. (wikipedia.org)
  • The 5-year survival rate of lung cancer is about 4-17% [ 3 ]. (hindawi.com)
  • In this study, we determined the difference in survival of right-sided versus left-sided colorectal cancer patients after surgery and adjuvant chemotherapy. (waocp.com)
  • The survival outcome of non-metastatic colorectal adenocarcinoma was not significantly different between RCC and LCC after surgery and adjuvant chemotherapy. (waocp.com)
  • Therefore, early detection of colorectal cancer dramatically increases survival (Weir HK et al 2003). (bioresonancetherapy.com.sg)
  • Whole blood NEAT1 expression is a novel diagnostic and prognostic biomarker of overall survival in colorectal cancer. (biomedcentral.com)
  • Earlier detection of colorectal cancer (CRC) results in improved survival. (springer.com)
  • Chemotherapy is also used to improve symptoms and prolong survival in people with stage IV colon cancer. (medlineplus.gov)
  • We examined the mediating effects of health insurance on poverty-colon cancer care and survival relationships and the moderating effects of poverty on health insurance-colon cancer care and survival relationships among women and men in California. (cdc.gov)
  • A study of cancer survival in low-income areas of Toronto, Ontario, and Detroit, Michigan, during the 1980s found advantages among Canadians for common cancers including colon cancer [ 1 ]. (cdc.gov)
  • The Canadian survival advantage was systematically replicated across diverse low-income Canadian and US contexts through the 1990s [ 2 - 8 ], culminating in a recent study of colon cancer treatment accessibility and survival in Toronto, Ontario, and San Francisco, California that followed its cohorts until 2006 [ 9 ]. (cdc.gov)
Oncology7
  • Cardiff Oncology is a clinical-stage biotechnology company leveraging PLK1 inhibition, a well-validated oncology drug target, to develop novel therapies across a range of cancers. (fox59.com)
  • In terms of the goal to make precision care mainstream, the field's most boast-worthy accomplishment has been in oncology where molecularly guided strategies - using those multi-gene panels that just a few years ago were thought too complex and expensive - have made their way into most large cancer research centers and are becoming a routine part of care. (genomeweb.com)
  • Chemotherapy and medical oncology can be lifesaving for people with cancer. (bjc.org)
  • Medical oncology is a cancer treatment that uses medications to destroy cancer cells or prevent them from spreading or growing. (bjc.org)
  • Depending on the type and stage of cancer, you may need chemotherapy alone or in combination with other treatments, like radiation oncology. (bjc.org)
  • What cancers are treated with medical oncology at BJC? (bjc.org)
  • A multidisciplinary approach that includes colorectal surgery, medical oncology, and radiation oncology is required for optimal treatment of patients with rectal cancer. (medscape.com)
Polyps3
  • In the general population, the risk of developing colorectal cancer is approximately 19 percent, and it is estimated that 2 percent to 5 percent of sporadic polyps will develop into an invasive cancer (Markowitz AJ et al 1997). (bioresonancetherapy.com.sg)
  • In industrialized Western societies, both polyps and colon cancer occur more frequently due in part to diets low in fruits, vegetables, vegetable protein, and fiber (Satia-Aboutaj J et al 2003). (bioresonancetherapy.com.sg)
  • This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. (springer.com)
Histologically1
EGFR2
  • This study assessed whether an Idylla EGFR prototype assay can be reliably applied to cytological lung cancer specimens. (bmj.com)
  • 1 The recent guidelines from the College of American Pathologists (CAP), International Association for the Study of Lung Cancer (IASLC) and the Association for Molecular Pathology (AMP) recommend EGFR testing in patients with lung adenocarcinoma, regardless of sex, race, smoking history, histological grade or other clinical risk factors. (bmj.com)
Cohorts1
  • The diagnostic value of whole blood NEAT1 expression was evaluated in test ( n = 60) and validation ( n = 200) cohorts of colorectal cancer patients and normal controls (NCs). (biomedcentral.com)
Therapeutic1
  • A listing of 144 Non-Small Cell Lung Cancer clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas. (policylab.us)
Biomarker2
  • Plasma NTS has the potential to be a non-invasive biomarker for colorectal neoplasia. (springer.com)
  • Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
Hereditary1
  • and family history of some hereditary breast and ovarian cancers. (msdmanuals.com)
Diagnostic8
  • Investigators wanted to analyze the diagnostic performance of methylation-sensitive restriction enzyme digestion followed by sequencing using cell-free DNA and explore the cancer signal origin of the cancer using DNN analyses for colorectal and lung cancers. (ajmc.com)
  • The aim of this study was to analyze the diagnostic performance of MRE-Seq using cfDNA and explore the cancer signal origin (CSO) of the cancer using DNN analyses on liquid biopsy of colorectal and lung cancers. (ajmc.com)
  • We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal cancer. (biomedcentral.com)
  • In the present study, we determined the diagnostic and prognostic significance and of whole blood NEAT1 in patients with colorectal cancer. (biomedcentral.com)
  • This methodology enables the detection of alternative splicing events in complex biological samples, providing a powerful tool to identify novel diagnostic and prognostic biomarkers for cancer and other pathologies. (biomedcentral.com)
  • The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. (mdanderson.org)
  • Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. (who.int)
  • Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)
Gastrointestinal1
  • Colorectal cancer (CRC) is the most common gastrointestinal (GI) cancer . (medscape.com)
Detection3
  • Our proposed MRE-seq performance is comparable to the previous bisulfite sequencing method in accuracy of the cancer detection and classification of CSO with use of [a] relatively smaller amount of blood from a single tube collection and [requires] lower sequencing depth coverage compared to the whole genome bisulfite sequencing analysis," said the researchers. (ajmc.com)
  • Strategies for earlier detection include screening and earlier recognition of cancer in symptomatic individuals. (springer.com)
  • Both of the above rely on colonoscopy, which remains the gold standard for the detection of colorectal neoplasia. (springer.com)
Chemotherapy4
  • It has been hypothesized that targeting Cdc42 in conjunction with chemotherapy may be an effective cancer treatment strategy. (wikipedia.org)
  • The results were compared between cancer patients with or without conventional chemotherapy, and normal control group with or without Huaier treatment. (fortunejournals.com)
  • Chemotherapy involves taking medicines that kill cancer cells. (medlineplus.gov)
  • Most people with stage III colon cancer receive chemotherapy after surgery for 3 to 6 months. (medlineplus.gov)
Epithelial5
  • During embryonic stages of lung organogenesis, TGF-β1 is pivotal in epithelial-mesenchymal interaction, during alveolarization and for airway branching morphology. (springer.com)
  • It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
  • Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)
  • Colorectal cancer develops through a process involving genetic change in the epithelial cells of the colon lining. (bioresonancetherapy.com.sg)
  • In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
Clinical8
  • Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. (bvsalud.org)
  • The study was supported by Swedish governmental funding of clinical research (ALF), the Franke and Margareta Bergqvist Foundation, and the Swedish Cancer Society. (lu.se)
  • The researchers determined that the MRE-seq method was more suitable for diagnosing early cancer in liquid biopsy using a small amount of cfDNA in regular clinical testing. (ajmc.com)
  • In the long process of cancer recovery, it is as much important to recognize the improvement by each individual patient day by day, together with the results obtained by clinical examinations at the hospitals and clinics. (fortunejournals.com)
  • Our physicians, researchers and scientists participate in groundbreaking cancer research and clinical trials. (bjc.org)
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • Association and clinical implication of the USP10 and MSH2 proteins in non-small cell lung cancer. (cdc.gov)
  • Clinical Colorectal Cancer. (lu.se)
Neoplasms1
  • Invasive neoplasms of the female pelvic organs account for almost 15% of all cancers in women. (medscape.com)
Tissues3
  • We detect mutational signatures in cancer cell line exomes (where matched healthy tissues are not available) by adjusting for the confounding germline mutation spectra across ancestries. (nature.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • These large-scale high-throughput analytical methods have been applied to the identification of differential splicing events in cancer tissues [ 8 ]. (biomedcentral.com)
Methods1
  • 2010). Polycyclic aromatic hydrocarbon exposure standard mammogram form and the interactive kinase in response to estradiol in breast cancer in oesophageal tissue and risk of oesophageal threshold measurement methods. (who.int)
Primary2
  • In comparison, SATB2 and CK20 showed higher specificity, with expression in 5% and 10% of mucinous primary lung adenocarcinomas and both in 0% of TTF-1-negative non-mucinous primary lung adenocarcinomas (25-50% and 5-16%, respectively, for GPA33/CDX2/CDH17). (lu.se)
  • However, no single or combination of markers can categorically distinguish primary lung cancers from metastatic GI tract cancer. (lu.se)
Malignancy1
  • Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in the United States and in most developed countries with access to sufficient health care. (medscape.com)
Breast4
  • Expression of this gene may play a role in breast cancer. (nih.gov)
  • Interestingly, 38 and 44% decreases in the levels of the farnesylated and acylated NRAS were observed in the two breast cancer cell lines, MDA-MB-231, and MDA-MB-468, respectively, while HRAS levels showed a 36% decrease only in MDA-MB-468 cells. (oncotarget.com)
  • It is the fourth most common cancer in women after breast, lung, and colorectal cancers. (labtube.tv)
  • It is the fourth most common cancer, accounting for 7% of female cancers, following breast, lung, and colorectal cancer. (medscape.com)
Prostate11
  • Currently, we are offering human brain and prostate cancer cells. (neuromics.com)
  • We provide customized treatment for all types of prostate cancer, from early-stage to aggressive cases. (bjc.org)
  • Prostate cancer is usually adenocarcinoma. (msdmanuals.com)
  • more men die with prostate cancer than of it. (msdmanuals.com)
  • General references Prostate cancer is usually adenocarcinoma. (msdmanuals.com)
  • autopsy studies show prostate cancer in 15 to 60% of men aged 60 to 90 years old, with incidence increasing with age. (msdmanuals.com)
  • The lifetime risk of being diagnosed with prostate cancer is 1 in 6. (msdmanuals.com)
  • Hormonal influences contribute to the course of adenocarcinoma but almost certainly not to other types of prostate cancer. (msdmanuals.com)
  • The effect of testosterone supplements on the risk of prostate cancer remains controversial. (msdmanuals.com)
  • Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate-specific antigen (PSA) level: A meta-analysis. (msdmanuals.com)
  • Prostate cancer usually progresses slowly and rarely causes symptoms until advanced. (msdmanuals.com)
Systemic therapy1
  • Approximately 80% of all patients with lung cancer are considered for systemic therapy at some point during the course of their illness. (medscape.com)
Symptoms4
  • Symptoms depend on the location of cancer. (medscape.com)
  • However, many rectal cancers produce no symptoms and are discovered during digital or proctoscopic screening examinations. (medscape.com)
  • Many cases of colon cancer have no symptoms. (medlineplus.gov)
  • Through screening tests, colon cancer can be detected before symptoms develop. (medlineplus.gov)
Mutation2
  • The most common BRAF mutation leading to cancer is substitution of adenine for thymine at nucleotide 1799. (news-medical.net)
  • Recognizing pattern and rule of mutation signatures corresponding to cancer types (Front Cell Dev Biol. (shsmu.edu.cn)
Analyses1
  • Recent synthetic and exploratory analyses have suggested the potential great policy importance of such study [ 13 , 14 ] and studies of colon cancer care may be particularly instructive in such contexts for several reasons. (cdc.gov)
Bladder Cancer1
  • Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies. (who.int)